Angiotensin-converting enzyme 2 inhibits inflammation and apoptosis in high glucose-stimulated microvascular endothelial cell damage by regulating the JAK2/STAT3 signaling pathway

References

• Li Y, Yao Z, Yue W, et al. Reusable, non-invasive, and ultrafast radio frequency biosensor based on optimized integrated passive device fabrication process for quantitative detection of glucose levels. Sensors. 2020;20(6):1565.
   Web of Science ®Google Scholar
• Hurlow JJ, Humphreys GJ, Bowling FL, et al. Diabetic foot infection: a critical complication. Int Wound J. 2018;15(5):814–821.
   PubMed Web of Science ®Google Scholar
• Qiu Y, Zhang C, Zhang G, et al. Endothelial progenitor cells in cardiovascular diseases. Aging medicine. 2018;1(2):204–208
   Google Scholar
• Knapp M, Tu X, Wu R. Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy. Acta Pharmacol Sin. 2019;40(1):1–8.
   PubMed Web of Science ®Google Scholar
• Ding X, Yao W, Zhu J, et al. Resveratrol attenuates high glucose-induced vascular endothelial cell injury by activating the e2f3 pathway. Biomed Res Int. 2020;2020:6173618.
   PubMed Web of Science ®Google Scholar
• Nakagami H, Kaneda Y, Ogihara T, et al. Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. Curr Diabetes Rev. 2005;1(1):59–63.
   PubMedGoogle Scholar
• Eelen G, de Zeeuw P, Simons M, et al. Endothelial cell metabolism in normal and diseased vasculature. Circ Res. 2015;116(7):1231–1244.
   PubMed Web of Science ®Google Scholar
• Pena Silva RA, Chu Y, Miller JD, et al. Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke. 2012;43(12):3358–3363.
   PubMed Web of Science ®Google Scholar
• Lin Z, Chen Y, Zhang W, et al. RNA interference shows interactions between mouse brainstem angiotensin AT 1 receptors and angiotensin-converting enzyme 2. Exp Physiol. 2008;93(5):676–684.
   PubMed Web of Science ®Google Scholar
• Wong DW, Oudit GY, Reich H, et al. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol. 2007;171:438–451.
   PubMed Web of Science ®Google Scholar
• Duan Y, Beli E, Li Calzi S, et al. Loss of angiotensin-converting enzyme 2 exacerbates diabetic retinopathy by promoting bone marrow dysfunction. Stem Cells. 2018;36(9):1430–1440.
   PubMed Web of Science ®Google Scholar
• Ye EA, Steinle JJ. miR-146a attenuates inflammatory pathways mediated by TLR4/NF-kappaB and TNFalpha to protect primary human retinal microvascular endothelial cells grown in high glucose. Mediators Inflamm. 2016;2016:3958453.
   PubMed Web of Science ®Google Scholar
• Kamal K, Du W, Mills I, et al. Antiproliferative effect of elevated glucose in human microvascular endothelial cells. J Cell Biochem. 1998;71(4):491–501.
   PubMed Web of Science ®Google Scholar
• Chen K, Zhao XL, Li LB, et al. miR-503/Apelin-12 mediates high glucose-induced microvascular endothelial cells injury via JNK and p38MAPK signaling pathway. Regener Ther. 2020;14:111–118.
   PubMed Web of Science ®Google Scholar
• Xu F, Liu Y, Zhu X, et al. Protective effects and mechanisms of vaccarin on vascular endothelial dysfunction in diabetic angiopathy. Int J Mol Sci. 2019;20(18):4587.
   PubMed Web of Science ®Google Scholar
• Lee CH, Shieh YS, Hsiao FC, et al. High glucose induces human endothelial dysfunction through an Axl-dependent mechanism. Cardiovasc Diabetol. 2014;13(1):53.
