Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-κB) pathway

References

• Raghu G, Chen SY, Hou Q, et al. Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18-64 years old. Eur Respir J. 2016;48:179–186.
   PubMed Web of Science ®Google Scholar
• Torrisi SE, Pavone M, Vancheri A, et al. When to start and when to stop antifibrotic therapies. Eur Respir Rev. 2017;26:170053. doi:10.1183/16000617.0053-2017.
   PubMed Web of Science ®Google Scholar
• Raghu G, Rochwerg B, Zhang Y, et al. An official ATS/ERS/JRS/ALAT clinical practice guideline: treatment of idiopathic pulmonary fibrosis. An update of the 2011 clinical practice guideline. Am J Respir Crit Care Med. 2015;192:e3–19.
   PubMed Web of Science ®Google Scholar
• Somogyi V, Chaudhuri N, Torrisi SE, et al. The therapy of idiopathic pulmonary fibrosis: what is next? Eur Respir Rev. 2019;28:190021. doi:10.1183/16000617.0021-2019.
   PubMed Web of Science ®Google Scholar
• Ruan H, Dong LQ. Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol. 2016;8:101–109.
   PubMed Web of Science ®Google Scholar
• Lee B, Shao J. Adiponectin and energy homeostasis. Rev Endocr Metab Disord. 2014;15:149–156.
   PubMed Web of Science ®Google Scholar
• López-Jaramillo P, Gómez-Arbeláez D, López-López J, et al. The role of leptin/adiponectin ratio in metabolic syndrome and diabetes. Horm Mol Biol Clin Investig. 2014;18:37–45.
   PubMedGoogle Scholar
• Kim JY, Barua S, Jeong YJ, et al. Adiponectin: the Potential regulator and therapeutic target of obesity and Alzheimer’s disease. Int J Mol Sci. 2020;21:6419. doi:10.3390/ijms21176419.
   PubMedGoogle Scholar
• Przybyciński J, Dziedziejko V, Puchałowicz K, et al. Adiponectin in chronic kidney disease. Int J Mol Sci. 2020;21:9375. doi:10.3390/ijms21249375.
   PubMedGoogle Scholar
• Szumilas K, Szumilas P, Słuczanowska-Głąbowska S, et al. Role of adiponectin in the pathogenesis of rheumatoid arthritis. Int J Mol Sci. 2020;21:8265. doi:10.3390/ijms21218265.
   PubMed Web of Science ®Google Scholar
• Karnati HK, Panigrahi MK, Li Y, et al. Adiponectin as a potential therapeutic target for prostate cancer. Curr Pharm Des. 2017;23:4170–4179.
   PubMed Web of Science ®Google Scholar
• Soumya D, Swetha D, Momin S, et al. Role of adiponectin in cervical cancer. Curr Drug Metab. 2019;20:1033–1038.
   PubMed Web of Science ®Google Scholar
• Wang ZV, Scherer PE. Adiponectin, the past two decades. J Mol Cell Biol. 2016;8(2):93–100.
   PubMed Web of Science ®Google Scholar
• Enomoto N, Oyama Y, Yasui H, et al. Analysis of serum adiponectin and leptin in patients with acute exacerbation of idiopathic pulmonary fibrosis. Scientific Reports. 2019;9(1):10484.
   PubMedGoogle Scholar
• d’Alessandro M, Bergantini L, Refini RM, et al. Adiponectin and leptin levels in idiopathic pulmonary fibrosis: a new method for BAL and serum assessment. Immunobiology. 2020;225:151997.
   PubMed Web of Science ®Google Scholar
• Yao R, Cao Y, He YR, et al. Adiponectin attenuates lung fibroblasts activation and pulmonary fibrosis induced by paraquat. PLoS One. 2015;10:e0125169.
