Engineering drug delivery systems to overcome mucosal barriers for immunotherapy and vaccination

References

• Brandtzaeg P. Mucosal immunity: induction, dissemination, and effector functions. Scand J Immunol. 2009;70(6):1–17. PubMed PMID: 19906191. doi:10.1111/j.1365-3083.2009.02319.x.
   PubMed Web of Science ®Google Scholar
• Cone RA. Mucus. Mucosal immunology. 3rded: Academic Press/Elsevier; 2005. 49–72 PubMed PMID: ISI:000311099400008. doi:10.1016/B978-012491543-5/50008-5.
   Google Scholar
• France MM, Turner JR. The mucosal barrier at a glance. J Cell Sci. 2017; 130(2):307–314. Epub 2017/01/06. PubMed PMID: 28062847; PMCID: PMC5278669. doi:10.1242/jcs.193482.
   PubMed Web of Science ®Google Scholar
• Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol PubMed PMID: 19855405. 2009;9(11):799–809. doi:10.1038/nri2653.
   PubMed Web of Science ®Google Scholar
• Cone RA. Barrier properties of mucus. Adv Drug Deliv Rev. 2009; 61(2):75–85. Epub 2009/ 01/13. PubMed PMID: 19135107. doi:10.1016/j.addr.2008.09.008.
   PubMed Web of Science ®Google Scholar
• Ensign LM, Cone R, Hanes J. Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv Drug Deliv Rev. 2012;64(6):557–570. Epub 2011/ 12/24 PubMed PMID: 22212900; PMCID: PMC3322271. doi: 10.1016/j.addr.2011.12.009.
   PubMed Web of Science ®Google Scholar
• Lai SK, Wang YY, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 2009;61(2):158–171. Epub 2008/ 12/13. doi: 10.1016/j.addr.2008.11.002. PubMed PMID: 19133304; PMCID: PMC2667119. doi:.
   PubMed Web of Science ®Google Scholar
• Islam MA, Firdous J, Badruddoza AZM, Reesor E, Azad M, Hasan A, Lim M, Cao W, Guillemette S, Cho CS. M cell targeting engineered biomaterials for effective vaccination. Biomaterials. 2019;192:75–94. Epub 2018/11/12. doi: 10.1016/j.biomaterials.2018.10.041. PubMed PMID: 30439573.
   PubMed Web of Science ®Google Scholar
• Lavelle EC, O’Hagan DT. Delivery systems and adjuvants for oral vaccines. Expert Opin Drug Deliv. 2006;3(6):747–762. PubMed PMID: 17076597 doi:10.1517/17425247.3.6.747.
   PubMedGoogle Scholar
• Miquel-Clopés A, Bentley EG, Stewart JP, Carding SR. Mucosal vaccines and technology. Clin Exp Immunol. 2019;196(2):205–214. Epub 2019/04/08 PubMed PMID: 30963541; PMCID: PMC6468177. doi: 10.1111/cei.13285.
   PubMed Web of Science ®Google Scholar
• Srivastava A, Gowda DV, Madhunapantula SV, Shinde CG, Iyer M. Mucosal vaccines: a paradigm shift in the development of mucosal adjuvants and delivery vehicles. APMIS. 2015;123(4):275–288. Epub 2015/ 01/29. doi: 10.1111/apm.12351. PubMed PMID: 25630573. doi:.
   PubMed Web of Science ®Google Scholar
• Murphy K, Travers P, Walport M, Janeway C. Janeway’s immunobiology. 8th ed. New York, NY: Garland Science; 2012. p. xix, 868.
   Google Scholar
• Olmsted SS, Padgett JL, Yudin AI, Whaley KJ, Moench TR, Cone RA. Diffusion of macromolecules and virus-like particles in human cervical mucus. Biophys J. 2001;81(4):1930–1937. PubMed PMID: 11566767; PMCID: 1301668 doi:10.1016/S0006-3495(01)75844-4.
   PubMed Web of Science ®Google Scholar
• Zeitlin L, Cone RA, Whaley KJ. Using monoclonal antibodies to prevent mucosal transmission of epidemic infectious diseases. Emerg Infect Dis. 1999;5(1):54–64. PubMed PMID: 10081672; PMCID: 2627706 doi:10.3201/eid0501.990107.
   PubMed Web of Science ®Google Scholar
• Dohrman A, Tsuda T, Escudier E, Cardone M, Jany B, Gum J, Kim Y, Basbaum C. Distribution of lysozyme and mucin (MUC2 and MUC3) mRNA in human bronchus. Exp Lung Res. 1994;20(4):367–380. PubMed PMID: 7988497 doi:10.3109/01902149409064393.
   PubMed Web of Science ®Google Scholar
• Porchet N, Pigny P, Buisine MP, Debailleul V, Degand P, Laine A, Aubert JP. Human mucin genes: genomic organization and expression of MUC4, MUC5AC and MUC5B. Biochem Soc Trans. 1995;23(4):800–805. PubMed PMID: 8654841 doi:10.1042/bst0230800.
   PubMed Web of Science ®Google Scholar
• Escande F, Porchet N, Aubert JP, Buisine MP. The mouse Muc5b mucin gene: cDNA and genomic structures, chromosomal localization and expression. Biochem J. 2002;363(Pt 3):589–598. PubMed PMID: 11964160; PMCID: PMC1222512 doi:10.1042/0264-6021:3630589.
   PubMedGoogle Scholar
• Davies JR, Herrmann A, Russell W, Svitacheva N, Wickström C, Carlstedt I. Respiratory tract mucins: structure and expression patterns. Novartis Found Symp. 2002;248:76–88. discussion −93, 277-82. PubMed PMID: 12568489.
   PubMed Web of Science ®Google Scholar
• Bobek LA, Tsai H, Biesbrock AR, Levine MJ. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). J Biol Chem. 1993;268(27):20563–20569. PubMed PMID: 7690757.
   PubMed Web of Science ®Google Scholar
• Moniaux N, Escande F, Batra SK, Porchet N, Laine A, Aubert JP. Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins. Eur J Biochem. 2000;267(14):4536–4544. PubMed PMID: 10880978 doi:10.1046/j.1432-1327.2000.01504.x.
