References
- Söhl G, Willecke K. Gap junctions and the connexin protein family. Cardiovasc Res. 2004;62(2):1–17. doi:https://doi.org/10.1016/j.cardiores.2003.11.013. PubMed-ID: 15094343
- Goodenough DA, Gilula NB. The splitting of hepatocyte gap junctions and zonulae occludentes with hypertonic disaccharides. J Cell Biol. 1974;61(3):575–590. doi:https://doi.org/10.1083/jcb.61.3.575. PubMed-ID: 4836384. PMCID: PMC2109309
- Bader A, Bintig W, Begandt D, Klett A, Siller IG, Gregor C, et al. Adenosine receptors regulate gap junction coupling of the human cerebral microvascular endothelial cells hCMEC/D3 by Ca2+ influx through cyclic nucleotide-gated channels. J Physiol. 2017;595(8):2497–2517. PubMed-ID: 28075020. PMCID: PMC5390872. doi:https://doi.org/10.1113/jp273150.
- Schadzek P, Schlingmann B, Schaarschmidt F, Lindner J, Koval M, Heisterkamp A, et al. The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels. Biochim Biophys Acta. 2016;1858(1):57–66. PubMed-ID: 26449341. doi:https://doi.org/10.1016/j.bbamem.2015.10.001.
- Bennett M, Verselis VK. Biophysics of gap junctions. Sem Cell Biol. 1992;3(1):29–47. doi:https://doi.org/10.1016/s1043-4682(10)80006-6. PubMed-ID: 1320429
- Neijssen J, Herberts C, Drijfhout JW, Reits E, Janssen L, Neefjes J. Cross-presentation by intercellular peptide transfer through gap junctions. Nature. 2005;434(7029):83–88. doi:https://doi.org/10.1038/nature03290. PubMed-ID: 15744304
- Niessen H, Harz H, Bedner P, Krämer K, Willecke K. Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate. J Cell Sci. 2000 PubMed-ID: 10725220;113(Pt 8)):1365–1372. doi:https://doi.org/10.1242/jcs.113.8.1365.
- Bedner P, Niessen H, Odermatt B, Kretz M, Willecke K, Harz H. Selective permeability of different connexin channels to the second messenger cyclic AMP. J Biol Chem. 2006;281(10):6673–6681. doi:https://doi.org/10.1074/jbc.M511235200. PubMed-ID: 16373337
- Kurtenbach S, Kurtenbach S, Zoidl G. Gap junction modulation and its implications for heart function. Front Biosci. 2014;5:82. PubMed-ID: 24578694. PMCID: PMC3936571. doi:https://doi.org/10.3389/fphys.2014.00082.
- Pogoda K, Kameritsch P, Mannell H, Pohl U. Connexins in the control of vasomotor function. Acta Physiol. 2019;225(1):e13108. doi:https://doi.org/10.1111/apha.13108. PubMed-ID: 29858558
- Paul DL, Ebihara L, Takemoto LJ, Swenson KI, Goodenough DA. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol. 1991;115(4):1077–1089. doi:https://doi.org/10.1083/jcb.115.4.1077. PubMed-ID: 1659572. PMCID: PMC2289939
- Ngezahayo A, Zeilinger C, Todt I, Marten I, Kolb HA. Inactivation of expressed and conducting rCx46 hemichannels by phosphorylation. Pflugers Arch. 1998;436(4):627–629. doi:https://doi.org/10.1007/s004240050681. PubMed-ID: 9683738
- Zhou JZ, Jiang JX. Gap junction and hemichannel-independent actions of connexins on cell and tissue functions--an update. FEBS Lett. 2014;588(8):1186–1192. doi:https://doi.org/10.1016/j.febslet.2014.01.001. PubMed-ID: 24434539. PMCID: PMC4122521
- Behrens J, Kameritsch P, Wallner S, Pohl U, Pogoda K. The carboxyl tail of Cx43 augments p38 mediated cell migration in a gap junction-independent manner. Eur J Cell Biol. 2010;89(11):828–838. doi:https://doi.org/10.1016/j.ejcb.2010.06.003. PubMed-ID: 20727616
- Cotrina ML, Lin JH-C, Nedergaard M. Adhesive properties of connexin hemichannels. Glia. 2008;56(16):1791–1798. doi:https://doi.org/10.1002/glia.20728. PubMed-ID: 18649405. PMCID: PMC2577568
- Elias LAB, Wang DD, Kriegstein AR. Gap junction adhesion is necessary for radial migration in the neocortex. Nature. 2007;448(7156):901–907. doi:https://doi.org/10.1038/nature06063. PubMed-ID: 17713529
- Kameritsch P, Pogoda K, Pohl U. Channel-independent influence of connexin 43 on cell migration. Biochim Biophys Acta. 2012;1818(8):1993–2001. doi:https://doi.org/10.1016/j.bbamem.2011.11.016. PubMed-ID: 22155212
- Kotini M, Mayor R. Connexins in migration during development and cancer. Dev Biol. 2015;401(1):143–151. doi:https://doi.org/10.1016/j.ydbio.2014.12.023. PubMed-ID: 25553982
- Naus CC, Aftab Q, Sin WC. Common mechanisms linking connexin43 to neural progenitor cell migration and glioma invasion. Semin Cell Dev Biol. 2016;50:59–66. PubMed-ID: 26706148. doi:https://doi.org/10.1016/j.semcdb.2015.12.008.
