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Research paper

IL-1β strengthens the physical barrier in gingival epithelial cells

, ORCID Icon, , , & ORCID Icon
Article: 1804249 | Received 18 Mar 2020, Accepted 23 Jul 2020, Published online: 23 Aug 2020

References

  • Hajishengallis G, Lamont RJ. Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur J Immunol. 2014;44(2):1–17. doi:10.1002/eji.201344202.
  • Meyle J, Chapple I. Molecular aspects of the pathogenesis of periodontitis. Periodontol 2000. 2015;69(1):7–17. doi:10.1111/prd.12104.
  • Demmer RT, Papapanou PN. Epidemiologic patterns of chronic and aggressive periodontitis. Periodontol 2000. 2010;53:28–44. doi:10.1111/j.1600-0757.2009.00326.x.
  • Kassebaum NJ, Bernabé E, Dahiya M, Bhandari B, Murray CJ, Marcenes W. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res. 2014;93(11):1045–1053. doi:10.1177/0022034514552491.
  • Preshaw PM, Alba AL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21–31. doi:10.1007/s00125-011-2342-y.
  • Tonetti MS, Van Dyke TE. Working group 1 of the joint EFP/AAP workshop. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Periodontol. 2013;84(4):S24–29. doi:10.1902/jop.2013.1340019.
  • Preshaw PM. Host modulation therapy with anti-inflammatory agents. Periodontol 2000. 2018;76(1):131–149. doi:10.1111/prd.12148.
  • Okada H, Murakami S. Cytokine expression in periodontal health and disease. Crit Rev Oral Biol Med. 1998;9(3):248–266. doi:10.1177/10454411980090030101.
  • Sfakianakis A, Barr CE, Kreutzer DL. Actinobacillus actinomycetemcomitans-induced expression of IL-1alpha and IL1beta in human gingival epithelial cells: role in IL-8 expression. Eur J Oral Sci. 2001;109:393–401. doi:10.1034/j.1600-0722.2001.00162.x.
  • Uchida Y, Shiba H, Komatsuzawa H, Takemoto T, Sakata M, Fujita T, Kawaguchi H, Sugai M, Kurihara H. Expression of IL-1 beta and IL-8 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans. Cytokine. 2001;14:152–161. doi:10.1006/cyto.2001.0863.
  • Ertugrul AS, Sahin H, Dikilitas A, Alpaslan N, Bozoglan A. Comparison of CCL28, interleukin-8, interleukin-1β and tumor necrosis factor-alpha in subjects with gingivitis, chronic periodontitis and generalized aggressive periodontitis. J Periodontal Res. 2013;48(1):44–51. doi:10.1111/j.1600-0765.2012.01500.x.
  • Stashenko P, Fujiyoshi P, Obernesser MS, Prostak L, Haffajee AD, Socransky SS. Levels of interleukin 1 beta in tissue from sites of active periodontal disease. J Clin Periodontol. 1991;18(7):548–554. doi:10.1111/j.1600-051X.1991.tb00088.x.
  • Faizuddin M, Bharathi SH, Rohini NV. Estimation of interleukin-1beta levels in the gingival crevicular fluid in health and in inflammatory periodontal disease. J Periodontal Res. 2003;38(2):111–114. doi:10.1034/j.1600-0765.2003.01649.x.
  • Groeger SE, Meyle J. Epithelial barrier and oral bacterial infection. Periodontol 2000. 2015;69(1):46–67. doi:10.1111/prd.12094.
  • Brandner JM, Zorn-Kruppa M, Yoshida T, Moll I, Beck LA, De Benedetto A. Epidermal tight junctions in health and disease. Tissue Barriers. 2015;3(1–2):e974451. doi:10.4161/21688370.2014.974451.
  • Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol. 1999;147(4):891–903. doi:10.1083/jcb.147.4.891.
  • Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol. 2002;156(6):1099–1111. doi:10.1083/jcb.200110122.
  • Krug SM, Schulzke JD, Fromm M. Tight junction, Selective Permeability, and Related Diseases. Sem Cell Dev Biol. 2014;36:166–176. doi:10.1016/j.semcdb.2014.09.002.
  • Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2001;2:285–293. doi:10.1038/35067088.
  • Gonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins. Prog Biophys Mol Biol. 2003;81:1–44. doi:10.1016/S0079-6107(02)00037-8.
  • Schneeberger EE, Lynch RD. The tight junction: a multifunctional complex. Am J Physiol Cell Physiol. 2004;286:C1213–C1228. doi:10.1152/ajpcell.00558.2003.
  • Kirschner N, Poetzl C, von den Driesch P, Wladykowski E, Moll I, Behne MJ, Brandner JM. Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines. Am J Pathol. 2009;175(3):1095–1106. doi:10.2353/ajpath.2009.080973.
