69
Views
1
CrossRef citations to date
0
Altmetric
LetterLetter

Inosine supplements only reach the CNS in molybdenum deficient humans and may cause astrocyte degeneration and bulbar–respiratory disease

Pages 154-156 | Received 07 May 2021, Accepted 14 Jun 2021, Published online: 10 Jul 2021

References

  • Bourke CA. Astrocyte dysfunction following molybdenum-associated purine loading could initiate Parkinson’s disease with dementia. NPJ Parkinson’s Dis. 2018;4:7.
  • Bourke CA. Motor neuron disease in molybdenum-deficient sheep fed the endogenous purine xanthosine: a possible mechanism for Tribulus staggers. Aust Vet J. 2012;90:272–4.
  • Bourke CA. Molybdenum deprivation, purine ingestion and an astrocyte-associated motor neuron syndrome in sheep: the assumed clinical effects of inosine. Aust Vet J. 2015;93:79–83.
  • Bourke CA. Molybdenum deficiency produces motor nervous effects that are consistent with amyotrophic lateral sclerosis. Front Neurol. 2016;7:28.
  • Nicholson K, Chan J, Macklin EA, Levine-Weinberg M, Breen C, Bakshi R, et al. Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2018;5:1522–33.
  • Lin G, Bedlack R, Crayle J, et al. ALS untangled no. 52: glutathione. Amyotroph Lat Scler Frontotemp Degener. 2020; 21:154–7.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.