Clinical markers of morbidity, mortality and survival in bladder cancer patients treated with radical cystectomy. A systematic review

References

• Kiss B, Burkhard F, Thalmann G. Open radical cystectomy: still the gold standard for muscle invasive bladder cancer. World J Urol. 2016;34:33–39.
   PubMed Web of Science ®Google Scholar
• Prout GR, Marshall VF. The prognosis with untreated bladder tumors. Cancer. 1956;9:551–558.
   PubMed Web of Science ®Google Scholar
• Alfred Witjes J, Lebret T, Comprat E, et al. Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur Urol. 2017;71:462–475.
   PubMed Web of Science ®Google Scholar
• Grossman HB, Natale R, Tangen C, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med. 2003;349:859–866.
   PubMed Web of Science ®Google Scholar
• Salminen A, Koskinen I, Montoya-Perez I, et al. Neoadjuvant chemotherapy does not increase the morbidity of radical cystectomy: a 10-year retrospective nationwide study. Eur Urol Oncol. 2018;1:525–530.
   PubMed Web of Science ®Google Scholar
• Hautmann R, Abol Enein H, Davidsson T, et al.; International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012. ICUD-EAU International Consultation on Bladder Cancer 2012: urinary diversion. Eur Urol. 2013;63:67–80.
   PubMed Web of Science ®Google Scholar
• Donat SM, Shabsigh A, Savage C, et al. Potential impact of postoperative early complications on the timing of adjuvant chemotherapy in patients undergoing radical cystectomy: a high-volume tertiary cancer center experience. Eur Urol. 2009;55:177–185.
   PubMed Web of Science ®Google Scholar
• Shabsigh A, Korets R, Vora K, et al. Defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology. Eur Urol. 2009;55:164–174.
   PubMed Web of Science ®Google Scholar
• Moher D, PRISMA Group, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62:1006–1012.
   PubMed Web of Science ®Google Scholar
• Gregg J, Cookson M, Phillips S, et al. Effect of preoperative nutritional deficiency on mortality after radical cystectomy for bladder cancer. J Urol. 2011;185:90–96.
   PubMed Web of Science ®Google Scholar
• Garg T, Chen L, Kim P, et al. Preoperative serum albumin is associated with mortality and complications after radical cystectomy. BJU Int. 2014;113:918–923.
   PubMed Web of Science ®Google Scholar
• Gierth M, Zeman F, Denzinger S, et al. Influence of body mass index on clinical outcome parameters, complication rate and survival after radical cystectomy: evidence from a prospective European multicentre study. Urol Int. 2018;101:16–24.
   PubMed Web of Science ®Google Scholar
• Johnson D, Riggs S, Nielsen M, et al. Nutritional predictors of complications following radical cystectomy. World J Urol. 2015;33:1129–1137.
   PubMed Web of Science ®Google Scholar
• Lambert J, Ingham M, Gibbs B, et al. Using preoperative albumin levels as a surrogate marker for outcomes after radical cystectomy for bladder cancer. Urology. 2013;81:587–592.
   PubMed Web of Science ®Google Scholar
• Djaladat H, Bruins H, Miranda G, et al. The association of preoperative serum albumin level and American Society of Anesthesiologists (ASA) score on early complications and survival of patients undergoing radical cystectomy for urothelial bladder cancer. BJU Int. 2014;113:887–893.
   PubMed Web of Science ®Google Scholar
• Psutka S, Boorjian S, Moynagh M, et al. Mortality after radical cystectomy: impact of obesity versus adiposity after adjusting for skeletal muscle wasting. J Urol. 2015;193:1507–1513.
   PubMed Web of Science ®Google Scholar
• Hirasawa Y, Nakashima J, Yunaiyama D, et al. Sarcopenia as a novel preoperative prognostic predictor for survival in patients with bladder cancer undergoing radical cystectomy. Ann Surg Oncol. 2016;23:1048–1054.
   PubMed Web of Science ®Google Scholar
• Lyon T, Farber N, Chen L, et al. Total psoas area predicts complications following radical cystectomy. Adv Urol. 2015;2015:901851.
   PubMed Web of Science ®Google Scholar
• Miyake M, Morizawa Y, Hori S, et al. Clinical impact of postoperative loss in psoas major muscle and nutrition index after radical cystectomy for patients with urothelial carcinoma of the bladder. BMC Cancer. 2017;17:237.
