Effects of ischemic postconditioning and long non-coding RNAs in ischemic stroke

References

• Mozaffarian D, Mozaffarian D, Benjamin EJ, et al. Heart Disease and Stroke Statistics-2016 Update: a Report From the American Heart Association. Circulation. 2016;133(4):e38–360.
   PubMed Web of Science ®Google Scholar
• Mitsios N, Gaffney J, Kumar P, et al. Pathophysiology of acute ischaemic stroke: an analysis of common signalling mechanisms and identification of new molecular targets. Pathobiology. 2006;73(4):159–175.
   PubMed Web of Science ®Google Scholar
• Deb P, Sharma S, Hassan KM. Pathophysiologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology. 2010;17(3):197–218.
   PubMedGoogle Scholar
• Gauberti M, De Lizarrondo SM, Vivien D. The “inflammatory penumbra” in ischemic stroke: from clinical data to experimental evidence. Eur Stroke J. 2016;1(1):20–27.
   PubMedGoogle Scholar
• Lambertsen KL, Biber K, Finsen B. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow and Metab. 2012;32(9):1677–1698.
   PubMed Web of Science ®Google Scholar
• Wang YS, Li YX, Zhao P, et al. Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia-Reperfusion Injury in Mice. Inflammation. 2015;38(6):2259–2268.
   PubMed Web of Science ®Google Scholar
• Nia AM, Kalantaripour TP, Basiri M, et al. Nepeta Dschuparensis Bornm Extract Moderates COX-2 and IL-1β Proteins in a Rat Model of Cerebral Ischemia. Iran J Med Sci. 2017;42(2):179–186.
   PubMedGoogle Scholar
• Lu WJ, Zeng LL, Wang Y, et al. Blood microRNA-15a Correlates with IL-6, IGF-1 and Acute Cerebral Ischemia. Curr Neurovasc Res. 2018;15(1):63–71.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang CS, Lu C, et al. A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation. Nat Commun. 2016;7:10879.
   PubMed Web of Science ®Google Scholar
• Fann DY-W, Lim Y-A, Cheng Y-L, et al. Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke. Mol Neurobiol. 2018;55(2):1082–1096.
   PubMed Web of Science ®Google Scholar
• Pluta R, Januszewski S, Czuczwar SJ. Neuroinflammation in Post-Ischemic Neurodegeneration of the Brain: friend, Foe, or Both? Int J Mol Sci. 2021;22(9):4405 .
   PubMed Web of Science ®Google Scholar
• Li L, Dong L, Zhao J, et al. Circulating miRNA-3552 as a Potential Biomarker for Ischemic Stroke in Rats. Biomed Res Int. 2020;2020:4501393.
   PubMed Web of Science ®Google Scholar
• Sekeljic V, Bataveljic D, Stamenkovic S, et al. Cellular markers of neuroinflammation and neurogenesis after ischemic brain injury in the long-term survival rat model. Brain Struct Funct. 2012;217(2):411–420.
   PubMed Web of Science ®Google Scholar
• Radenovic L, Nenadic M, Ułamek-Kozioł M, et al. Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer’s disease after 2 years of survival. Aging (Albany NY). 2020;12(12):12251–12267.
   PubMedGoogle Scholar
• Maida CD, Norrito RL, Daidone M, et al. Neuroinflammatory Mechanisms in Ischemic Stroke: focus on Cardioembolic Stroke, Background, and Therapeutic Approaches. Int J Mol Sci. 2020;21(18):6454.
   PubMed Web of Science ®Google Scholar
• Cui Y, Zhang Y, Zhao X, et al. ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Brain Behav Immun. 2021;93:312–321.
   PubMed Web of Science ®Google Scholar
• Wang D, Liu F, Zhu L, et al. FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. J Neuroinflammation. 2020;17(1):257.
