U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells

References

• Saluja TS, Iyer J, Singh SK. Leiomyosarcoma: prognostic outline of a rare head and neck malignancy. Oral Oncol. 2019;95:100–105.
   PubMed Web of Science ®Google Scholar
• Farid M, Ngeow J. Sarcomas associated with genetic cancer predisposition syndromes: a review. Oncologist. 2016;21(8):1002–1013.
   PubMed Web of Science ®Google Scholar
• Chen J, Liang T, Cen J, et al. A seven-gene signature and the C-C motif chemokine receptor family genes are the sarcoma-related immune genes. Bioengineered. 2021;12(1):7616–7630.
   PubMed Web of Science ®Google Scholar
• George S, Serrano C, Hensley ML, et al. Soft tissue and uterine leiomyosarcoma. J Clin Oncol. 2018;36(2):144–150.
   PubMed Web of Science ®Google Scholar
• Millevoi S, Loulergue C, Dettwiler S, et al. An interaction between U2AF 65 and CF I(m) links the splicing and 3’ end processing machineries. EMBO J. 2006;25(20):4854–4864.
   PubMed Web of Science ®Google Scholar
• David CJ, Boyne AR, Millhouse SR, et al. The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. Genes Dev. 2011;25(9):972–983.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Zhou J, Zhao J, et al. The U2AF2 /circRNA ARF1/miR-342–3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells. J Exp Clin Cancer Res. 2020;39(1):182.
   PubMed Web of Science ®Google Scholar
• Zhang P, Feng S, Liu G, et al. CD82 suppresses CD44 alternative splicing-dependent melanoma metastasis by mediating U2AF2 ubiquitination and degradation. Oncogene. 2016;35(38):5056–5069.
   PubMed Web of Science ®Google Scholar
• Li J, Cheng D, Zhu M, et al. OTUB2 stabilizes U2AF2 to promote the warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Theranostics. 2019;9(1):179–195.
   PubMed Web of Science ®Google Scholar
• Mao L, Dauchy RT, Blask DE, et al. Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma. J Pineal Res. 2016;60(2):167–177.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Wang L, Cao L, et al. Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA. Bioengineered. 2021;12(2):9965–9975.
   PubMed Web of Science ®Google Scholar
• Fornes O, Castro-Mondragon JA, Khan A, et al. JASPAR 2020: update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2020;48(D1):D87–D92.
   PubMed Web of Science ®Google Scholar
• Uhlen M, Oksvold P, Fagerberg L, et al. Towards a knowledge-based Human Protein Atlas. Nat Biotechnol. 2010;28(12):1248–1250.
   PubMed Web of Science ®Google Scholar
• Chudasama P, Mughal SS, Sanders MA, et al. Integrative genomic and transcriptomic analysis of leiomyosarcoma. Nat Commun. 2018;9(1):144.
   PubMedGoogle Scholar
• Yang C, Wu J, Liu X, et al. Circadian rhythm is disrupted by znf704 in breast carcinogenesis. Cancer Res. 2020;80(19):4114–4128.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Mahmood T, Yang PC. Western blot: technique, theory, and trouble shooting. N Am J Med Sci. 2012;4(9):429–434.
   PubMedGoogle Scholar
• Stoddart MJ. Cell viability assays: introduction. Methods Mol Biol. 2011;740:1–6.
   PubMedGoogle Scholar
• Tan S, Zhang M, Shi X, et al. CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression. J Exp Clin Cancer Res. 2021;40(1):85.
   PubMed Web of Science ®Google Scholar
• Iuso A, Repp B, Biagosch C, et al. Assessing mitochondrial bioenergetics in isolated mitochondria from various mouse tissues using seahorse XF96 analyzer. Methods Mol Biol. 2017;1567:217–230.
   PubMedGoogle Scholar
• Olympus Life Science Europa Gmb H. Flexible applications for olympus digital microscope camera. Biotechnol J. 2008;3(1):31.
   PubMedGoogle Scholar
• Sherf B, Navarro S, Hannah R, et al. Dual-Luciferase TM reporter assay: an advanced co-reporter technology integrating firefly and renilla luciferase assays. Promega Notes. 1996;57.
   Google Scholar
• Gade P, Kalvakolanu DV. Chromatin immunoprecipitation assay as a tool for analyzing transcription factor activity. Methods Mol Biol. 2012;809:85–104.