   PubMedGoogle Scholar
• Amin MM, Rafiei N, Poursafa P, et al. Association of benzene exposure with insulin resistance, SOD, and MDA as markers of oxidative stress in children and adolescents. Environ. Sci. Pollut. Res. Int. 2018;25(34):34046–34052
   Google Scholar
• Cui ZT, Liu JP, Wei WL. The effects of tanshinone IIA on hypoxia/reoxygenation-induced myocardial microvascular endothelial cell apoptosis in rats via the JAK2/STAT3 signaling pathway. Biomed Pharmacother. 2016;83:1116–1126.
   PubMed Web of Science ®Google Scholar
• Wu L, Tan JL, Wang ZH, et al. ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca(2+) overload and contractile dysfunction via the JAK2/STAT3 pathway. J Mol Cell Cardiol. 2015;81:150–161.
   PubMed Web of Science ®Google Scholar
• Li L, Li M, Li Y, et al. Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-kappaB and JAK2-STAT3 pathways in the aging cardiomyocytes. Cell Biosci. 2016;6(1):26.
   PubMedGoogle Scholar
• Hu TY, Li LM, Pan YZ. CTRP3 inhibits high glucose-induced human glomerular mesangial cell dysfunction. J Cell Biochem. 2019;120(4):5729–5736.
   PubMed Web of Science ®Google Scholar
• Yang M, Tian M, Zhang X, et al. Role of the JAK2/STAT3 signaling pathway in the pathogenesis of type 2 diabetes mellitus with macrovascular complications. Oncotarget. 2017;8(57):96958–96969.
   PubMedGoogle Scholar
• Cosentino F, Eto M, De Paolis P, et al. High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation. 2003;107(7):1017–1023.
   PubMed Web of Science ®Google Scholar
• Lotfy M, Adeghate J, Kalasz H, et al. Chronic complications of diabetes mellitus: a mini review. Curr Diabetes Rev. 2017;13(1):3–10.
   PubMed Web of Science ®Google Scholar
• Yan R, Zhang Y, Li Y, et al. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020;367(6485):1444–1448.
   PubMed Web of Science ®Google Scholar
• Patel VB, Zhong JC, Grant MB, et al. Role of the ACE2/Angiotensin 1-7 axis of the renin-angiotensin system in heart failure. Circ Res. 2016;118(8):1313–1326.
   PubMed Web of Science ®Google Scholar
• Lai L, Chen J, Wang N, et al. MiRNA-30e mediated cardioprotection of ACE2 in rats with Doxorubicin-induced heart failure through inhibiting cardiomyocytes autophagy. Life Sci. 2017;169:69–75.
   PubMed Web of Science ®Google Scholar
• Zhang R, Su H, Ma X, et al. MiRNA let-7b promotes the development of hypoxic pulmonary hypertension by targeting ACE2. Am J Physiol Lung Cell Mol Physiol. 2019;316(3):L547–L557.
   PubMed Web of Science ®Google Scholar
• Verma A, Shan Z, Lei B, et al. ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Mol Ther. 2012;20(1):28–36.
   PubMed Web of Science ®Google Scholar
• Xie W, Wu D, Ren Y, et al. OIP5-AS1 attenuates microangiopathy in diabetic mouse by regulating miR-200b/ACE2. World Neurosurg. 2020;139:e52–e60.
   PubMed Web of Science ®Google Scholar
• Duan W, Yang Y, Yan J, et al. The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway. Basic Res Cardiol. 2012;107(3):263.
   PubMed Web of Science ®Google Scholar
• Qi QR, Yang ZM. Regulation and function of signal transducer and activator of transcription 3. World J. Biol. Chem. 2014;5(2):231–239
   Google Scholar
• Sun M, Bu W, Li Y, et al. Danzhi Jiangtang Capsule ameliorates kidney injury via inhibition of the JAK-STAT signaling pathway and increased antioxidant capacity in STZ-induced diabetic nephropathy rats. Biosci Trends. 2019;12(6):595–604.
   PubMed Web of Science ®Google Scholar
• Xiao F, Li L, Fu JS, et al. Regulation of the miR-19b-mediated SOCS6-JAK2/STAT3 pathway by lncRNA MEG3 is involved in high glucose-induced apoptosis in hRMECs. Biosci Rep. 2020;40(7). doi: 10.1042/BSR20194370.
   Google Scholar