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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 19, 2018 - Issue 3-4
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Clinical Trial

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

Christina N. Fournier1 Department of Neurology, Emory University, Atlanta, GA, USA, Correspondence[email protected]
,
David Schoenfeld2 Department of Medicine, Harvard Chan School of Public Health, Department of Biostatistics, Massachusetts General Hospital, Boston, MA, USA,
,
James D. Berry3 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA,
,
Merit E. Cudkowicz3 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA,
,
James Chan2 Department of Medicine, Harvard Chan School of Public Health, Department of Biostatistics, Massachusetts General Hospital, Boston, MA, USA,
,
Colin Quinn4 Department of Neurology, University of Massachusetts, Worcester, MA, USA,
,
Robert H. Brown4 Department of Neurology, University of Massachusetts, Worcester, MA, USA,
,
Johnny S. Salameh4 Department of Neurology, University of Massachusetts, Worcester, MA, USA,
,
Malu G. Tansey5 Department of Physiology, Emory University, Atlanta, GA, USA, and
,
David R. Beers6 Department of Neurology, Houston Methodist Neurologic Institute, Houston, TX, USA
,
Stanley H. Appel6 Department of Neurology, Houston Methodist Neurologic Institute, Houston, TX, USA
&
Jonathan D. Glass1 Department of Neurology, Emory University, Atlanta, GA, USA,
show all
Pages 242-249 | Received 12 Oct 2017, Accepted 19 Dec 2017, Published online: 08 Jan 2018

References

  • Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, et al. Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. Stem Cells. 2012;30:1144–51.
  • Taylor AA, Fournier C, Polak M, Wang L, Zach N, Keymer M, et al. Predicting disease progression in amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2016;3:866–75.
  • Beers DR, Henkel JS, Zhao W, Wang J, Huang A, Wen S, et al. Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain. 2011;134:1293–314.
  • Hooten KG, Beers DR, Zhao W, Appel SH. Protective and toxic neuroinflammation in amyotrophic lateral sclerosis. Neurotherapeutics. 2015;12:364–75.
  • Zhao W, Beers DR, Liao B, Henkel JS, Appel SH. Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms. Neurobiol Dis. 2012;48:418–28.
  • Rentzos M, Evangelopoulos E, Sereti E, Zouvelou V, Marmara S, Alexakis T, et al. Alterations of T cell subsets in ALS: a systemic immune activation? Acta Neurol Scand. 2012;125:260–4.
  • Henkel JS, Beers DR, Wen S, Rivera AL, Toennis KM, Appel JE, et al. Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival. EMBO Mol Med. 2013;5:64–79.
  • Schwartz M, Kipnis J. A conceptual revolution in the relationships between the brain and immunity. Brain Behav Immun. 2011;25:817–19.
  • Appel SH, Beers DR, Henkel JS. T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening? Trends Immunol. 2010;31:7–17.
  • The Amyotrophic Lateral Sclerosis Functional Rating Scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I–II Study Group. Arch Neurol. 1996;53:141–7.
  • Henkel JS, Beers DR, Siklos L, Appel SH. The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS. Mol Cell Neurosci. 2006;31:427–37.
  • Baumann J. Results of treatment of certain diseases of the central nervous system with ACTH and corticosteroids. Acta Neurol Scand Suppl. 1965;13 Pt 2:453–61.
  • Brown RH Jr, Hauser SL, Harrington H, Weiner HL. Failure of immunosuppression with a ten- to 14-day course of high-dose intravenous cyclophosphamide to alter the progression of amyotrophic lateral sclerosis. Arch Neurol. 1986;43:383–4.
  • Drachman DB, Chaudhry V, Cornblath D, Kuncl RW, Pestronk A, Clawson L, et al. Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation. Ann Neurol. 1994;35:142–50.
  • Monstad I, Dale I, Petlund CF, Sjaastad O. Plasma exchange in motor neuron disease. A controlled study. J Neurol. 1979;221:59–66.
  • Appel SH, Engelhardt JI, Henkel JS, Siklos L, Beers DR, Yen AA, et al. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology. 2008;71:1326–34.
  • Trias E, Ibarburu S, Barreto-Nunez R, Babdor J, Maciel TT, Guillo M, et al. Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis. J Neuroinflamm. 2016;13:177.
  • Depper JM, Leonard WJ, Robb RJ, Waldmann TA, Greene WC. Blockade of the interleukin-2 receptor by anti-Tac antibody: inhibition of human lymphocyte activation. J Immunol. 1983;131:690–6.
  • Beers DR, Zhao W, Liao B, Kano O, Wang J, Huang A, et al. Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice. Brain Behav Immun. 2011;25:1025–35.

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