64
Views
1
CrossRef citations to date
0
Altmetric
Review

The use of ibrutinib before and after allogeneic stem cell transplantation

ORCID Icon, , , , , , , , , , & show all
Pages 171-180 | Received 30 Dec 2018, Accepted 17 Apr 2019, Published online: 28 Apr 2019

References

  • Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013;369:32–42.
  • Wang ML, Rule S, Martin P, et al. Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. N Engl J Med. 2013;369:507–516.
  • Burger JA, Chiorazzi N. B cell receptor signaling in chronic lymphocytic leukemia. Trends Immunol. 2013 Dec;34(12):592–601.
  • Fu L, Lin-Lee YC, Pham LV, et al. Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas. Blood. 2006 Jun 1;107(11):4540–4548.
  • Maharaj K, Sahakian E, Pinilla-Ibarz J. Emerging role of BCR signaling inhibitors in immunomodulation of chronic lymphocytic leukemia. Blood Adv. 2017 Sep 26;1(21):1867–1875.
  • Mohamed AJ, Yu L, Bäckesjö CM, et al. Bruton‘s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev. 2009;228(1):58–73.
  • Satterthwaite AB, Witte ON. The role of Bruton’s tyrosine kinase in B-cell development and function: a genetic perspective. Immunol Rev. 2000;175(1):120–127.
  • Novero A, Ravella PM, Chen Y, et al. Ibrutinib for B cell malignancies. Exp Hematol Oncol. 2014;3:4.
  • Kawakami Y, Kitaura J, Hata D, et al. Functions of Bruton’s tyrosine kinase in mast and B cells. J Leukoc Biol. 1999;65:286–290.
  • Pan Z, Scheerens H, Li SJ, et al. Discovery of selective irreversible inhibitors for Bruton’s tyrosine kinase. Chem Med Chem. 2007;2(1):58–61.
  • Honigberg LA, Smith AM, Sirisawad M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA. 2010;107(29):13075–13080.
  • Dubovsky JA, Beckwith KA, Natarajan G, et al. Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood. 2013;122(15):2539–2549.
  • Cooke KR, Luznik L, Sarantopoulos S, et al. The biology of chronic graft-versus-host disease: a task force report from the national institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2017;23(2):211–234.
  • MacDonald KP, Blazar BR, Hill GR. Cytokine mediators of chronic graft-versus-host disease. J Clin Invest. 2017;127(7):2452–2463.
  • Rozmus J, Schultz KR, Wynne K, et al. Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the children’s oncology group study ASCT0031. Biol Blood Marrow Transplant. 2011;17(12):1804–1813.
  • Forcade E, Paz K, Flynn R, et al. An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition. JCI Insight. 2017;2(12):e92111.
  • Jaglowski SM, Blazar BR. How ibrutinib, a B-cell malignancy drug, became an FDA-approved second-line therapy for steroid-resistant chronic GVHD. Blood Adv. 2018 Aug 14;2(15):2012–2019. .
  • Honigberg LA, Smith AM, Sirisawad M, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA. 2010;107:13075–13080.
  • Cinar M, Hamedani F, Mo Z, et al. Bruton tyrosine kinase is commonly overexpressed in mantle cell lymphoma and its attenuation by Ibrutinib induces apoptosis. Leuk Res. 2013;37:1271–1277.
  • Product Information: Imbruvica (ibrutinib) oral capsules. Sunnyvale, CA: Pharmacyclics Inc; Feb 2014.
  • Dreyling M, Jurczak W, Jerkeman M, et al. Rule S. Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study. Lancet. 2016 Feb 20;387(10020):770–778.
  • Burger JA, Tedeschi A, Barr PM, et al. Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia. N Engl J Med. 2015 Dec 17;373(25):2425–2437.
  • Treon SP, Tripsas CK, Meid K, et al. Ibrutinib in previously treated Waldenström‘s macroglobulinemia. N Engl J Med. 2015 Apr 9;372(15):1430–1440.
