Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications

References

• Manfrão-Netto JHC, Queiroz EB, de Oliveira Junqueira AC, et al. Genetic strategies for improving hyaluronic acid production in recombinant bacterial culture. J Appl Microbiol. 2021. DOI:10.1111/jam.15242
   PubMed Web of Science ®Google Scholar
• Dovedytis M, Liu JZ, Bartlett S. Hyaluronic acid and its biomedical applications: a review. Eng Regen. 2020;1:102–113.
   Google Scholar
• Necas J, Bartosikova L, Brauner P, et al. Hyaluronic acid (hyaluronan): a review.Vet. Med. 2008;53(8):397–411.
   Google Scholar
• Schiraldi C, Gatta AL, Rosa MD. Biotechnological production and application of Hyaluronan. Biopolymers. 2010;20:387–412.
   Google Scholar
• Li C, Cao Z, Li W, et al. A review on the wide range applications of hyaluronic acid as a promising rejuvenating biomacromolecule in the treatments of bone related diseases. Int J Biol Macromol. 2020;165(Pt A):1264–1275.
   PubMedGoogle Scholar
• Snetkov P, Zakharova K, Morozkina S, et al. Hyaluronic acid: the influence of molecular weight on structural, physical, physico-chemical, and degradable properties of biopolymer. Polymers. 2020;12(8):1800.
   PubMed Web of Science ®Google Scholar
• Chen F, Ni Y, Liu B, et al. Self-crosslinking and injectable hyaluronic acid/RGD-functionalized pectin hydrogel for cartilage tissue engineering. Carbo Polym. 2017;166(15):31–44.
   PubMedGoogle Scholar
• Fiorica C, Palumbo FS, Pitarresi G, et al. Hyaluronic acid and beta cyclodextrins films for the release of corneal epithelial cells and dexamethasone. Carbo Polym. 2017;166:281–290.
   PubMed Web of Science ®Google Scholar
• Hemshekhar M, Thushara RM, Chandranayaka S, et al. Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine. Int J Biol Macromol. 2016;86:917–919.
   PubMed Web of Science ®Google Scholar
• Larrañeta E, Henry M, Irwin NJ, et al. Synthesis and characterization of hyaluronic acid hydrogels crosslinked using a solvent-free process for potential biomedical applications. Carbo Polym. 2018;181:1194–1205.
   PubMed Web of Science ®Google Scholar
• Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J. 2015;65:252–267.
   Web of Science ®Google Scholar
• Tripodo G, Trapani A, Torre ML, et al. Hyaluronic acid and its derivatives in drug delivery and imaging: recent advances and challenges. Eur J Pharm Biopharm. 2015;97(B):400–416.
   PubMedGoogle Scholar
• Tiwari S, Bahadur P. Modified hyaluronic acid based materials for biomedical applications. Int J Biol Macromol. 2019;121:556–571.
   PubMed Web of Science ®Google Scholar
• Dodero A, Williams R, Gagliardi S, et al. A micro-rheological and rheological study of biopolymers solutions: hyaluronic acid. Carbohydr Polym. 2019;203:349–355.
   PubMed Web of Science ®Google Scholar
• Deangelis PL. Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow. Appl Microbiol Biotechnol. 2012;94:295–305.
   PubMed Web of Science ®Google Scholar
• Zhong W, Pang L, Feng HH, et al. Recent advantage of hyaluronic acid for anti-cancer application: a review of “3S” transition approach. Carbohydr Polym. 2020;238:11.
   Web of Science ®Google Scholar
• Maytin EV. Hyaluronan: more than just a wrinkle filler. Glycobiology. 2016;26(6):553–559.
   PubMed Web of Science ®Google Scholar
• Huang G, Huang H. Application of hyaluronic acid as carriers in drug delivery. Drug Deliv. 2018;25(1):766–772.
   PubMed Web of Science ®Google Scholar
• Krolikoski M, Monslow J, Puré E. The CD44-HA axis and inflammation in atherosclerosis: a temporal perspective. Matrix Biol. 2019;78-79:201–218.
