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Research Paper

Geniposide promotes splenic Treg differentiation to alleviate colonic inflammation and intestinal barrier injury in ulcerative colitis mice

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Pages 14616-14631 | Received 23 Apr 2022, Accepted 17 Jun 2022, Published online: 24 Jan 2023

References

  • Eisenstein M. Ulcerative colitis: towards remission. Nature. 2018;563(7730):S33.
  • Gajendran M, Loganathan P, Jimenez G, et al. A comprehensive review and update on ulcerative colitis(). Dis Mon. 2019;65(12):100851.
  • Du L, Ha C. Epidemiology and pathogenesis of ulcerative colitis. Gastroenterol Clin North Am. 2020;49(4):643–654.
  • Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology. 2012;142(1):46–54 e42. quiz e30.
  • Ungaro R, Mehandru S, Allen PB, et al. Ulcerative colitis. Lancet. 2017;389(10080):1756–1770.
  • Singh S, Allegretti JR, Siddique SM, et al. AGA technical review on the management of moderate to severe ulcerative colitis. Gastroenterology. 2020;158(5):1465–1496 e1417.
  • Bressler B, Marshall JK, Bernstein CN, et al. Clinical practice guidelines for the medical management of nonhospitalized ulcerative colitis: the Toronto consensus. Gastroenterology. 2015;148(5):1035–1058 e1033.
  • Feuerstein JD, Cheifetz AS. Ulcerative colitis: epidemiology, diagnosis, and management. Mayo Clin Proc. 2014;89(11):1553–1563.
  • Alsoud D, Verstockt B, Fiocchi C, et al. Breaking the therapeutic ceiling in drug development in ulcerative colitis. Lancet Gastroenterol Hepatol. 2021;6(7):589–595.
  • Hirten RP, Sands BE. New therapeutics for ulcerative colitis. Annu Rev Med. 2021;72(1):199–213.
  • Naganuma M, Sugimoto S, Mitsuyama K, et al. Efficacy of indigo naturalis in a multicenter randomized controlled trial of patients with ulcerative colitis. Gastroenterology. 2018;154(4):935–947.
  • Cao SY, Ye SJ, Wang WW, et al. Progress in active compounds effective on ulcerative colitis from Chinese medicines. Chin J Nat Med. 2019;17(2):81–102.
  • Ran D, Hong W, Yan W, et al. Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases. J Ethnopharmacol. 2021;273:113958.
  • Li N, Li L, Wu H, et al. Antioxidative property and molecular mechanisms underlying geniposide-mediated therapeutic effects in diabetes mellitus and cardiovascular disease. Oxid Med Cell Longev. 2019;2019:7480512.
  • Xu B, Li YL, Xu M, et al. Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function. Acta Pharmacol Sin. 2017;38(5):688–698.
  • Lu Y, Chen J, He X, et al. Combined administration of vitamin D3 and geniposide is less effective than single use of vitamin D3 or geniposide in the treatment of ulcerative colitis. Front Pharmacol. 2021;12:714065.
  • Yang H, Yue Y, Li Y, et al. Geniposide attenuates dextran sulfate sodium-induced colitis in mice via Nrf-2/HO-1/NF-kappaB pathway. Ann Palliat Med. 2020;9(5):2826–2836.
  • Zhang Z, Li Y, Shen P, et al. Administration of geniposide ameliorates dextran sulfate sodium-induced colitis in mice via inhibition of inflammation and mucosal damage. Int Immunopharmacol. 2017;49:168–177.
  • Pu Z, Liu Y, Li C, et al. Using network pharmacology for systematic understanding of geniposide in ameliorating inflammatory responses in colitis through suppression of NLRP3 inflammasome in macrophage by AMPK/Sirt1 dependent signaling. Am J Chin Med. 2020;48(7):1693–1713.
  • Hindryckx P, Jairath V, D’Haens G. Acute severe ulcerative colitis: from pathophysiology to clinical management. Nat Rev Gastroenterol Hepatol. 2016;13(11):654–664.
  • Neurath MF. Targeting immune cell circuits and trafficking in inflammatory bowel disease. Nat Immunol. 2019;20(8):970–979.
  • Chen G, Ran X, Li B, et al. Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model. EBioMedicine. 2018;30:317–325.
  • Lian P, Braber S, Varasteh S, et al. Hypoxia and heat stress affect epithelial integrity in a Caco-2/HT-29 co-culture. Sci Rep. 2021;11(1):13186.
  • Meng Q, Li Y, Ji T, et al. Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor alpha-mediated autophagy. J Adv Res. 2021;28:149–164.
  • Zhang H, Yuan Z, Zhu Y, et al. Th17/Treg imbalance mediates hepatic intolerance to exogenous lipopolysaccharide and exacerbates liver injury in triptolide induced excessive immune response. J Ethnopharmacol. 2022;295:115422.
  • Meng Q, Yu X, Chen Q, et al. Liuwei Dihuang soft capsules inhibits the phenotypic conversion of VSMC to prevent the menopausal atherosclerosis by up-regulating the expression of myocardin. J Ethnopharmacol. 2020;246:112207.