   PubMed Web of Science ®Google Scholar
• Smith A, Deal A, Yu H, et al. Sarcopenia as a predictor of complications and survival following radical cystectomy. J Urol. 2014;191:1714–1720.
   PubMed Web of Science ®Google Scholar
• Mayr R, Gierth M, Zeman F, et al. Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer. J Cachexia Sarcopenia Muscle. 2018;9:505–513.
   PubMed Web of Science ®Google Scholar
• Kasahara R, Kawahara T, Ohtake S, et al. A low psoas muscle index before treatment can predict a poorer prognosis in advanced bladder cancer patients who receive gemcitabine and nedaplatin therapy. Biomed Res Int. 2017;2017:1–4.
   Web of Science ®Google Scholar
• Ritch C, Cookson M, Clark P, et al. Perioperative oral nutrition supplementation reduces prevalence of sarcopenia following radical cystectomy: results of a prospective randomized controlled trial. J Urol. 2019;201:470–477.
   PubMed Web of Science ®Google Scholar
• Liu J, Mullane P, Kates M, et al. Infectious complications in transfused patients after radical cystectomy. Can J Urol. 2016;23:8342–8347.
   PubMed Web of Science ®Google Scholar
• Rivas J, Gregorio SAY, Ledo J, et al. The role of perioperative blood transfusion on postoperative outcomes and overall survival in patients after laparoscopic radical cystectomy. J Cancer Res Ther. 2016;12:146–149.
   PubMed Web of Science ®Google Scholar
• Sui W, Onyeji I, Matulay J, et al. Perioperative blood transfusion in radical cystectomy: analysis of the National Surgical Quality Improvement Program database. Int J Urol. 2016;23:745–750.
   PubMed Web of Science ®Google Scholar
• Lee S, Seo H, Kim H, et al. Effect of intraoperative red blood cell transfusion on postoperative complications after open radical cystectomy: old versus fresh stored blood. Clin Genitourin Cancer. 2015;13:581–587.
   PubMed Web of Science ®Google Scholar
• Moschini M, Dell' Oglio P, Capogrosso P, et al. Effect of allogeneic intraoperative blood transfusion on survival in patients treated with radical cystectomy for nonmetastatic bladder cancer: results from a single high-volume institution. Clin Genitourin Cancer. 2015;13:562–567.
   PubMed Web of Science ®Google Scholar
• Schubert T, Todenhöfer T, Mischinger J, et al. The prognostic role of pre-cystectomy hemoglobin levels in patients with invasive bladder cancer. World J Urol. 2016;34:829–834.
   PubMed Web of Science ®Google Scholar
• Isbarn H, Jeldres C, Zini L, et al. A population based assessment of perioperative mortality after cystectomy for bladder cancer. J Urol. 2009;182:70–77.
   PubMed Web of Science ®Google Scholar
• Aziz A, May M, Burger M, et al. Prediction of 90-day mortality after radical cystectomy for bladder cancer in a prospective European multicenter cohort. Eur Urol. 2014;66:156–163.
   PubMed Web of Science ®Google Scholar
• Taylor J, Feifer A, Savage C, et al. Evaluating the utility of a preoperative nomogram for predicting 90-day mortality following radical cystectomy for bladder cancer. BJU Int. 2012;109:855–859.
   PubMed Web of Science ®Google Scholar
• D’Elia C, Comploj E, Cerruto MA, et al. 90-Day mortality after radical cystectomy for bladder cancer: prognostic factors in a multicenter case series. Urol Int. 2017;98:255–261.
   PubMed Web of Science ®Google Scholar
• Morgan T, Keegan K, Barocas D, et al. Predicting the probability of 90-day survival of elderly patients with bladder cancer treated with radical cystectomy. J Urol. 2011;186:829–834.
   PubMed Web of Science ®Google Scholar
• Le Manach Y, Collins G, Rodseth R, et al. Preoperative score to predict postoperative mortality (POSPOM): derivation and validation. Anesthesiology. 2016;124:570–579.
   PubMed Web of Science ®Google Scholar
• Froehner M, Brausi M, Herr H, et al. Complications following radical cystectomy for bladder cancer in the elderly. Eur Urol. 2009;56:443–454.