  • Langbein L. Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. Eur J Cell Biol. 2002;81:419–435. doi:10.1078/0171-9335-00270.
  • Brandner JM, Kief S, Grund C, Rendl M, Houdek P, Kuhn C, Tschachler E, Franke WW, Moll I. Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. Eur J Cell Biol. 2002;81:253-263. doi:10.1078/0171-9335-00244.
  • Schlüter H, Moll I, Wolburg H, Franke WW. The different structures containing tight junction proteins in epidermal and other stratified epithelial cells, including squamous cell metaplasia. Eur J Cell Biol. 2007;86(11–12).
  • Franke WW, Pape FU. Diverse types of junctions containing tight junction proteins in stratified mammalian epithelia. Ann NY Acad Sci. 2012;1257:152–157. doi:10.1111/j.1749-6632.2012.06504.x.
  • Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol. 1986;103(3):755–766. doi:10.1083/jcb.103.3.755.
  • Fujita T, Firth JD, Kittaka M, Ekuni D, Kurihara H, Putnins EE. Loss of claudin-1 in lipopolysaccharide-treated periodontal epithelium. J Periodontal Res. 2012;47:222–227. doi:10.1111/j.1600-0765.2011.01424.x.
  • Groeger S, Doman E, Chakraborty T, Meyle J. Effects of Porphyromonas gingivalis infection on human gingival epithelial barrier function in vitro. Eur J Oral Sci. 2010;118(6):582–589. doi:10.1111/j.1600-0722.2010.00782.x.
  • Gröger S, Michel J, Meyle J. Establishment and characterization of immortalized human gingival keratinocyte cell lines. J Periodontal Res. 2008;43(6):604-614. doi:10.1111/jre.2008.43.issue-6.
  • Groeger S, Meyle J. Oral Mucosal Epithelial Cells. Front Immunol. 2019;10:208. doi:10.3389/fimmu.2019.00208.
  • Belibasakis GN, Kast JI, Thurnheer T, Akdis CA, Bostanci N. The expression of gingival epithelial junctions in response to subgingival biofilms. Virulence. 2015;6(7):704–709. doi:10.1080/21505594.2015.1081731.
  • Hatakeyama S, Ishida K, Takeda Y. Changes in cell characteristics due to retinoic acid; specifically, a decrease in the expression of claudin-1 and increase in claudin-4 within tight junctions in stratified oral keratinocytes. J Periodontal Res. 2010;45(2):207–215. doi:10.1111/j.1600-0765.2009.01219.x.
  • Zihni C, Balda MS, Matter K. Signalling at tight junctions during epithelial differentiation and microbial pathogenesis. J Cell Sci. 2014;127(16):3401–3413. doi:10.1242/jcs.145029.
  • Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Weinberg RA, Louis DN, Li FP, Rheinwald JG. Human keratinocytes that express hTERT and also bypass a p16(ink4a)-enforced mechanism that limits lifespan become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol. 2000;20(4):1436–1447. doi:10.1128/MCB.20.4.1436-1447.2000.
  • Lindberg K, Rheinwald JG. Three distinct keratinocyte subtypes identified in human oral epithelium by their patterns of keratin expression in culture and in xenografts. Differentiation. 1990;45(3):230–241. doi:10.1111/j.1432-0436.1990.tb00477.x.
  • Cheng R, Wu Z, Li M, Shao M, Hu T. Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review. Int J Oral Sci. 2020;12:2–9. doi:10.1038/s41368-019-0068-8.
  • Steinberg T, Dannewitz B, Tomakidi P, Hoheisel JD, Müssig E, Kohl A, Nees M. Analysis of interleukin-1β-modulated mRNA gene transcription in human gingival keratinocytes by epithelia-specific cDNA microarrays. J Periodont Res. 2006;41(5):426–446. doi:10.1111/j.1600-0765.2006.00884.x.
  • Guo W, Wang P, Liu ZH, Ye P. Analysis of differential expression of tight junction proteins in cultured oral epithelial cells altered by Porphyromonas gingivalis, Porphyromonas gingivalis lipopolysaccharide, and extracellular adenosine triphosphate. Int J Oral Sci. 2018;10(1):e8. doi:10.1038/ijos.2017.51.
  • Meyle J, Gültig K, Rascher G, Wolburg H. Transepithelial electrical resistance and tight junctions of human gingival keratinocytes. J Periodontal Res. 1999;34(4):214–222. doi:10.1111/j.1600-0765.1999.tb02244.x.
  • Kirschner N, Brandner JM. Barriers and more: functions of tight junction proteins in the skin. Annals of the New York Academy of Sciences. 2012;1257:158-166 1 doi:10.1111/j.1749-6632.2012.06554.x