- Polusani SR, Kalmykov EA, Chandrasekhar A, Zucker SN, Nicholson BJ. Cell coupling mediated by connexin 26 selectively contributes to reduced adhesivity and increased migration. J Cell Sci. 2016;129(23):4399–4410. doi:https://doi.org/10.1242/jcs.185017. PubMed-ID: 27777264. PMCID: PMC5201008
- Xu X, Francis R, Wei CJ, Linask KL, Lo CW. Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells. Development. 2006;133(18):3629–3639. doi:https://doi.org/10.1242/dev.02543. PubMed-ID: 16914489
- Rodríguez-Sinovas A, Ruiz-Meana M, Denuc A, García-Dorado D. Mitochondrial Cx43, an important component of cardiac preconditioning. Biochim Biophys Acta. 2018;1860(1):174–181. doi:https://doi.org/10.1016/j.bbamem.2017.06.011. PubMed-ID: 28642043
- Davies TC, Barr KJ, Jones DH, Zhu D, Kidder GM. Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet. 1996;18(3):234–243. doi:https://doi.org/10.1002/(SICI)1520-6408(1996)18:3<234::AID-DVG4>3.0.CO;2-A. PubMed-ID: 8934879
- Harris AL. Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys. 2001;34(3):325–472. doi:https://doi.org/10.1017/s0033583501003705. PubMed-ID: 11838236
- Kolios G, Moodley Y. Introduction to stem cells and regenerative medicine. Respiration. 2013;85(1):3–10. doi:https://doi.org/10.1159/000345615. PubMed-ID: 23257690
- Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res. 2019;10(1):68. doi:https://doi.org/10.1186/s13287-019-1165-5. PubMed-ID: 30808416. PMCID: PMC6390367
- Lu F, Zhang Y. Cell totipotency: molecular features, induction, and maintenance. Natl Sci Rev. 2015;2(2):217–225. doi:https://doi.org/10.1093/nsr/nwv009. PubMed-ID: 26114010. PMCID: PMC4477869
- van de Velde H, Cauffman G, Tournaye H, Devroey P, Liebaers I. The four blastomeres of a 4-cell stage human embryo are able to develop individually into blastocysts with inner cell mass and trophectoderm. Hum Reprod. 2008;23(8):1742–1747. doi:https://doi.org/10.1093/humrep/den190. PubMed-ID: 18503052
- Yamanaka S, Li J, Kania G, Elliott S, Wersto RP, van Eyk J, et al. Pluripotency of embryonic stem cells. Cell. Tissue Res. 2008;331(1):5–22. PubMed-ID: 18026755. doi:https://doi.org/10.1007/s00441-007-0520-5.
- Kashyap V, Rezende NC, Scotland KB, Shaffer SM, Persson JL, Gudas LJ, et al. Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs. Stem Cell Dev. 2009;18(7):1093–1108. PubMed-ID: 19480567. PMCID: PMC3135180. doi:https://doi.org/10.1089/scd.2009.0113.
- Yeo J-C, Ng -H-H. The transcriptional regulation of pluripotency. Cell Res. 2013;23(1):20–32. doi:https://doi.org/10.1038/cr.2012.172. PubMed-ID: 23229513. PMCID: PMC3541660
- Young RA. Control of the embryonic stem cell state. Cell. 2011;144(6):940–954. doi:https://doi.org/10.1016/j.cell.2011.01.032. PubMed-ID: 21414485. PMCID: PMC3099475
- Boroviak T, Nichols J. Primate embryogenesis predicts the hallmarks of human naïve pluripotency. Development. 2017;144(2):175–186. doi:https://doi.org/10.1242/dev.145177. PubMed-ID: 28096211. PMCID: PMC5430762
- Dixon JE, Dick E, Rajamohan D, Shakesheff KM, Denning C. Directed differentiation of human embryonic stem cells to interrogate the cardiac gene regulatory network. Mol Ther. 2011;19(9):1695–1703. doi:https://doi.org/10.1038/mt.2011.125. PubMed-ID: 21694703. PMCID: PMC3182351
- Tapia N, Araúzo-Bravo MJ, Ko K, Schöler HR. Concise review: challenging the pluripotency of human testis-derived ESC-like cells. Stem Cells. 2011;29(8):1165–1169. doi:https://doi.org/10.1002/stem.669. PubMed-ID: 21648019
- Theunissen TW, Friedli M, He Y, Planet E, O’Neil RC, Markoulaki S, et al. Molecular criteria for defining the naive human pluripotent state. Cell Stem Cell. 2016;19(4):502–515. PubMed-ID: 27424783. PMCID: PMC5065525. doi:https://doi.org/10.1016/j.stem.2016.06.011.
- Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–872. PubMed-ID: 18035408. doi:https://doi.org/10.1016/j.cell.2007.11.019.
- Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science. 2008;322(5903):945–949. doi:https://doi.org/10.1126/science.1162494. PubMed-ID: 18818365. PMCID: PMC3987909
- Lau F, Ahfeldt T, Osafune K, Akustsu H, Cowan CA. Induced pluripotent stem (iPS) cells: an up-to-the-minute review. F1000 Biol Rep. 2009;1:84. PubMed-ID: 20948605. PMCID: PMC2948253. doi:https://doi.org/10.3410/B1-84.
- Chen G, Guo Y, Li C, Li S, Wan X. Small molecules that promote self-renewal of stem cells and somatic cell reprogramming. Stem Cell Rev Rep. 2020;16(3):511–523. doi:https://doi.org/10.1007/s12015-020-09965-w. PubMed-ID: 32185667
- Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013;341(6146):651–654. PubMed-ID: 23868920. doi:https://doi.org/10.1126/science.1239278.
- Zhao T, Fu Y, Zhu J, Liu Y, Zhang Q, Yi Z, et al. Single-cell RNA-seq reveals dynamic early embryonic-like programs during chemical reprogramming. Cell Stem Cell. 2018;23(1):31–45.e7. PubMed-ID: 29937202. doi:https://doi.org/10.1016/j.stem.2018.05.025.
- Hsu Y-C, Fuchs E. A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol. 2012;13(2):103–114. doi:https://doi.org/10.1038/nrm3272. PubMed-ID: 22266760. PMCID: PMC3280338
- Bühring H-J, Battula VL, Treml S, Schewe B, Kanz L, Vogel W. Novel markers for the prospective isolation of human MSC. Ann N Y Acad Sci. 2007;1106(1):262–271. doi:https://doi.org/10.1196/annals.1392.000. PubMed-ID: 17395729
- Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315–317. PubMed-ID: 16923606. doi:https://doi.org/10.1080/14653240600855905.
- Pazhanisamy S. Adult stem cell and embryonic stem cell markers. Mater Methods. 2013:3. doi:https://doi.org/10.13070/mm.en.3.200;.
- Hassan HT, El-Sheemy M. Adult bone-marrow stem cells and their potential in medicine. J R Soc Med. 2004;97(10):465–471. doi:https://doi.org/10.1258/jrsm.97.10.465. PubMed-ID: 15459256. PMCID: PMC1079613
- Chao YX, He BP, Cao Q, Tay SSW. Protein aggregate-containing neuron-like cells are differentiated from bone marrow mesenchymal stem cells from mice with neurofilament light subunit gene deficiency. Neurosci Lett. 2007;417(3):240–245. doi:https://doi.org/10.1016/j.neulet.2007.02.082. PubMed-ID: 17395374
- Deng J, Petersen BE, Steindler DA, Jorgensen ML, Laywell ED. Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation. Stem Cells. 2006;24(4):1054–1064. doi:https://doi.org/10.1634/stemcells.2005-0370. PubMed-ID: 16322639.
- George S, Hamblin MR, Abrahamse H. Differentiation of mesenchymal stem cells to neuroglia: in the context of cell signalling. Stem Cell Rev Rep. 2019;15(6):814–826. doi:https://doi.org/10.1007/s12015-019-09917-z. PubMed-ID: 31515658. PMCID: PMC6925073
- Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211–228. PubMed-ID: 11304456. doi:https://doi.org/10.1089/107632701300062859.
- Mollinari C, Zhao J, Lupacchini L, Garaci E, Merlo D, Pei G. Transdifferentiation: a new promise for neurodegenerative diseases. Cell Death Dis. 2018;9(8):830. doi:https://doi.org/10.1038/s41419-018-0891-4;. PubMed-ID: 30082779. PMCID: PMC6078988
- Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views. Stem Cells. 2007;25(11):2896–2902. doi:https://doi.org/10.1634/stemcells.2007-0637. PubMed-ID: 17901396
- Dilger N, Neehus A-L, Grieger K, Hoffmann A, Menssen M, Ngezahayo A. Gap junction dependent cell communication is modulated during transdifferentiation of mesenchymal stem/stromal cells towards neuron-like cells. Front Cell Dev Biol. 2020;8:869. PubMed-ID: 32984345. PMCID: PMC7487424. doi:https://doi.org/10.3389/fcell.2020.00869.