  • https://www.drugs.com/history/imbruvica.html
  • Fact Sheet: Breathrough Therapies. US Food and Drug Administration, [cited 2014 Sept 11] Available from: http://www.fda.gov/RegulatoryInformation/Legislation/FederalFoodDrugandCosmeticActFDCAct/SignificantAmendmentstotheFDCAct/FDASIA/ucm329491.htm
  • Natarajan G, Oghumu S, Terrazas C, et al. A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells
  • Long M, Beckwith K, Do P, et al. Ibrutinib treatment improves T cell number and function in CLL patients. J Clin Invest. 2017 Aug 1;127(8):3052–3064.
  • Woyach JA, Furman RR, Liu TM, et al. Resistance mechanisms for the Bruton’s tyrosine kinase inhibitor ibrutinib. N Engl J Med. 2014;370(24):2286–22294.
  • Kaur V, Swami A. brutinib in CLL: a focus on adverse events, resistance, and novel approaches beyond ibrutinib. Ann Hematol. 2017 Jul;96(7):1175–1184.
  • Brown JR. How I treat CLL patients with ibrutinib. Blood.. 2018 Jan 25;131(4):379–386.
  • Mistry H, Nduka C, Connock M, et al. Venetoclax for treating chronic lymphocytic leukaemia: an evidence review group perspective of a NICE single technology appraisal. Pharmacoeconomics. 2018 Apr;36(4):399–406.
  • Rai KR, Jain P. Chronic lymphocytic leukemia (CLL)-Then and now. Am J Hematol. 2016 Mar;91(3):330–340.
  • Payandeh Z, Bahrami AA, Hoseinpoor R, et al. The applications of anti-CD20 antibodies to treat various B cells disorders. Biomed Pharmacother. 2019;109:2415–2426.
  • Jones JA, Robak T, Brown JR, et al. Efficacy and safety of idelalisib in combination with ofatumumab for previously treated chronic lymphocytic leukaemia: an open-label, randomised phase 3 trial. Lancet Haematol. 2017 Mar;4(3):e114–e126.
  • Passweg JR, Baldomero H, Bader P, et al. Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transplant. 2017 Jun;52(6):811–817.
  • D’Souza A Fretham C. Current Uses and Outcomes of Hematopoietic Cell Transplantation (HCT): CIBMTR Summary Slides, 2017. http://www.cibmtr.org
  • Davids MS. How should we sequence and combine novel therapies in CLL? Hematol Am Soc Hematol Educ Program. 2017;2017:346–353.
  • Martin P. Optimizing therapy for mantle cell lymphoma. Hematol Am Soc Hematol Educ Program. 2017;2017:304–309.
  • Byrd JC, Furman RR, Coutre SE, et al. Three-year follow-up of treatment-naive and previously treated patients with CLL and SLL receiving single-agent ibrutinib. Blood. 2015;125:2497–2506.
  • Jain P, Thompson PA, Keating M, et al. Long-term outcomes for patients with chronic lymphocytic leukemia who discontinue ibrutinib. Cancer. 2017;123:2268–2273.
  • Martin P, Maddocks K, Leonard JP, et al. Postibrutinib outcomes in patients with mantle cell lymphoma. Blood. 2016;127:1559–1563.
  • Mato A, Porter DL. A drive through cellular therapy for CLL in 2015: allogeneic cell transplantation and CARs. Blood. 2015;1(26):478–485.
  • Gribben JG. How and when I do allogeneic transplant in CLL. Blood. 2018 Jul 5;132(1):31–39.
  • Kharfan-Dabaja MA, Kumar A, Hamadani M, et al. Clinical practice recommendations for use of allogeneic hematopoietic cell transplantation in chronic lymphocytic leukemia on behalf of the guidelines committee of the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2016;22(12):2117–2125. doi: 10.1016/j.bbmt.2016.09.013.
  • McKay P, Leach M, Jackson B, et al. Guideline for the management of mantle cell lymphoma. Br J Haematol. 2018;182:46–62.
