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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 21, 2020 - Issue 7-8
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Brief Report

Concurrent sodium channelopathies and amyotrophic lateral sclerosis supports shared pathogenesis

John P. Franklin1 Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UKView further author information
,
Johnathan Cooper-Knock1 Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UKView further author information
,
Aravindhan Baheerathan2 Department of Neurology, University College London Hospitals NHS Foundation Trust, London, UKView further author information
,
Tobias Moll1 Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UKView further author information
,
Roope Männikkö3 MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK, andView further author information
,
Mark Heverin4 School of Medicine, Trinity College Dublin, Dublin, IrelandView further author information
,
Orla Hardiman4 School of Medicine, Trinity College Dublin, Dublin, IrelandView further author information
,
Pamela J. Shaw1 Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8925-2567View further author information
ORCID Icon &
Michael G. Hanna2 Department of Neurology, University College London Hospitals NHS Foundation Trust, London, UK;3 MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK, andView further author information
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Pages 627-630 | Received 02 Apr 2020, Accepted 17 Jun 2020, Published online: 03 Jul 2020

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  • Duan BC, Wong LC, Lee WT. Alternating hemiplegia and paroxysmal torticollis caused by SCN4A mutation: a new phenotype? Neurology 2019;93:673–4.
  • Mi W, Rybalchenko V, Cannon SC. Disrupted coupling of gating charge displacement to Na + current activation for DIIS4 mutations in hypokalemic periodic paralysis. J Gen Physiol. 2014;144:137–45.
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  • Hiyama TY, Watanabe E, Ono K, Inenaga K, Tamkun MM, Yoshida S, et al. Na(x) channel involved in CNS sodium-level sensing. Nat Neurosci. 2002;5:511–2.
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