200
Views
4
CrossRef citations to date
0
Altmetric
Review

Therapeutic targets and investigated treatments for Ataxia-Telangiectasia

, , , , , & show all
Pages 1263-1276 | Received 19 Aug 2016, Accepted 26 Oct 2016, Published online: 11 Nov 2016

References

  • Savitsky K, Bar-Shira A, Gilad S, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science. 1995;268:1749–1753.
  • Boder E, Sedgwick RP Ataxia-telangiectasia; a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection. A Preliminary Report on 7 children, an autopsy, and a case history: USC Med Bull; 1957.
  • Biemond A. [Acute ataxia in children]. Ned Tijdschr Geneeskd. 1957;101:529–532.
  • Sedgewick RP, Boder E. Ataxia-telangiectasia. In: Vinken BG, editor. Handbook of clinical neurology. Vol. 14. Amsterdam: North Holland Publishers; 1972. p. 267–339.
  • Taylor AMR, Byrd PJ. Molecular pathology of ataxia telangiectasia. J Clin Pathol. 2005;58:1009–1015.
  • Verhagen MMM, Martin JJ, Van Deuren M, et al. Neuropathology in classical and variant ataxia-telangiectasia. Neuropathology. 2012;32:234–244. .
  • Mcfarlin DE, Waldmann TA, Strober W. Ataxia-telangiectasia. Medicine. 1972;51:281.
  • Peterson RD, Kelly WD, Good RA. Ataxia-telangiectasia: Its association with a defective thymus, immunological-deficiency disease, and malignancy. Lancet 1964; 13:1189–1193
  • Schroeder SA, Zielen S. Infections of the respiratory system in patients with ataxia-telangiectasia. Pediatr Pulm. 2014;49:389–399. .
  • Bhatt JM, Bush A. Microbiological surveillance in lung disease in ataxia telangiectasia. Eur Respir J. 2014;43:1797–1801.
  • McGrath-Morrow SA, Collaco JM, Crawford TO, et al. Elevated serum IL-8 levels in ataxia telangiectasia. J Pediatr-US. 2010;156:682–U213.
  • Hartlova A, Erttmann SF, Raffi FAM, et al. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Immunity. 2015;42:332–343.
  • Erttmann SF, Hartlova A, Sloniecka M, et al. Loss of the DNA damage repair kinase ATM impairs inflammasome-dependent anti-bacterial innate immunity. Immunity. 2016;45:106–118.
  • McGrath-Morrow SA, Gower WA, Rothblum-Oviatt C, et al. Evaluation and management of pulmonary disease in ataxia-telangiectasia. Pediatr Pulmonol. 2010;45:847–859.
  • McGrath-Morrow SA, Lederman HM, Aherrera AD, et al. Pulmonary function in children and young adults with ataxia telangiectasia. Pediatr Pulm. 2014;49:84–90.
  • Spector BD, Filipovich AH, Perry GSI, et al. Epidemiology of cancer in ataxia-telangiectasia. In: Bridges BA, Harnden DG, editors. Ataxia telangiectasia: a cellular and molecular link between cancer, neuropathology and immune deficiency. New York: Wiley; 1982. p. 103–138.
  • Lavin MF, Gueven N, Bottle S, et al. Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia. Brit Med Bull. 2007;81-82:129–147.
  • Davis MM, Gatti RA, Sparks RS. Neoplasia and chromosomal breakage in ataxia-telangiectasia. In: Gatti R, Harnden DG, editors. Ataxia telangiectasia: a cellular and molecular link between cancer, neuropathology and immune deficiency. New York: Alan R. Liss, Inc; 1985. p. 197–203.
  • Barlow C, Hirotsune S, Paylor R, et al. ATM-deficient mice: a paradigm of ataxia telangiectasia. Cell. 1996;86:159–171.
  • Xu Y, Baltimore D. Dual roles of ATM in the cellular response to radiation and in cell growth control. Gene Dev. 1996;10:2401–2410.
  • Hecht F, Hecht BK. Cancer in ataxia-telangiectasia patients. Cancer Genet Cytogen. 1990;46:9–19.
