2,217
Views
0
CrossRef citations to date
0
Altmetric
ALS Untangled

ALSUntangled # 69: astaxanthin

, , , , , ORCID Icon, , ORCID Icon, , , , , , , , , , ORCID Icon, , , ORCID Icon & show all
Pages 553-557 | Received 29 Dec 2022, Accepted 16 Jan 2023, Published online: 24 Jan 2023

References

  • Zheng Yf, Bae Sh, Kwon Mj, Park Jb, Choi Hd, Shin Wg, et al. Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities. Food Chem Toxicol. 2013;59:78–85.
  • Hu J, Nagarajan D, Zhang Q, Chang Js, Lee DJ. Heterotrophic cultivation of microalgae for pigment production: A review. Biotechnol Adv. 2018;36:54–67.
  • Donoso A, González-Durán J, Muñoz Aa, González Pa, Agurto-Muñoz C. “Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials”. Pharmacol Res. 2021;166:105479.
  • Patil Ad, Kasabe Pj, Dandge PB. Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin. Nat Prod Bioprospect. 2022;12:25.
  • Capelli B, Bagchi D, Cysewski GR. Synthetic astaxanthin is significantly inferior to algal-based astaxanthin as an antioxidant and may not be suitable as a human nutraceutical supplement. Nutrafoods 2013;12:145–52.
  • Ambati R, Phang Sm, Ravi S, Aswathanarayana R. Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review. Mar Drugs 2014;12:128–52.
  • Yuan Jp, Peng J, Yin K, Wang JH. Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 2011;55:150–65.
  • Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea FM. Astaxanthin: A Review of its Chemistry and Applications. Crit Rev Food Sci Nutr. 2006;46:185–96.
  • Si P, Zhu C. Biological and neurological activities of astaxanthin (Review). Mol Med Rep 2022;26:300.
  • Miki W. Biological functions and activities of animal carotenoids. Pure and Applied Chemistry 1991;63:141–6.
  • Kurashige M, Okimasu E, Inoue M, Utsumi K. Inhibition of oxidative injury of biological membranes by astaxanthin. Physiol Chem Phys Med Nmr. 1990;22:27–38.
  • Barber Sc, Shaw PJ. Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target. Free Radic Biol Med. 2010;48:629–41.
  • Zuo X, Zhou J, Li Y, Wu K, Chen Z, Luo Z, et al. TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS. Nat Struct Mol Biol. 2021;28:132–42.
  • Isonaka R, Hiruma H, Katakura T, Kawakami T. Inhibition of superoxide dismutase selectively suppresses growth of rat spinal motor neurons: Comparison with phosphorylated neurofilament-containing spinal neurons. Brain Res. 2011;1425:13–9.
  • Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod. 2006;69:443–9.
  • Wang HQ, Sun XB, Xu YX, Zhao H, Zhu QY, Zhu CQ. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res. 2010;1360:159–67.
  • Li Z, Dong X, Liu H, Chen X, Shi H, Fan Y, et al. Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt. Mol Vis 2013;19:1656–66.
  • Wu Q, Zhang XS, Wang HD, Zhang X, Yu Q, Li W, et al. Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury. Mar Drugs. 2014;12:6125–41.
  • Zarneshan SN, Fakhri S, Farzaei MH, Khan H, Saso L. Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications. Food Chem Toxicol. 2020;145:111714.
  • Wu H, Niu H, Shao A, Wu C, Dixon B, Zhang J, et al. Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases. Mar Drugs. 2015;13:5750–66.
  • Yamagishi R, Aihara M. Neuroprotective effect of astaxanthin against rat retinal ganglion cell death under various stresses that induce apoptosis and necrosis. Mol Vis. 2014;20:1796–805.
  • Fakhri S, Dargahi L, Abbaszadeh F, Jorjani M. Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: Involvement of ERK and AKT signaling pathway. Eur J Pain. 2019;23:750–64.