   PubMedGoogle Scholar
• Kim TK. T test as a parametric statistic. Korean J Anesthesiol. 2015;68(6):540–546.
   PubMed Web of Science ®Google Scholar
• Porporato PE, Dhup S, Dadhich RK, et al. Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol. 2011;2:49.
   PubMed Web of Science ®Google Scholar
• Drucker E, Holzer K, Pusch S, et al. Karyopherin alpha2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer. Cell Commun Signal. 2019;17(1):159.
   PubMed Web of Science ®Google Scholar
• Yasui K, Okamoto H, Arii S, et al. Association of over-expressed TFDP1 with progression of hepatocellular carcinomas. J Hum Genet. 2003;48(12):609–613.
   PubMed Web of Science ®Google Scholar
• Zhan W, Wang W, Han T, et al. COMMD9 promotes TFDP1/E2F1 transcriptional activity via interaction with TFDP1 in non-small cell lung cancer. Cell Signal. 2017;30:59–66.
   PubMed Web of Science ®Google Scholar
• Wilkinson ME, Charenton C, Nagai K. RNA Splicing by the spliceosome. Annu Rev Biochem. 2020;89:359–388.
   PubMed Web of Science ®Google Scholar
• Bonnal SC, Lopez-Oreja I, Valcarcel J. Roles and mechanisms of alternative splicing in cancer - implications for care. Nat Rev Clin Oncol. 2020;17(8):457–474.
   PubMed Web of Science ®Google Scholar
• Yang H, Beutler B, Zhang D. Emerging roles of spliceosome in cancer and immunity. Protein Cell. 2021. DOI:10.1007/s13238-021-00856-5
   Web of Science ®Google Scholar
• Di C, Syafrizayanti, Zhang Q, et al. Function, clinical application, and strategies of Pre-mRNA splicing in cancer. Cell Death Differ. 2019;26(7):1181–1194.
   PubMed Web of Science ®Google Scholar
• Maji D, Glasser E, Henderson S, et al. Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing. J Biol Chem. 2020;295(50):17148–17157.
   PubMed Web of Science ®Google Scholar
• Laliotis GI, Chavdoula E, Paraskevopoulou MD, et al. AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing. Nat Commun. 2021;12(1):4624.
   PubMed Web of Science ®Google Scholar
• Liberti MV, Locasale JW. The warburg effect: how does it benefit cancer cells? Trends Biochem Sci. 2016;41(3):211–218.
   PubMed Web of Science ®Google Scholar
• Duncan L, Shay C, Teng Y. PGK1: an essential player in modulating tumor metabolism. Methods Mol Biol. 2022;2343:57–70.
   PubMedGoogle Scholar
• Zhang S, Qin YP, Kuang JM, et al. Proteomic investigation of resistance to chemotherapy drugs in osteosarcoma. Technol Health Care. 2018;26(1):145–153.
   PubMed Web of Science ®Google Scholar
• Duan Z, Lamendola DE, Yusuf RZ, et al. Overexpression of human phosphoglycerate kinase 1 (PGK1) induces a multidrug resistance phenotype. Anticancer Res. 2002;22(4):1933–1941.
   PubMed Web of Science ®Google Scholar
• Glasser E, Agrawal AA, Jenkins JL, et al. Cancer-Associated mutations mapped on high-resolution structures of the U2AF2 RNA recognition motifs. Biochemistry. 2017;56(36):4757–4761.
   PubMed Web of Science ®Google Scholar
• Pellicelli M, Picard C, Wang D, et al. E2F1 and TFDP1 regulate PITX1 expression in normal and osteoarthritic articular chondrocytes. PLoS One. 2016;11(11):e0165951.
   PubMed Web of Science ®Google Scholar
• Chen YL, Uen YH, Li CF, et al. The E2F transcription factor 1 transactives stathmin 1 in hepatocellular carcinoma. Ann Surg Oncol. 2013;20(12):4041–4054.
   PubMed Web of Science ®Google Scholar
• Wang CI, Chen YY, Wang CL, et al. Yu CJ. mTOR regulates proteasomal degradation and Dp1/E2F1- mediated transcription of KPNA2 in lung cancer cells. Oncotarget. 2016;7(18):25432–25442.
   PubMedGoogle Scholar