   PubMed Web of Science ®Google Scholar
• Ouyang YB, Giffard RG. MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia. Neurochem Int. 2014;77:2–8.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Li YW, Wang YX, et al. Remifentanil preconditioning alleviating brain damage of cerebral ischemia reperfusion rats by regulating the JNK signal pathway and TNF-α/TNFR1 signal pathway. Mol Biol Rep. 2013;40(12):6997–7006.
   PubMed Web of Science ®Google Scholar
• Yan H, Yuan J, Gao L, et al. Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke. Neuroscience. 2016;337:191–199.
   PubMed Web of Science ®Google Scholar
• Kumar VS, Gopalakrishnan A, Naziroğlu M, et al. Calcium ion–the key player in cerebral ischemia. Curr Med Chem. 2014;21(18):2065–2075.
   PubMed Web of Science ®Google Scholar
• Wu QJ, Tymianski M. Targeting NMDA receptors in stroke: new hope in neuroprotection. Mol Brain. 2018;11(1):15.
   PubMedGoogle Scholar
• Cappelli J, Khacho P, Wang B, et al. Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke. iScience. 2022;25(1):103539.
   PubMed Web of Science ®Google Scholar
• Kahles T, Brandes RP. NADPH oxidases as therapeutic targets in ischemic stroke. Cell Mol Life Sci. 2012;69(14):2345–2363.
   PubMed Web of Science ®Google Scholar
• Chen H, Yoshioka H, Kim GS, et al. Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal. 2011;14(8):1505–1517.
   PubMed Web of Science ®Google Scholar
• Kahles T, Luedike P, Endres M, et al. NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke. 2007;38(11):3000–3006.
   PubMed Web of Science ®Google Scholar
• Casas AI, Geuss E, Kleikers PWM, et al. NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proc Natl Acad Sci USA. 2017;114(46):12315–12320.
   PubMed Web of Science ®Google Scholar
• Canty TG Jr.Jr., Boyle EM Jr.Jr., Farr A, et al. Oxidative stress induces NF-kappaB nuclear translocation without degradation of IkappaBalpha. Circulation. 1999;100(19 Suppl):Ii361–4.
   PubMed Web of Science ®Google Scholar
• Kleinschnitz C, Grund H, Wingler K, et al. Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol. 2010;8(9):e1000479.
   PubMed Web of Science ®Google Scholar
• Su J, Zhang T, Wang K, et al. Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats. Neurochem Res. 2014;39(11):2068–2077.
   PubMed Web of Science ®Google Scholar
• Fan YY, Hu WW, Nan F, et al. Postconditioning-induced neuroprotection, mechanisms and applications in cerebral ischemia. Neurochem Int. 2017;107:43–56.
   PubMed Web of Science ®Google Scholar
• Wang P, Liang J, Li Y, et al. Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing beclin 1-mediated autophagy. Neurochem Res. 2014;39(7):1279–1291.
   PubMed Web of Science ®Google Scholar
• Su XT, Wang L, Ma SM, et al. Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke. Oxid Med Cell Longev. 2020;2020:7875396.
   PubMed Web of Science ®Google Scholar
• Jickling GC, Liu D, Stamova B, et al. Hemorrhagic transformation after ischemic stroke in animals and humans. J Cereb Blood Flow and Metab. 2014;34(2):185–199.
   PubMed Web of Science ®Google Scholar
• Ham PB 3rd, Raju R. Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol. 2017;157:92–116.
   PubMed Web of Science ®Google Scholar
• Jiang S, Li T, Ji T, et al. AMPK: potential Therapeutic Target for Ischemic Stroke. Theranostics. 2018;8(16):4535–4551.
   PubMed Web of Science ®Google Scholar
• Si Z, Liu J, Hu K, et al. Effects of thrombolysis within 6 hours on acute cerebral infarction in an improved rat embolic middle cerebral artery occlusion model for ischaemic stroke. J Cell Mol Med. 2019;23(4):2468–2474.
   PubMed Web of Science ®Google Scholar
• Jayaraj RL, Azimullah S, Beiram R, et al. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16(1):142.
