Proteomics identifies new potential therapeutic targets of diabetic retinopathy

References

• Flaxel CJ, Adelman RA, Bailey ST, et al. Diabetic retinopathy preferred practice pattern(R). Ophthalmology. 2020;127:66–145.
   PubMed Web of Science ®Google Scholar
• American Diabetes A. Standards of medical care in diabetes–2012. Diabetes Care. 2012;35(Suppl 1):S11–63.
   PubMed Web of Science ®Google Scholar
• Fong DS, Aiello L, Gardner TW, et al. Diabetic retinopathy. Diabetes Care. 2003;26(Suppl 1):S99–S102.
   PubMed Web of Science ®Google Scholar
• Ma Y, Yang C, Tao Y, et al. Recent technological developments in proteomics shed new light on translational research on diabetic microangiopathy. FEBS J. 2013;280(22):5668–5681.
   PubMed Web of Science ®Google Scholar
• Xia T, Rizzolo LJ. Effects of diabetic retinopathy on the barrier functions of the retinal pigment epithelium. Vision Res. 2017;139:72–81.
   PubMed Web of Science ®Google Scholar
• Erickson KK, Sundstrom JM, Antonetti DA. Vascular permeability in ocular disease and the role of tight junctions. Angiogenesis. 2007;10(2):103–117.
   PubMedGoogle Scholar
• Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85(3):845–881.
   PubMed Web of Science ®Google Scholar
• Reichhart N, Strauss O. Ion channels and transporters of the retinal pigment epithelium. Exp Eye Res. 2014;126:27–37.
   PubMed Web of Science ®Google Scholar
• Tso MO, Cunha-Vaz JG, Shih CY, et al. Clinicopathologic study of blood-retinal barrier in experimental diabetes mellitus. Arch Ophthalmol. 1980;98(11):2032–2040.
   PubMedGoogle Scholar
• Tarchick MJ, Bassiri P, Rohwer RM, et al. Early functional and morphologic abnormalities in the diabetic Nyx nob mouse retina. Invest Ophthalmol Vis Sci. 2016;57(7):3496–3508.
   PubMed Web of Science ®Google Scholar
• Blair NP, Tso MO, Dodge JT. Pathologic studies of the blood–retinal barrier in the spontaneously diabetic BB rat. Invest Ophthalmol Vis Sci. 1984;25(3):302–311.
   PubMed Web of Science ®Google Scholar
• Wallow IH. Posterior and anterior permeability defects? Morphologic observations on streptozotocin-treated rats. Invest Ophthalmol Vis Sci. 1983;24(9):1259–1268.
   PubMed Web of Science ®Google Scholar
• Pautler EL, Ennis SR. The effect of induced diabetes on the electroretinogram components of the pigmented rat. Invest Ophthalmol Vis Sci. 1980;19(6):702–705.
   PubMed Web of Science ®Google Scholar
• Samuels IS, Bell BA, Pereira A, et al. Early retinal pigment epithelium dysfunction is concomitant with hyperglycemia in mouse models of type 1 and type 2 diabetes. J Neurophysiol. 2015;113(4):1085–1099.
   PubMed Web of Science ®Google Scholar
• Hao LN, Zhang YQ, Shen YH, et al. Effect of puerarin on retinal pigment epithelial cells apoptosis induced partly by peroxynitrite via Fas/FasL pathway. Int J Ophthalmol. 2010;3(4):283–287.
   PubMed Web of Science ®Google Scholar
• Kim DI, Park MJ, Choi JH, et al. Hyperglycemia-induced GLP-1R downregulation causes RPE cell apoptosis. Int J Biochem Cell Biol. 2015;59:41–51.
   PubMed Web of Science ®Google Scholar
• Feng L, Liang L, Zhang S, et al. HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway. Autophagy. 2021;18(2):320–339.
   PubMed Web of Science ®Google Scholar
• Zhou HR, Ma XF, Lin WJ, et al. Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy. Front Pharmacol. 2020;11:589114.
   PubMed Web of Science ®Google Scholar
• Xie H, Zhang C, Liu D, et al. Erythropoietin protects the inner blood-retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy. Diabetologia. 2021;64(1):211–225.
   PubMed Web of Science ®Google Scholar
• Klaassen I, Van Noorden CJ, Schlingemann RO. Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. Prog Retin Eye Res. 2013;34:19–48.
   PubMed Web of Science ®Google Scholar
• Ahern-Rindell AJ, Murnane RD, Prieur DJ. Beta-galactosidase activity in fibroblasts and tissues from sheep with a lysosomal storage disease. Biochem Genet. 1988;26(11–12):733–746.
   PubMed Web of Science ®Google Scholar
• Bajaj L, Lotfi P, Pal R, et al. Lysosome biogenesis in health and disease. J Neurochem. 2019;148(5):573–589.
   PubMed Web of Science ®Google Scholar
• Henry AG, Aghamohammadzadeh S, Samaroo H, et al. Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression. Hum Mol Genet. 2015;24(21):6013–6028.
   PubMed Web of Science ®Google Scholar
• Carroll B, Dunlop EA. The lysosome: a crucial hub for AMPK and mTORC1 signalling. Biochem J. 2017;474(9):1453–1466.
   PubMed Web of Science ®Google Scholar
• Devi TS, Yumnamcha T, Yao F, et al. TXNIP mediates high glucose-induced mitophagic flux and lysosome enlargement in human retinal pigment epithelial cells. Biol Open. 2019;8(4).
   PubMed Web of Science ®Google Scholar
• Konig J, Ott C, Hugo M, et al. Mitochondrial contribution to lipofuscin formation. Redox Biol. 2017;11:673–681.
   PubMed Web of Science ®Google Scholar
• Terman A, Kurz T. Lysosomal iron, iron chelation, and cell death. Antioxid Redox Signal. 2013;18(8):888–898.
   PubMed Web of Science ®Google Scholar
• Zhou XY, Luo Y, Zhu YM, et al. Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes. Cell Death Dis. 2017;8(2):e2618.
   PubMedGoogle Scholar
• Du Y, Veenstra A, Palczewski K, et al. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013;110(41):16586–16591.
   PubMed Web of Science ®Google Scholar
• Fu Z, Lofqvist CA, Liegl R, et al. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018;10(1):76–90.
   PubMed Web of Science ®Google Scholar
• Tonade D, Liu H, Palczewski K, et al. Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017;60(10):2111–2120.
   PubMed Web of Science ®Google Scholar
• Devi TS, Somayajulu M, Kowluru RA, et al. TXNIP regulates mitophagy in retinal Muller cells under high-glucose conditions: implications for diabetic retinopathy. Cell Death Dis. 2017;8(5):e2777.
   PubMedGoogle Scholar
• Singh LP, Devi TS, Yumnamcha T. The Role of Txnip in Mitophagy Dysregulation and Inflammasome Activation in Diabetic Retinopathy: a New Perspective. JOJ Ophthalmol. 2017;4(4).
   PubMedGoogle Scholar
• Trist BG, Davies KM, Cottam V, et al. Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson’s disease brain. Acta Neuropathol. 2017;134(1):113–127.
   PubMed Web of Science ®Google Scholar
• Van Damme P, Robberecht W, Van Den Bosch L. Modelling amyotrophic lateral sclerosis: progress and possibilities. Dis Model Mech. 2017;10(5):537–549.
   PubMed Web of Science ®Google Scholar
• LaBaer J, Garrett MD, Stevenson LF, et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 1997;11(7):847–862.
   PubMed Web of Science ®Google Scholar
• Matsuura I, Denissova NG, Wang G, et al. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature. 2004;430(6996):226–231.
   PubMed Web of Science ®Google Scholar