- Aurich H, Sgodda M, Kaltwasser P, Vetter M, Weise A, Liehr T, et al. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut. 2009;58(4):570–581. PubMed-ID: 19022918. doi:https://doi.org/10.1136/gut.2008.154880.
- Freitas GP, Souza ATP, Lopes HB, Trevisan RLB, Oliveira FS, Fernandes RR, et al. Mesenchymal stromal cells derived from bone marrow and adipose tissue: isolation, culture, characterization and differentiation. Bio Protoc. 2020;10(4):e3534. PubMed-ID: 33654758. PMCID: PMC7842647. doi:https://doi.org/10.21769/BioProtoc.3534.
- Krampera M, Marconi S, Pasini A, Galiè M, Rigotti G, Mosna F, et al. Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus. Bone. 2007;40(2):382–390. PubMed-ID: 17049329. doi:https://doi.org/10.1016/j.bone.2006.09.006.
- Snykers S, Kock JD, Tamara V, Rogiers V. Hepatic differentiation of mesenchymal stem cells: in vitro strategies. Methods Mol Biol. 2011;698:305–314. PubMed-ID: 21431528. doi:https://doi.org/10.1007/978-1-60761-999-4_23.
- Almalki SG, Agrawal DK. Key transcription factors in the differentiation of mesenchymal stem cells. Differentiation. 2016;92(1–2):41–51. doi:https://doi.org/10.1016/j.diff.2016.02.005. PubMed-ID: 27012163. PMCID: PMC5010472
- Barzilay R, Melamed E, Offen D. Introducing transcription factors to multipotent mesenchymal stem cells: making transdifferentiation possible. Stem Cells. 2009;27(10):2509–2515. doi:https://doi.org/10.1002/stem.172. PubMed-ID: 19591229
- Aguilera-Castrejon A, Pasantes-Morales H, Montesinos JJ, Cortés-Medina LV, Castro-Manrreza ME, Mayani H, et al. Improved proliferative capacity of NP-like cells derived from human mesenchymal stromal cells and neuronal transdifferentiation by small molecules. Neurochem Research. 2017;42(2):415–427. PubMed-ID: 27804011. doi:https://doi.org/10.1007/s11064-016-2086-7.
- Behfar A, Terzic A. Derivation of a cardiopoietic population from human mesenchymal stem cells yields cardiac progeny. Nat Clin Pract Cardiovasc Med. 2006;3(Suppl 1):S78–82. doi:https://doi.org/10.1038/ncpcardio0429. PubMed-ID: 16501637
- Bi Y, Gong M, Zhang X, Zhang X, Jiang W, Zhang Y, et al. Pre-activation of retinoid signaling facilitates neuronal differentiation of mesenchymal stem cells. Dev Growth Differ. 2010;52(5):419–431. PubMed-ID: 20507357. doi:https://doi.org/10.1111/j.1440-169x.2010.01182.x.
- Cheng Y-H, Dong J-C, Bian Q. Small molecules for mesenchymal stem cell fate determination. World J Stem Cells. 2019;11(12):1084–1103. doi:https://doi.org/10.4252/wjsc.v11.i12.1084. PubMed-ID: 31875870. PMCID: PMC6904864
- Conover JC, Notti RQ. The neural stem cell niche. Cell Tissue Res. 2008;331(1):211–224. doi:https://doi.org/10.1007/s00441-007-0503-6. PubMed-ID: 17922142
- Johansson CB, Momma S, Clarke DL, Risling M, Lendahl U, Frisén J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell. 1999;96(1):25–34. doi:https://doi.org/10.1016/S0092-8674(00)80956-3;.
- Llorens-Bobadilla E, Chell JM, Le Merre P, Wu Y, Zamboni M, Bergenstråhle J, et al. A latent lineage potential in resident neural stem cells enables spinal cord repair. Science. 2020;370(6512):eabb8795. PubMed-ID: 33004487. doi:https://doi.org/10.1126/science.abb8795.
- Alvarez-Buylla A, Seri B, Doetsch F. Identification of neural stem cells in the adult vertebrate brain. Brain Res Bull. 2002;57(6):751–758. doi:https://doi.org/10.1016/S0361-9230(01)00770-5;.
- Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science. 1992;255(5052):1707–1710. doi:https://doi.org/10.1126/science.1553558. PubMed-ID: 1553558;
- Jagannathan-Bogdan M, Zon LI. Hematopoiesis. Development. 2013;140(12):2463–2467. doi:https://doi.org/10.1242/dev.083147. PubMed-ID: 23715539. PMCID: PMC3666375
- Houghton FD, Barr KJ, Walter G, Gabriel H-D, Grümmer R, Traub O, et al. Functional significance of gap junctional coupling in preimplantation development. Biol Reprod. 2002;66(5):1403–1412. PubMed-ID: 11967204. doi:https://doi.org/10.1095/biolreprod66.5.1403.