   PubMed Web of Science ®Google Scholar
• Bonova P, Burda J, Danielisova V, et al. Delayed post-conditioning reduces post-ischemic glutamate level and improves protein synthesis in brain. Neurochem Int. 2013;62(6):854–860.
   PubMed Web of Science ®Google Scholar
• You J, Feng L, Xin M, et al. Cerebral Ischemic Postconditioning Plays a Neuroprotective Role through Regulation of Central and Peripheral Glutamate. Biomed Res Int. 2018;2018:6316059.
   PubMed Web of Science ®Google Scholar
• Graham SH, Chen J, Sharp FR, et al. Limiting ischemic injury by inhibition of excitatory amino acid release. J Cereb Blood Flow and Metab. 1993;13(1):88–97.
   PubMed Web of Science ®Google Scholar
• Liu Y, Chu S, Hu Y, et al. Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes. Cell Mol Neurobiol. 2021;41(4):687–704.
   PubMed Web of Science ®Google Scholar
• Wang Y, Lu S, Chen Y, et al. Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke. Sci Transl Med. 2021;13(610):eaba3444.
   PubMed Web of Science ®Google Scholar
• Nagelhus EA, Ottersen OP. Physiological roles of aquaporin-4 in brain. Physiol Rev. 2013;93(4):1543–1562.
   PubMed Web of Science ®Google Scholar
• Patabendige A, Singh A, Jenkins S, et al. Astrocyte Activation in Neurovascular Damage and Repair Following Ischaemic Stroke. Int J Mol Sci. 2021;22(8):4280.
   PubMed Web of Science ®Google Scholar
• Hess DC, Khan MB, Kamat P, et al. Conditioning medicine for ischemic and hemorrhagic stroke. Conditioning med. 2021;4(3): 124–129.
   PubMedGoogle Scholar
• Weston RM, Jarrott B, Ishizuka Y, et al. AM-36 modulates the neutrophil inflammatory response and reduces breakdown of the blood brain barrier after endothelin-1 induced focal brain ischaemia. Br J Pharmacol. 2006;149(6):712–723.
   PubMed Web of Science ®Google Scholar
• Ruhnau J, Schulze J, Dressel A, et al. Neuroinflammation, and Poststroke Infection: the Multifaceted Role of Neutrophils in Stroke. J Immunol Res. 2017;2017:5140679.
   PubMed Web of Science ®Google Scholar
• Kurzepa J, Kurzepa J, Golab P, et al. The significance of matrix metalloproteinase (MMP)-2 and MMP-9 in the ischemic stroke. Int J Neurosci. 2014;124(10):707–716.
   PubMed Web of Science ®Google Scholar
• Zhang H, Xie Q, Hu J. Neuroprotective Effect of Physical Activity in Ischemic Stroke: focus on the Neurovascular Unit. Front Cell Neurosci. 2022;16:860573.
   PubMed Web of Science ®Google Scholar
• Zhong C, Yang J, Xu T, et al. Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke. Neurology. 2017;89(8):805–812.
   PubMed Web of Science ®Google Scholar
• Wang H, Song G, Chuang H, et al. Portrait of glial scar in neurological diseases. Int J Immunopathol Pharmacol. 2018;31:2058738418801406.
   Web of Science ®Google Scholar
• Nour M, Scalzo F, Liebeskind DS. Ischemia-reperfusion injury in stroke. Interv Neurol. 2013;1(3–4):185–199.
   PubMedGoogle Scholar
• Halkos ME, Kerendi F, Corvera JS, et al. Myocardial protection with postconditioning is not enhanced by ischemic preconditioning. Ann Thorac Surg. 2004;78(3):961–969.
   PubMed Web of Science ®Google Scholar
• Wang M, Qi DS, Zhou C, et al. Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway. Brain Res. 2016;1634:140–149.
   PubMed Web of Science ®Google Scholar
• Xing B, Chen H, Zhang M, et al. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke. 2008;39(8):2362–2369.