   PubMed Web of Science ®Google Scholar
• Rong Y, He Y, Zhi Z, et al. Protective effect of adiponectin on paraquat-induced pulmonary fibrosis in mice. Mol Cell Toxicol. 2015;11:247–255.
   Web of Science ®Google Scholar
• Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86.
   PubMed Web of Science ®Google Scholar
• Liu M, Ning X, Li R, et al. Signalling pathways involved in hypoxia-induced renal fibrosis. J Cell Mol Med. 2017;21:1248–1259.
   PubMed Web of Science ®Google Scholar
• Lan HY. Diverse roles of TGF-β/Smads in renal fibrosis and inflammation. Int J Biol Sci. 2011;7:1056–1067.
   PubMed Web of Science ®Google Scholar
• Gong J, Gong H, Liu Y, et al. Calcipotriol attenuates liver fibrosis through the inhibition of vitamin D receptor-mediated NF-κB signaling pathway. Bioengineered. 2022;13:2658–2672.
   PubMed Web of Science ®Google Scholar
• Kim JY, Jeon S, Yoo YJ, et al. The Hsp27-Mediated IkBα-NFκB signaling axis promotes radiation-induced lung fibrosis. Clin Cancer Res off J Am Assoc Cancer Res. 2019;25:5364–5375.
   PubMed Web of Science ®Google Scholar
• Dong Z, Zhuang Q, Ye X, et al. Adiponectin inhibits NLRP3 inflammasome activation in nonalcoholic steatohepatitis via AMPK-JNK/ErK1/2-NFκB/ROS signaling pathways. Front Med (Lausanne). 2020;7:546445.
   PubMed Web of Science ®Google Scholar
• Jian M, Kwan JS, Bunting M, et al. Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway. J Neuroinflammation. 2019;16:110. doi:10.1186/s12974-019-1492-6.
   PubMed Web of Science ®Google Scholar
• Lodyga M, Hinz B. TGF-β1 - A truly transforming growth factor in fibrosis and immunity. Semin Cell Dev Biol. 2020;101:123–139.
   PubMed Web of Science ®Google Scholar
• Choudhury M, Yin X, Schaefbauer KJ, et al. SIRT7-mediated modulation of glutaminase 1 regulates TGF-β-induced pulmonary fibrosis. FASEB J. 2020;34:8920–8940.
   PubMed Web of Science ®Google Scholar
• Andugulapati SB, Gourishetti K, Tirunavalli SK, et al. Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-β mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo systems. Phytomedicine. 2020;78:153298.
   PubMed Web of Science ®Google Scholar
• Sun L, Zhu M. Exosomal miRNA Let-7 from menstrual blood-derived endometrial stem cells alleviates pulmonary fibrosis through regulating mitochondrial DNA damage. Oxid Med Cell Longev. 2019;2019:4506303. doi:10.1155/2019/4506303.
   PubMed Web of Science ®Google Scholar
• Yamanishi H, Imai N, Suehisa E, et al. Determination of leukocyte counts in cerebrospinal fluid with a disposable plastic hemocytometer. J Clin Lab Anal. 2007;21:282–285.
   PubMed Web of Science ®Google Scholar
• Mori N, Yamada Y, Ikeda S, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood. 2002;100:1828–1834.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Jiao H, Wu Y, et al. P120-catenin regulates pulmonary fibrosis and TGF-β induced lung fibroblast differentiation. Life Sci. 2019;230:35–44.
   PubMed Web of Science ®Google Scholar
• Liu DH, Cui W, Chen Q, et al. Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? Scand J Clin Lab Invest. 2011;71:593–597.
   PubMed Web of Science ®Google Scholar
• Hoshino T, Kato S, Oka N, et al. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med. 2007;176:49–62.
   PubMed Web of Science ®Google Scholar
• Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1:a001651.
   PubMed Web of Science ®Google Scholar
• Liu T, De Los Santos FG, Phan SH. The bleomycin model of pulmonary fibrosis. Methods Mol Biol. 2017;1627:27–42.