  • Swift M, Morrell D, Massey RB, et al. Incidence of cancer in 161 families affected by ataxia-telangiectasia. New Engl J Med. 1991;325:1831–1836.
  • Bhatt JM, A B, van Gerven M, et al. ERS statement on the multidisciplinary respiratory management of ataxia telangiectasia. Eur Respir Rev. 2015;24:565–581 .
  • Waldmann TA, Mcintire KR. Serum-alpha-fetoprotein levels in patients with ataxia-telangiectasia. Lancet. 1972;2:1112.
  • Jung CG, Kim HJ, Kawaguchi M, et al. Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation. Development. 2005;132:5137–5145.
  • Schalch DS, McFarlin DE, Barlow MH. An unusual form of diabetes mellitus in ataxia telangiectasia. N Engl J Med. 1970;282:1396–1402.
  • Srisirirojanakorn N, Finegold MJ, Gopalakrishna GS, et al. Hepatic veno-occlusive disease in ataxia-telangiectasia. J Pediatr. 1999;134:786–788.
  • Amromin GD, Boder E, Teplitz R. Ataxia-telangiectasia with a 32 year survival. A clinicopathological report. J Neuropathol Exp Neurol. 1979;38:621–643.
  • Caballero T, Caba-Molina M, Salmeron J, et al. Nonalcoholic steatohepatitis in a patient with ataxia-telangiectasia. Case Reports Hepatol. 2014;2014:761250.
  • Weiss B, Krauthammer A, Soudack M, et al. Liver disease in pediatric patients with ataxia telangiectasia: a novel report. J Pediatr Gastroenterol Nutr. 2016;62:550–555.
  • Mercer JR, Cheng KK, Figg N, et al. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res. 2010;107:1021–1031.
  • Bar RS, Levis WR, Rechler MM, et al. Extreme insulin resistance in ataxia telangiectasia - defect in affinity of insulin receptors. New Engl J Med. 1978;298:1164–1171.
  • Yang DQ, Kastan MB. Participation of ATM in insulin signalling through phosphorylation of eIf-4E-binding protein 1. Nat Cell Biol. 2000;2:893–898.
  • Schneider JG, Finck BN, Ren J, et al. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab. 2006;4:377–389.
  • Takagi M, Uno H, Nishi R, et al. ATM regulates adipocyte differentiation and contributes to glucose homeostasis. Cell Rep. 2015;10(6):957–967.
  • Reina-San-Martin B, Chen HT, Nussenzweig A, et al. ATM is required for efficient recombination between immunoglobulin switch regions. J Exp Med. 2004;200:1103–1110.
  • Lumsden J, McCarty T, Petiniot L, et al. Immunoglobulin class switch recombination is impaired in ATM-deficient mice. Faseb J. 2005;19:A16–A.
  • Vacchio MS, Olaru A, Livak F, et al. ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor a locus coding end breaks. P Natl Acad Sci USA. 2007;104:6323–6328.
  • McConville CM, Stankovic T, Byrd PJ, et al. Mutations associated with variant phenotypes in ataxia-telangiectasia. Am J Hum Genet. 1996;59:320–330.
  • Nakamura K, Du LT, Tunuguntla R, et al. Functional characterization and targeted correction of ATM mutations identified in japanese patients with ataxia-telangiectasia. Hum Mutat. 2012;33:198–208.
  • Aurias A, Dutrillaux B, Buriot D, et al. High-frequencies of inversions and translocations of chromosomes 7 and 14 in ataxia telangiectasia. Mutat Res. 1980;69:369–374.
  • Meyn MS. High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia. Science. 1993;260:1327–1330.
  • Taylor AMR. Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations. Mutat Res. 1978;50:407–418.
  • Gotoff SP, Amirmokri E, Liebner EJ. Ataxia telangiectasia - neoplasia untoward response to X-irradiation and tuberous sclerosis. Am J Dis Child. 1967;114:617.
  • Morgan JL, Holcomb TM, Morrissey R. Radiation reaction in ataxia telangiectasia. Am J Dis Child. 1968;116:557.
