Ibuprofen promotes p75 neurotrophin receptor expression through modifying promoter methylation and N6-methyladenosine-RNA-methylation in human gastric cancer cells

References

• Hung W-C. Anti-metastatic action of non-steroidal anti-inflammatory drugs. Kaohsiung J Med Sci. 2008;24(8):392–397.
   PubMed Web of Science ®Google Scholar
• Wechter WJ, Kantoci D, Murray ED, et al. R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer. Cancer Res. 1997;57(19):4316–4324.
   PubMed Web of Science ®Google Scholar
• Wechter WJ, Leipold DD, Murray ED, et al. E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse. Cancer Res. 2000;60(8):2203–2208.
   PubMed Web of Science ®Google Scholar
• Jin H, Wang Z, Liu L, et al. R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. Mol Pharm. 2010;7(1):156–168.
   PubMedGoogle Scholar
• Kang H-K, Lee E, Pyo H, et al. Cyclooxygenase-independent down-regulation of multidrug resistance-associated protein-1 expression by celecoxib in human lung cancer cells. Mol Cancer Ther. 2005;4(9):1358–1363.
   PubMed Web of Science ®Google Scholar
• Matos P, Jordan P. Beyond COX-inhibition: ‘side-effects’ of ibuprofen on neoplastic development and progression. Curr Pharm Des. 2015;21(21):2978–2982.
   PubMed Web of Science ®Google Scholar
• Heuer JG, Fatemie-Nainie S, Wheeler EF, et al. Structure and developmental expression of the chicken NGF receptor. Dev Biol. 1990;137(2):287–304.
   PubMed Web of Science ®Google Scholar
• Wislet S, Vandervelden G, Rogister B. From neural crest development to cancer and vice versa: how p75 and (Pro)neurotrophins could act on cell migration and invasion? Front Mol Neurosci. 2018;11:244.
   PubMed Web of Science ®Google Scholar
• Zanin JP, Battiato NL, Rovasio RA. Neurotrophic factor NT-3 displays a non-canonical cell guidance signaling function for cephalic neural crest cells. Eur J Cell Biol. 2013;92(8–9):264–279.
   PubMed Web of Science ®Google Scholar
• Vega-Lopez GA, Cerrizuela S, Aybar MJ. Trunk neural crest cells: formation, migration and beyond. Int J Dev Biol. 2017;61:1–2.
   PubMed Web of Science ®Google Scholar
• Marchetti D, Aucoin R, Blust J, et al. p75 neurotrophin receptor functions as a survival receptor in brain-metastatic melanoma cells. J Cell Biochem. 2004;91(1):206–215.
   PubMed Web of Science ®Google Scholar
• Khwaja F, Allen J, Lynch J, et al. Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein. Cancer Res. 2004;64(17):6207–6213.
   PubMed Web of Science ®Google Scholar
• Jin H, Pan Y, He L, et al. p75 neurotrophin receptor inhibits invasion and metastasis of gastric cancer. Mol Cancer Res. 2007;5(5):423–433.
   PubMed Web of Science ®Google Scholar
• Woo -H-H, Chambers SK. Human ALKBH3-induced mA demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells. Biochim Biophys Acta Gene Regul Mech. 2019;1862(1):35–46.
   PubMed Web of Science ®Google Scholar
• Fu Y, Dominissini D, Rechavi G, et al. Gene expression regulation mediated through reversible m6A RNA methylation. Nat Rev Genet. 2014;15(5):293–306.
   PubMed Web of Science ®Google Scholar
• Geula S, Moshitch-Moshkovitz S, Dominissini D, et al. Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation. Science. 2015;347(6225):1002–1006.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhao BS, Roundtree IA, et al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell. 2015;161(6):1388–1399.
   PubMed Web of Science ®Google Scholar
• Xiao W, Adhikari S, Dahal U, et al. Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Mol Cell. 2016;61(4):507–519.
   PubMed Web of Science ®Google Scholar
• Wang X, Lu Z, Gomez A, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505(7481):117–120.
   PubMed Web of Science ®Google Scholar
• Batista PJ, Molinie B, Wang J, et al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014;15(6):707–719.
   PubMed Web of Science ®Google Scholar
• Lin S, Choe J, Du P, et al. The m(6)A methyltransferase METTL3 promotes translation in human cancer cells. Mol Cell. 2016;62(3):335–345.
   PubMed Web of Science ®Google Scholar
• Wei W, Ji X, Guo X, et al. Regulatory role of N -methyladenosine (m A) methylation in RNA processing and human diseases. J Cell Biochem. 2017;118(9):2534–2543.
   PubMed Web of Science ®Google Scholar
• Ghazi T, Nagiah S, Chuturgoon AA. Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells. Epigenetics. 2020;16:79–91.
   PubMed Web of Science ®Google Scholar
• Ghazi T, Nagiah S, Naidoo P, et al. Fusaric acid-induced promoter methylation of DNA methyltransferases triggers DNA hypomethylation in human hepatocellular carcinoma (HepG2) cells. Epigenetics. 2019;14(8):804–817.
   PubMed Web of Science ®Google Scholar
• Meyer KD, Patil DP, Zhou J, et al. 5’ UTR m(6)A promotes cap-independent translation. Cell. 2015; 163(4):999–1010.
   PubMed Web of Science ®Google Scholar
• Heo S-H, Kwak J, Jang KL. All-trans retinoic acid induces p53-dependent apoptosis in human hepatocytes by activating p14 expression via promoter hypomethylation. Cancer Lett. 2015;362(1):139–148.
   PubMed Web of Science ®Google Scholar
• Qing Y, Hu H, Liu Y, et al. Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter. Cell Biol Int. 2014;38(5):563–570.
   PubMed Web of Science ®Google Scholar
• Dominissini D, Moshitch-Moshkovitz S, Schwartz S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485(7397):201–206.
   PubMed Web of Science ®Google Scholar
• Li J, Han Y, Zhang H, et al. The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA. Biochem Biophys Res Commun. 2019;512(3):479–485.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhu L, Chen J, et al. mRNA m6A methylation downregulates adipogenesis in porcine adipocytes. Biochem Biophys Res Commun. 2015;459(2):201–207.
   PubMed Web of Science ®Google Scholar
• Zhong X, Yu J, Frazier K, et al. Circadian clock regulation of hepatic lipid metabolism by modulation of mA mRNA methylation. Cell Rep. 2018;25(7):1816–1828.e4.
   PubMed Web of Science ®Google Scholar
• Zhang C, Samanta D, Lu H, et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc Natl Acad Sci U S A. 2016;113(14):E2047–E2056.
   PubMed Web of Science ®Google Scholar
• Chen M, Wei L, Law C-T, et al. RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Hepatology. 2018;67(6):2254–2270.
   PubMed Web of Science ®Google Scholar
• Cui Q, Shi H, Ye P, et al. mA RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Rep. 2017;18(11):2622–2634.
   PubMed Web of Science ®Google Scholar
• Liu J, Li K, Cai J, et al. Landscape and regulation of mA and mAm methylome across human and mouse tissues. Mol Cell. 2020;77(2):426–440.e6.
   PubMed Web of Science ®Google Scholar
• Huang B, Ding C, Zou Q, et al. Cyclophosphamide Regulates N6-methyladenosine and m6A RNA enzyme levels in human granulosa cells and in ovaries of a premature ovarian aging mouse model. Front Endocrinol (Lausanne). 2019;10:415.
   PubMed Web of Science ®Google Scholar
• Liu J, Ren D, Du Z, et al. mA demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression. Biochem Biophys Res Commun. 2018;502(4):456–464.
   PubMed Web of Science ®Google Scholar