   PubMedGoogle Scholar
• Pallesen LT, Berglund L, Rasmussen LK, Petersen TE, Rasmussen JT. Isolation and characterization of MUC15, a novel cell membrane-associated mucin. Eur J Biochem. 2002;269(11):2755–2763. PubMed PMID: 12047385 doi:10.1046/j.1432-1033.2002.02949.x.
   PubMedGoogle Scholar
• Widdicombe JG. Rôle of lipids in airway function. Eur J Respir Dis Suppl. 1987;153:197–204. PubMed PMID: 3322862.
   PubMedGoogle Scholar
• Creeth JM. Constituents of mucus and their separation. Br Med Bull. 1978;34(1):17–24. PubMed PMID: 342044 doi:10.1093/oxfordjournals.bmb.a071454.
   PubMed Web of Science ®Google Scholar
• O’Dwyer DN, Dickson RP, Moore BB. The lung microbiome, immunity, and the pathogenesis of chronic lung disease. J Immunol. 2016;196(12):4839–4847. PubMed PMID: 27260767; PMCID: PMC4894335 doi:10.4049/jimmunol.1600279.
   PubMed Web of Science ®Google Scholar
• Mak TW, Saunders ME. Primer to the immune response. Academic Press/Elsevier; 2008. 436.
   Google Scholar
• Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR, Byrd JC, Siddiki B, Kim YS. Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem. 1993;268(8):5879–5885. PubMed PMID: 7680650.
   PubMed Web of Science ®Google Scholar
• Bartman AE, Buisine MP, Aubert JP, Niehans GA, Toribara NW, Kim YS, Kelly EJ, Crabtree JE, Ho SB. The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues. J Pathol. 1998;186(4):398–405. PubMed PMID: 10209489 doi:10.1002/(SICI)1096-9896(199812)186:4<398::AID-PATH192>3.0.CO;2-X.
   PubMed Web of Science ®Google Scholar
• Gum JR, Crawley SC, Hicks JW, Szymkowski DE, Kim YS. MUC17, a novel membrane-tethered mucin. Biochem Biophys Res Commun. 2002;291(3):466–475. PubMed PMID: 11855812 doi:10.1006/bbrc.2002.6475.
   PubMed Web of Science ®Google Scholar
• Gum JR, Byrd JC, Hicks JW, Toribara NW, Lamport DT, Kim YS. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J Biol Chem. 1989;264(11):6480–6487. PubMed PMID: 2703501.
   PubMed Web of Science ®Google Scholar
• Ogata S, Uehara H, Chen A, Itzkowitz SH. Mucin gene expression in colonic tissues and cell lines. Cancer Res. 1992;52(21):5971–5978. PubMed PMID: 1394223.
   PubMed Web of Science ®Google Scholar
• Pratt WS, Crawley S, Hicks J, Ho J, Nash M, Kim YS, Gum JR, Swallow DM. Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B. Biochem Biophys Res Commun. 2000;275(3):916–923. PubMed PMID: 10973822 doi:10.1006/bbrc.2000.3406.
   PubMed Web of Science ®Google Scholar
• Barko PC, McMichael MA, Swanson KS, Williams DA. The gastrointestinal microbiome: a review. J Vet Intern Med. 2018;32(1):9–25. Epub 2017/ 11/24 PubMed PMID: 29171095; PMCID: PMC5787212. doi: 10.1111/jvim.14875.
   PubMed Web of Science ®Google Scholar
• Brandtzaeg P, Bjerke K, Kvale D, Rognum TO, Scott H, Sollid LM, Valnes K. Production and secretion of immunoglobulins in the gastrointestinal tract. Ann Allergy. 1987;59(5 Pt 2):21–39. PubMed PMID: 3318585.
   PubMedGoogle Scholar
• Linden SK, Sutton P, Karlsson NG, Korolik V, McGuckin MA. Mucins in the mucosal barrier to infection. Mucosal Immunol. 2008;1(3):183–197. Epub 2008/03/05. doi: 10.1038/mi.2008.5. PubMed PMID: 19079178. doi:.
   PubMed Web of Science ®Google Scholar
• Rogier EW, Frantz AL, Bruno ME, Kaetzel CS. Secretory IgA is concentrated in the outer layer of colonic mucus along with gut bacteria. Pathogens. 2014;3(2):390–403. Epub 2014/04/29. doi: 10.3390/pathogens3020390. PubMed PMID: 25437806; PMCID: PMC4243452. doi:.
   PubMedGoogle Scholar
• Gipson IK, Ho SB, Spurr-Michaud SJ, Tisdale AS, Zhan Q, Torlakovic E, Pudney J, Anderson DJ, Toribara NW, Hill JA. Mucin genes expressed by human female reproductive tract epithelia. Biol Reprod. 1997;56(4):999–1011. PubMed PMID: 9096884 doi:10.1095/biolreprod56.4.999.
   PubMed Web of Science ®Google Scholar
• Gipson IK, Moccia R, Spurr-Michaud S, Argüeso P, Gargiulo AR, Hill JA, Offner GD, Keutmann HT. The Amount of MUC5B mucin in cervical mucus peaks at midcycle. J Clin Endocrinol Metab. 2001;86(2):594–600. PubMed PMID: 11158014 doi:10.1210/jcem.86.2.7174.
   PubMed Web of Science ®Google Scholar
• Gipson IK, Spurr-Michaud S, Moccia R, Zhan Q, Toribara N, Ho SB, Gargiulo AR, Hill JA. MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix. Biol Reprod. 1999;60(1):58–64. PubMed PMID: 9858486 doi:10.1095/biolreprod60.1.58.
   PubMed Web of Science ®Google Scholar
• Andersch-Björkman Y, Thomsson KA, Holmén Larsson JM, Ekerhovd E, Hansson GC. Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle. Mol Cell Proteomics. 2007;6(4):708–716. Epub 2007/01/12. doi: 10.1074/mcp.M600439-MCP200. PubMed PMID: 17220477. doi:.
   PubMed Web of Science ®Google Scholar
• Adnane M, Meade KG, O’Farrelly C. Cervico-vaginal mucus (CVM) - an accessible source of immunologically informative biomolecules. Vet Res Commun. 2018;42(4):255–263. Epub 2018/ 08/16. doi: 10.1007/s11259-018-9734-0. PubMed PMID: 30117040; PMCID: PMC6244541.