   PubMed Web of Science ®Google Scholar
• Cheng Z, Li L, Mo X, et al. Non-invasive remote limb ischemic postconditioning protects rats against focal cerebral ischemia by upregulating STAT3 and reducing apoptosis. Int J Mol Med. 2014;34(4):957–966.
   PubMed Web of Science ®Google Scholar
• Zhao H, Ren C, Chen X, et al. From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia. Curr Drug Targets. 2012;13(2):173–187.
   PubMed Web of Science ®Google Scholar
• Zhou M, Xia ZY, Lei SQ, et al. Role of mitophagy regulated by Parkin/DJ-1 in remote ischemic postconditioning-induced mitigation of focal cerebral ischemia-reperfusion. Eur Rev Med Pharmacol Sci. 2015;19(24):4866–4871.
   PubMed Web of Science ®Google Scholar
• Gao L, Jiang T, Guo J, et al. Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PloS one. 2012;7(9):e46092.
   PubMed Web of Science ®Google Scholar
• Wang J, Han D, Sun M, et al. A Combination of Remote Ischemic Perconditioning and Cerebral Ischemic Postconditioning Inhibits Autophagy to Attenuate Plasma HMGB1 and Induce Neuroprotection Against Stroke in Rat. J Mol Neurosci. 2016;58(4):424–431.
   PubMed Web of Science ®Google Scholar
• Baek SH, Noh AR, Kim KA, et al. Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage. Stroke. 2014;45(8):2438–2443.
   PubMed Web of Science ®Google Scholar
• Qi ZF, Luo YM, Liu XR, et al. AKT/GSK3β-dependent autophagy contributes to the neuroprotection of limb remote ischemic postconditioning in the transient cerebral ischemic rat model. CNS Neurosci Ther. 2012;18(12):965–973.
   PubMed Web of Science ®Google Scholar
• Zhang X, Yan H, Yuan Y, et al. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy. 2013;9(9):1321–1333.
   PubMed Web of Science ®Google Scholar
• Wei C, Li H, Han L, et al. Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts. J Cardiovasc Pharmacol. 2013;61(5):416–422.
   PubMed Web of Science ®Google Scholar
• Qi Z, Dong W, Shi W, et al. Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke. Transl Stroke Res. 2015;6(3):198–206.
   PubMed Web of Science ®Google Scholar
• Sun Y, Zhang T, Zhang Y, et al. Ischemic Postconditioning Alleviates Cerebral Ischemia-Reperfusion Injury Through Activating Autophagy During Early Reperfusion in Rats. Neurochem Res. 2018;43(9):1826–1840.
   PubMed Web of Science ®Google Scholar
• Chen G, Thakkar M, Robinson C, et al. Limb Remote Ischemic Conditioning: mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options. Front Neurol. 2018;9:40.
   PubMed Web of Science ®Google Scholar
• Han D, Sun M, He PP, et al. Ischemic Postconditioning Alleviates Brain Edema After Focal Cerebral Ischemia Reperfusion in Rats Through Down-Regulation of Aquaporin-4. J Mol Neurosci. 2015;56(3):722–729.
   PubMed Web of Science ®Google Scholar
• Weir P, Maguire R, O’Sullivan SE, et al. A meta-analysis of remote ischaemic conditioning in experimental stroke. J Cereb Blood Flow and Metab. 2021;41(1):3–13.
   PubMed Web of Science ®Google Scholar
• Li CY, Ma W, Liu KP, et al. Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning. Metab Brain Dis. 2021;36(1):53–65.
   PubMed Web of Science ®Google Scholar
• Liu C, Yang J, Zhang C, et al. Remote ischemic conditioning reduced cerebral ischemic injury by modulating inflammatory responses and ERK activity in type 2 diabetic mice. Neurochem Int. 2020;135:104690.
   PubMed Web of Science ®Google Scholar
• Li CY, Ma W, Liu KP, et al. Different ischemic duration and frequency of ischemic postconditioning affect neuroprotection in focal ischemic stroke. J Neurosci Methods. 2020;346:108921.