  • Fakhri S, Dargahi L, Abbaszadeh F, Jorjani M. Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury. Brain Res Bull. 2018;143:217–24.
  • Nakagawa K, Kiko T, Miyazawa T, Carpentero Burdeos G, Kimura F, Satoh A, et al. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. Br J Nutr. 2011;105:1563–71.
  • Chen L, Na R, Danae McLane K, Thompson CS, Gao J, Wang X, et al. Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice. Sci Rep. 2021;11:12890.
  • Liu J, Wang F. Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications. Front Immunol. 2017;8:1005.
  • Ranga Rao A, Raghunath Reddy RL, Baskaran V, Sarada R, Ravishankar GA. Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model. J Agric Food Chem. 2010;58:8553–9.
  • Yang C, Hassan YI, Liu R, Zhang H, Chen Y, Zhang L, et al. Anti-Inflammatory Effects of Different Astaxanthin Isomers and the Roles of Lipid Transporters in the Cellular Transport of Astaxanthin Isomers in Caco-2 Cell Monolayers. J Agric Food Chem. 2019;67:6222–31.
  • Chang MX, Xiong F. Astaxanthin and its effects in inflammatory responses and inflammation-associated diseases: recent advances and future directions. Molecules. MDPI 2020;25:5342.
  • Andersen LP, Holck S, Kupcinskas L, Kiudelis G, Jonaitis L, Janciauskas D, et al. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. FEMS Immunol Med Microbiol. 2007;50:244–8.
  • Baralic I, Andjelkovic M, Djordjevic B, Dikic N, Radivojevic N, Suzin-Zivkovic V, et al. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. Evid Based Complement Alternat Med. 2015;2015:783761.
  • Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab (Lond). 2010;7:18.
  • Dafinca R, Barbagallo P, Talbot K. The Role of Mitochondrial Dysfunction and ER Stress in TDP-43 and C9ORF72 ALS. Front Cell Neurosci. 2021;15:653688.
  • Kim SH, Kim H. Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review. Nutrients 2018;10:1137.
  • Kandy SK, Nimonkar MM, Dash SS, Mehta B, Markandeya YS. Astaxanthin protection against neuronal excitotoxicity via glutamate receptor inhibition and improvement of mitochondrial function. Mar Drugs 2022;20:645.
  • PatientsLikeMe. 2022. https://www.patientslikeme.com/patients/searches/detail_search?s%5Bexclude_deceased%5D=true&s%5Bt%5D=5380
  • ALS winners - the road to recovery. 2022. https://www.alswinners.com/.
  • Harrison D, Mehta P, van Es MA, Stommel E, Drory VE, Nefussy B, Pooled Resource Open-Access ALS Clinical Trials Consortium, et al. “ALS reversals”: demographics, disease characteristics, treatments, and co-morbidities. Amyotroph Lateral Scler Frontotemporal Degener. 2018;19:495–9.
  • ALS Reversals. 2022. https://alsreversals.com/.
  • Katagiri M, Satoh A, Tsuji S, Shirasawa T. Effects of astaxanthin-rich Haematococcus pluvialis extract on cognitive function: a randomised, double-blind, placebo-controlled study. J Clin Biochem Nutr. 2012;51:102–7.
  • Hayashi M, Ishibashi T, Maoka T. Effect of astaxanthin-rich extract derived from Paracoccus carotinifaciens on cognitive function in middle-aged and older individuals. J Clin Biochem Nutr. 2018;62:195–205.
  • Edwards JA, Bellion P, Beilstein P, Rümbeli R, Schierle J. Review of genotoxicity and rat carcinogenicity investigations with astaxanthin. Regul Toxicol Pharmacol. 2016;75:5–19.
  • Brendler T, Williamson EM. Astaxanthin: How much is too much? A safety review. Phytother Res. 2019;33:3090–111.
  • Astaxanthin Search Results. 2022. https://www.amazon.com/s?k=astaxanthin&crid=3TV11DGDMU5H0&sprefix=astaxanthin%2Caps%2C123&ref=nb_sb_noss_1

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.