  • Pasparakis M. Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat Rev Immunol. 2009;9(11):778–788. doi:10.1038/nri2655.
  • Choi YS, Kim YC, Jo AR, Ji S, Koo KT, KO Y, Choi Y. Porphyromonas gingivalis and dextran sulfate sodium induce periodontitis through the disruption of physical barriers in mice. Eur J Inflammation. 2013;11(2):419–431. doi:10.1177/1721727X1301100212.
  • Kinane DF, Winstanley FP, Adonogianaki E, Moughal NA. Bioassay of interleukin 1 (IL-1) in human gingival crevicular fluid during experimental gingivitis. Arch Oral Biol. 1992;37(2):153–156. doi:10.1016/0003-9969(92)90011-V.
  • Stathopoulou PG, Benakanakere MR, Galicia JC, Kinane DF. Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species. J Clin Periodontol. 2010;37:24–29. doi:10.1111/j.1600-051X.2009.01505.x.
  • Boch JA, Wara-aswapati N, Auron PE. Interleukin 1 signal transduction - current concepts and relevance to periodontitis. J Dent Res. 2001;80(2):400–470. doi:10.1177/00220345010800020101.
  • Delima AJ, Karatzas S, Amar S, Graves DT. Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists. J Infect Dis. 2002;186:511–516. doi:10.1086/341778.
  • Jennings LR, Colley HE, Ong J, Panagakos F, Masters JG, Trivedi HM, Murdoch C, Whawell S. Development and characterization of in vitro human oral mucosal equivalents derived from immortalized oral keratinocytes. Tissue Engineering: Part C. 2016;22(12):1108–1117. doi:10.1089/ten.tec.2016.0310.
  • Park I, Gu H, Park KK. Molecular pathogenesis of bacteria-induced periodontitis. Int J Clin Exp Med. 2018;11:5513–5522.
  • Gumbiner B, Simons K. A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide. J Cell Biol. 1986;102(2):457–468. doi:10.1083/jcb.102.2.457.
  • Schlage WK, Iskandar AR, Kostadinova R, Xiang Y, Sewer A, Majeed S, Kuehn D, Frentzel S, Talikka M, Geertz M, et al. In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures. Toxicol Mech Methods. 2014;24(7):470–487. doi:10.3109/15376516.2014.943441.
  • Bierbaumer L, Schwarze UY, Gruber R, Neuhaus W. Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties. Tissue Barriers. 2018;6(3):1479568. doi:10.1080/21688370.2018.1479568.
  • Coisne C, Engelhardt B. Tight junctions in brain barriers during central nervous system inflammation. Antioxid Redox Signal. 2011;15(5):1285–1303. doi:10.1089/ars.2011.3929.
  • Engelhardt B. Development of the blood-brain barrier. Cell Tissue Res. 2003;314(1):119–129. doi:10.1007/s00441-003-0751-z.
  • Labus J, Häckel S, Lucka L, Danker K. Interleukin-1β induces an inflammatory response and the breakdown of the endothelial cell layer in an improved human THBMEC-based in vitro blood-brain barrier model. J Neurosci Methods. 2014;228:35–45. doi:10.1016/j.jneumeth.2014.03.002.
  • Schmitz H, Fromm M, Bentzel CJ, Scholz P, Detjen K, Mankertz J, Bode H, Epple HJ, Riecken EO, Schulzke JD. Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci. 1999;112:137–146.
  • Brandner JM, Schulzke JD. Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine. Cell Tissue Res. 2015;360:723–748. doi:10.1007/s00441-014-2096-1.
  • Pummi K, Malminen M, Aho H, Karvonen SL, Peltonen J, Peltonen S. Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes. J Invest Dermatol. 2001;117(5):1050–1058. doi:10.1046/j.0022-202x.2001.01493.x.
  • Ohnemus U, Kohrmeyer K, Houdek P, Rohde H, Wladykowski E, Vidal S, Horstkotte MA, Aepfelbacher M, Kirschner N, Behne MJ, et al. Regulation of epidermal tight junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains. J Invest Dermatol. 2008;128(4):906–916. doi:10.1038/sj.jid.5701070.
  • Ward C, Schlingmann B, Stecenko AA, Guidot DM, Koval M. NF-κB inhibitors impair lung epithelial tight junctions in the absence of inflammation. Tissue Barriers. 2015;3(1–2):e982424. doi:10.4161/21688370.2014.982424.
  • Dommisch H, Jepsen S. Diverse functions of defensins and other antimicrobial peptides in periodontal tissues. Periodontol 2000. 2015;69:96–110. doi:10.1111/prd.12093.

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