   PubMed Web of Science ®Google Scholar
• Voigt J, Driver VR. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials. Wound Repair Regenerat. 2012;20(3):317–331.
   PubMed Web of Science ®Google Scholar
• Pauline J, Arif AA, Lee-Sayer SSM, et al. Hyaluronan and its interactions with immune cells in the healthy and inflamed lung. Front Immunol. 2018;9:2787.
   PubMed Web of Science ®Google Scholar
• Cui Z, Liao J, Cheong N, et al. The receptor for hyaluronan-mediated motility (CD168) promotes inflammation and fibrosis after acute lung injury. Matrix Biol. 2019;78–79:255–271.
   PubMed Web of Science ®Google Scholar
• Garantziotis S, Savani RC. Hyaluronan biology: a complex balancing act of structure, function, location and context. Matrix Biol. 2019;78–79:1–10.
   PubMed Web of Science ®Google Scholar
• Yao ZY, Qin J, Gong JS, et al. Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology. Carbohyd Polym. 2021;264:118015.
   PubMed Web of Science ®Google Scholar
• Shah MV, Badle SS, Ramachandran KB. Hyaluronic acid production and molecular weight improvement by redirection of carbon flux towards its biosynthesis pathway. Biochem Eng J. 2013;80:53–60.
   Web of Science ®Google Scholar
• Mohan N, Tadi, SRR, Pavan, SS, Sivaprakasam, S. Deciphering the role of dissolved oxygen and N-acetyl glucosamine in governing higher molecular weight hyaluronic acid synthesis in Streptococcus zooepidemicuscell factory. Appl Microbiol Biotechnol. 2020;104(8):3349–3365.
   PubMed Web of Science ®Google Scholar
• Zheng Y, Cheng F, Zheng B, et al. Enhancing single-cell hyaluronic acid biosynthesis by microbial morphology engineering. Synth Syst Biotechnol. 2020;5(4):316–323.
   PubMed Web of Science ®Google Scholar
• Attia YA, Kobeasy MI, Samer M. Evaluation of magnetic nanoparticles influence on hyaluronic acid production from Streptococcus equi. Carbohydr. Polym. 2018;192:135–142.
   Web of Science ®Google Scholar
• Chong BF, Blank LM, Mclaughlin R, et al. Microbial hyaluronic acid production. Appl Microbiol Biotechnol. 2005;66:341–351.
   PubMed Web of Science ®Google Scholar
• Deangelis PL. Enzymological characterization of the Pasteurella multocida hyaluronic acid synthase. Biochem. 1996;35:9768–9771.
   PubMed Web of Science ®Google Scholar
• Vazquez JA, Montemayor MI, Fraguas J, et al. Hyaluronic acid production by Streptococcus zooepidemicus in marine by-products media from mussel processing wastewaters and tuna peptone viscera. Microb Cell Fact. 2010;9:46.
   PubMed Web of Science ®Google Scholar
• Blank LM, Mclaughlin RL, Nielsen LK. Stable production of hyaluronic acid in streptococcus zooepidemicus chemostats operated at high dilution rate. Biotechnol Bioeng. 2005;90(6):685–693.
   PubMed Web of Science ®Google Scholar
• Duan X, Yang L, Zhang X, et al. Effect of oxygen and shear stress on M of HA Px by Streptococcus zooepidemicus. J Microbiol Biotechnol. 2008;18(4):718–724.
   PubMed Web of Science ®Google Scholar
• Rangaswamy V, Jain D. An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus Biotechnol Lett. 2008;30(3):493–496.
   PubMed Web of Science ®Google Scholar
• Armstrong DC, Cooney MJ, Johns MR. Growth and amino acid requirements of hyaluronic-acid-producing Streptococcus zooepidemicus. Appl Microbiol Biotechnol. 1997;47:309–312.