   PubMed Web of Science ®Google Scholar
• Hein M, Petersen AC, Helmig RB, Uldbjerg N, Reinholdt J. Immunoglobulin levels and phagocytes in the cervical mucus plug at term of pregnancy. Acta Obstet Gynecol Scand. 2005;84(8):734–742. PubMed PMID: 16026397 doi:10.1111/j.0001-6349.2005.00525.x.
   PubMed Web of Science ®Google Scholar
• Wang YY, Schroeder HA, Nunn KL, Woods K, Anderson DJ, Lai SK, Cone RA. Diffusion of immunoglobulin G in shed vaginal epithelial cells and in cell-free regions of human cervicovaginal mucus. PLoS One. 2016;11(6):e0158338. Epub 2016/06/30. doi: 10.1371/journal.pone.0158338. PubMed PMID: 27362256; PMCID: PMC4928780.
   PubMed Web of Science ®Google Scholar
• Berry M, Ellingham RB, Corfield AP. Human preocular mucins reflect changes in surface physiology. Br J Ophthalmol. 2004;88(3):377–383. PubMed PMID: 14977773; PMCID: PMC1772032 doi:10.1136/bjo.2003.026583.
   PubMed Web of Science ®Google Scholar
• Inatomi T, Spurr-Michaud S, Tisdale AS, Zhan Q, Feldman ST, Gipson IK. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci. 1996;37(8):1684–1692. PubMed PMID: 8675412.
   PubMed Web of Science ®Google Scholar
• Spurr-Michaud S, Argüeso P, Gipson I. Assay of mucins in human tear fluid. Exp Eye Res. 2007;84(5):939–950. Epub 2007/02/07. doi: 10.1016/j.exer.2007.01.018. PubMed PMID: 17399701; PMCID: PMC1950265. doi:.
   PubMed Web of Science ®Google Scholar
• Yu DF, Chen Y, Han JM, Zhang H, Chen XP, Zou WJ, Liang LY, Xu CC, Liu ZG. MUC19 expression in human ocular surface and lacrimal gland and its alteration in Sjögren syndrome patients. Exp Eye Res. 2008;86(2):403–411. Epub 2007/ 11/28. doi: 10.1016/j.exer.2007.11.013. PubMed PMID: 18184611. doi:.
   PubMed Web of Science ®Google Scholar
• Gipson IK. Distribution of mucins at the ocular surface. Exp Eye Res. 2004;78(3):379–388. PubMed PMID: 15106916 doi:10.1016/s0014-4835(03)00204-5.
   PubMed Web of Science ®Google Scholar
• Hori Y, Spurr-Michaud S, Russo CL, Argüeso P, Gipson IK. Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest Ophthalmol Vis Sci. 2004;45(1):114–122. PubMed PMID: 14691162 doi:10.1167/iovs.03-0903.
   PubMed Web of Science ®Google Scholar
• Bansil R, Turner BS. The biology of mucus: composition, synthesis and organization. Adv Drug Deliv Rev. 2018;124:3–15. Epub 2017/ 09/29. doi: 10.1016/j.addr.2017.09.023. PubMed PMID: 28970050. doi:.
   PubMed Web of Science ®Google Scholar
• Kim DY, Furuta GT, Nguyen N, Inage E, Masterson JC. Epithelial claudin proteins and their role in gastrointestinal diseases. J Pediatr Gastroenterol Nutr. 2019;68(5):611–614. PubMed PMID: 30724794; PMCID: PMC6483856 doi:10.1097/MPG.0000000000002301.
   PubMed Web of Science ®Google Scholar
• Anderson JM, Van Itallie CM. Physiology and function of the tight junction. Cold Spring Harb Perspect Biol. 2009;1(2):a002584. PubMed PMID: 20066090; PMCID: PMC2742087 doi:10.1101/cshperspect.a002584.
   PubMed Web of Science ®Google Scholar
• Garcia-Hernandez V, Quiros M, Nusrat A. Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation. Ann N Y Acad Sci. 2017;1397(1):66–79. Epub 2017/ 05/10. doi: 10.1111/nyas.13360. PubMed PMID: 28493289; PMCID: PMC5545801.
   PubMed Web of Science ®Google Scholar
• Mitchell LA, Overgaard CE, Ward C, Margulies SS, Koval M. Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function. Am J Physiol Lung Cell Mol Physiol. 2011;301(1):L40–9. Epub 2011/04/22. doi: 10.1152/ajplung.00299.2010. PubMed PMID: 21515662; PMCID: PMC3129905. doi:.
   PubMed Web of Science ®Google Scholar
• Hashimoto Y, Tachibana K, Krug SM, Kunisawa J, Fromm M, Kondoh M. Potential for tight junction protein-directed drug development using claudin binders and angubindin-1. Int J Mol Sci. 2019;20(16). Epub 2019/08/17. doi: 10.3390/ijms20164016. PubMed PMID: 31426497; PMCID: PMC6719960.
   Web of Science ®Google Scholar
• Konjar Š, Ferreira C, Blankenhaus B, Veldhoen M. Intestinal Barrier Interactions with Specialized CD8 T Cells. Front Immunol. 2017;8:1281. Epub 2017/10/11. doi: 10.3389/fimmu.2017.01281. PubMed PMID: 29075263; PMCID: PMC5641586. doi:.
   PubMed Web of Science ®Google Scholar
• Takamura S. Niches for the long-term maintenance of tissue-resident memory T cells. Front Immunol. 2018;9:1214. Epub 2018/05/31. doi: 10.3389/fimmu.2018.01214. PubMed PMID: 29904388; PMCID: PMC5990602.
   PubMed Web of Science ®Google Scholar
• McDermott AJ, Huffnagle GB. The microbiome and regulation of mucosal immunity. Immunology. 2014;142(1):24–31. PubMed PMID: 24329495; PMCID: PMC3992044 doi:10.1111/imm.12231.
   PubMed Web of Science ®Google Scholar
• McGhee JR, Fujihashi K. Inside the mucosal immune system. PLoS Biol. 2012;10(9):e1001397. Epub 2012/09/25. doi: 10.1371/journal.pbio.1001397. PubMed PMID: 23049482; PMCID: PMC3457930. doi:.
   PubMed Web of Science ®Google Scholar
• Fahrbach KM, Malykhina O, Stieh DJ, Hope TJ. Differential binding of IgG and IgA to mucus of the female reproductive tract. PLoS One. 2013;8(10):e76176. Epub 2013/10/02. doi: 10.1371/journal.pone.0076176. PubMed PMID: 24098437; PMCID: PMC3788792.