   PubMed Web of Science ®Google Scholar
• Xiao B, Chai Y, Lv S, et al. Endothelial cell-derived exosomes protect SH-SY5Y nerve cells against ischemia/reperfusion injury. Int J Mol Med. 2017;40(4):1201–1209.
   PubMed Web of Science ®Google Scholar
• Kalani A, Chaturvedi P, Kamat PK, et al. Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury. Int J Biochem Cell Biol. 2016;79:360–369.
   PubMed Web of Science ®Google Scholar
• Lee HK, Finniss S, Cazacu S, et al. Mesenchymal stem cells deliver exogenous miRNAs to neural cells and induce their differentiation and glutamate transporter expression. Stem Cells Dev. 2014;23(23):2851–2861.
   PubMed Web of Science ®Google Scholar
• Ripley AJ, Jeffers MS, McDonald MW, et al. Neuroprotection by Remote Ischemic Conditioning in Rodent Models of Focal Ischemia: a Systematic Review and Meta-Analysis. Transl Stroke Res. 2021;12(3):461–473.
   PubMed Web of Science ®Google Scholar
• Chen G, Zhang J, Sheng M, et al. Serum of limb remote ischemic postconditioning inhibits fMLP-triggered activation and reactive oxygen species releasing of rat neutrophils. Redox Rep. 2021;26(1):176–183.
   PubMed Web of Science ®Google Scholar
• Sengul D, Sengul I. Connection of reactive oxygen species as an essential factor for the mechanism of phenomena; ischemic preconditioning and postconditioning: come to age or ripening. North Clin Istanb. 2021;8(6):644–649.
   PubMed Web of Science ®Google Scholar
• Li J, Hu XS, Zhou FF, et al. Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke. Neural Regen Res. 2018;13(9):1585–1593.
   PubMed Web of Science ®Google Scholar
• Doeppner TR, Kaltwasser B, Kuckelkorn U, et al. Systemic Proteasome Inhibition Induces Sustained Post-stroke Neurological Recovery and Neuroprotection via Mechanisms Involving Reversal of Peripheral Immunosuppression and Preservation of Blood-Brain-Barrier Integrity. Mol Neurobiol. 2016;53(9):6332–6341.
   PubMed Web of Science ®Google Scholar
• Landman TRJ, Schoon Y, Warlé MC, et al. Remote Ischemic Conditioning as an Additional Treatment for Acute Ischemic Stroke. Stroke. 2019;50(7):1934–1939.
   PubMed Web of Science ®Google Scholar
• Doeppner TR, Zechmeister B, Kaltwasser B, et al. Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal. Front Cell Neurosci. 2018;12:383.
   PubMed Web of Science ®Google Scholar
• Abbasi-Habashi S, Jickling GC, Winship IR. Immune Modulation as a Key Mechanism for the Protective Effects of Remote Ischemic Conditioning After Stroke. Front Neurol. 2021;12:746486.
   PubMed Web of Science ®Google Scholar
• Torres-Querol C, Quintana-Luque M, Arque G, et al. Preclinical evidence of remote ischemic conditioning in ischemic stroke, a metanalysis update. Sci Rep. 2021;11(1):23706.
   PubMed Web of Science ®Google Scholar
• Kitagawa K, Saitoh M, Ishizuka K, et al. Remote Limb Ischemic Conditioning during Cerebral Ischemia Reduces Infarct Size through Enhanced Collateral Circulation in Murine Focal Cerebral Ischemia. J Stroke Cerebrovasc Dis. 2018;27(4):831–838.
   PubMed Web of Science ®Google Scholar
• Pignataro G, Esposito E, Sirabella R, et al. nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion. Neurobiol Dis. 2013;54:105–114.
   PubMed Web of Science ®Google Scholar
• Gulati P, Singh N, Muthuraman A. Pharmacologic evidence for role of endothelial nitric oxide synthase in neuroprotective mechanism of ischemic postconditioning in mice. J Surg Res. 2014;188(1):349–360.
