Therapeutic targets and investigated treatment strategies in Acanthamoeba keratitis

References

• Lorenzo-Morales J, Khan NA, Walochnik J. An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment. Parasite. 2015;22:10.
   PubMed Web of Science ®Google Scholar
• Cope JR, Collier SA, Schein OD, et al. Acanthamoeba keratitis among rigid gas permeable contact lens wearers in the United States, 2005 through 2011. Ophthalmol. 2016;S0161–6420(16):30085–30089.
   Google Scholar
• Khan NA. Acanthamoeba – biology and pathogenesis. Norfolk (Great Britain): Caister Academic Press; 2009; p. 290.
   Google Scholar
• Khan NA. Acanthamoeba: biology and increasing importance in human health. FEMS Microbiol Rev. 2006;30:564–569.
   PubMed Web of Science ®Google Scholar
• Lorenzo-Morales J, Martín-Navarro CM, López-Arencibia A, et al. Acanthamoeba keratitis: an emerging disease gathering importance worldwide? Trends Parasitol. 2013;29(4):181–187.
   PubMed Web of Science ®Google Scholar
• Mahittikorn A, Kittichathanakul T, To-Im J, et al. Free-living amoebae contamination of cosmetic contact lens among university wearers in Thailand: a cross-sectional study. Eye Contact Lens. 2016 Mar 9. [ Epub ahead of print].
   PubMedGoogle Scholar
• Sun Y, Hong J, Zhang P, et al. Pathological characteristics of the different stages of Acanthamoeba keratitis. Histopathol. 2013;63(6):862–868.
   PubMed Web of Science ®Google Scholar
• Dart JK, Saw VP, Kilvington S. Acanthamoeba keratitis: diagnosis and treatment update 2009. Am J Ophthalmol. 2009;148(4):487–499.
   PubMed Web of Science ®Google Scholar
• Roberts CW, Henriquez FL. Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections. Exp Parasitol. 2010;126:91–96.
   PubMed Web of Science ®Google Scholar
• Arnalich-Montiel F, Martín-Navarro CM, Alió JL, et al. Successful monitoring and treatment of intraocular dissemination of Acanthamoeba with voriconazole. Arch Ophthalmol. 2012;130:1474–1475.
   PubMedGoogle Scholar
• Lim N, Goh D, Bunce C, et al. Comparison of polyhexamethylene biguanide and chlorhexidine as monotherapy agents in the treatment of Acanthamoeba keratitis. Am J Ophthalmol. 2008;145:130–135.
   PubMed Web of Science ®Google Scholar
• Polat ZA, Walochnik J, Obwaller A, et al. Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis. Clin Exp Ophthalmol. 2014;42(2):151–158.
   PubMed Web of Science ®Google Scholar
• Ficker L, Seal D, Warhurst D, et al. Acanthamoeba keratitis-resistance to medical therapy. Eye. 1990;4:835–838.
   PubMedGoogle Scholar
• Marciano-Cabral F, Cabral G. Acanthamoeba spp. as agents of disease in humans. Clin Microbiol Rev. 2003;16(2):273–307.
   PubMed Web of Science ®Google Scholar
• Turner NA, Russell AD, Furr JR, et al. biguanide sorption and biguanide-induced pentose leakage during encystment of Acanthamoeba castellanii. J Appl Microbiol. 2004;96(6):1287–1295.
   PubMed Web of Science ®Google Scholar
• Turner NA, Russell AD, Furr JR, et al. Emergence of resistance to biocides during differentiation of Acanthamoeba castellanii. J Antimicrob Chemother. 2000;46(1):27–34.
   PubMed Web of Science ®Google Scholar
• Ueki N, Eguchi H, Oogi Y, et al. Three cases of Acanthamoeba keratitis diagnosed and treated in the early stage. J Med Invest. 2009;56(3–4):166–169.