   PubMed Web of Science ®Google Scholar
• Saltzman WM, Radomsky ML, Whaley KJ, Cone RA. Antibody diffusion in human cervical mucus. Biophys J. 1994;66(2 Pt 1):508–515. PubMed PMID: 8161703; PMCID: 1275717.
   PubMed Web of Science ®Google Scholar
• Castle PE, Whaley KJ, Hoen TE, Moench TR, Cone RA. Contraceptive effect of sperm-agglutinating monoclonal antibodies in rabbits. Biol Reprod. 1997;56(1):153–159. PubMed PMID: 9002644.
   PubMed Web of Science ®Google Scholar
• Zeitlin L, Cone RA, Moench TR, Whaley KJ. Preventing infectious disease with passive immunization. Microbes Infect. 2000;2(6):701–708. PubMed PMID: 10884621.
   PubMed Web of Science ®Google Scholar
• Platt AM, Randolph GJ. Dendritic cell migration through the lymphatic vasculature to lymph nodes. Adv Immunol. 2013;120:51–68. PubMed PMID: 24070380. doi:10.1016/B978-0-12-417028-5.00002-8.
   PubMed Web of Science ®Google Scholar
• Randolph GJ, Angeli V, Swartz MA. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol. 2005;5(8):617–628. PubMed PMID: 16056255 doi:10.1038/nri1670.
   PubMed Web of Science ®Google Scholar
• Steele L, Mayer L, Berin MC. Mucosal immunology of tolerance and allergy in the gastrointestinal tract. Immunol Res. 2012;54(1–3):75–82. PubMed PMID: 22447352; PMCID: PMC3807575 doi:10.1007/s12026-012-8308-4.
   PubMed Web of Science ®Google Scholar
• Cesta MF. Normal structure, function, and histology of mucosa-associated lymphoid tissue. Toxicol Pathol. 2006;34(5):599–608. PubMed PMID: 17067945 doi:10.1080/01926230600865531.
   PubMed Web of Science ®Google Scholar
• Baluk P, Adams A, Phillips K, Feng J, Hong YK, Brown MB, McDonald DM. Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation. Am J Pathol. 2014;184(5):1577–1592. PubMed PMID: 24631179; PMCID: 4005985 doi:10.1016/j.ajpath.2014.01.021.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yano A, Watanabe S, Langella P, Bermúdez-Humarán LG, Inoue N. M cell-targeting strategy enhances systemic and mucosal immune responses induced by oral administration of nuclease-producing L. lactis. Appl Microbiol Biotechnol. 2018;102(24):10703–10711. Epub 2018/10/11. doi: 10.1007/s00253-018-9427-1. PubMed PMID: 30310964.
   PubMed Web of Science ®Google Scholar
• Randall TD. Bronchus-associated lymphoid tissue (BALT) structure and function. Adv Immunol. 2010;107:187–241. PubMed PMID: 21034975. doi:10.1016/B978-0-12-381300-8.00007-1.
   PubMed Web of Science ®Google Scholar
• Randolph GJ, Bala S, Rahier JF, Johnson MW, Wang PL, Nalbantoglu I, Dubuquoy L, Chau A, Pariente B, Kartheuser A, et al. Lymphoid aggregates remodel lymphatic collecting vessels that serve mesenteric lymph nodes in crohn disease. Am J Pathol. 2016 12;186:3066–3073. Epub 2016/10/13. doi: 10.1016/j.ajpath.2016.07.026. PubMed PMID: 27746181; PMCID: PMC5225286.
   PubMed Web of Science ®Google Scholar
• Esterházy D, Canesso MCC, Mesin L, Muller PA, de Castro TBR, Lockhart A, ElJalby M, Faria AMC, Mucida D. Compartmentalized gut lymph node drainage dictates adaptive immune responses. Nature. 2019;569(7754):126–130. Epub 2019/ 04/15. doi: 10.1038/s41586-019-1125-3. PubMed PMID: 30988509; PMCID: PMC6587593.
   PubMed Web of Science ®Google Scholar
• Nelson RP, Ballow M. 26. Immunomodulation and immunotherapy: drugs, cytokines, cytokine receptors, and antibodies. J Allergy Clin Immunol. 2003;111(2 Suppl):S720–43. PubMed PMID: 12592317 doi:10.1067/mai.2003.146.
   PubMedGoogle Scholar
• Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011;480(7378):480–489. PubMed PMID: 22193102; PMCID: 3967235 doi:10.1038/nature10673.
   PubMed Web of Science ®Google Scholar
• Lycke N. Recent progress in mucosal vaccine development: potential and limitations. Nat Rev Immunol. 2012 25;12(8):592–605. Epub 2012/ 07/. doi: 10.1038/nri3251. PubMed PMID: 22828912. doi:.
   PubMed Web of Science ®Google Scholar
• Kammona O, Kiparissides C. Recent advances in nanocarrier-based mucosal delivery of biomolecules. J Controlled Release. 2012;161(3):781–794. PubMed PMID: WOS:000308077000009 doi:10.1016/j.jconrel.2012.05.040.
   PubMed Web of Science ®Google Scholar
• Kammona O, Bourganis V, Karamanidou T, Kiparissides C. Recent developments in nanocarrier-aided mucosal vaccination. Nanomedicine. 2017;12(9):1057–1074. PubMed PMID: WOS:000401014000009 doi:10.2217/nnm-2017-0015.
   PubMed Web of Science ®Google Scholar
• Kim S-H, Jang Y-S. The development of mucosal vaccines for both mucosal and systemic immune induction and the roles played by adjuvants. Clin Exp Vaccine Res. 2017;6(1):15. doi:10.7774/cevr.2017.6.1.15.
   PubMed Web of Science ®Google Scholar
• Lai SK, O’Hanlon DE, Harrold S, Man ST, Wang YY, Cone R, Hanes J. Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci U S A. 2007;104(5):1482–1487. Epub 2007/01/23. doi: 10.1073/pnas.0608611104. PubMed PMID: 17244708; PMCID: PMC1785284. doi:.
   PubMed Web of Science ®Google Scholar
• Ensign LM, Tang BC, Wang YY, Tse TA, Hoen T, Cone R, Hanes J. Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus. Sci Transl Med. 2012;4(138):138ra79. PubMed PMID: 22700955; PMCID: PMC3817739 doi:10.1126/scitranslmed.3003453.