   PubMed Web of Science ®Google Scholar
• Yang F, Zhang X, Sun Y, et al. Ischemic postconditioning decreases cerebral edema and brain blood barrier disruption caused by relief of carotid stenosis in a rat model of cerebral hypoperfusion. PloS one. 2013;8(2):e57869.
   PubMed Web of Science ®Google Scholar
• Wei N, Xiao L, Xue R, et al. MicroRNA-9 Mediates the Cell Apoptosis by Targeting Bcl2l11 in Ischemic Stroke. Mol Neurobiol. 2016;53(10):6809–6817.
   PubMed Web of Science ®Google Scholar
• Xu Q, Deng F, Xing Z, et al. Long non-coding RNA C2dat1 regulates CaMKIIδ expression to promote neuronal survival through the NF-κB signaling pathway following cerebral ischemia. Cell Death Dis. 2016;7(3):e2173.
   PubMed Web of Science ®Google Scholar
• Qureshi IA, Mehler MF. Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci. 2012;13(8):528–541.
   PubMed Web of Science ®Google Scholar
• Schaukowitch K, Kim TK. Emerging epigenetic mechanisms of long non-coding RNAs. Neuroscience. 2014;264:25–38.
   PubMed Web of Science ®Google Scholar
• Briggs JA, Wolvetang EJ, Mattick JS, et al. Mechanisms of Long Non-coding RNAs in Mammalian Nervous System Development, Plasticity, Disease, and Evolution. Neuron. 2015;88(5):861–877.
   PubMed Web of Science ®Google Scholar
• Shi X, Sun M, Wu Y, et al. Post-transcriptional regulation of long noncoding RNAs in cancer. Tumour Biol. 2015;36(2):503–513.
   PubMedGoogle Scholar
• Kornienko AE, Guenzl PM, Barlow DP, et al. Gene regulation by the act of long non-coding RNA transcription. BMC Biol. 2013;11:59.
   PubMed Web of Science ®Google Scholar
• Fatica A, Bozzoni I. Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet. 2014;15(1):7–21.
   PubMed Web of Science ®Google Scholar
• Wang J, Gong C, Maquat LE. Control of myogenesis by rodent SINE-containing lncRNAs. Genes Dev. 2013;27(7):793–804.
   PubMed Web of Science ®Google Scholar
• Zhao F, Qu Y, Liu J, et al. Microarray Profiling and Co-Expression Network Analysis of LncRNAs and mRNAs in Neonatal Rats Following Hypoxic-ischemic Brain Damage. Sci Rep. 2015;5:13850.
   PubMed Web of Science ®Google Scholar
• Ren H, Wang G, Chen L, et al. Genome-wide analysis of long non-coding RNAs at early stage of skin pigmentation in goats (Capra hircus). BMC Genomics. 2016;17:67.
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang D, Ji TF, et al. Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model. Oncotarget. 2017;8(10):17347–17359.
   PubMedGoogle Scholar
• Cao Y. Positive and negative modulation of angiogenesis by VEGFR1 ligands. Sci Signal. 2009;2(59):re1.
   PubMed Web of Science ®Google Scholar
• Smith EM, Gregg M, Hashemi F, et al. Corticotropin Releasing Factor (CRF) activation of NF-kappaB-directed transcription in leukocytes. Cell Mol Neurobiol. 2006;26(4–6):1021–1036.
   PubMed Web of Science ®Google Scholar
• Ye J, Das S, Roy A, et al. Ischemic Injury-Induced CaMKIIδ and CaMKIIγ Confer Neuroprotection Through the NF-κB Signaling Pathway. Mol Neurobiol. 2019;56(3):2123–2136.
   PubMed Web of Science ®Google Scholar
• Li J, Hao M, Yang B, et al. Long non-coding RNAs expression profile and functional analysis of acute ischemic stroke. Medicine. 2020;99(50):e22964.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhao H, Fan Z, et al. Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization. Stroke. 2017;48(8):2211–2221.
