Suppression of lncRNA Gm47283 attenuates myocardial infarction via miR-706/ Ptgs2/ferroptosis axis

References

• Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135:e146–e603.
   PubMed Web of Science ®Google Scholar
• Petrie MC, Jhund PS, Connolly E, et al. High-dose intravenous iron reduces myocardial infarction in patients on haemodialysis. Cardiovasc Res. 2021. DOI:10.1093/cvr/cvab317.
   PubMedGoogle Scholar
• Qin YY, Huang XR, Zhang J, et al. Neuropeptide Y attenuates cardiac remodeling and deterioration of function following myocardial infarction. Mol Ther. 2021;30(2):881–897.
   Web of Science ®Google Scholar
• Wu X, Wang L, Wang K, et al. ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity. Mol Ther. 2021;30(1):400–414.
   Web of Science ®Google Scholar
• Sun G, Shen JF, Wei XF, et al. Circular RNA Foxo3 relieves myocardial ischemia/Reperfusion injury by suppressing autophagy via inhibiting HMGB1 by repressing KAT7 in myocardial infarction. J Inflamm Res. 2021;14:6397–6407.
   PubMed Web of Science ®Google Scholar
• Janbandhu V, Tallapragada V, Patrick R, et al. Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction . Cell Stem Cell; 2021;29(2):281–297.
   Google Scholar
• Li Y, Chen X, Jin R, et al. Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Sci Adv. 2021;7(9):eabd6740.
   Web of Science ®Google Scholar
• Sun B, Liu S, Hao R, et al. RGD-PEG-PLA delivers MiR-133 to infarct lesions of acute myocardial infarction model rats for cardiac protection. Pharmaceutics. 2020;12(6):575.
   Web of Science ®Google Scholar
• Zhang Y, Jiao L, Sun L, et al. LncRNA ZFAS1 as a SERCA2a inhibitor to cause intracellular Ca(2+) overload and contractile dysfunction in a mouse model of myocardial infarction. Circ Res. 2018;122:1354–1368.
   PubMed Web of Science ®Google Scholar
• Wei L, Sun J, Zhang N, et al. Novel implications of MicroRNAs, long non-coding RNAs and circular RNAs in drug resistance of esophageal cancer. Front Cell Dev Biol. 2021;9:764313.
   PubMed Web of Science ®Google Scholar
• Song C, Qi H, Liu Y, et al. Inhibition of lncRNA Gm15834 attenuates autophagy-mediated myocardial hypertrophy via the miR-30b-3p/ULK1 axis in mice. Mol Ther. 2021;29:1120–1137.
   PubMed Web of Science ®Google Scholar
• Chen G, Li H, Li X, et al. Loss of long non-coding RNA CRRL promotes cardiomyocyte regeneration and improves cardiac repair by functioning as a competing endogenous RNA. J Mol Cell Cardiol. 2018;122:152–164.
   PubMed Web of Science ®Google Scholar
• Wang K, Liu CY, Zhou LY, et al. APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. Nat Commun. 2015;6:6779.
   PubMed Web of Science ®Google Scholar
• Hu H, Wu J, Li D, et al. Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis. Biomed Pharmacother. 2018;106:738–746.
   PubMed Web of Science ®Google Scholar
• Wu X, Iroegbu CD, Peng J, et al. Cell death and exosomes regulation after myocardial infarction and ischemia-reperfusion. Front Cell Dev Biol. 2021;9:673677.
   PubMed Web of Science ®Google Scholar
• Luo MY, Su JH, Gong SX, et al. Ferroptosis: new dawn for overcoming the cardio-cerebrovascular diseases. Front Cell Dev Biol. 2021;9:733908.
   PubMed Web of Science ®Google Scholar
• Wang K, Li Z, Sun Y, et al. Dapagliflozin improves cardiac function, remodeling, myocardial apoptosis, and inflammatory cytokines in mice with myocardial infarction. J Cardiovasc Transl Res. 2021. DOI:10.1007/s12265-021-10192-y.
   Web of Science ®Google Scholar
• Zhou L, Sun J, Gu L, et al. Programmed cell death: complex regulatory networks in cardiovascular disease. Front Cell Dev Biol. 2021;9:794879.
   PubMed Web of Science ®Google Scholar
• Demuynck R, Efimova I, Naessens F, et al. Immunogenic ferroptosis and where to find it? J Immunother Cancer. 2021;9:e003430.
   PubMed Web of Science ®Google Scholar
• Chen Z, Yan Y, Qi C, et al. The role of ferroptosis in cardiovascular disease and its therapeutic significance. Front Cardiovasc Med. 2021;8:733229.
   PubMed Web of Science ®Google Scholar
• Liang C, Zhang X, Yang M, et al. Recent progress in ferroptosis inducers for cancer therapy. Adv Mater. 2019;31:e1904197.