   PubMed Web of Science ®Google Scholar
• Ensign LM, Henning A, Schneider CS, Maisel K, Wang YY, Porosoff MD, Cone R, Hanes J. Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues. Mol Pharm. 2013;10(6):2176–2182. Epub 2013/05/23. doi: 10.1021/mp400087y. PubMed PMID: 23617606; PMCID: PMC3711090. doi:.
   PubMedGoogle Scholar
• Lai SK, Wang YY, Hida K, Cone R, Hanes J. Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses. Proc Natl Acad Sci U S A. 2010;107(2):598–603. Epub 2009/12/16. doi: 10.1073/pnas.0911748107. PubMed PMID: 20018745; PMCID: PMC2818964.
   PubMed Web of Science ®Google Scholar
• Maisel K, Ensign L, Reddy M, Cone R, Hanes J. Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse. J Control Release. 2015;197:48–57. Epub 2014/ 11/04. doi: 10.1016/j.jconrel.2014.10.026. PubMed PMID: 25449804; PMCID: PMC4272879.
   PubMed Web of Science ®Google Scholar
• Maisel K, Reddy M, Xu Q, Chattopadhyay S, Cone R, Ensign LM, Hanes J. Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo. Nanomedicine (Lond). 2016;11(11):1337–1343. Epub 2016/ 05/12. doi: 10.2217/nnm-2016-0047. PubMed PMID: 27171816; PMCID: PMC4897967.
   PubMed Web of Science ®Google Scholar
• Schneider CS, Xu Q, Boylan NJ, Chisholm J, Tang BC, Schuster BS, Henning A, Ensign LM, Lee E, Adstamongkonkul P, et al. Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation. Sci Adv. 2017;3(4):e1601556. Epub 2017/04/05. doi: 10.1126/sciadv.1601556. PubMed PMID: 28435870; PMCID: PMC5381952. doi:.
   PubMed Web of Science ®Google Scholar
• Xu Q, Ensign LM, Boylan NJ, Schön A, Gong X, Yang JC, Lamb NW, Cai S, Yu T, Freire E, et al. Impact of Surface Polyethylene Glycol (PEG) density on biodegradable nanoparticle transport in mucus ex vivo and distribution in vivo. ACS Nano. 2015;9(9):9217–9227. Epub 2015/08/31. doi: 10.1021/acsnano.5b03876. PubMed PMID: 26301576; PMCID: PMC4890729.
   PubMed Web of Science ®Google Scholar
• Suk JS, Xu Q, Kim N, Hanes J, Ensign LM. PEGylation as a strategy for improving nanoparticle-based drug and gene delivery. Adv Drug Deliv Rev. 2016;99(Pt A):28–51. Epub 2015/ 10/09. doi: 10.1016/j.addr.2015.09.012. PubMed PMID: 26456916; PMCID: PMC4798869.
   PubMed Web of Science ®Google Scholar
• Khutoryanskiy VV. Beyond PEGylation: alternative surface-modification of nanoparticles with mucus-inert biomaterials. Adv Drug Deliv Rev. 2018;124:140–149. Epub 2017/ 07/20. doi: 10.1016/j.addr.2017.07.015. PubMed PMID: 28736302.
   PubMed Web of Science ®Google Scholar
• Huckaby JT, Lai SK. PEGylation for enhancing nanoparticle diffusion in mucus. Adv Drug Deliv Rev. 2018;124:125–139. Epub 2017/ 09/04. doi: 10.1016/j.addr.2017.08.010. PubMed PMID: 28882703.
   PubMed Web of Science ®Google Scholar
• Maher S, Mrsny RJ, Brayden DJ. Intestinal permeation enhancers for oral peptide delivery. Adv Drug Deliv Rev. 2016;106(Pt B):277–319. Epub 2016/06/16. doi: 10.1016/j.addr.2016.06.005. PubMed PMID: 27320643.
   PubMed Web of Science ®Google Scholar
• Chen R, Lim JH, Jono H, Gu -X-X, Kim YS, Basbaum CB, Murphy TF, Li J-D. Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2–TAK1-dependent p38 MAPK-AP1 and IKKβ-IκBα-NF-κB signaling pathways. Biochem Biophys Res Commun. 2004;324(3):1087–1094. doi:10.1016/j.bbrc.2004.09.157.
   PubMed Web of Science ®Google Scholar
• Hertz CJ, Wu Q, Porter EM, Zhang YJ, K-H W, Godowski PJ, Ganz T, Randell SH, Modlin RL. Activation of toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human β Defensin-2. J Immunol. 2003;171(12):6820–6826. doi:10.4049/jimmunol.171.12.6820.
   PubMed Web of Science ®Google Scholar
• Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem. 2003;278(52):53035–53044. doi:10.1074/jbc.m308093200.
   PubMed Web of Science ®Google Scholar
• Lee H, Lee J, Hong S-H, Rahman I, Yang S-R. Inhibition of RAGE attenuates cigarette smoke-induced lung epithelial cell damage via RAGE-mediated Nrf2/DAMP signaling. Front Pharmacol. 2018:9. doi:10.3389/fphar.2018.00684.
   PubMed Web of Science ®Google Scholar
• Yong JM, Mantaj J, Cheng Y, Vllasaliu D. Delivery of nanoparticles across the intestinal epithelium via the transferrin transport pathway. Pharmaceutics. 2019;11(7):298. doi:10.3390/pharmaceutics11070298.
   PubMed Web of Science ®Google Scholar
• Sockolosky JT, Szoka FC. The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. Adv Drug Deliv Rev. 2015;91:109–124. doi:10.1016/j.addr.2015.02.005.
   PubMed Web of Science ®Google Scholar
• Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, Miura T, Haba T, Scherer DC, Wei J, et al. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med. 2001;7(9):1052–1056. doi:10.1038/nm0901-1052.
   PubMed Web of Science ®Google Scholar
• Maher S, Brayden DJ, Casettari L, Illum L. Application of permeation enhancers in oral delivery of macromolecules: an update. Pharmaceutics. 2019;11(1). Epub 2019/ 01/19. doi: 10.3390/pharmaceutics11010041. PubMed PMID: 30669434; PMCID: PMC6359609.