   PubMed Web of Science ®Google Scholar
• May M, Herrmann E, Bolenz C, et al. Association between the number of dissected lymph nodes during pelvic lymphadenectomy and cancer-specific survival in patients with lymph node-negative urothelial carcinoma of the bladder undergoing radical cystectomy. Ann Surg Oncol. 2011;18:2018–2025.
   PubMed Web of Science ®Google Scholar
• Larcher A, Sun M, Schiffmann J, et al. Differential effect on survival of pelvic lymph node dissection at radical cystectomy for muscle invasive bladder cancer. Eur J Surg Oncol. 2015;41:353–360.
   PubMed Web of Science ®Google Scholar
• Karl A, Carroll P, Gschwend J, et al. The impact of lymphadenectomy and lymph node metastasis on the outcomes of radical cystectomy for bladder cancer. Eur Urol. 2009;55:826–835.
   PubMed Web of Science ®Google Scholar
• Wright J, Lin D, Porter M. The association between extent of lymphadenectomy and survival among patients with lymph node metastases undergoing radical cystectomy. Cancer. 2008;112:2401–2408.
   PubMed Web of Science ®Google Scholar
• Steven K, Poulsen A. Radical cystectomy and extended pelvic lymphadenectomy: survival of patients with lymph node metastasis above the bifurcation of the common iliac vessels treated with surgery only. J Urol. 2007;178:1218–1223. discussion 1223.
   PubMed Web of Science ®Google Scholar
• Herr H, Bochner B, Dalbagni G, et al. Impact of the number of lymph nodes retrieved on outcome in patients with muscle invasive bladder cancer. J Urol. 2002;167:1295–1298.
   PubMed Web of Science ®Google Scholar
• Knap MM, Lundbeck F, Overgaard J. The role of pelvic lymph node dissection as a predictive and prognostic factor in bladder cancer. Eur J Cancer. 2003;39:604–613.
   PubMed Web of Science ®Google Scholar
• Leissner J, Ghoneim MA, Abol Enein H, et al. Extended radical lymphadenectomy in patients with urothelial bladder cancer: results of a prospective multicenter study. J Urol. 2004;171:139–144.
   PubMed Web of Science ®Google Scholar
• Crozier J, Papa N, Perera M, et al. Lymph node yield in node-negative patients predicts cancer specific survival following radical cystectomy for transitional cell carcinoma. Investig Clin Urol. 2017;58:416–422.
   PubMed Web of Science ®Google Scholar
• Dorin R, Daneshmand S, Eisenberg M, et al. Lymph node dissection technique is more important than lymph node count in identifying nodal metastases in radical cystectomy patients: a comparative mapping study. Eur Urol. 2011;60:946–952.
   PubMed Web of Science ®Google Scholar
• Moschini M, Arbelaez E, Cornelius J, et al. Pattern of node metastases in patients treated with radical cystectomy and extended or superextended pelvic lymph node dissection due to bladder cancer. Urol Oncol. 2018;36:307.e9–307.e14.
   Web of Science ®Google Scholar
• von Landenberg N, Speed J, Cole A, et al. Impact of adequate pelvic lymph node dissection on overall survival after radical cystectomy: a stratified analysis by clinical stage and receipt of neoadjuvant chemotherapy. Urol Oncol. 2018;36:78.e13–78.e19.
   Web of Science ®Google Scholar
• Gschwend J, Heck M, Lehmann J, et al. Extended versus limited lymph node dissection in bladder cancer patients undergoing radical cystectomy: survival results from a prospective, randomized trial. Eur Urol. 2019;75:604–611.
   PubMed Web of Science ®Google Scholar
• Mandel P, Tilki D, Eslick G. Extent of lymph node dissection and recurrence-free survival after radical cystectomy: a meta-analysis. Urol Oncol. 2014;32:1184–1190.
   PubMed Web of Science ®Google Scholar
• Li F, Hong X, Hou L, et al. A greater number of dissected lymph nodes is associated with more favorable outcomes in bladder cancer treated by radical cystectomy: a meta-analysis. Oncotarget. 2016;7:61284–61294.
   PubMedGoogle Scholar
• Fleischmann A, Thalmann G, Markwalder R, et al. Extracapsular extension of pelvic lymph node metastases from urothelial carcinoma of the bladder is an independent prognostic factor. J Clin Oncol. 2005;23:2358–2365.