  • Taylor AM, Harnden DG, Arlett CF, et al. Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature. 1975;258:427–429.
  • Gatti RA, Berkel I, Boder E, et al. Localization of an ataxia-telangiectasia gene to chromosome 11q22-23. Nature. 1988;336:577–580.
  • Matsuoka S, Ballif BA, Smogorzewska A, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007;316:1160–1166.
  • Brown KD, Ziv Y, Sadanandan SN, et al. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. P Natl Acad Sci USA. 1997;94:1840–1845.
  • Lavin MF. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol. 2008;9:759–769.
  • McKinnon PJ. ATM and the molecular pathogenesis of ataxia telangiectasia. Annu Rev Pathol-Mech. 2012;7:303–321.
  • Shiloh Y, Lederman HM. Ataxia-telangiectasia (A-T): an emerging dimension of premature ageing. Ageing Res Rev. 2016 May 12. pii: S1568–1637(16)30078-2. doi:10.1016/j.arr.2016.05.002. [Epub ahead of print].
  • Watters D, Kedar P, Spring K, et al. Localization of a portion of extranuclear ATM to peroxisomes. J Biol Chem. 1999;274:34277–34282.
  • Zhang JW, Tripathi DN, Jing J, et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015;17:1259.
  • Valentin-Vega YA, MacLean KH, Tait-Mulder J, et al. Mitochondrial dysfunction in ataxia-telangiectasia. Blood. 2012;119:1490–1500.
  • Guo Z, Kozlov S, Lavin MF, et al. ATM activation by oxidative stress. Science. 2010;330:517–521.
  • Morita A, Tanimoto K, Murakami T, et al. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells. Biochem Bioph Res Co. 2014;443:1286–1290.
  • Nakamura K, Fike F, Haghayegh S, et al. A-TWinnipeg: pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity. Mol Genet Genomic Med. 2014;2:332–340.
  • Verhagen MM, Last JI, Hogervorst FB, et al. Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study. Hum Mutat. 2012;33:561–571.
  • Barone G, Groom A, Reiman A, et al. Modeling ATM mutant proteins from missense changes confirms retained kinase activity. Hum Mutat. 2009;30:1222–1230.
  • Romano S, Coarelli G, Marcotulli C, et al. Riluzole in patients with hereditary cerebellar ataxia: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015;14:985–991.
  • Pommerening H, van Dullemen S, Kieslich M, et al. Body composition, muscle strength and hormonal status in patients with ataxia telangiectasia: a cohort study. Orphanet J Rare Dis. 2015 Dec 9;10:155. doi:10.1186/s13023-015-0373-z
  • Voss S, Pietzner J, Hoche F, et al. Growth retardation and growth hormone deficiency in patients with ataxia telangiectasia. Growth Factors. 2014;32:123–129.
  • Dzieciatkowska M, Qi G, You J, et al. Proteomic characterization of cerebrospinal fluid from ataxia-telangiectasia (A-T) patients using a LC/MS-based label-free protein quantification technology. Int J Proteomics. 2011;2011:578903.
  • Sandlund JT, Hudson MM, Kennedy W, et al. Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies. Pediatr Blood Cancer. 2014;61:360–362. .
  • Nowak-Wegrzyn A, Crawford TO, Winkelstein JA, et al. Immunodeficiency and infections in ataxia-telangiectasia. J Pediatr-Us. 2004;144:505–511.
  • Dournes G, Menut F, Macey J, et al. Lung morphology assessment of cystic fibrosis using MRI with ultra-short echo time at submillimeter spatial resolution. Eur Radiol. 2016; 26(11):3811–3820.
  • Tiddens HA, Stick SM, Wild JM, et al. Respiratory tract exacerbations revisited: ventilation, inflammation, perfusion, and structure (VIPS) monitoring to redefine treatment. Pediatr Pulmonol. 2015;50(Suppl 40):S57–S65.