   PubMed Web of Science ®Google Scholar
• Wang J, Cao B, Han D, et al. Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy. Aging Dis. 2017;8(1):71–84.
   PubMed Web of Science ®Google Scholar
• Tao H, Cao W, Yang JJ, et al. Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Cardiovasc pathol. 2016;25(5):381–389.
   PubMed Web of Science ®Google Scholar
• Han W, Fu X, Xie J, et al. MiR-26a enhances autophagy to protect against ethanol-induced acute liver injury. J Mol Med. 2015;93(9):1045–1055.
   PubMed Web of Science ®Google Scholar
• Zhang X, Tang X, Liu K, et al. Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke. J Neurosci. 2017;37(7):1797–1806.
   PubMed Web of Science ®Google Scholar
• Wang H, Zheng X, Jin J, et al. LncRNA MALAT1 silencing protects against cerebral ischemia-reperfusion injury through miR-145 to regulate AQP4. J Biomed Sci. 2020;27(1):40.
   PubMed Web of Science ®Google Scholar
• Xiang Y, Zhang Y, Xia Y, et al. LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke. Aging (Albany NY). 2020;12(4):3156–3174.
   PubMedGoogle Scholar
• Zhang X, Zhu XL, Ji BY, et al. LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke. J Neuroinflammation. 2019;16(1):75.
   PubMedGoogle Scholar
• Long FQ, Su QJ, Zhou JX, et al. LncRNA SNHG12 ameliorates brain microvascular endothelial cell injury by targeting miR-199a. Neural Regen Res. 2018;13(11):1919–1926.
   PubMed Web of Science ®Google Scholar
• Zhao M, Wang J, Xi X, et al. SNHG12 Promotes Angiogenesis Following Ischemic Stroke via Regulating miR-150/VEGF Pathway. Neuroscience. 2018;390:231–240.
   PubMed Web of Science ®Google Scholar
• Yin WL, Yin WG, Huang BS, et al. LncRNA SNHG12 inhibits miR-199a to upregulate SIRT1 to attenuate cerebral ischemia/reperfusion injury through activating AMPK signaling pathway. Neurosci Lett. 2019;690:188–195.
   PubMed Web of Science ®Google Scholar
• Bhattarai S, Pontarelli F, Prendergast E, et al. Discovery of novel stroke-responsive lncRNAs in the mouse cortex using genome-wide RNA-seq. Neurobiol Dis. 2017;108:204–212.
   PubMed Web of Science ®Google Scholar
• Dharap A, Pokrzywa C, Vemuganti R. Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST. ASN neuro. 2013;5(4):283–289.
   PubMed Web of Science ®Google Scholar
• Mehta SL, Kim T, Vemuganti R. Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins. J Neurosci. 2015;35(50):16443–16449.
   PubMed Web of Science ®Google Scholar
• Mehta SL, Chokkalla AK, Kim T, et al. Long Noncoding RNA Fos Downstream Transcript Is Developmentally Dispensable but Vital for Shaping the Poststroke Functional Outcome. Stroke. 2021;52(7):2381–2392.
   PubMed Web of Science ®Google Scholar
• Zhao J, He L, Yin L. lncRNA NEAT1 Binds to MiR-339-5p to Increase HOXA1 and Alleviate Ischemic Brain Damage in Neonatal Mice. Mol Ther Nucleic Acids. 2020;20:117–127.
   PubMedGoogle Scholar
• Jin F, Ou W, Wei B, et al. Transcriptome-Wide Analysis to Identify the Inflammatory Role of lncRNA Neat1 in Experimental Ischemic Stroke. J Inflamm Res. 2021;14:2667–2680.
   PubMed Web of Science ®Google Scholar
• Huang Y, Wang Y, Liu X, et al. Silencing lncRNA HOTAIR improves the recovery of neurological function in ischemic stroke via the miR-148a-3p/KLF6 axis. Brain Res Bull. 2021;176:43–53.
