Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells

References

• Sun SJ, Wu XP, Song HL, et al. Baicalin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation, oxidative stress and P38MAPK pathway in rat. Int J Clin Exp Med. 2015;8:22063–22072.
   PubMed Web of Science ®Google Scholar
• Gerczuk PZ, Kloner RA. An update on cardioprotection: a review of the latest adjunctive therapies to limit myocardial infarction size in clinical trials. J Am Coll Cardiol. 2012;59:969–978.
   PubMed Web of Science ®Google Scholar
• Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet. 2003;361:13–20.
   PubMed Web of Science ®Google Scholar
• Hsu YW, Cortinez LI, Robertson KM, et al. Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology. 2004;101:1066–1076.
   PubMed Web of Science ®Google Scholar
• Xie MY, Hou LJ. Dexmedetomidine down-regulates lncRNA MALAT1 to attenuate myocardial ischemia reperfusion-induced injury by increasing miR-346. Int J Cardiol. 2021;334:104.
   PubMed Web of Science ®Google Scholar
• Zhang X, Xu M, Che X, et al. Dexmedetomidine reduces myocardial ischemia-reperfusion injury in rats through PI3K/AKT/GSK-3beta signaling pathway. Minerva Cardioangiol. 2020;68:58–59.
   PubMed Web of Science ®Google Scholar
• Kumar MM, Goyal R. LncRNA as a therapeutic target for angiogenesis. Curr Top Med Chem. 2017;17:1750–1757.
   PubMed Web of Science ®Google Scholar
• Hou J, Zhou C, Long H, et al. Long noncoding RNAs: novel molecules in cardiovascular biology, disease and regeneration. Exp Mol Pathol. 2016;100:493–501.
   PubMed Web of Science ®Google Scholar
• Shen Y, Gao X, Tan W, et al. STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ. Gene. 2018;666:64–71.
   PubMed Web of Science ®Google Scholar
• Sun T, Cheng YT, Yan LX, et al. LncRNA MALAT1 knockdown alleviates myocardial apoptosis in rats with myocardial ischemia-reperfusion through activating PI3K/AKT signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23:10523–10531.
   PubMed Web of Science ®Google Scholar
• Hao L, Wang J, Bi SJ, et al. Upregulation of long noncoding RNA FGD5-AS1 Ameliorates myocardial ischemia/Reperfusion injury via MicroRNA-106a-5p and MicroRNA-106b-5p. J Cardiovasc Pharmacol. 2021;78:e45–e54.
   PubMed Web of Science ®Google Scholar
• Liu X, Hua Y, Hu M, et al. Knockdown of lncRNA Abhd11os attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis in cardiomyocytes. J Cardiovasc Pharmacol. 2021. DOI:10.1097/FJC.0000000000001074.
   Web of Science ®Google Scholar
• Zhang C, Li XY, Luo ZZ, et al. Upregulation of LINC00982 inhibits cell proliferation and promotes cell apoptosis by regulating the activity of PI3K/AKT signaling pathway in renal cancer. Eur Rev Med Pharmacol Sci. 2019;23:1443–1450.
   PubMed Web of Science ®Google Scholar
• Hao W, Lin F, Shi H, et al. Long non-coding RNA OIP5-AS1 regulates smoke-related chronic obstructive pulmonary disease via targeting micro RNA −410-3p/IL-13. Bioengineered. 2021;12:11664–11676.
   PubMed Web of Science ®Google Scholar
• Liu J, Jiang M, Deng S, et al. miR-93-5p-containing exosomes treatment attenuates acute myocardial infarction-induced myocardial damage. Molecular Therapy - Nucleic Acids. 2018;11:103–115.
   Google Scholar
• Zhang Y, Zhang Y, Wang S, et al. SP1-induced lncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) aggravates glioma progression via the miR-515-5p/Superoxide dismutase 2 (SOD2) axis. Bioengineered. 2021;12:2299–2310.
   PubMed Web of Science ®Google Scholar
• Vilahur G, Gutierrez M, Casani L, et al. P2Y12 antagonists and cardiac repair post-myocardial infarction: global and regional heart function analysis and molecular assessments in pigs. Cardiovasc Res. 2018;114:1860–1870.
   PubMedGoogle Scholar
• Song J, Du J, Tan X, et al. Dexmedetomidine protects the heart against ischemia reperfusion injury via regulation of the bradykinin receptors. Eur J Pharmacol. 2021;911:174493.
   PubMed Web of Science ®Google Scholar
• Huang Y. Exosomal lncRNAs from mesenchymal stem cells as the novel modulators to cardiovascular disease. Stem Cell Res Ther. 2020;11:315.
   PubMed Web of Science ®Google Scholar
• Jiang X, Ning Q. The emerging roles of long noncoding RNAs in common cardiovascular diseases. Hypertens Res. 2015;38:375–379.
   PubMed Web of Science ®Google Scholar
• Liu Z, Jin W, Han M, et al. [Silencing LncRNA SNHG7 alleviates hypoxia/reoxygenation-induced cardiomyocyte damage by regulating the expression of miR-181b-5p]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2021;38:812–817.
   PubMedGoogle Scholar
• Mo Y, Wu H, Zheng X, et al. LncRNA CHRF aggravates myocardial ischemia/reperfusion injury by enhancing autophagy via modulation of the miR-182-5p/ATG7 pathway. J Biochem Mol Toxicol. 2021;35:e22709.
   PubMed Web of Science ®Google Scholar
• Xu D, Yu J, Zhuang S, et al. Overexpression of long non-coding RNA LINC00982 suppresses cell proliferation and tumor growth of papillary thyroid carcinoma through PI3K-ATK signaling pathway. Biosci Rep. 2019;39. DOI:10.1042/BSR20191210
   Web of Science ®Google Scholar
• Niu L, Zhao Y, Liu S, et al. Silencing of long noncoding RNA HRIM protects against myocardial ischemia/reperfusion injury via inhibition of NFkappaB signaling. Mol Med Rep. 2020;22:5454–5462.
   PubMed Web of Science ®Google Scholar
• Huang F, Zhao JL, Wang L, et al. miR-148a-3p mediates notch signaling to promote the differentiation and M1 activation of macrophages. Front Immunol. 2017;8:1327.
   PubMed Web of Science ®Google Scholar
• Yao H, Han X, Han X. The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway. Am J Cardiovasc Drugs. 2014;14:433–442.
   PubMed Web of Science ®Google Scholar
• Shen D, Chen R, Zhang L, et al. Sulodexide attenuates endoplasmic reticulum stress induced by myocardial ischaemia/reperfusion by activating the PI3K/Akt pathway. J Cell Mol Med. 2019;23:5063–5075.
   PubMed Web of Science ®Google Scholar
• Zhang BF, Jiang H, Chen J, et al. Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway. Int Immunopharmacol. 2019;73:98–107.
   PubMed Web of Science ®Google Scholar