   Web of Science ®Google Scholar
• Boisguérin P, Deshayes S, Gait MJ, O’Donovan L, Godfrey C, Betts CA, Wood MJ, Lebleu B. Delivery of therapeutic oligonucleotides with cell penetrating peptides. Adv Drug Deliv Rev. 2015;87:52–67. Epub 2015/03/04. doi: 10.1016/j.addr.2015.02.008. PubMed PMID: 25747758.
   PubMed Web of Science ®Google Scholar
• Komin A, Russell LM, Hristova KA, Searson PC. Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: mechanisms and challenges. Adv Drug Deliv Rev. 2017;110-111:52–64. Epub 2016/ 06/13. doi: 10.1016/j.addr.2016.06.002. PubMed PMID: 27313077. doi:.
   PubMed Web of Science ®Google Scholar
• Malhaire H, Gimel JC, Roger E, Benoît JP, Lagarce F. How to design the surface of peptide-loaded nanoparticles for efficient oral bioavailability? Adv Drug Deliv Rev. 2016;106(Pt B):320–336. Epub 2016/04/04. doi: 10.1016/j.addr.2016.03.011. PubMed PMID: 27058155. doi:.
   PubMedGoogle Scholar
• Toorisaka E, Ono H, Arimori K, Kamiya N, Goto M. Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (S/O/W) emulsion. Int J Pharm. 2003 PubMed PMID: 12550804;252(1–2):271–274. doi:10.1016/S0378-5173(02)00674-9.
   PubMedGoogle Scholar
• Toorisaka E, Hashida M, Kamiya N, Ono H, Kokazu Y, Goto M. An enteric-coated dry emulsion formulation for oral insulin delivery. J Control Release. 2005;107(1):91–96. PubMed PMID: 16039746 doi:10.1016/j.jconrel.2005.05.022.
   PubMed Web of Science ®Google Scholar
• Sha X, Yan G, Wu Y, Li J, Fang X. Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Eur J Pharm Sci. 2005;24(5):477–486. PubMed PMID: 15784337 doi:10.1016/j.ejps.2005.01.001.
   PubMed Web of Science ®Google Scholar
• Venkatesan N, Yoshimitsu J, Ito Y, Shibata N, Takada K. Liquid filled nanoparticles as a drug delivery tool for protein therapeutics. Biomaterials. 2005;26(34):7154–7163. PubMed PMID: 15967493 doi:10.1016/j.biomaterials.2005.05.012.
   PubMed Web of Science ®Google Scholar
• Merisko-Liversidge E, McGurk SL, Liversidge GG. Insulin nanoparticles: a novel formulation approach for poorly water soluble Zn-insulin. Pharm Res. 2004 PubMed PMID: 15497677;21(9):1545–1553. doi:10.1023/B:PHAM.0000041446.14569.e2.
   PubMed Web of Science ®Google Scholar
• Cadete A, Figueiredo L, Lopes R, Calado CC, Almeida AJ, Gonçalves LM. Development and characterization of a new plasmid delivery system based on chitosan-sodium deoxycholate nanoparticles. Eur J Pharm Sci. 2012;45(4):451–458. Epub 2011/ 10/01. doi: 10.1016/j.ejps.2011.09.018. PubMed PMID: 21986445. doi:.
   PubMed Web of Science ®Google Scholar
• Welling SH, Hubálek F, Jacobsen J, Brayden DJ, Rahbek UL, Buckley ST. The role of citric acid in oral peptide and protein formulations: relationship between calcium chelation and proteolysis inhibition. Eur J Pharm Biopharm. 2014;86(3):544–551. Epub 2013/ 12/31. doi: 10.1016/j.ejpb.2013.12.017. PubMed PMID: 24384069.
   PubMed Web of Science ®Google Scholar
• Zhu X, Shan W, Zhang P, Jin Y, Guan S, Fan T, Yang Y, Zhou Z, Huang Y. Penetratin derivative-based nanocomplexes for enhanced intestinal insulin delivery. Mol Pharm. 2014;11(1):317–328. Epub 2013/ 11/25. doi: 10.1021/mp400493b. PubMed PMID: 24255985.
   PubMed Web of Science ®Google Scholar
• Jin Y, Song Y, Zhu X, Zhou D, Chen C, Zhang Z, Huang Y. Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport. Biomaterials. 2012;33(5):1573–1582. Epub 2011/ 11/16. doi: 10.1016/j.biomaterials.2011.10.075. PubMed PMID: 22093292. doi:.
   PubMed Web of Science ®Google Scholar
• Porsio B, Craparo EF, Mauro N, Giammona G, Cavallaro G. Mucus and cell-penetrating nanoparticles embedded in nano-into-micro formulations for pulmonary delivery of ivacaftor in patients with cystic fibrosis. ACS Appl Mater Interfaces. 2018 10(1):165–181. Epub 2017/ 12/26. doi: 10.1021/acsami.7b14992. PubMed PMID: 29235345.
   PubMed Web of Science ®Google Scholar
• Tan X, Zhang Y, Wang Q, Ren T, Gou J, Guo W, Yin T, He H, Zhang X, Tang X. Cell-penetrating peptide together with PEG-modified mesostructured silica nanoparticles promotes mucous permeation and oral delivery of therapeutic proteins and peptides. Biomater Sci. 2019;7(7):2934–2950. PubMed PMID: 31094367 doi:10.1039/c9bm00274j.
   PubMed Web of Science ®Google Scholar
• Martínez-Gómez JM, Johansen P, Erdmann I, Senti G, Crameri R, Kündig TM. Intralymphatic injections as a new administration route for allergen-specific immunotherapy. Int Arch Allergy Immunol. 2009;150(1):59–65. Epub 2009/04/02. doi: 10.1159/000210381. PubMed PMID: 19339803.
   PubMed Web of Science ®Google Scholar
• Senti G, Prinz Vavricka BM, Erdmann I, Diaz MI, Markus R, McCormack SJ, Simard JJ, Wüthrich B, Crameri R, Graf N, et al. Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial. Proc Natl Acad Sci U S A. 2008;105(46):17908–17912. Epub 2008/ 11/10. doi: 10.1073/pnas.0803725105. PubMed PMID: 19001265; PMCID: PMC2582048.