- Fleming TP. Cell adhesion in the preimplantation mammalian embryo and its role in trophectoderm differentiation and blastocyst morphogenesis. Front Biosci. 2001;6(3):d1000–1007. doi:https://doi.org/10.2741/A662;.
- Sousa PA, de, Valdimarsson G, Nicholson BJ, Kidder GM. Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos. Development. 1993 PubMed-ID: 8404537;117(4):1355–1367. doi:https://doi.org/10.1242/dev.117.4.1355.
- Carpenter MK, Rosler ES, Fisk GJ, Brandenberger R, Ares X, Miura T, et al. Properties of four human embryonic stem cell lines maintained in a feeder-free culture system. Dev Dyn. 2003;229(2):243–258. doi:https://doi.org/10.1002/dvdy.10431;.
- Oyamada M, Takebe K, Endo A, Hara S, Oyamada Y. Connexin expression and gap-junctional intercellular communication in ES cells and iPS cells. Front Pharmacol. 2013;4:85. PubMed-ID: 23840189. PMCID: PMC3699729. doi:https://doi.org/10.3389/fphar.2013.00085.
- Huettner JE, Lu A, Qu Y, Wu Y, Kim M, McDonald JW. Gap junctions and connexon hemichannels in human embryonic stem cells. Stem Cells. 2006;24(7):1654–1667. doi:https://doi.org/10.1634/stemcells.2005-0003. PubMed-ID: 16574755
- Wong RCB, Dottori M, Koh KLL, Nguyen LTV, Pera MF, Pébay A. Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. Biochem Biophys Res Commun. 2006;344(1):181–188. doi:https://doi.org/10.1016/j.bbrc.2006.03.127. PubMed-ID: 16616002
- Wong RCB, Pébay A, Nguyen LTV, Koh KLL, Pera MF. Presence of functional gap junctions in human embryonic stem cells. Stem Cells. 2004;22(6):883–889. doi:https://doi.org/10.1634/stemcells.22-6-883. PubMed-ID: 15536180
- Wong RCB, Pera MF, Pébay A. Role of gap junctions in embryonic and somatic stem cells. Stem Cell Rev. 2008;4(4):283–292. doi:https://doi.org/10.1007/s12015-008-9038-9. PubMed-ID: 18704771
- Hardy K, Warner A, Winston RM, Becker DL. Expression of intercellular junctions during preimplantation development of the human embryo. Mol Hum Reprod. 1996;2(8):621–632. doi:https://doi.org/10.1093/molehr/2.8.621. PubMed-ID: 9239675
- McLachlin JR, Caveney S, Kidder GM. Control of gap junction formation in early mouse embryos. Dev Biol. 1983;98(1):155–164. doi:https://doi.org/10.1016/0012-1606(83)90344-5.
- Becker DL, Leclerc-David C, Warner A. The relationship of gap junctions and compaction in the preimplantation mouse embryo. Dev Suppl. 1992 PubMed-ID: 1338577;113–118.
- Assou S, Le Carrour T, Tondeur S, Ström S, Gabelle A, Marty S, et al. A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells. 2007;25(4):961–973. PubMed-ID: 17204602. PMCID: PMC1906587. doi:https://doi.org/10.1634/stemcells.2006-0352.
- Pébay A, Wong RCB. Study of gap junctions in human embryonic stem cells. Methods Mol Biol. 2016;1307:105–121. PubMed-ID: 24859928. doi:https://doi.org/10.1007/7651_2014_83.
- Ke Q, Li L, Cai B, Liu C, Yang Y, Gao Y, et al. Connexin 43 is involved in the generation of human-induced pluripotent stem cells. Hum Mol Genet. 2013;22(11):2221–2233. PubMed-ID: 23420013. doi:https://doi.org/10.1093/hmg/ddt074.
- Oyamada Y, Komatsu K, Kimura H, Mori M, Oyamada M. Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro. Exp Cell Res. 1996;229(2):318–326. doi:https://doi.org/10.1006/excr.1996.0377. PubMed-ID: 8986615
- Wang Z, Huang J. Neuregulin-1 increases connexin-40 and connexin-45 expression in embryonic stem cell-derived cardiomyocytes. Appl Biochem Biotechnol. 2014;174(2):483–493. doi:https://doi.org/10.1007/s12010-014-1089-6. PubMed-ID: 25080381
- Moscato S, Cabiati M, Bianchi F, Vaglini F, Morales MA, Burchielli S, et al. Connexin 26 expression in mammalian cardiomyocytes. Sci Rep. 2018;8(1):13975. PubMed-ID: 30228305. PMCID: PMC6143590. doi:https://doi.org/10.1038/s41598-018-32405-2.