   PubMed Web of Science ®Google Scholar
• Fajkovic H, Cha E, Jeldres C, et al. Extranodal extension is a powerful prognostic factor in bladder cancer patients with lymph node metastasis. Eur Urol. 2013;64:837–845.
   PubMed Web of Science ®Google Scholar
• Parkash V, Bifulco C, Feinn R, et al. To count and how to count, that is the question: interobserver and intraobserver variability among pathologists in lymph node counting. Am J Clin Pathol. 2010;134:42–49.
   PubMed Web of Science ®Google Scholar
• Kassouf W, Agarwal P, Herr H, et al. Lymph node density is superior to TNM nodal status in predicting disease-specific survival after radical cystectomy for bladder cancer: analysis of pooled data from MDACC and MSKCC. J Clin Oncol. 2008;26:121–126.
   PubMed Web of Science ®Google Scholar
• Herr H. Superiority of ratio based lymph node staging for bladder cancer. J Urol. 2003;169:943–945.
   PubMed Web of Science ®Google Scholar
• Stein J, Cai J, Groshen S, et al. Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density. J Urol. 2003;170:35–41.
   PubMed Web of Science ®Google Scholar
• Lerner SP, Skinner DG, Lieskovsky G, et al. The rationale for en bloc pelvic lymph node dissection for bladder cancer patients with nodal metastases: long-term results. J Urol. 1993;149:758–764; discussion 764.
   PubMed Web of Science ®Google Scholar
• May M, Herrmann E, Bolenz C, et al. Lymph node density affects cancer-specific survival in patients with lymph node-positive urothelial bladder cancer following radical cystectomy. Eur Urol. 2011;59:712–718.
   PubMed Web of Science ®Google Scholar
• Kassouf W, Svatek R, Shariat S, et al. Critical analysis and validation of lymph node density as prognostic variable in urothelial carcinoma of bladder. Urol Oncol. 2013;31:480–486.
   PubMed Web of Science ®Google Scholar
• Hong B, Park S, Hong J, et al. Prognostic value of lymphovascular invasion in transitional cell carcinoma of upper urinary tract. Urology. 2005;65:692–696.
   PubMed Web of Science ®Google Scholar
• Streeper N, Simons C, Konety B, et al. The significance of lymphovascular invasion in transurethral resection of bladder tumour and cystectomy specimens on the survival of patients with urothelial bladder cancer. BJU Int. 2009;103:475–479.
   PubMed Web of Science ®Google Scholar
• Werntz R, Smith Z, Packiam V, et al. The impact of lymphovascular invasion on risk of upstaging and lymph node metastasis at the time of radical cystectomy. Eur Urol Focus. 2020;6:292–297.
   PubMedGoogle Scholar
• Yuk H, Jeong C, Kwak C, et al. Lymphovascular invasion have a similar prognostic value as lymph node involvement in patients undergoing radical cystectomy with urothelial carcinoma. Sci Rep. 2018;8:15928.
   PubMed Web of Science ®Google Scholar
• Shariat S, Svatek R, Tilki D, et al. International validation of the prognostic value of lymphovascular invasion in patients treated with radical cystectomy. BJU Int. 2010;105:1402–1412.
   PubMed Web of Science ®Google Scholar
• Lotan Y, Gupta A, Shariat S, et al. Lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomy. J Clin Oncol. 2005;23:6533–6539.
   PubMed Web of Science ®Google Scholar
• Quek M, Stein J, Nichols P, et al. Prognostic significance of lymphovascular invasion of bladder cancer treated with radical cystectomy. J Urol. 2005;174:103–106.
   PubMed Web of Science ®Google Scholar
• Canter D, Guzzo T, Resnick M, et al. The presence of lymphovascular invasion in radical cystectomy specimens from patients with urothelial carcinoma portends a poor clinical prognosis. BJU Int. 2008;102:952–957.
   PubMed Web of Science ®Google Scholar
• Manoharan M, Katkoori D, Kishore TA, et al. Lymphovascular invasion in radical cystectomy specimen: is it an independent prognostic factor in patients without lymph node metastases? World J Urol. 2010;28:233–237.