  • Czovek D, Shackleton C, Hantos Z, et al. 2016. Tidal changes in respiratory resistance are sensitive indicators of airway obstruction in children. Thorax. Epub in press. doi:10.1136/thoraxjnl-2015-208182
  • Felix E, Gimenes AC, Costa-Carvalho BT. Effects of inspiratory muscle training on lung volumes, respiratory muscle strength, and quality of life in patients with ataxia telangiectasia. Pediatr Pulmonol. 2014;49:238–244.
  • Varon R, Demuth I, Digweed M. Nijmegen Breakage Syndrome. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews(R). Seattle (WA): University of Washington; 1993.
  • Waltes R, Kalb R, Gatei M, et al. Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. Am J Hum Genet. 2009;84:605–616.
  • Nissenkorn A, Levi YB, Vilozni D, et al. Neurologic presentation in children with ataxia-telangiectasia: is small head circumference a hallmark of the disease? J Pediatr-Us. 2011;159:466–U526.
  • Crawford TO, Mandir AS, Lefton-Greif MA, et al. Quantitative neurologic assessment of ataxia-telangiectasia. Neurology. 2000;54:1505–1509.
  • Jackson TJ, Chow G, Suri M, et al. Longitudinal analysis of the neurological features of ataxia-telangiectasia. Dev Med Child Neurol. 2016;58:690–697.
  • Woods CG, Taylor AM. Ataxia telangiectasia in the British Isles: the clinical and laboratory features of 70 affected individuals. Q J Med. 1992;82:169–179.
  • Moin M, Aghamohammadi A, Kouhi A, et al. Ataxia-telangiectasia in Iran: clinical and laboratory features of 104 patients. Pediatr Neurol. 2007;37:21–28.
  • Berkun Y, Vilozni D, Levi Y, et al. Reversible airway obstruction in children with ataxia telangiectasia. Pediatr Pulm. 2010;45:230–235.
  • Kieslich M, Hoche F, Reichenbach J, et al. Extracerebellar MRI-lesions in ataxia telangiectasia go along with deficiency of the GH/IGF-1 axis, markedly reduced body weight, high ataxia scores and advanced age. Cerebellum. 2010;9:190–197.
  • Ross LJ, Capra S, Baguley B, et al. Nutritional status of patients with ataxia-telangiectasia: a case for early and ongoing nutrition support and intervention. J Paediatr Child H. 2015;51:802–807. .
  • Stewart E, Prayle AP, Tooke A, et al. Growth and nutrition in children with ataxia telangiectasia. Arch Dis Child. 2016. doi:10.1136/archdischild-2015-310373
  • da Silva R, Dos Santos-Valente EC, Scomparini FB, et al. The relationship between nutritional status, vitamin A and zinc levels and oxidative stress in patients with ataxia-telangiectasia. Allergol Immunopath. 2014;42:329–335.
  • Boder E. Ataxia-telangiectasia: an overview. Kroc Found Ser. 1985;19:1–63.
  • Bagley J, Cortes ML, Breakefield XO, et al. Bone marrow transplantation restores immune system function and prevents lymphoma in ATM-deficient mice. Blood. 2004;104:572–578.
  • Ghosh S, Schuster FR, Binder V, et al. Fatal outcome despite full lympho-hematopoietic reconstitution after allogeneic stem cell transplantation in atypical ataxia telangiectasia. J Clin Immunol. 2012;32:438–440.
  • Ussowicz M, Musial J, Duszenko E, et al. Long-term survival after allogeneic-matched sibling PBSC transplantation with conditioning consisting of low-dose busilvex and fludarabine in a 3-year-old boy with ataxia-telangiectasia syndrome and ALL. Bone Marrow Transpl. 2013;48:740–741.
  • Beier R, Sykora KW, Woessmann W, et al. Allogeneic-matched sibling stem cell transplantation in a 13-year-old boy with ataxia telangiectasia and EBV-positive non-Hodgkin lymphoma. Bone Marrow Transplant. 2016;51:1271–1274.
  • Sandoval C, Swift M. Treatment of lymphoid malignancies in patients with ataxia-telangiectasia. Med Pediatr Oncol. 1998;31:491–497.
  • Stewart R, Kozlov S, Matigian N, et al. A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics. 2013;22:2495–2509.