- Yang W, Lampe PD, Kensel-Hammes P, Hesson J, Ware CB, Crisa L, et al. Connexin 43 functions as a positive regulator of stem cell differentiation into definitive endoderm and pancreatic progenitors. iScience. 2019;19:450–460. PubMed-ID: 31430690. PMCID: PMC6708988. doi:https://doi.org/10.1016/j.isci.2019.07.033.
- Petersen BE. Hepatic “stem” cells: coming full circle. Blood Cells Mol Dis. 2001;27(3):590–600. doi:https://doi.org/10.1006/bcmd.2001.0422. PubMed-ID: 11482872
- Vessey CJ, La Hall PMD. Hepatic stem cells: a review. Pathology. 2001 PubMed-ID: 11358043;33(2):130–141. doi:https://doi.org/10.1080/00313020124028.
- Zhang M, Thorgeirsson SS. Modulation of connexins during differentiation of oval cells into hepatocytes. Exp Cell Res. 1994;213(1):37–42. doi:https://doi.org/10.1006/excr.1994.1170. PubMed-ID: 7517369
- Qin J, Chang M, Wang S, Liu Z, Zhu W, Wang Y, et al. Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells. Sci Rep. 2016;6(1):37388. PubMed-ID: 27874032. PMCID: PMC5118817. doi:https://doi.org/10.1038/srep37388.
- Yancey SB, Biswal S, Revel JP. Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis. Development. 1992 PubMed-ID: 1315676;114(1):203–212. doi:https://doi.org/10.1242/dev.114.1.203.
- Nombela-Arrieta C, Ritz J, Silberstein LE. The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol. 2011;12(2):126–131. doi:https://doi.org/10.1038/nrm3049. PubMed-ID: 21253000. PMCID: PMC3346289
- Pelaez D, Huang C-YC, Cheung HS. Isolation of pluripotent neural crest-derived stem cells from adult human tissues by connexin-43 enrichment. Stem Cell Dev. 2013;22(21):2906–2914. doi:https://doi.org/10.1089/scd.2013.0090. PubMed-ID: 23750535
- Mannino G, Vicario N, Parenti R, Giuffrida R, Lo Furno D. Connexin expression decreases during adipogenic differentiation of human adipose-derived mesenchymal stem cells. Mol Biol Rep. 2020;47(12):9951–9958. doi:https://doi.org/10.1007/s11033-020-05950-1. PubMed-ID: 33141287
- Yang J, Darley RL, Hallett M, Evans WH. Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: probing mechanisms of autologous stem cell therapy. Cell Commun Adhes. 2009;16(5–6):138–145. doi:https://doi.org/10.3109/15419061003653763. PubMed-ID: 20298144. PMCID: PMC2956170
- Bodi E, Hurtado SP, Carvalho MA, Borojevic R, Carvalho ACCD. Gap junctions in hematopoietic stroma control proliferation and differentiation of blood cell precursors. An Acad Bras Cienc. 2004;76(4):743–756. doi:https://doi.org/10.1590/s0001-37652004000400009. PubMed-ID: 15558154
- Esseltine JL, Brooks CR, Edwards NA, Subasri M, Sampson J, Séguin C, et al. Dynamic regulation of connexins in stem cell pluripotency. Stem Cells. 2019;38(1):52–66. doi:https://doi.org/10.1002/stem.3092.
- Valiunas V, Doronin S, Valiuniene L, Potapova I, Zuckerman J, Walcott B, et al. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J Physiol. 2004;555(3):617–626. PubMed-ID: 14766937. PMCID: PMC1664864. doi:https://doi.org/10.1113/jphysiol.2003.058719.
- Swayne LA, Bennett SAL. Connexins and pannexins in neuronal development and adult neurogenesis. BMC Cell Biol. 2016;17(Suppl 1):10. doi:https://doi.org/10.1186/s12860-016-0089-5. PubMed-ID: 27230672. PMCID: PMC4896249
- Cina C, Bechberger JF, Ozog MA, Naus CCG. Expression of connexins in embryonic mouse neocortical development. J Comp Neurol. 2007;504(3):298–313. doi:https://doi.org/10.1002/cne.21426. PubMed-ID: 17640036
- Nualart-Marti A, Solsona C, Fields RD. Gap junction communication in myelinating glia. Biochim Biophys Acta. 2013;1828(1):69–78. doi:https://doi.org/10.1016/j.bbamem.2012.01.024. PubMed-ID: 22326946. PMCID: PMC4474145
- Rash JE, Yasumura T, Davidson KG, Furman CS, Dudek FE, Nagy JI. Identification of cells expressing Cx43, Cx30, Cx26, Cx32 and Cx36 in gap junctions of rat brain and spinal cord. Cell Commun Adhes. 2001;8(4–6):315–320. doi:https://doi.org/10.3109/15419060109080745. PubMed-ID: 12064610. PMCID: PMC1805789
- Rozental R, Srinivas M, Gökhan S, Urban M, Dermietzel R, Kessler JA, et al. Temporal expression of neuronal connexins during hippocampal ontogeny. Brain Res Brain Res Rev. 2000;32(1):57–71. doi:https://doi.org/10.1016/s0165-0173(99)00096-x.