   PubMed Web of Science ®Google Scholar
• Kim M, Kwak C, Kim H, et al. Prognostic significance of lymphovascular invasion in radical cystectomy on patients with bladder cancer: a systematic review and meta-analysis. PLoS ONE. 2014;9:e89259.
   PubMed Web of Science ®Google Scholar
• Karakiewicz P, Shariat S, Palapattu G, et al. Precystectomy nomogram for prediction of advanced bladder cancer stage. Eur Urol. 2006;50:1254–1260. Discussion 1261.
   PubMed Web of Science ®Google Scholar
• Ku J, Kim M, Byun S, et al. External validation of models for prediction of lymph node metastasis in urothelial carcinoma of the bladder. PLoS ONE. 2015;10:e0120552.
   PubMed Web of Science ®Google Scholar
• Di Trapani E, Sanchez Salas R, Gandaglia G, et al. A nomogram predicting the cancer-specific mortality in patients eligible for radical cystectomy evaluating clinical data and neoadjuvant cisplatinum-based chemotherapy. World J Urol. 2016;34:207–213.
   PubMed Web of Science ®Google Scholar
• Bochner B, Kattan M, Vora K. Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer. J Clin Oncol. 2006;24:3967–3972.
   PubMed Web of Science ®Google Scholar
• Zaak D, Burger M, Otto W, et al. Predicting individual outcomes after radical cystectomy: an external validation of current nomograms. BJU Int. 2010;106:342–348.
   PubMed Web of Science ®Google Scholar
• Shariat S, Karakiewicz P, Palapattu G, et al. Nomograms provide improved accuracy for predicting survival after radical cystectomy. Clin Cancer Res. 2006;12:6663–6676.
   PubMed Web of Science ®Google Scholar
• Brooks M, Godoy G, Sun M, et al. External validation of bladder cancer predictive nomograms for recurrence, cancer-free survival and overall survival following radical cystectomy. J Urol. 2016;195:283–289.
   PubMed Web of Science ®Google Scholar
• Nuhn P, May M, Sun M, et al. External validation of postoperative nomograms for prediction of all-cause mortality, cancer-specific mortality, and recurrence in patients with urothelial carcinoma of the bladder. Eur Urol. 2012;61:58–64.
   PubMed Web of Science ®Google Scholar
• Moon K, Kim M, Kwak C, et al. External validation of online predictive models for prediction of cancer-specific mortality and all-cause mortality in patients with urothelial carcinoma of the urinary bladder. Ann Surg Oncol. 2014;21:3132–3141.
   PubMed Web of Science ®Google Scholar
• Karakiewicz P, Shariat S, Palapattu G, et al. Nomogram for predicting disease recurrence after radical cystectomy for transitional cell carcinoma of the bladder. J Urol. 2006;176:1354–1361. Discussion 1361.
   PubMed Web of Science ®Google Scholar
• Simone G, Bianchi M, Giannarelli D, et al. Development and external validation of nomograms predicting disease-free and cancer-specific survival after radical cystectomy. World J Urol. 2015;33:1419–1428.
   PubMed Web of Science ®Google Scholar
• Williams S, Huo J, Chu Y, et al. Cancer and all-cause mortality in bladder cancer patients undergoing radical cystectomy: development and validation of a nomogram for treatment decision-making. Urology. 2017;110:76–83.
   PubMed Web of Science ®Google Scholar
• Hu G, Xu F, Zhong K, et al. The prognostic role of preoperative circulating neutrophil-lymphocyte ratio in primary bladder cancer patients undergoing radical cystectomy: a meta-analysis. World J Urol. 2019;37:1817–1825.
   PubMed Web of Science ®Google Scholar
• Hermanns T, Bhindi B, Wei Y, et al. Pre-treatment neutrophil-to-lymphocyte ratio as predictor of adverse outcomes in patients undergoing radical cystectomy for urothelial carcinoma of the bladder. Br J Cancer. 2014;111:444–451.
   PubMed Web of Science ®Google Scholar
• Bhindi B, Hermanns T, Wei Y, et al. Identification of the best complete blood count-based predictors for bladder cancer outcomes in patients undergoing radical cystectomy. Br J Cancer. 2016;114:207–212.