   PubMedGoogle Scholar
• McClellan K, Howard K, Niederkorn JY, et al. Effect of steroids on Acanthamoeba cysts and trophozoites. Invest Ophthalmol Vis Scien. 2001;42:2885–2893.
   PubMed Web of Science ®Google Scholar
• Robaei D, Carnt N, Minassian DC, et al. The impact of topical corticosteroid use before diagnosis on the outcome of Acanthamoeba keratitis. Ophthalmol. 2014;121(7):1383–1388.
   PubMed Web of Science ®Google Scholar
• Carnt N, Robaei D, Watson SL, et al. The impact of topical corticosteroids used in conjunction with antiamoebic therapy on the outcome of Acanthamoeba keratitis. Ophthalmol. 2016;123(5):984–990.
   PubMed Web of Science ®Google Scholar
• Beattie TK, Seal DV, Tomlinson A, et al. Determination of amoebicidal activities of multipurpose contact lens solutions by using a most probable number enumeration technique. J Clin Microbiol. 2003;41:2992–3000.
   PubMed Web of Science ®Google Scholar
• Khunkitti W, Avery SV, Lloyd D, et al. Effects of biocides on Acanthamoeba castellanii as measured by flow cytometry and plaque assay. J Antimicrob Chemother. 1997;40:227–233.
   PubMed Web of Science ®Google Scholar
• Martin-Navarro CM, Lorenzo-Morales J, Cabrera-Serra MG, et al. The potential pathogenicity of chlorhexidine-sensitive Acanthamoeba strains isolated from contact lens cases from asymptomatic individuals in Tenerife, Canary Islands, Spain. J Med Microbiol. 2008;57:1399–1404.
   PubMed Web of Science ®Google Scholar
• McBride J, Ingram PR, Henriquez FL, et al. Development of a colorimetric microtitre plate assay for assessment of antimicrobials against Acanthamoeba. J Clin Microbiol. 2005;43:629–634.
   PubMed Web of Science ®Google Scholar
• Martín-Navarro CM, López-Arencibia A, Sifaoui I, et al. Statins and voriconazole induce programmed cell death in Acanthamoeba castellanii. Antimicrob Agents Chemother. 2015;59(5):2817–2824.
   PubMed Web of Science ®Google Scholar
• Feldman ST, Speaker M, Cleveland P. Effect of magainins on Acanthamoeba castellanii. Rev Infect Dis. 1991;13(Suppl 5):S439.
   Google Scholar
• Schuster FL, Jacob LS. Effects of magainins on ameba and cyst stages of Acanthamoeba polyphaga. Antimicrob Agents Chemother. 1992;36(6):1263–1271.
   PubMed Web of Science ®Google Scholar
• Sifaoui I, López-Arencibia A, Martín-Navarro CM, et al. Activity assessment of Tunisian olive leaf extracts against the trophozoite stage of Acanthamoeba. Parasitol Res. 2013;112(8):2825–2829.
   PubMed Web of Science ®Google Scholar
• Sifaoui I, López-Arencibia A, Ticona JC, et al. Bioassay guided isolation and identification of anti-Acanthamoeba compounds from Tunisian olive leaf extracts. Exp Parasitol. 2014;145(Suppl):S111–S114.
   Google Scholar
• Vunda SL, Sauter IP, Cibulski SP, et al. Chemical composition and amoebicidal activity of Croton pallidulus, Croton ericoides, and Croton isabelli (Euphorbiaceae) essential oils. Parasitol Res. 2012;111(3):961–966.
   PubMed Web of Science ®Google Scholar
• Degerli S, Tepe B, Celiksoz A, et al. In vitro amoebicidal activity of Origanum syriacum and Origanum laevigatum on Acanthamoeba castellanii cysts and trophozoites. Exp Parasitol. 2012;131(1):20–24.