   PubMedGoogle Scholar
• Steele MP, Schwartz DA. Molecular mechanisms in progressive idiopathic pulmonary fibrosis. Annu Rev Med. 2013;64:265–276.
   PubMed Web of Science ®Google Scholar
• Huang C, Xiao X, Yang Y, et al. MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation. J Biol Chem. 2017;292:16420–16439.
   PubMed Web of Science ®Google Scholar
• Luo L, Li J, Liu H, et al. Adiponectin is involved in connective tissue growth factor-induced proliferation, migration and overproduction of the extracellular matrix in keloid fibroblasts. Int J Mol Sci. 2017;18:1044. doi:10.3390/ijms18051044.
   PubMed Web of Science ®Google Scholar
• Xiao-jun C, Min F, Liang C, et al. Expression and role of adiponectin receptor 1 in lipopolysaccharide-induced proliferation of cultured rat adventitial fibroblasts. Cell Biol Int. 2010;34:163–169.
   PubMed Web of Science ®Google Scholar
• Cai XJ, Chen L, Li L, et al. Adiponectin inhibits lipopolysaccharide-induced adventitial fibroblast migration and transition to myofibroblasts via AdipoR1-AMPK-iNOS pathway. Mol Endocrinol (Baltimore, Md). 2010;24:218–228.
   PubMedGoogle Scholar
• Heukels P, Moor CC, von der Thüsen JH, et al. Inflammation and immunity in IPF pathogenesis and treatment. Respir Med. 2019;147:79–91.
   PubMed Web of Science ®Google Scholar
• Della Latta V, Cabiati M, Burchielli S, et al. Lung inflammation after bleomycin treatment in mice: selection of an accurate normalization strategy for gene expression analysis in an ex-vivo and in-vitro model. Int J Biochem Cell Biol. 2017;88:145–154.
   PubMed Web of Science ®Google Scholar
• Mackinnon AC, Gibbons MA, Farnworth SL, et al. Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012;185:537–546.
   PubMed Web of Science ®Google Scholar
• Amarsaikhan N, Tsoggerel A, Hug C, et al. The metabolic cytokine adiponectin inhibits inflammatory lung pathology in invasive aspergillosis. J Immunol. 2019;203:956–963. doi:10.4049/jimmunol.1900174.
   PubMed Web of Science ®Google Scholar
• Mitchell S, Vargas J. Signaling via the NFκB system. Wiley Interdiscip Rev Syst Biol Med. 2016;8:227–241. doi:10.1002/wsbm.1331.
   PubMed Web of Science ®Google Scholar
• Liu C, Yuan X, Tao L, et al. Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-κB and TGF-β1 signaling pathways. BMC Complement Altern Med. 2015;15:201.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yang H, Su X, et al. SREBP2 promotes the viability, proliferation, and migration and inhibits apoptosis in TGF-β1-induced airway smooth muscle cells by regulating TLR2/NF-κB/NFATc1/ABCA1 regulatory network. Bioengineered. 2022;13:3137–3147.
   PubMed Web of Science ®Google Scholar
• Wang X, Chen Q, Pu H, et al. Adiponectin improves NF-κB-mediated inflammation and abates atherosclerosis progression in apolipoprotein E-deficient mice. Lipids Health Dis. 2016;15:33.
   PubMed Web of Science ®Google Scholar
• Chen G, Huang L, Wu X, et al. Adiponectin inhibits osteoclastogenesis by suppressing NF-κB and p38 signaling pathways. Biochem Biophys Res Commun. 2018;503:2075–2082.
   PubMed Web of Science ®Google Scholar
• Dikmen K, Bostanci H, Gobut H, et al. Recombinant adiponectin inhibits inflammation processes via NF-kB pathway in acute pancreatitis. Bratisl Lek Listy. 2018;119:619–624.
   PubMed Web of Science ®Google Scholar