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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 21, 2020 - Issue 7-8
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Brief Report

NEK1 and GRN mutations coexist in a sporadic Chinese Hui descent ALS patient

Kang Zhang1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing, ChinaORCID Iconhttps://orcid.org/0000-0002-0170-1314View further author information
ORCID Icon,
Yan Lu2 Department of Intensive Care Unit, The First People’s Hospital of Yinchuan City, Yinchuan, ChinaView further author information
,
Jianhong Chen3 Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaView further author information
,
Jian Li3 Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaView further author information
,
Kamal Kishor Yadav3 Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaView further author information
,
Jiao Yin3 Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaView further author information
&
Xiao Yang3 Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, ChinaCorrespondence[email protected]
View further author information
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Pages 624-626 | Received 10 Apr 2020, Accepted 03 Jun 2020, Published online: 08 Aug 2020

References

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  • Naruse H, Ishiura H, Mitsui J, Takahashi Y, Matsukawa T, Tanaka M, et al. Burden of rare variants in causative genes for amyotrophic lateral sclerosis (ALS) accelerates age at onset of ALS. J Neurol Neurosurg Psychiatry. 2019;90:537–42.
  • Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, et al. Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. Neurology 2008;71:656–64.
  • Piaceri I, Pradella S, Cupidi C, Nannucci S, Polito C, Bagnoli S, et al. Association of the variant Cys139Arg at GRN gene to the clinical spectrum of frontotemporal lobar degeneration. J Alzheimers Dis. 2014;40:679–85.

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