   PubMed Web of Science ®Google Scholar
• Gondo T, Nakashima J, Ohno Y, et al. Prognostic value of neutrophil-to-lymphocyte ratio and establishment of novel preoperative risk stratification model in bladder cancer patients treated with radical cystectomy. Urology. 2012;79:1085–1091.
   PubMed Web of Science ®Google Scholar
• Krane LS, Richards K, Kader AK, et al. Preoperative neutrophil/lymphocyte ratio predicts overall survival and extravesical disease in patients undergoing radical cystectomy. J Endourol. 2013;27:1046–1050.
   PubMed Web of Science ®Google Scholar
• Viers B, Boorjian S, Frank I, et al. Pretreatment neutrophil-to-lymphocyte ratio is associated with advanced pathologic tumor stage and increased cancer-specific mortality among patients with urothelial carcinoma of the bladder undergoing radical cystectomy. Eur Urol. 2014;66:1157–1164.
   PubMed Web of Science ®Google Scholar
• D’Andrea D, Moschini M, Gust KM, et al. Lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio as biomarkers for predicting lymph node metastasis and survival in patients treated with radical cystectomy. J Surg Oncol. 2017;115:455–461.
   PubMed Web of Science ®Google Scholar
• Kang M, Jeong C, Kwak C, et al. The prognostic significance of the early postoperative neutrophil-to-lymphocyte ratio in patients with urothelial carcinoma of the bladder undergoing radical cystectomy. Ann Surg Oncol. 2016;23:335–342.
   PubMed Web of Science ®Google Scholar
• van Kessel KEM, de Haan LM, Fransen van de Putte EE, et al. Elevated derived neutrophil-to-lymphocyte ratio corresponds with poor outcome in patients undergoing pre-operative chemotherapy in muscle-invasive bladder cancer. Bladder Cancer. 2016;2:351–360.
   PubMed Web of Science ®Google Scholar
• Buisan O, Orsola A, Areal J, et al. Low pretreatment neutrophil-to-lymphocyte ratio predicts for good outcomes in patients receiving neoadjuvant chemotherapy before radical cystectomy for muscle invasive bladder cancer. Clin Genitourin Cancer. 2017;15:145–151.e2.
   PubMed Web of Science ®Google Scholar
• Morizawa Y, Miyake M, Shimada K, et al. Neutrophil-to-lymphocyte ratio as a detection marker of tumor recurrence in patients with muscle-invasive bladder cancer after radical cystectomy. Urol Oncol. 2016;34:257.e11–257.e17.
   Web of Science ®Google Scholar
• Lucca I, Jichlinski P, Shariat S, et al. The neutrophil-to-lymphocyte ratio as a prognostic factor for patients with urothelial carcinoma of the bladder following radical cystectomy: validation and meta-analysis. Eur Urol Focus. 2016;2:79–85.
   PubMedGoogle Scholar
• Kang M, Balpukov U, Jeong C, et al. Can the preoperative neutrophil-to-lymphocyte ratio significantly predict the conditional survival probability in muscle-invasive bladder cancer patients undergoing radical cystectomy? Clin Genitourin Cancer. 2017;15:e411–e420.
   PubMed Web of Science ®Google Scholar
• Ozcan C, Telli O, Ozturk E, et al. The prognostic significance of preoperative leukocytosis and neutrophil-to-lymphocyte ratio in patients who underwent radical cystectomy for bladder cancer. Can Urol Assoc J. 2015;9:E789–E794.
   PubMed Web of Science ®Google Scholar
• Temraz S, Mukherji D, Farhat ZAA, et al. Preoperative lymphocyte-to-monocyte ratio predicts clinical outcome in patients undergoing radical cystectomy for transitional cell carcinoma of the bladder: a retrospective analysis. BMC Urol. 2014;14:76.
   PubMed Web of Science ®Google Scholar
• Khan M, Omar K, Ahmed K, et al. Long-term oncological outcomes from an early phase randomised controlled three-arm trial of open, robotic, and laparoscopic radical cystectomy (CORAL). Eur Urol. 2020;77:110–118.
   PubMed Web of Science ®Google Scholar
• Saad M, Moschini M, Stabile A, et al. Long-term functional and oncological outcomes of nerve-sparing and prostate capsule-sparing cystectomy: a single-centre experience. BJU Int. 2020;125:253–259.
   PubMed Web of Science ®Google Scholar