   Web of Science ®Google Scholar
• Liu L, Du G, Chen J, et al. Enhanced hyaluronic acid production by a two-stage culture strategy based on the modeling of batch and fed-batch cultivation of Streptococcus zooepidemicus. Bioresour Technol. 2008;99(17):8532–8536.
   PubMed Web of Science ®Google Scholar
• Liu L, Du G, Chen J, et al. Comparative study on the influence of dissolved oxygen control approaches on the microbial hyaluronic acid production of Streptococcus zooepidemicus. Bioprocess Biosyst Eng. 2009a;32(6):755–763.
   PubMed Web of Science ®Google Scholar
• Liu L, Sun J, Xu W, et al. Modeling and optimization of microbial hyaluronic acid production by streptococcus zooepidemicus using radial basis function neural network coupling quantum-behaved particle swarm optimization algorithm. Biotechnol Prog. 2009b;25(6):1819–1825.
   PubMed Web of Science ®Google Scholar
• Chen SJ, Chen JL, Huang WC, et al. Fermentation process development for hyaluronic acid production by Streptococcus zooepidemicus ATCC 39920. Korean J Chem Eng. 2009a;26:426–432.
   Web of Science ®Google Scholar
• Marcellin E, Chen W, Nielsen LK (2009). Microbial hyaluronic acid biosynthesis. Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives. Edited by Rehm BHA. Norfolk: Caister Academic Press. 163–180.
   Google Scholar
• Huang WC, Chen SJ, Chen TL. Production of hyaluronic acid by repeated batch fermentation. Biochem Eng J. 2008;40(3):460–464.
   Web of Science ®Google Scholar
• Wang SP, Zhang JM, Wang YT, et al. Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy. Nanomed -Nanotechnol Biol Med. 2016;12(2):411–420.
   PubMed Web of Science ®Google Scholar
• Liu J, Wang Y, Li Z, et al. Efficient production of high-molecular-weight hyaluronic acid with a two-stage fermentation. RSC Adv. 2018;8(63):36167–36171.
   PubMed Web of Science ®Google Scholar
• Liu L, Liu Y, J L, et al. Microbial production of hyaluronic acid: current state, challenges, and perspectives. Microb Cell Fact. 2011;10. 1–9.
   PubMed Web of Science ®Google Scholar
• Widner B, Behr R, Von Dollen S, et al. Hyaluronic acid production in Bacillus subtilis. Appl Environ Microbiol. 2005;71(7):3747–3752.
   PubMed Web of Science ®Google Scholar
• Jing W, Deangelis PL. Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide. Glycobiology. 2000;10:883–889.
   PubMed Web of Science ®Google Scholar
• Jing W, Deangelis PL. Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers. J Biol Chem. 2004;279:42345–42349.
   PubMed Web of Science ®Google Scholar
• Mao Z, Shin HD, Chen R. A recombinant E. coli bioprocess for hyaluronan synthesis. Appl Microbiol Biotechnol. 2009;84:63–69.
   PubMed Web of Science ®Google Scholar
• Yu H, Stephanopoulos G. Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid. Metab Eng. 2008;10:24–32.
   PubMed Web of Science ®Google Scholar
• Oliveira JD, Carvalho LS, Gomes AMV, et al. Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms. Microb Cell Fact. 2016;15(1):1–20.
   PubMedGoogle Scholar
• Badri A, Raman K, Jayaraman G. Uncovering novel pathways for enhancing hyaluronan synthesis in recombinant Lactococcus lactis: Genome-scale metabolic modeling and experimental validation. Processes. 2019;7(6):343.
   Web of Science ®Google Scholar
• Jia YN, Zhu J, Chen XF, et al. Metabolic engineering of Bacillus subtilis for the efficient biosynthesis of uniform hyaluronic acid with controlled molecular weights. Bioresour Technol. 2013;132:427–431.
   PubMed Web of Science ®Google Scholar
• Chen WY, Marcellin E, Hung J, et al. Hyaluronan molecular weight is controlled by UDP-N-acetylglucosamine concentration in Streptococcus zooepidemicus. J Biol Chem. 2009b;284(27):18007–18014.