   PubMed Web of Science ®Google Scholar
• Santos IG, Scher R, Rott MB, et al. Amebicidal activity of the essential oils of Lippia spp. (Verbenaceae) against Acanthamoeba polyphaga trophozoites. Parasitol Res. 2016;115(2):535–540.
   PubMed Web of Science ®Google Scholar
• Kuźma Ł, Derda M, Hadaś E, et al. Abietane diterpenoids from Salvia sclarea transformed roots as growth inhibitors of pathogenic Acanthamoeba spp. Parasitol Res. 2015;114(1):323–327.
   PubMed Web of Science ®Google Scholar
• Abdulhalim B, Wagih MM, Gad AA, et al. Amniotic membrane graft to conjunctival flap in treatment of non-viral resistant infectious keratitis: a randomised clinical study. Br J Ophthalmol. 2015;99(1):59–63.
   PubMed Web of Science ®Google Scholar
• Kashiwabuchi RT, Carvalho FR, Khan YA, et al. Assessing efficacy of combined riboflavin and UV-A light (365 nm) treatment of Acanthamoeba trophozoites. Invest Ophthal Vis Sci. 2011;52(13):9333–9338.
   PubMed Web of Science ®Google Scholar
• Del Buey MA, Cristóbal JA, Casas P, et al. Evaluation of in vitro efficacy of combined riboflavin and ultraviolet A for Acanthamoeba isolates. Am J Ophthalmol. 2012;153(3):399–404.
   PubMed Web of Science ®Google Scholar
• Garduño-Vieyra L, González-Sánchez CR, Hernández-Da Mota SE. Ultraviolet-a light and riboflavin therapy for Acanthamoeba keratitis: a case report. Case Rep Ophthalmol. 2011;2(2):291–295.
   PubMedGoogle Scholar
• Khan YA, Kashiwabuchi RT, Martins SA, et al. Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases. Ophthalmol. 2011;118(2):324–331.
   PubMed Web of Science ®Google Scholar
• Aichelburg AC, Walochnik J, Assadian O, et al. Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine. Emerg Infect Dis. 2008;14(11):1743–1746.
   PubMed Web of Science ®Google Scholar
• Walochnik J, Obwaller A, Gruber F, et al. Anti-Acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent. J Antimicrob Chemother. 2009;64(3):539–545.
   PubMed Web of Science ®Google Scholar
• Polat ZA, Obwaller A, Vural A, et al. Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters. Parasitol Res. 2012;110(2):515–520.
   PubMed Web of Science ®Google Scholar
• Timko L, Fischer-Fodor E, Garajová M, et al. Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity. Eur J Med Chem. 2015;93:263–273.
   PubMed Web of Science ®Google Scholar
• Lorenzo-Morales J, Ortega-Rivas A, Foronda P, et al. RNA interference (RNAi) for the silencing of extracellular serine proteases genes in Acanthamoeba: molecular analysis and effect on pathogenecity. Mol Biochem Parasitol. 2005;144:10–15.
   PubMed Web of Science ®Google Scholar
• Lorenzo-Morales J, Kliescikova J, Martinez-Carretero E, et al. Glycogen phosphorylase in Acanthamoeba spp.: determining the role of the enzyme during the encystment process using RNA interference. Euk Cell. 2008;7(3):509–517.
   PubMed Web of Science ®Google Scholar
• Martín-Navarro CM, Lorenzo-Morales J, López-Arencibia A, et al. Evaluation of Acanthamoeba myosin-IC as a potential therapeutic target. Antimicrob Agents Chemother. 2014;58(4):2150–2155.
   PubMed Web of Science ®Google Scholar
• Martín-Navarro CM, Lorenzo-Morales J, Machin RP, et al. Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and the application of statins as a novel effective therapeutic approach against Acanthamoeba infections. Antimicrob Agents Chemother. 2013;57(1):375–381.
   PubMed Web of Science ®Google Scholar
• Clarke M, Lohan AJ, Liu B, et al. Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biol. 2013;14(2):R11.
   Google Scholar