- Leung DSY, Unsicker K, Reuss B. Expression and developmental regulation of gap junction connexins cx26, cx32, cx43 and cx45 in the rat midbrain‐floor. Int J Dev Neurosci. 2002;20(1):63–75. doi:https://doi.org/10.1016/s0736-5748(01)00056-9.
- Beheshti S, Zeinali R, Esmaeili A. Rapid upregulation of the hippocampal connexins 36 and 45 mRNA levels during memory consolidation. Behav Brain Res. 2017;320:85–90. PubMed-ID: 27913256. doi:https://doi.org/10.1016/j.bbr.2016.11.048.
- Altevogt BM, Kleopa KA, Postma FR, Scherer SS, Paul DL. Connexin29 Is Uniquely Distributed within Myelinating Glial Cells of the Central and Peripheral Nervous Systems. J Neurosci. 2002;22(15):6458–6470. doi:https://doi.org/10.1523/JNEUROSCI.22-15-06458.2002.
- Dermietzel R, Gao Y, Scemes E, Vieira D, Urban M, Kremer M, et al. Connexin43 null mice reveal that astrocytes express multiple connexins. Brain Res Brain Res Rev. 2000;32(1):45–56. doi:https://doi.org/10.1016/S0165-0173(99)00067-3.
- Vance MM, Wiley LM. Gap junction intercellular communication mediates the competitive cell proliferation disadvantage of irradiated mouse preimplantation embryos in aggregation chimeras. Radiat Res. 1999;152(5):544. doi:https://doi.org/10.2307/3580152.
- Togashi K, Kumagai J, Sato E, Shirasawa H, Shimoda Y, Makino K, et al. Dysfunction in gap junction intercellular communication induces aberrant behavior of the inner cell mass and frequent collapses of expanded blastocysts in mouse embryos. J Assist Reprod Genet. 2015;32(6):969–976. PubMed-ID: 25917498. PMCID: PMC4491087. doi:https://doi.org/10.1007/s10815-015-0479-1.
- Reaume AG, Sousa PAD, Kulkarni S, Langille BL, Zhu D, Davies TC, et al. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267(5205):1831–1834. PubMed-ID: 7892609. doi:https://doi.org/10.1126/science.7892609.
- Peng Q, Yue C, Chen ACH, Lee KC, Fong SW, Yeung WSB, et al. Connexin 43 is involved in early differentiation of human embryonic stem cells. Differentiation. 2019;105:33–44. PubMed-ID: 30599359. doi:https://doi.org/10.1016/j.diff.2018.12.003.
- Dierks A, Bader A, Lehrich T, Ngezahayo A. Stimulation of the A2B adenosine receptor subtype enhances connexin26 hemichannel activity in small airway epithelial cells. Cell Physiol Biochem. 2019;53(4):606–622. doi:https://doi.org/10.33594/000000160. PubMed-ID: 31550088
- Sousa PA, de, Juneja SC, Caveney S, Houghton FD, Davies TC, Reaume AG, et al. Normal development of preimplantation mouse embryos deficient in gap junctional coupling. J Cell Sci. 1997;110(15):1751–1758. PubMed-ID: 9264462. doi:https://doi.org/10.1242/jcs.110.15.1751.
- Kidder GM, Winterhager E. Intercellular communication in preimplantation development: the role of gap junctions. Front Biosci. 2001;6:D731–6. PubMed-ID: 11333207. doi:https://doi.org/10.2741/kidder.
- Kim J-S, Kwon D, Hwang S-T, Lee DR, Shim SH, Kim H-C, et al. hESC expansion and stemness are independent of connexin forty-three-mediated intercellular communication between hESCs and hASC feeder cells. PLoS ONE. 2013;8(7):e69175. PubMed-ID: 23922689. PMCID: PMC3724839. doi:https://doi.org/10.1371/journal.pone.0069175.
- Todorova MG, Soria B, Quesada I. Gap junctional intercellular communication is required to maintain embryonic stem cells in a non-differentiated and proliferative state. J Cell Physiol. 2008;214(2):354–362. doi:https://doi.org/10.1002/jcp.21203. PubMed-ID: 17654515
- Grümmer R, Reuss B, Winterhager E. Expression pattern of different gap junction connexins is related to embryo implantation. Int J Dev Biol. 1996;40(1):361–367. PubMed-ID: 8735949
- Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, et al. Abrogation of gap junctional communication in ES cells results in a disruption of primitive endoderm formation in embryoid bodies. Stem Cells. 2017;35(4):859–871. PubMed-ID: 27870307. doi:https://doi.org/10.1002/stem.2545.