   PubMed Web of Science ®Google Scholar
• Cheng FY, Yu HM, Stephanopoulos G. Engineering Corynebacterium glutamicumfor high-titer biosynthesis of hyaluronic acid. Metabol Eng. 2019;55:276–289.
   PubMed Web of Science ®Google Scholar
• Pourzardosht N, Rasaee MJ. Improved yield of high molecular weight hyaluronic acid production in a stable strain of Streptococcus zooepidemicusvia the elimination of the hyaluronidase-encoding gene. Mol Biotechnol. 2017;59(6):192–199.
   PubMed Web of Science ®Google Scholar
• Bicudo RCS, Santana MHA. Effects of organic solvents on hyaluronic acid nanoparticles obtained by precipitation and chemical crosslinking. J Nanosci Nanotech. 2012;12(3):2849–2857.
   PubMed Web of Science ®Google Scholar
• Cowman MK, Matsuoka S. Experimental approaches to hyaluronan structure. Carbo Res. 2005;340(5):791–809.
   PubMed Web of Science ®Google Scholar
• Cheng F, Gong Q, Yu H, et al. High-titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum. Biotechnol J. 2016;11(4):574–584.
   PubMed Web of Science ®Google Scholar
• Jeong E, Shim WY, Kim JH. Metabolic engineering of Pichia pastoris for production of hyaluronic acid with high molecular weight. J Biotechnol. 2014;185:28–36.
   PubMed Web of Science ®Google Scholar
• Liu K, Catchmark JM. Bacterial cellulose/hyaluronic acid nanocomposites production through co-culturing Gluconacetobacter hansenii and Lactococcus lactis in a two-vessel circulating system. Bioresour Technol. 2019;290:121715.
   PubMed Web of Science ®Google Scholar
• Abdallah MM, Fernández N, Matias AA, et al. Hyaluronic acid and Chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. Carbohydr Polym. 2020;243:116441.
   PubMed Web of Science ®Google Scholar
• Grand View Research. hyaluronic acid raw material market size, share & trends analysis report by application (ophthalmology, orthopedics, dermatology, drug delivery), By Region, And Segment Forecasts, 2018-2024. Accessed 02 Jan 2022. Available in: <https://www.grandviewresearch.com/industry-analysis/hyaluronic-acid-ha-raw-material-market>.
   Google Scholar
• Sze JH, Brownlie JC, Love CA. Biotechnological production of hyaluronic acid: a mini review. 3 Biotech. 2016;6(1):1–9.
   PubMedGoogle Scholar
• Abdel-Mohsen AM, Hrdina R, Burgert L, et al. Green synthesis of hyaluronan fibers with silver nanoparticles. Carbohydr Polym. 2012;89(2):411–422.
   PubMed Web of Science ®Google Scholar
• Abdel-Mohsen AM, Pavliňák D, Čileková M, et al. Electrospinning of hyaluronan/polyvinyl alcohol in presence of in-situ silver nanoparticles: preparation and characterization. Int J Biol Macromol. 2019;139:730–739.
   PubMed Web of Science ®Google Scholar
• Xu X, Jha AK, Harrington DA, et al. Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks. Soft Matter. 2012;8(12):3280–3294.
   PubMed Web of Science ®Google Scholar
• Allison DD, Grande-Allen KJ. Review. Hyaluronan: a powerful tissue engineering tool. Tissue Eng. 2006;12(8):2131–2140.
   PubMedGoogle Scholar
• Fagien S, Cassuto D. Reconstituted injectable hyaluronic acid: expanded applications in facial aesthetics and additional thoughts on the mechanism of action in cosmetic medicine. Plast Reconstr Surg. 2012;30(1):208–217.
   Google Scholar
• Kogan G, Soltés L, Stern R, et al. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett. 2007;29(1):17–25.
   PubMed Web of Science ®Google Scholar
• Jagannath S, Ramachandran KB. Influence of competing metabolic processes on the molecular weight of hyaluronic acid synthesized by Streptococcus zooepidemicus. Biochem Eng J. 2010;48(2):148–158.