   PubMed Web of Science ®Google Scholar
• Wang W, Green M, Choi JE, et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270–274.
   PubMed Web of Science ®Google Scholar
• Mahoney-Sanchez L, Bouchaoui H, Ayton S, et al. Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease. Prog Neurobiol. 2021;196:101890.
   PubMed Web of Science ®Google Scholar
• Alim I, Caulfield JT, Chen Y, et al. Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell. 2019;177:1262–79 e25.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Nastou KC, et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 2021;49:D605–D12.
   PubMed Web of Science ®Google Scholar
• Agarwal V, Bell GW, Nam JW, et al. Predicting effective microRNA target sites in mammalian mRNAs. Elife. 2015;4:e05005.
   Web of Science ®Google Scholar
• Gao RF, Li X, Xiang HY, et al. The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice. Int Immunopharmacol. 2021;90:107133.
   PubMed Web of Science ®Google Scholar
• Dang Z, Su S, Jin G, et al. Tsantan Sumtang attenuated chronic hypoxia-induced right ventricular structure remodeling and fibrosis by equilibrating local ACE-AngII-AT1R/ACE2-Ang1-7-Mas axis in rat. J Ethnopharmacol. 2020;250:112470.
   PubMed Web of Science ®Google Scholar
• Shi P, Li M, Song C, et al. Neutrophil-like cell membrane-coated siRNA of lncRNA AABR07017145.1 therapy for cardiac hypertrophy via inhibiting ferroptosis of CMECs. Mol Ther Nucleic Acids. 2022;27:16–36.
   PubMedGoogle Scholar
• Wang M, Xin Y, Cao H, et al. Recent advances in mesenchymal stem cell membrane-coated nanoparticles for enhanced drug delivery. Biomater Sci. 2021;9:1088–1103.
   PubMed Web of Science ®Google Scholar
• Armstrong AW. Do TNF inhibitors reduce the risk of myocardial infarction in psoriasis patients? JAMA. 2013;309:2043–2044.
   PubMed Web of Science ®Google Scholar
• Somasuntharam I, Yehl K, Carroll SL, et al. Knockdown of TNF-alpha by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction. Biomaterials. 2016;83:12–22.
   PubMed Web of Science ®Google Scholar
• Ge ZW, Zhu XL, Wang BC, et al. MicroRNA-26b relieves inflammatory response and myocardial remodeling of mice with myocardial infarction by suppression of MAPK pathway through binding to PTGS2. Int J Cardiol. 2019;280:152–159.
   PubMed Web of Science ®Google Scholar
• Zhao Z, Qu F, Liu R, et al. Differential expression of miR-142-3p protects cardiomyocytes from myocardial ischemia-reperfusion via TLR4/NFkB axis. J Cell Biochem. 2019. doi:10.1002/jcb.29506.
   Web of Science ®Google Scholar
• Zhang M, Jiang Y, Guo X, et al. Long non-coding RNA cardiac hypertrophy-associated regulator governs cardiac hypertrophy via regulating miR-20b and the downstream PTEN/AKT pathway. J Cell Mol Med. 2019;23:7685–7698.
   PubMed Web of Science ®Google Scholar
• Thomson DW, Dinger ME. Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet. 2016;17:272–283.
   PubMed Web of Science ®Google Scholar
• Jens M, Rajewsky N. Competition between target sites of regulators shapes post-transcriptional gene regulation. Nat Rev Genet. 2015;16:113–126.
   PubMed Web of Science ®Google Scholar
• Yin R, Guo D, Zhang S, et al. miR-706 inhibits the oxidative stress-induced activation of PKCalpha/TAOK1 in liver fibrogenesis. Sci Rep. 2016;6:37509.
   PubMed Web of Science ®Google Scholar
• Roy S, Khanna S, Hussain SR, et al. MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res. 2009;82:21–29.
   PubMed Web of Science ®Google Scholar
• Dong S, Cheng Y, Yang J, et al. MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J Biol Chem. 2009;284:29514–29525.
   PubMed Web of Science ®Google Scholar
• Chen C, Chen J, Wang Y, et al. Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance. J Biol Chem. 2021;296:100187.
   PubMed Web of Science ®Google Scholar
• Zhang H, Deng T, Liu R, et al. CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. Mol Cancer. 2020;19:43.
   PubMed Web of Science ®Google Scholar
• Friedmann Angeli JP, Schneider M, Proneth B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16:1180–1191.
   PubMed Web of Science ®Google Scholar
• Whitehead KA, Langer R, Anderson DG. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov. 2009;8:129–138.
   PubMed Web of Science ®Google Scholar
• Kanasty R, Dorkin JR, Vegas A, et al. Delivery materials for siRNA therapeutics. Nat Mater. 2013;12:967–977.
   PubMed Web of Science ®Google Scholar