  • Nayler S, Gatei M, Kozlov S, et al. Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype. Stem Cell Transl Med. 2012;1:523–535.
  • Olsen JH, Hahnemann JM, Borresen-Dale AL, et al. Cancer in patients with ataxia-telangiectasia and in their relatives in the Nordic countries. J Natl Cancer I. 2001;93:121–127.
  • Chessa L, Micheli R, Molinaro A. Focusing new ataxia telangiectasia therapeutic approaches. J Rare Disorders. 2016;2:2.
  • Seidemann K, Henze G, Beck JD, et al. Non-Hodgkin’s lymphoma in pediatric patients with chromosomal breakage syndromes (AT and NBS): experience from the BFM trials. Ann Oncol. 2000;11:141–145.
  • Bienemann K, Burkhardt B, Modlich S, et al. Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen-breakage syndrome): a retrospective survey. Brit J Haematol. 2011;155:468–476.
  • Dembowska-Baginska B, Perek D, Brozyna A, et al. Non-Hodgkin Lymphoma (NHL) in children with Nijmegen Breakage Syndrome (NBS). Pediatr Blood Cancer. 2009;52:186–190.
  • Patte C, Auperin A, Michon J, et al. The Societe Francaise d’Oncologie pediatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia. Blood. 2001;97:3370–3379.
  • Perlman SL. Cerebellar ataxia. Curr Treat Options Neurol. 2000;2:215–224.
  • Perlman S, Becker-Catania S, Gatti RA. Ataxia-telangiectasia: diagnosis and treatment. Semin Pediatr Neurol. 2003;10:173–182.
  • Takei A, Hamada T, Yabe I, et al. Treatment of cerebellar ataxia with 5-HT1A agonist. Cerebellum. 2005;4:211–215.
  • Hoche F, Seidel K, Theis M, et al. Neurodegeneration in ataxia telangiectasia: what is new? What is evident? Neuropediatrics. 2012;43:119–129.
  • Broccoletti T, Del Giudice E, Amorosi S, et al. Steroid-induced improvement of neurological signs in ataxia-telangiectasia patients. Eur J Neurol. 2008;15:223–228.
  • Russo I, Cosentino C, Del Giudice E, et al. In ataxia-teleangiectasia betamethasone response is inversely correlated to cerebellar atrophy and directly to antioxidative capacity. Eur J Neurol. 2009;16:755–759.
  • Broccoletti T, Del Giudice E, Cirillo E, et al. Efficacy of very-low-dose betamethasone on neurological symptoms in ataxia-telangiectasia. Eur J Neurol. 2011;18:564–570.
  • Zannolli R, Buoni S, Betti G, et al. A randomized trial of oral betamethasone to reduce ataxia symptoms in ataxia telangiectasia. Movement Disord. 2012;27:1312–1316.
  • Chessa L, Leuzzi V, Plebani A, et al. Intra-erythrocyte infusion of dexamethasone reduces neurological symptoms in ataxia teleangiectasia patients: results of a phase 2 Trial. Orphanet J Rare Dis. 2014;9:5. doi:10.1186/1750-1172-9-5
  • Leuzzi V, Micheli R, D’Agnano D, et al. Positive effect of erythrocyte-delivered dexamethasone in ataxia-telangiectasia. Neurol Neuroimmunol Neuroinflamm. 2015;2:e98.
  • Biagiotti S, Menotta M, Orazi S, et al. Dexamethasone improves redox state in Ataxia Telangiectasia cells by promoting NRF2-mediated antioxidant response. FEBS J. 2016. doi:10.1111/febs.13901
  • Nissenkorn A, Borgohain R, Micheli R, et al. Development of global rating instruments for pediatric patients with ataxia telangiectasia. Eur J Paediatr Neuro. 2016;20:140–146.
  • Nissenkorn A, Hassin-Baer S, Lerman SF, et al. Movement disorder in ataxia-telangiectasia: treatment with amantadine sulfate. J Child Neurol. 2013;28:155–160.