   Web of Science ®Google Scholar
• Tammi RH, Kultti A, Kosma VM, et al. Hyaluronan in human tumors: pathobiological and prognostic messages from cell-associated and stromalhyaluronan. Semin Cancer Biol. 2008;18(4):288–295.
   PubMed Web of Science ®Google Scholar
• Grand View Research. Hyaluronic acid market size, share & trends analysis report by application (dermal fillers, osteoarthritis (single injection, three injection, five injection), Ophthalmic, Vesicoureteral Reflux), By Region, And Segment Forecasts, 2020-2027. Accessed 04 Jan 2022. Available in: <https://www.grandviewresearch.com/industry-analysis/hyaluronic-acid-market>.
   Google Scholar
• Mikulic MUS. Hyaluronic acid raw material market size 2014-2024, by application Hyaluronic acid raw material market size in the U. S from 2014 to 2024, by application. Statista. 2018;212:1–2.
   Google Scholar
• Wong S. Total sales volume of the hyaluronic acid raw materials in China from 2014 to 2018. Statista. 2020;2018:2020–2021.
   Google Scholar
• Blatter G, Jacquinet JC. The use of 2-deoxy-2-trichloroacetamido-D-glucopyranose derivatives in syntheses of hyaluronic acid-related tetra-, hexa-, and octa-saccharides having a methyl β-D-glucopyranosiduronic acid at the reducing end. Carbohydr Res. 1996;288(1):109–125.
   PubMedGoogle Scholar
• Lu X, Kamat MN, Huang L, et al. Chemical synthesis of a hyaluronic acid decasaccharide. J Organic Chem. 2009;74(20):7608–7617.
   PubMed Web of Science ®Google Scholar
• Cerminati S, Leroux M, Anselmi P, et al. Low cost and sustainable hyaluronic acid production in a manufacturing platform based on Bacillus subtilis 3NA strain. Appl Microbiol Biotechnol. 2021;105(8):3075–3086.
   PubMed Web of Science ®Google Scholar
• Ferreira RG, Azzoni AR, Santana MHA, et al. Techno-economic analysis of a hyaluronic acid production process utilizing streptococcal fermentation. Processes. 2021;9(2):1–16.
   Web of Science ®Google Scholar
• Torres-Acosta MA, Castaneda-Aponte HM, Mora-Galvez LM, et al. Comparative economic analysis between endogenous and recombinant production of hyaluronic acid. Front Bioeng Biotechnol. 2021;9:1–14.
   Web of Science ®Google Scholar
• Wang Y, Wu H, Jiang XR, et al. Engineering Escherichia coli for enhanced production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in larger cellular space. Metabol Eng. 2014;25:183–193.
   PubMed Web of Science ®Google Scholar
• Bi E, Lutkenhaus J. Cell-division inhibitors SULA and MINCD prevent formation of the FTSZ ring. J Bacteriol. 1993;175(4):1118–1125.
   PubMed Web of Science ®Google Scholar
• Jiang XR, Chen GQ. Morphology engineering of bacteria for bio-production. Biotechnol Adv. 2016;34(4):435–440.
   PubMed Web of Science ®Google Scholar
• Tan D, Wu Q, Chen JC, et al. Engineering HalomonasTD01 for the low-cost production of polyhydroxyalkanoates. Metabol Eng. 2014;26:34–47.
   PubMed Web of Science ®Google Scholar
• Yue HT, Ling C, Yang T, et al. A seawater-based open and continuous process for polyhydroxyalkanoates production by recombinant HalomonascampaniensisLS21 grown in mixed substrates. Biotechnol Biofuel. 2014;7:12.
   PubMed Web of Science ®Google Scholar
• Barcelos MCS, Vespermann KAC, Pelissari FM, et al. Current status of biotechnological production and applications of microbial exopolysaccharides. Crit Rev Food Sci Nutri. 2020;60(9):1475–1495.