   PubMed Web of Science ®Google Scholar
• Wang Y, Mao J, Li X, et al. lncRNA HOTAIR mediates OGD/R-induced cell injury and angiogenesis in a EZH2-dependent manner. Exp Ther Med. 2022;23(1):99.
   PubMed Web of Science ®Google Scholar
• Fu J, Yu Q, Xiao J, et al. Long noncoding RNA as a biomarker for the prognosis of ischemic stroke: a protocol for meta-analysis and bioinformatics analysis. Medicine (Baltimore). 2021;100(17):e25596.
   PubMed Web of Science ®Google Scholar
• Karner H, Webb CH, Carmona S, et al. Functional Conservation of LncRNA JPX Despite Sequence and Structural Divergence. J Mol Biol. 2020;432(2):283–300.
   PubMed Web of Science ®Google Scholar
• Miao W, Yan Y, Bao TH, et al. Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124. Biomed Pharmacothe. 2020;126:109786.
   PubMed Web of Science ®Google Scholar
• Dharap A, Nakka VP, Vemuganti R. Effect of focal ischemia on long noncoding RNAs. Stroke. 2012;43(10):2800–2802.
   PubMed Web of Science ®Google Scholar
• Della-Morte D, Guadagni F, Palmirotta R, et al. Genetics and genomics of ischemic tolerance: focus on cardiac and cerebral ischemic preconditioning. Pharmacogenomics. 2012;13(15):1741–1757.
   PubMed Web of Science ®Google Scholar
• Zhang J, Yuan L, Zhang X, et al. Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol. 2016;277:162–170.
   PubMed Web of Science ®Google Scholar
• Liu J, Wang Y, Akamatsu Y, et al. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol. 2014;115:138–156.
   PubMed Web of Science ®Google Scholar
• Dhami KS, Churchward MA, Baker GB, et al. Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult. Mol Cell Neurosci. 2013;56:365–374.
   PubMed Web of Science ®Google Scholar
• Shin TH, Lee DY, Basith S, et al. Metabolome Changes in Cerebral Ischemia. Cells. 2020;9(7):1630.
   PubMed Web of Science ®Google Scholar
• Ma W, Li CY, Zhang SJ, et al. Neuroprotective effects of long noncoding RNAs involved in ischemic postconditioning after ischemic stroke. Neural Regen Res. 2022;17(6):1299–1309.
   PubMed Web of Science ®Google Scholar
• Li P, Duan S, Fu A. Long noncoding RNA NEAT1 correlates with higher disease risk, worse disease condition, decreased miR-124 and miR-125a and predicts poor recurrence-free survival of acute ischemic stroke. J Clin Lab Anal. 2020;34(2):e23056.
   PubMed Web of Science ®Google Scholar
• Zhu M, Li N, Luo P, et al. Peripheral Blood Leukocyte Expression of lncRNA MIAT and Its Diagnostic and Prognostic Value in Ischemic Stroke. J Stroke Cerebrovasc Dis. 2018;27(2):326–337.
   PubMed Web of Science ®Google Scholar
• Zeng W, Jin J. The correlation of serum long non-coding RNA ANRIL with risk factors, functional outcome, and prognosis in atrial fibrillation patients with ischemic stroke. J Clin Lab Anal. 2020;34(8):e23352.
   PubMed Web of Science ®Google Scholar
• Ren B, Song Z, Chen L, et al. Long non-coding RNA UCA1 correlates with elevated disease severity, Th17 cell proportion, inflammatory cytokines, and worse prognosis in acute ischemic stroke patients. J Clin Lab Anal. 2021;35(3):e23697.
   PubMed Web of Science ®Google Scholar
• Won SJ, Kim JE, Cittolin-Santos GF, et al. Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress. J Neurosci. 2015;35(18):7143–7152.
   PubMed Web of Science ®Google Scholar