  • Meng Q, Li J, Chao Y, et al. beta-estradiol adjusts intestinal function via ERbeta and GPR30 mediated PI3K/AKT signaling activation to alleviate postmenopausal dyslipidemia. Biochem Pharmacol. 2020;180:114134.
  • Luz-Crawford P, Kurte M, Bravo-Alegria J, et al. Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells. Stem Cell Res Ther. 2013;4(3):65.
  • Miao Y, Zheng Y, Geng Y, et al. The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARgamma agonists. Theranostics. 2021;11(9):4531–4548.
  • Conrad K, Roggenbuck D, Laass MW. Diagnosis and classification of ulcerative colitis. Autoimmun Rev. 2014;13(4–5):463–466.
  • Kobayashi T, Siegmund B, Le Berre C, et al. Ulcerative colitis. Nat Rev Dis Primers. 2020;6(1):74.
  • Zhou YX, Zhang RQ, Rahman K, et al. Diverse pharmacological activities and potential medicinal benefits of geniposide. Evid Based Complement Alternat Med. 2019;2019:4925682.
  • Balestrieri P, Ribolsi M, Guarino MPL, et al. Nutritional aspects in inflammatory bowel diseases. Nutrients. 2020;12(2):372.
  • Mizukawa K, Takayama H, Sato H, et al. Alterations of muscarinic cholinergic receptors in the hippocampal formation of stressed rat: in vitro quantitative autoradiographic analysis. Brain Res. 1989;478(1):187–192.
  • Cabre E, Gassull MA. Nutrition in inflammatory bowel disease: impact on disease and therapy. Curr Opin Gastroenterol. 2001;17(4):342–349.
  • Li Y, Zhang K, Liu J, et al. Geniposide suppresses thermogenesis via regulating PKA catalytic subunit in adipocytes. Toxicology. 2021;464:153014.
  • Michielan A, D’Inca R. Intestinal permeability in inflammatory bowel disease: pathogenesis, clinical evaluation, and therapy of leaky gut. Mediators Inflamm. 2015;2015:628157.
  • Buckley A, Turner JR. Cell biology of tight junction barrier regulation and mucosal disease. Cold Spring Harb Perspect Biol. 2018;10(1):a029314.
  • Gunzel D, Fromm M. Claudins and other tight junction proteins. Compr Physiol. 2012;2(3):1819–1852.
  • Gunzel D, Yu AS. Claudins and the modulation of tight junction permeability. Physiol Rev. 2013;93(2):525–569.
  • Otani T, Furuse M. Tight junction structure and function revisited. Trends Cell Biol. 2020;30(10):805–817.
  • SharmaD, Malik A, Guy CS, et al. Pyrin inflammasome regulates tight junction integrity to restrict colitis and tumorigenesis. Gastroenterology. 2018;154(4):948–964 e948.
  • Steinbach EC, Plevy SE. The role of macrophages and dendritic cells in the initiation of inflammation in IBD. Inflamm Bowel Dis. 2014;20(1):166–175.
  • Saraiva M, Vieira P, O’Garra A. Biology and therapeutic potential of interleukin-10. J Exp Med. 2020;217(1). DOI:10.1084/jem.20190418
  • Geng Y, Yue Y, Guan Q, et al. Cereal vinegar sediment alleviates spontaneous ulcerative colitis in Il-10 deficient mice. Mol Nutr Food Res. 2021;65(24):e2001227.
  • Murphy SF, Rhee L, Grimm WA, et al. Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014;307(9):G871–882.
  • Chen XY, Jiang WW, Liu YL, et al. Anti-inflammatory action of geniposide promotes wound healing in diabetic rats. Pharm Biol. 2022;60(1):294–299.
  • Yao Y, Simard AR, Shi FD, et al. IL-10-producing lymphocytes in inflammatory disease. Int Rev Immunol. 2013;32(3):324–336.
  • Melgar S, Yeung MM, Bas A, et al. Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis. Clin Exp Immunol. 2003;134(1):127–137.
  • Geremia A, Biancheri P, Allan P, et al. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;13(1):3–10.
  • Corridoni D, Antanaviciute A, Gupta T, et al. Single-cell atlas of colonic CD8(+) T cells in ulcerative colitis. Nat Med. 2020;26(9):1480–1490.
  • Cook L, Stahl M, Han X, et al. Suppressive and gut-reparative functions of human type 1 T regulatory cells. Gastroenterology. 2019;157(6):1584–1598.
  • Schmitt H, Ulmschneider J, Billmeier U, et al. The TLR9 AGONIST COBITOLIMOD INDUCES IL10-producing wound healing macrophages and regulatory T cells in ulcerative colitis. J Crohns Colitis. 2020;14(4):508–524.
  • Rosenzwajg M, Lorenzon R, Cacoub P, et al. Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial. Ann Rheum Dis. 2019;78(2):209–217.
  • Liao P, Liu L, Wang B, et al. Baicalin and geniposide attenuate atherosclerosis involving lipids regulation and immunoregulation in ApoE-/- mice. Eur J Pharmacol. 2014;740:488–495.
  • Deng G, Song X, Fujimoto S, et al. Foxp3 post-translational modifications and treg suppressive activity. Front Immunol. 2019;10:2486.
  • Long Y, Wang C, Xia C, et al. Recovery of CD226-TIGIT(+)FoxP3(+) and CD226-TIGIT-FoxP3(+) regulatory T cells contributes to clinical remission from active stage in ulcerative colitis patients. Immunol Lett. 2020;218:30–39.