   PubMed Web of Science ®Google Scholar
• Tammaro O, Costagliola Di Polidoro A, Romano E, et al. A microfluidic platform to design multimodal peg - crosslinked hyaluronic acid nanoparticles (PEG-cHANPs) for diagnostic applications. Sci Rep. 2020;10:6028.
   PubMed Web of Science ®Google Scholar
• Amado IR, Vázquez JA, Pastrana L, et al. Microbial production of hyaluronic acid from agro-industrial by-products: molasses and corn steep liquor. Biochem Eng J. 2021;117:181–187.
   Google Scholar
• Balazs EA. Ultrapure hyaluronic acid and the use thereof. U S Appl. 1977;844(19):833.
   Google Scholar
• Chahuki FF, Aminzadeh S, Jafarian V, et al. Hyaluronic acid production enhancement via genetically modification and culture medium optimization in Lactobacillus acidophilus. Int J Biol Macromol. 2019;121:870–881.
   PubMed Web of Science ®Google Scholar
• Chong BF, Nielsen LK. Aerobic cultivation of Streptococcus zooepidemicus and the role of NADH oxidase. Biochem Eng J. 2003;16:153–162.
   Web of Science ®Google Scholar
• Im JH, Song JM, Kang JH, et al. Optimization of medium components for high-molecular-weight hyaluronic acid production by Streptococcus sp. ID9102 via a statistical approach. J Indust Microbiol Biotechnol. 2009;36(11):1337–1344.
   PubMed Web of Science ®Google Scholar
• Li J, Qiao M, Ji Y, et al. Chemical, enzymatic and biological synthesis of hyaluronic acids. Int J Biol Macromol. 2020;152:199–206.
   PubMed Web of Science ®Google Scholar
• Wang J, Liu D, Guan S, et al. Hyaluronic acid-modified liposomal honokiol nanocarrier: enhance anti-metastasis and antitumor efficacy against breast cancer. Carbohydr Polym. 2020;235:115981.
   PubMed Web of Science ®Google Scholar
• Westbrook AW, Ren X, Oh J, et al. Metabolic engineering to enhance heterologous production of hyaluronic acid in Bacillus subtilis. Metabol Eng. 2018;47:401–413.
   PubMed Web of Science ®Google Scholar
• Zhang LP, Huang H, Wang H, et al. Rapid evolution of hyaluronan synthase to improve hyaluronan production and molecular mass in Bacillus subtilis. Biotechnol Lett. 2016a;38(12):2103–2108.
   PubMed Web of Science ®Google Scholar
• Buffa R, Nesporova K, Basarabova I, et al. Synthesis and study of branched hyaluronic acid with potential anticancer activity. Carbohydr Polym. 2019;223:115047.
   PubMed Web of Science ®Google Scholar
• Ferreira RG , Azzoni, AR, Santana, MHA, Petrides, D. Techno-Economic Analysis of a Hyaluronic Acid Production Process Utilizing Streptococcal Fermentation. Processes . 2021;9:241. https://doi.org/10.3390/pr9020241.
   Web of Science ®Google Scholar
• Kim JH, Moon MJ, Kim DY, et al. Hyaluronic acid-based nanomaterials for cancer therapy. Polymers. 2018;10(10):15.
   Web of Science ®Google Scholar
• Pedron S, Wolter GL, Chen JWE, et al. Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens. Biomaterials. 2019;219:119371.
   PubMed Web of Science ®Google Scholar
• Zhang YL, Luo KL, Zhao QS, et al. Genetic and biochemical characterization of genes involved in hyaluronic acid synthesis in Streptococcus zooepidemicus. Appl Microbiol Biotechnol. 2016b;100(8):3611–3620.
   PubMed Web of Science ®Google Scholar
• Zhu J, Tang X, Jia Y, et al. Applications and delivery mechanisms of hyaluronic acid used for topical/transdermal delivery – a review. Int J Pharm. 2020;578:119127.
   PubMed Web of Science ®Google Scholar