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Clincial

Progressive arm muscle weakness in ALS follows the same sequence regardless of onset site: use of TOMS, a novel analytic method to track limb strength

ORCID Icon, , &
Pages 380-387 | Received 12 Nov 2020, Accepted 07 Feb 2021, Published online: 23 Feb 2021

References

  • Ravits JM, La Spada AR. ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration. Neurology. 2009;73:805–11.
  • Vucic S. Split elbow sign: more evidence for the importance of cortical dysfunction in ALS. J Neurol Neurosurg Psychiatry. 2019;90:729.
  • Ludolph AC, Emilian S, Dreyhaupt J, Rosenbohm A, Kraskov A, Lemon RN, et al. Pattern of paresis in ALS is consistent with the physiology of the corticomotoneuronal projections to different muscle groups. J Neurol Neurosurg Psychiatry. 2020;91:991–8.
  • Devine MS, Woodhouse H, McCombe PA, Henderson RD. The relationship between limb dominance, disease lateralization and spread of weakness in amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler Frontotemporal Degener. 2013;14:150–1.
  • Shayya L, Babu S, Pioro EP, Li J, Li Y. Distal predominance of electrodiagnostic abnormalities in early-stage amyotrophic lateral sclerosis. Muscle Nerve. 2018;58:389–95.
  • Hansen S, Ballantyne JP. A quantitative electrophysiological study of motor neurone disease. J Neurol Neurosurg Psychiatry. 1978;41:773–83.
  • Wilbourn AJ. The “split hand syndrome”. Muscle Nerve. 2000;23:138.
  • Simon NG, Lee M, Bae JS, Mioshi E, Lin CS-Y, Pfluger CM, et al. Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis. J Neurol. 2015;262:1424–32.
  • Khalaf R, Martin S, Ellis C, Burman R, Sreedharan J, Shaw C, et al. Relative preservation of triceps over biceps strength in upper limb-onset ALS: the “split elbow”. J Neurol Neurosurg Psychiatry. 2019;90:730–3.
  • Shefner JM. Strength testing in motor neuron diseases. Neurotherapeutics. 2017;14:154–60.
  • Bohannon RW. Considerations and practical options for measuring muscle strength: a narrative review. Biomed Res Int. 2019;2019:8194537.
  • Shefner JM, Liu D, Leitner ML, Schoenfeld D, Johns DR, Ferguson T, et al. Quantitative strength testing in ALS clinical trials. Neurology. 2016;87:617–24.
  • Cudkowicz ME, Titus S, Kearney M, Yu H, Sherman A, Schoenfeld D, et al. Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014;13:1083–91.
  • Bohannon RW, Magasi SR, Bubela DJ, Wang Y-C, Gershon RC. Grip and knee extension muscle strength reflect a common construct among adults. Muscle Nerve. 2012;46:555–8.
  • Rushton DJ, Andres PL, Allred P, Baloh RH, Svendsen CN. Patients with ALS show highly correlated progression rates in left and right limb muscles. Neurology. 2017;89:196–206.
  • Seber GA, Lee AJ. Linear regression analysis. 2nd ed. Hoboken, NJ: John Wiley & Sons, Inc.; 2003.
  • Pinheiro J, Bates D, DebRoy S, Sarkar D. R Core Team. nlme: linear and nonlinear mixed effects models [Internet]; 2020. Available at: https://CRAN.R-project.org/package=nlme.
  • Eisen A, Kim S, Pant B. Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron? Muscle Nerve. 1992;15:219–24.
  • Eisen A, Braak H, Del Tredici K, Lemon R, Ludolph AC, Kiernan MC. Cortical influences drive amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2017;88:917–24.
  • Turner MR, Wicks P, Brownstein CA, Massagli MP, Toronjo M, Talbot K, et al. Concordance between site of onset and limb dominance in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatr. 2011;82:853–4.
  • Pioro E, Thakore N. Handedness and side of onset in limb-onset ALS: is there a connection? Amyotroph Lateral Scler Frontotemporal Degener. 2016;17:86–100.
  • Walhout R, Verstraete E, van den Heuvel MP, Veldink JH, van den Berg LH. Patterns of symptom development in patients with motor neuron disease. Amyotroph Lateral Scler Frontotemporal Degener. 2018;19:21–8.
  • Bohannon RW. Measuring knee extensor muscle strength. Am J Phys Med Rehabil. 2001;80:13–8.
  • Bromberg MB, Forshew DA, Nau KL, Bromberg J, Simmons Z, Fries TJ. Motor unit number estimation, isometric strength, and electromyographic measures in amyotrophic lateral sclerosis. Muscle Nerve. 1993;16:1213–9.
  • Johns D, Liu D, Ferguson T, Cedarbaum JM. Methods for evaluating patients (application number 15/629,424, publication number 20180064386) [Internet]; 2018. Available at: www.uspto.gov. Accessed August 31, 2020.

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