- Parekkadan B, Berdichevsky Y, Irimia D, Leeder A, Yarmush G, Toner M, et al. Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells. Neurosci Lett. 2008;438(2):190–195. PubMed-ID: 18467031. PMCID: PMC2448393. doi:https://doi.org/10.1016/j.neulet.2008.03.094.
- Kibschull M, Colaco K, Matysiak-Zablocki E, Winterhager E, Lye SJ. Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development. Stem Cell Dev. 2014;23(21):2649–2660. doi:https://doi.org/10.1089/scd.2014.0013. PubMed-ID: 24866916. PMCID: PMC4201296
- Bhattacharya B, Cai J, Luo Y, Miura T, Mejido J, Brimble SN, et al. Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies. BMC Dev Biol. 2005;5(1):22. PubMed-ID: 16207381. PMCID: PMC1260016. doi:https://doi.org/10.1186/1471-213X-5-22.
- Richards M, Tan S-P, Tan J-H, Chan W-K, Bongso A. The transcriptome profile of human embryonic stem cells as defined by SAGE. Stem Cells. 2004;22(1):51–64. doi:https://doi.org/10.1634/stemcells.22-1-51. PubMed-ID: 14688391
- Ke Q, Li L, Yao X, Lai X, Cai B, Chen H, et al. Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45. Sci Rep. 2017;7(1):458. PubMed-ID: 28352086. PMCID: PMC5428559. doi:https://doi.org/10.1038/s41598-017-00523-y.
- Forsberg EC, Prohaska SS, Katzman S, Heffner GC, Stuart JM, Weissman IL. Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet. 2005;1(3):e28. doi:https://doi.org/10.1371/journal.pgen.0010028. PubMed-ID: 16151515. PMCID: PMC1200425
- Trowbridge JJ, Snow JW, Kim J, Orkin SH. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 2009;5(4):442–449. doi:https://doi.org/10.1016/j.stem.2009.08.016. PubMed-ID: 19796624. PMCID: PMC2767228
- Taniguchi Ishikawa E, Gonzalez-Nieto D, Ghiaur G, Dunn SK, Ficker AM, Murali B, et al. Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells. Proc Natl Acad Sci U S A. 2012;109(23):9071–9076. PubMed-ID: 22611193. PMCID: PMC3384185. doi:https://doi.org/10.1073/pnas.1120358109.
- Dyce PW, Li D, Barr KJ, Kidder GM. Connexin43 is required for the maintenance of multipotency in skin-derived stem cells. Stem Cells Dev. 2014;23(14):1636–1646. doi:https://doi.org/10.1089/scd.2013.0459. PubMed-ID: 24694074. PMCID: PMC4086243
- Shao Q, Esseltine JL, Huang T, Novielli-Kuntz N, Ching JE, Sampson J, et al. Connexin43 is dispensable for early stage human mesenchymal stem cell adipogenic differentiation but is protective against cell senescence. Biomolecules. 2019;9(9):474. PubMed-ID: 31514306. PMCID: PMC6770901. doi:https://doi.org/10.3390/biom9090474.
- Wang D, Shen W, Zhang F, Chen M, Chen H, Cao K. Connexin43 promotes survival of mesenchymal stem cells in ischaemic heart. Cell Biol Int. 2010;34(4):415–423. doi:https://doi.org/10.1042/CBI20090118. PubMed-ID: 20067445
- Zhang X, Sun Y, Wang Z, Huang Z, Li B, Fu J. Up-regulation of connexin-43 expression in bone marrow mesenchymal stem cells plays a crucial role in adhesion and migration of multiple myeloma cells. Leuk Lymphoma. 2015;56(1):211–218. doi:https://doi.org/10.3109/10428194.2014.913289. PubMed-ID: 24724781
- Batra N, Kar R, Jiang JX. Gap junctions and hemichannels in signal transmission, function and development of bone. Biochim Biophys Acta. 2012;1818(8):1909–1918. doi:https://doi.org/10.1016/j.bbamem.2011.09.018. PubMed-ID: 21963408. PMCID: PMC3440861
- Ciciarello M, Zini R, Rossi L, Salvestrini V, Ferrari D, Manfredini R, et al. Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages. Stem Cells Dev. 2013;22(7):1097–1111. PubMed-ID: 23259837. PMCID: PMC3608030. doi:https://doi.org/10.1089/scd.2012.0432.
- Schrobback K, Klein TJ, Woodfield TBF. The importance of connexin hemichannels during chondroprogenitor cell differentiation in hydrogel versus microtissue culture models. