CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis

References

• Travis WD, W.D. Travis, Pathology of lung cancer. Clin Chest Med. 2002;23(1):65–81.
   PubMed Web of Science ®Google Scholar
• Ye Y-T, Zhong W, Sun P, et al. Apoptosis induced by the methanol extract of salvia miltiorrhiza bunge in non-small cell lung cancer through PTEN-mediated inhibition of PI3K/Akt pathway. J Ethnopharmacol. 2017;200:107–116.
   PubMed Web of Science ®Google Scholar
• Rotow J, Bivona TG. Understanding and targeting resistance mechanisms in NSCLC. Nat Rev Cancer. 2017;17(11):637.
   PubMed Web of Science ®Google Scholar
• Castellanos E, Feld E, Horn L. Driven by mutations: the predictive value of mutation subtype in EGFR-mutated non–small cell lung cancer. J Thorac Oncol. 2017;12(4):612–623.
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Andersen MS, Stagsted LV, et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675–691.
   PubMed Web of Science ®Google Scholar
• Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014;56(1):55–66.
   PubMed Web of Science ®Google Scholar
• Zhang W, Qian S, Yang G, et al. MicroRNA-199 suppresses cell proliferation, migration and invasion by downregulating RGS17 in hepatocellular carcinoma. Gene. 2018;659:22–28.
   PubMed Web of Science ®Google Scholar
• Ma H-B, Yao Y-N, Yu -J-J, et al. Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Am J Transl Res. 2018;10(2):592.
   PubMed Web of Science ®Google Scholar
• Li H, Jin X, Liu B, et al. 11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer. BMC Cancer. 2019;19(1):1–14.
   PubMed Web of Science ®Google Scholar
• Gaffo E, Boldrin E, Dal Molin A, et al. Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia. Sci Rep. 2019;9(1):1–12.
   PubMedGoogle Scholar
• Poliseno L, Salmena L, Zhang J, et al. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature. 2010;465(7301):1033–1038.
   PubMed Web of Science ®Google Scholar
• Conte F, Fiscon G, Sibilio P, et al. An overview of the computational models dealing with the regulatory ceRNA mechanism and ceRNA deregulation in cancer. Methods Mol Biol. 2021;2324:149–164.
   PubMedGoogle Scholar
• Liang Z, Guo W, Fang S, et al. CircRNAs: emerging bladder cancer biomarkers and targets. Front Oncol. 2021;10:2991.
   Web of Science ®Google Scholar
• Wang Y, Liu J, Ma J, et al. Exosomal circRNAs: biogenesis, effect and application in human diseases. Mol Cancer. 2019;18(1):1–10.
   PubMedGoogle Scholar
• Han B, Chao J, Yao H. Circular RNA and its mechanisms in disease: from the bench to the clinic. Pharmacol Ther. 2018;187:31–44.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yang T, Xiao J. Circular RNAs: promising biomarkers for human diseases. EBioMedicine. 2018;34:267–274.
   PubMed Web of Science ®Google Scholar
• Xiao Z, Chen X, Lu X, et al. Accuracy evaluation of circular RNA in diagnosing lung cancer in a Chinese population. Dis Markers. 2019;2019 :7485389.
   PubMedGoogle Scholar
• Tansey WP. Mammalian MYC proteins and cancer. Hindawi Publ Corp New J Sci. 2014(757534):27. Article ID
   Google Scholar
• Luo Y, Ma J, Liu F, et al. Diagnostic value of exosomal circMYC in radioresistant nasopharyngeal carcinoma. Head Neck. 2020;42(12):3702–3711.
   PubMed Web of Science ®Google Scholar
• Luo Y, Gui R. Circulating exosomal circmyc is associated with recurrence and bortezomib resistance in patients with multiple myeloma. Turkish J Hematol. 2020;37(4):248.
   PubMed Web of Science ®Google Scholar
• Jin C, Dong D, Yang Z, et al. CircMYC regulates glycolysis and cell proliferation in melanoma. Cell Biochem Biophys. 2020;78(1):77–88.
   PubMed Web of Science ®Google Scholar
• Luo Y, Ma J, Liu F, et al. Diagnostic value of exosomal circMYC in radioresistant nasopharyngeal carcinoma. Head Neck. 2020;42(12):3702–3711.
   PubMed Web of Science ®Google Scholar
• Suzuki H, Tsukahara T. A view of pre-mRNA splicing from RNase R resistant RNAs. Int J Mol Sci. 2014;15(6):9331–9342.
   PubMed Web of Science ®Google Scholar
• Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333–338.
   PubMed Web of Science ®Google Scholar
• Zhang P, Zhang X-O, Jiang T, et al. Comprehensive identification of alternative back-splicing in human tissue transcriptomes. Nucleic Acids Res. 2020;48(4):1779–1789.
   PubMed Web of Science ®Google Scholar
• Gong B, Xu J, Tong W. Landscape of circRNAs across 11 organs and 4 ages in Fischer 344 rats. Chem Res Toxicol. 2020;34(2): 240–264.
   PubMed Web of Science ®Google Scholar
• Patop IL, Wüst S, Kadener S. Past, present, and future of circ RNA s. EMBO J. 2019;38(16):e100836.
   PubMed Web of Science ®Google Scholar
• Zong L, Sun Q, Zhang H, et al. Increased expression of circRNA_102231 in lung cancer and its clinical significance. Biomed Pharmacother. 2018;102:639–644.
   PubMed Web of Science ®Google Scholar
• Liu Y, Yang C, Cao C, et al. Hsa_circ_RNA_0011780 represses the proliferation and metastasis of non-small cell lung cancer by decreasing FBXW7 via targeting miR-544a. Onco Targets Ther. 2020;13:745.
   PubMed Web of Science ®Google Scholar
• Zhao D, Liu H, Liu H, et al. Downregulated expression of hsa_circ_0037515 and hsa_circ_0037516 as novel biomarkers for non-small cell lung cancer. Am J Transl Res. 2020;12(1):162.
   PubMed Web of Science ®Google Scholar
• Tong S. Circular RNA SMARCA5 may serve as a tumor suppressor in non‐small cell lung cancer. J Clin Lab Anal. 2020;34(5):e23195.
   PubMed Web of Science ®Google Scholar
• Wang L, Liang Y, Mao Q, et al. Circular RNA circ CRIM 1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)-182/miR-93-leukemia inhibitory factor receptor pathway. Cancer Sci. 2019;110(9):2960.
   PubMed Web of Science ®Google Scholar
• Wan L, Zhang L, Fan K, et al. Circular RNA-ITCH suppresses lung cancer proliferation via inhibiting the Wnt/β-catenin pathway. Biomed Res Int. 2016;2016:1579490.
   PubMed Web of Science ®Google Scholar
• Yao J, Xu G, Zhu L, et al. circGFRA1 enhances NSCLC progression by sponging miR-188-3p. Onco Targets Ther. 2020;13:549.
   PubMed Web of Science ®Google Scholar
• Qin H, Liu J, Du Z, et al. Circular RNA hsa_circ_0012673 facilitates lung cancer cell proliferation and invasion via miR-320a/LIMK18521 axis. Eur Rev Med Pharmacol Sci. 2020;24(4):1841–1852.
   PubMed Web of Science ®Google Scholar
• Li X, Yang B, Ren H, et al. Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p. Cell Death Dis. 2019;10(12):1–12.
   Google Scholar
• Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384–388.
   PubMed Web of Science ®Google Scholar
• Rossbach O. Artificial circular RNA sponges targeting microRNAs as a novel tool in molecular biology, molecular therapy. Nucleic acids. 2019;17:452.
   Google Scholar
• Xu Z-Y, Peng J, Shi Z-Z, et al., Silencing linc00662 inhibits cell proliferation and colony formation of lung cancer cells via regulating miR-145-5p/PAFAH1B2 axis. Biochem Cell Biol. 2020;99(3): 330–338.
   PubMedGoogle Scholar
• Pei X, Chen S-W, Long X, et al. circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis. Aging (Albany NY). 2020;12(13):13038.
   PubMedGoogle Scholar
• Shi W, Gao Z, Song J, et al., Silence of FOXD2-AS1 inhibited the proliferation and invasion of esophagus cells by regulating miR-145-5p/CDK6 axis, Histology and histopathology, (2020) 18232.
   Google Scholar
• Lei C, Du F, Sun L, et al. miR-143 and miR-145 inhibit gastric cancer cell migration and metastasis by suppressing MYO6. Cell Death Dis. 2017;8(10):e3101–e3101.
   PubMed Web of Science ®Google Scholar
• Zeinali T, Mansoori B, Mohammadi A, et al. Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasis. Biomed Pharmacother. 2019;109:195–207.
   PubMed Web of Science ®Google Scholar
• Chen GM, Zheng AJ, Cai J, et al. Retracted: microRNA-145-3p inhibits non-small cell lung cancer cell migration and invasion by targeting PDK1 via the mTOR signaling pathway. J Cell Biochem. 2018;119(1):885–895.
   PubMed Web of Science ®Google Scholar
• Han L, Sheng B, Zeng Q, et al. Correlation between MMP2 expression in lung cancer tissues and clinical parameters: a retrospective clinical analysis. BMC Pulm Med. 2020;20(1):1–9.
   PubMed Web of Science ®Google Scholar
• Iniesta P, Morán A, De Juan C, et al. Biological and clinical significance of MMP-2, MMP-9, TIMP-1 and TIMP-2 in non-small cell lung cancer. Oncol Rep. 2007;17(1):217–223.
   PubMed Web of Science ®Google Scholar
• Guo C-B, Wang S, Deng C, et al. Relationship between matrix metalloproteinase 2 and lung cancer progression. Mol Diagn Ther. 2007;11(3):183–192.
   PubMed Web of Science ®Google Scholar
• Zaytseva O, Kim N-H, Quinn LM. MYC in brain development and cancer. Int J Mol Sci. 2020;21(20):7742.
   PubMed Web of Science ®Google Scholar
• Schulze A, Oshi M, Endo I, et al. MYC targets scores are associated with cancer aggressiveness and poor survival in ER-positive primary and metastatic breast cancer. Int J Mol Sci. 2020;21(21):8127.
   PubMed Web of Science ®Google Scholar