  • Yorek MA, Dunlap JA, Manzo-Fontes A, et al. Abnormal myo-inositol and phospholipid metabolism in cultured fibroblasts from patients with ataxia telangiectasia. Biochim Biophys Acta. 1999;1437:287–300.
  • Adams BR, Hawkins AJ, Povirk LF, et al. ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells. Aging (Albany NY). 2010;2:582–596.
  • Fukawatase Y, Toyoda M, Okamura K, et al. Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instability. Sci Rep-Uk. 2014;4. Article number: 5421. doi:10.1038/srep05421
  • Li HL, Gee P, Ishida K, et al. Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system. Methods. 2016;101:27–35.
  • Yusa K, Rashid ST, Strick-Marchand H, et al. Targeted gene correction of alpha(1)-antitrypsin deficiency in induced pluripotent stem cells. Nature. 2011;478:391.
  • Keeling KM, Wang D, Conard SE, et al. Suppression of premature termination codons as a therapeutic approach. Crit Rev Biochem Mol. 2012;47:444–463.
  • Du LT, Damoiseaux R, Nahas S, et al. Nonaminoglycoside compounds induce readthrough of nonsense mutations. J Exp Med. 2009;206:2285–2297.
  • Du LT, Jung ME, Darnoiseaux R, et al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013;21:1653–1660.
  • Reichenbach J, Schubert R, Schindler D, et al. Elevated oxidative stress in patients with ataxia telangiectasia. Antioxid Redox Sign. 2002;4:465–469.
  • Reliene R, Schiestl RH. Experimental antioxidant therapy in ataxia telangiectasia. Clin Med Oncol. 2008;2:431–436.
  • Gueven N, Luff J, Peng C, et al. Dramatic extension of tumor latency and correction of neurobehavioral phenotype in ATM-mutant mice with a nitroxide antioxidant. Free Radical Bio Med. 2006;41:992–1000.
  • Reliene R, Fleming SM, Chesselet MF, et al. Effects of antioxidants on cancer prevention and neuromotor performance in ATM deficient mice. Food Chem Toxicol. 2008;46:1371–1377.
  • Schubert R, Erker L, Barlow C, et al. Cancer chemoprevention by the antioxidant tempol in ATM-deficient mice. Hum Mol Genet. 2004;13:1793–1802.
  • Chin T, Alonazi N B-cell and T-cell combined disorders medication 2014. Available from: http://emedicine.medscape.com/article/885493-medication#showall
  • Chen WT, Ebelt ND, Stracker TH, et al. ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion. Elife. 2015;4. doi:10.7554/eLife.07270
  • Yang Y, Hui CW, Li JL, et al. The Interaction of the ATM Genotype with inflammation and oxidative stress (vol 9, e85863, 2014). Plos One. 2014. Jan 20;9(1):e85863. doi:10.1371/journal.pone.0085863. eCollection 2014.
  • Kamsler A, Daily D, Hochman A, et al. Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from ATM-deficient mice. Cancer Res. 2001;61:1849–1854.
  • Chen P, Peng C, Luff J, et al. Oxidative stress is responsible for deficient survival and dendritogenesis in Purkinje neurons from ataxia-telangiectasia mutated mutant mice. J Neurosci. 2003;23:11453–11460.
  • Paull TT, Lee JH, Ditch S, et al. Mechanisms of ATM activation. Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr SY11-03. doi:10.1158/1538-7445.AM2012-SY11-03.
  • Rai P, Parrish M, Tay IJJ, et al. Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells. P Natl Acad Sci USA. 2015;112:E3421–E3430.
  • Quick KL, Dugan LL. Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia. Ann Neurol. 2001;49:627–635.
  • Kim J, Wong PKY. Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes. J Biol Chem. 2009;284:14396–14404.
  • McDonald CJ, Ostini L, Wallace DF, et al. Iron loading and oxidative stress in the ATM(-/-) mouse liver. Am J Physiol-Gastr L. 2011;300:G554–G60.
  • Shackelford RE, Fu YM, Manuszak RP, et al. Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells. DNA Repair. 2006;5:1327–1336.
  • Winterbourn CC. Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol Lett. 1995;82–3:969–974.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.