   PubMed Web of Science ®Google Scholar
• Smith KA, Meisenburg BL, Tam VL, Pagarigan RR, Wong R, Joea DK, Lantzy L, Carrillo MA, Gross TM, Malyankar UM, et al. Lymph node-targeted immunotherapy mediates potent immunity resulting in regression of isolated or metastatic human papillomavirus-transformed tumors. Clin Cancer Res. 2009;15(19):6167–6176. Epub 2009/09/29. doi: 10.1158/1078-0432.CCR-09-0645. PubMed PMID: 19789304; PMCID: PMC2756704. doi:10.1158/1078-0432.CCR-09-0645.
   PubMed Web of Science ®Google Scholar
• Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 2014;507(7493):519–522. Epub 2014/ 02/16. doi: 10.1038/nature12978. PubMed PMID: 24531764; PMCID: PMC4069155.
   PubMed Web of Science ®Google Scholar
• von Beust BR, Johansen P, Smith KA, Bot A, Storni T, Kündig TM. Improving the therapeutic index of CpG oligodeoxynucleotides by intralymphatic administration. Eur J Immunol. 2005;35(6):1869–1876. PubMed PMID: 15909311 doi:10.1002/eji.200526124.
   PubMed Web of Science ®Google Scholar
• Maloy KJ, Erdmann I, Basch V, Sierro S, Kramps TA, Zinkernagel RM, Oehen S, Kündig TM. Intralymphatic immunization enhances DNA vaccination. Proc Natl Acad Sci U S A. 2001;98(6):3299–3303. Epub 2001/02/27. doi: 10.1073/pnas.051630798. PubMed PMID: 11248073; PMCID: PMC30648.
   PubMed Web of Science ®Google Scholar
• Johansen P, Häffner AC, Koch F, Zepter K, Erdmann I, Maloy K, Simard JJ, Storni T, Senti G, Bot A, et al. Direct intralymphatic injection of peptide vaccines enhances immunogenicity. Eur J Immunol. 2005;35(2):568–574. PubMed PMID: 15682446 doi:10.1002/eji.200425599.
   PubMed Web of Science ®Google Scholar
• Komori J, Boone L, DeWard A, Hoppo T, Lagasse E. The mouse lymph node as an ectopic transplantation site for multiple tissues. Nat Biotechnol. 2012;30(10):976–983. Epub 2012/09/23. doi: 10.1038/nbt.2379. PubMed PMID: 23000933; PMCID: PMC3469750. doi:.
   PubMed Web of Science ®Google Scholar
• Maisel K, Sasso MS, Potin L, Swartz MA. Exploiting lymphatic vessels for immunomodulation: rationale, opportunities, and challenges. Adv Drug Deliv Rev. 2017;114:43–59. PubMed PMID: 28694027; PMCID: 6026542. doi:10.1016/j.addr.2017.07.005.
   PubMed Web of Science ®Google Scholar
• Reddy ST, Rehor A, Schmoekel HG, Hubbell JA, Swartz MA. In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles. J Control Release. 2006;112(1):26–34. PubMed PMID: 16529839 doi:10.1016/j.jconrel.2006.01.006.
   PubMed Web of Science ®Google Scholar
• Manolova V, Flace A, Bauer M, Schwarz K, Saudan P, Bachmann MF. Nanoparticles target distinct dendritic cell populations according to their size. Eur J Immunol. 2008;38(5):1404–1413. PubMed PMID: 18389478 doi:10.1002/eji.200737984.
   PubMed Web of Science ®Google Scholar
• Varypataki EM, Silva AL, Barnier-Quer C, Collin N, Ossendorp F, Jiskoot W. Synthetic long peptide-based vaccine formulations for induction of cell mediated immunity: A comparative study of cationic liposomes and PLGA nanoparticles. J Control Release. 2016;226:98–106. Epub 2016/ 02/11. doi: 10.1016/j.jconrel.2016.02.018. PubMed PMID: 26876760. doi:.
   PubMed Web of Science ®Google Scholar
• Kobayashi H, Kawamoto S, Bernardo M, Brechbiel MW, Knopp MV, Choyke PL. Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging. J Control Release. 2006;111(3):343–351. Epub 2006/ 02/21. doi: 10.1016/j.jconrel.2005.12.019. PubMed PMID: 16490277.
   PubMed Web of Science ®Google Scholar
• Rao DA, Forrest ML, Alani AW, Kwon GS, Robinson JR. Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery. J Pharm Sci. 2010;99(4):2018–2031. PubMed PMID: 19902520; PMCID: PMC5178132 doi:10.1002/jps.21970.
   PubMed Web of Science ®Google Scholar
• Zeng Q, Jiang H, Wang T, Zhang Z, Gong T, Sun X. Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses. J Control Release. 2015;200:1–12. Epub 2014/ 12/23. doi: 10.1016/j.jconrel.2014.12.024. PubMed PMID: 25540903.
   PubMed Web of Science ®Google Scholar
• De Koker S, Cui J, Vanparijs N, Albertazzi L, Grooten J, Caruso F, De Geest BG. Engineering Polymer hydrogel nanoparticles for lymph node-targeted delivery. Angew Chem Int Ed Engl. 2016;55(4):1334–1339. Epub 2015/ 12/15. doi: 10.1002/anie.201508626. PubMed PMID: 26666207.
   PubMed Web of Science ®Google Scholar
• Mao Y, Feng S, Li S, Zhao Q, Di D, Liu Y, Wang S. Chylomicron-pretended nano-bio self-assembling vehicle to promote lymphatic transport and GALTs target of oral drugs. Biomaterials. 2019;188:173–186. Epub 2018/ 10/18. doi: 10.1016/j.biomaterials.2018.10.012. PubMed PMID: 30359884.
   PubMed Web of Science ®Google Scholar
• Triacca V, Guc E, Kilarski WW, Pisano M, Swartz MA. Transcellular pathways in lymphatic endothelial cells regulate changes in solute transport by fluid stress. Circ Res. 2017;120(9):1440–1452. PubMed PMID: 28130294 doi:10.1161/CIRCRESAHA.116.309828.
   PubMed Web of Science ®Google Scholar
• Jackson RJ, Fujihashi K, Xu-Amano J, Kiyono H, Elson CO, McGhee JR. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infect Immun. 1993;61(10):4272–4279. PubMed PMID: 8406816; PMCID: PMC281154.