  • Le Gouill S, Thieblemont C, Oberic L, et al. Rituximab after autologous stem-cell transplantation in mantle-cell lymphoma. N Engl J Med. 2017 Sep 28;377(13):1250–1260.
  • Robinson S, Dreger P, Caballero D, et al. The EBMT/EMCL consensus project on the role of autologous and allogeneic stem cell transplantation in mantle cell lymphoma. Leukemia. 2015 Feb;29(2):464–473.
  • Vaughn JE, Sorror ML, Storer BE, et al. Long-term sustained disease control in patients with mantle cell lymphoma with or without active disease after treatment with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. Cancer. 2015 Oct 15;121(20):3709–3716.
  • Kruger WH, Hirt C, Basara N, et al. Allogeneic stem cell transplantation for mantle cell lymphoma—final report from the prospective trials of the East German Study Group Haematology/Oncology (OSHO). Ann Hematol. 2014;93:1587–1597.
  • Rule S, Cook G, Russell NH, et al. Allogeneic stem cell transplantation as part of front line therapy for Mantle cell lymphoma. Br J Haematol. 2018 Dec 17. DOI:10.1111/bjh.15723.
  • Dreger P, Michallet M, Bosman P, et al.Ibrutinib for bridging to allogeneic hematopoietic cell transplantation in patients with chronic lymphocytic leukemia or mantle cell lymphoma: a study by the EBMT chronic malignancies and lymphoma working parties. Bone Marrow Transplant. 2018;May 4 doi: 10.1038/s41409-018-0207-4
  • Annalisa A, Simona B, Lara P, et al. Ibrutinib as a bridge to transplant in high-risk chronic lymphocytic leukemia: A case report and review of the literature. Leuk Res Rep. 2017 Nov 15;8:21–23.
  • Coutre S, O‘Brien S, Byrd JC, et al. Safety and efficacy of ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma who have undergone prior allogeneic stem cell transplant. Blood. 2014;124:4697.
  • Michallet M, Dreger P, Sobh M, et al. Salvage use of ibrutinib after Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) for B cell malignancies: a study of the French Cooperative Group for CLL, the French Soceity for Blood and Marrow Transplantation (SFGM-TC), and the European Society for Blood and Marrow Transplantation (EBMT) chronic malignancy and lymphoma working parties. Blood. 2016;128:4659.
  • Ryan CE, Sahaf B, Logan AC, et al. Ibrutinib efficacy and tolerability in patients with relapsed chronic lymphocytic leukemia following allogeneic HCT. Blood. 2016 Dec 22;128(25):2899–2908.
  • Link CS, Teipel R, Heidenreich F, et al. Durable responses to ibrutinib in patients with relapsed CLL after allogeneic stem cell transplantation. Bone Marrow Transplant. 2016 Jun;51(6):793–798.
  • Quinquenel A, Sicre de Fontbrune F, Durot E, et al. Recovery of full donor chimerism with ibrutinib therapy in relapsed CLL after allogeneic stem cell transplantation. Br J Haematol. 2017 Mar;176(6):997–999. Epub 2016 Mar 15.
  • Dubovsky JA, Beckwith KA, Natarajan G, et al. Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood. 2013 Oct 10;122(15):2539–2549.
  • Center for International Blood and Marrow Transplant Research. CIBMTR 2014. [cited 2014 Aug 5] Available from: http://www.cibmtr.org.
  • Lee SJ, Vogelsang G, Flowers ME. Chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2003;9(4):215–233.
  • Flowers ME, Parker PM, Johnston LJ, et al. Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trial. Blood. 2002;100(2):415–419.
  • Anasetti C, Logan BR, Lee SJ, et al. Peripheral blood stem cells versus bone marrow from unrelated donors. N Engl J Med. 2012;367(16):1487–1496.
  • Gooley TA, Chien JW, Pergam SA, et al. Reduced mortality after allogeneic hematopoietic-cell transplantation. N Engl J Med. 2010;363(22):2091–2101.