   PubMed Web of Science ®Google Scholar
• Garinot M, Fiévez V, Pourcelle V, Stoffelbach F, Des Rieux A, Plapied L, Theate I, Freichels H, Jérôme C, Marchand-Brynaert J, et al. PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination. J Control Release. 2007;120(3):195–204. Epub 2007/05/22. doi: 10.1016/j.jconrel.2007.04.021. PubMed PMID: 17586081.
   PubMed Web of Science ®Google Scholar
• Lee DY, Nurunnabi M, Kang SH, Nafiujjaman M, Huh KM, Lee YK, Kim YC. Oral gavage delivery of PR8 Antigen with β-glucan-conjugated GRGDS carrier to enhance M-cell targeting ability and induce immunity. Biomacromolecules. 2017;18(4):1172–1179. Epub 2017/03/21. doi: 10.1021/acs.biomac.6b01855. PubMed PMID: 28278374.
   PubMed Web of Science ®Google Scholar
• Fievez V, Plapied L, Des Rieux A, Pourcelle V, Freichels H, Wascotte V, Vanderhaeghen ML, Jerôme C, Vanderplasschen A, Marchand-Brynaert J, et al. Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination. Eur J Pharm Biopharm. 2009;73(1):16–24. Epub 2009/05/04. doi: 10.1016/j.ejpb.2009.04.009. PubMed PMID: 19409989.
   PubMed Web of Science ®Google Scholar
• Nochi T, Yuki Y, Matsumura A, Mejima M, Terahara K, Kim DY, Fukuyama S, Iwatsuki-Horimoto K, Kawaoka Y, Kohda T, et al. A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med. 2007;204(12):2789–2796. Epub 2007/11/05. doi: 10.1084/jem.20070607. PubMed PMID: 17984304; PMCID: PMC2118513.
   PubMed Web of Science ®Google Scholar
• Shima H, Watanabe T, Fukuda S, Fukuoka S, Ohara O, Ohno H. A novel mucosal vaccine targeting Peyer’s patch M cells induces protective antigen-specific IgA responses. Int Immunol. 2014;26(11):619–625. Epub 2014/06/07. doi: 10.1093/intimm/dxu061. PubMed PMID: 24908678.
   PubMed Web of Science ®Google Scholar
• Mattila JP, Mirandola L, Chiriva-Internati M. Development of a M cell-targeted microparticulate platform, BSK02™, for oral immunization against the ovarian cancer antigen, sperm protein 17. J Biomed Mater Res B Appl Biomater. 2019;107(1):29–36. Epub 2018/ 03/04. doi: 10.1002/jbm.b.34092. PubMed PMID: 29504239.
   PubMed Web of Science ®Google Scholar
• Yoo MK, Kang SK, Choi JH, Park IK, Na HS, Lee HC, Kim EB, Lee NK, Nah JW, Choi YJ, et al. Targeted delivery of chitosan nanoparticles to Peyer’s patch using M cell-homing peptide selected by phage display technique. Biomaterials. 2010;31(30):7738–7747. Epub 2010/07/24. doi: 10.1016/j.biomaterials.2010.06.059. PubMed PMID: 20656343. doi:.
   PubMed Web of Science ®Google Scholar
• Singh B, Maharjan S, Jiang T, Kang SK, Choi YJ, Cho CS. Combinatorial approach of antigen delivery using M cell-homing peptide and mucoadhesive vehicle to enhance the efficacy of oral vaccine. Mol Pharm. 2015;12(11):3816–3828. Epub 2015/10/02. doi: 10.1021/acs.molpharmaceut.5b00265. PubMed PMID: 26394158.
   PubMed Web of Science ®Google Scholar
• Du L, Yu Z, Pang F, Xu X, Mao A, Yuan W, He K, Li B. Targeted Delivery of GP5 Antigen of PRRSV to M cells enhances the antigen-specific systemic and mucosal immune responses. Front Cell Infect Microbiol. 2018;8:7. Epub 2018/01/25. doi: 10.3389/fcimb.2018.00007. PubMed PMID: 29423381; PMCID: PMC5788884. doi:.
   PubMed Web of Science ®Google Scholar
• Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O’Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, et al. Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus. J Infect Dis. 2014;209(9):1479–1484. Epub 2013/ 11/22. doi: 10.1093/infdis/jit636. PubMed PMID: 24273045; PMCID: PMC4813749.
   PubMed Web of Science ®Google Scholar
• Liu L, Zhang W, Song Y, Wang W, Zhang Y, Wang T, Li K, Pan Q, Qi X, Gao Y, et al. Recombinant Lactococcus lactis co-expressing OmpH of an M cell-targeting ligand and IBDV-VP2 protein provide immunological protection in chickens. Vaccine. 2018;36(5):729–735. Epub 2017/ 12/27. doi: 10.1016/j.vaccine.2017.12.027. PubMed PMID: 29289381.
   PubMed Web of Science ®Google Scholar
• Rochereau N, Pavot V, Verrier B, Ensinas A, Genin C, Corthésy B, Paul S. Secretory IgA as a vaccine carrier for delivery of HIV antigen to M cells. Eur J Immunol. 2015;45(3):773–779. Epub 2015/01/14. doi: 10.1002/eji.201444816. PubMed PMID: 25412898.
   PubMed Web of Science ®Google Scholar
• Rochereau N, Pavot V, Verrier B, Jospin F, Ensinas A, Genin C, Corthésy B, Paul S. Delivery of antigen to nasal-associated lymphoid tissue microfold cells through secretory IgA targeting local dendritic cells confers protective immunity. J Allergy Clin Immunol. 2016;137(1):214–22.e2. Epub 2015/ 09/26. doi: 10.1016/j.jaci.2015.07.042. PubMed PMID: 26414879.
   PubMed Web of Science ®Google Scholar
• Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, et al. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009;462(7270):226–230. PubMed PMID: 19907495 doi:10.1038/nature08529.
   PubMed Web of Science ®Google Scholar
• Maharjan S, Singh B, Jiang T, Yoon SY, Li HS, Kim G, Gu MJ, Kim SJ, Park OJ, Han SH, et al. Systemic administration of RANKL overcomes the bottleneck of oral vaccine delivery through microfold cells in ileum. Biomaterials. 2016;84:286–300. Epub 2016/01/23 PubMed PMID: 26851393. doi: 10.1016/j.biomaterials.2016.01.043.
   PubMed Web of Science ®Google Scholar