  • Stem Cell Trialists’ Collaborative Group. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies: an individual patient data meta-analysis of nine randomized trials. J Clin Oncol. 2005;23(22):5074–5087.
  • Rhoades R, Gaballa S. The role of B cell targeting in chronic graft-versus-host disease. Biomedicines. 2017 Oct 17;5(4):pii: E61. .
  • Dubovsky JA, Flynn R, Du J, et al. Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. J Clin Invest. 2014 Nov;124(11):4867–4876. Epub 2014 Oct 1.
  • Duarte RF, Greinix H, Rabin B, et al. Uptake and use of recommendations for the diagnosis, severity scoring and management of chronic GVHD: an international survey of the EBMT-NCI Chronic GVHD task force. Bone Marrow Transplant. 2014 Jan;49(1):49–54.
  • Flowers ME, Martin PJ. How we treat chronic graft-versus-host disease. Blood. 2015 Jan 22;125(4):606–615. .
  • Martin PJ, Inamoto Y, Carpenter PA, et al. Treatment of chronic graft-versushost disease: past, present and future. Korean J Hematol. 2011;46(3):153–163.
  • Martin PJ, Storer BE, Rowley SD, et al. Evaluation of mycophenolate mofetil for initial treatment of chronic graft-versus-host disease. Blood. 2009;113(21):5074–5082.
  • Sullivan KM, Witherspoon RP, Storb R, et al. Prednisone and azathioprine compared with prednisone and placebo for treatment of chronic graft-versus-host disease: prognostic influence of prolonged thrombocytopenia after allogeneic marrow transplantation. Blood. 1988;72(2):546–554.
  • Flowers ME, Martin PJ. Evaluation of thalidomide for treatment or prevention of chronic graftversus-host disease. Leuk Lymphoma. 2003;44(7):1141–1146.
  • Gilman AL, Schultz KR, Goldman FD, et al. Randomized trial of hydroxychloroquine for newly diagnosed chronic graft-versus-host disease in children: a children’s oncology group study. Biol Blood Marrow Transplant. 2012;18(1):84–91.
  • Flowers ME, Storer B, Carpenter P, et al. Treatment change as a predictor of outcome among patients with classic chronic graft-versus host disease. Biol Blood Marrow Transplant. 2008;14(12):1380–1384.
  • Inamoto Y, Flowers ME, Sandmaier BM, et al. Failure-free survival after initial systemic treatment of chronic graft-versus host disease. Blood. 2014;124(8):1363–1371.
  • Flowers ME, Apperley JF, van Besien K, et al. A multicenter prospective phase II randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood. 2008;112(7):2667–2674.
  • Wolff D, Schleuning M, von Harsdorf S, et al. Consensus conference on clinical practice in chronic GVHD: second-line treatment of chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2011;17(1):1–17.
  • Flowers MED, Deeg HJ. Chronic graft-versushost disease. In: Treleaven J, Barrett AJ, editors. Hematopoietic stem cell transplantation in clinical practice. Edinburgh, UK: Elsevier Ltd; 2009. p. 401–407.
  • U.S. Food and Drug Administration: FDA expands ibrutinib indications to chronic GVHD. [cited 2017 Nov 8] Available from: https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm569711.htm
  • Miklos D, Cutler CS, Arora M, et al. Ibrutinib for chronic graft-versus-host disease after failure of prior therapy. Blood. 2017;130:2243–2250.
  • Khouri IF, Jabbour E, Saliba RM, et al. Ibrutinib in patients with mantle cell lymphoma and chronic lymphocytic leukemia with relapsed disease post allogeneic stem cell transplantation. Blood. 2015;126:4345, [abstract]
  • Available from: https://clinicaltrials.gov/ct2/show/NCT02959944
  • Available from: https://clinicaltrials.gov/ct2/show/NCT02869633
  • Available from: https://clinicaltrials.gov/ct2/show/NCT03267186
  • Du J, Flynn R, Paz K, et al. Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients. Blood. 2018;131(15):1743–1754.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.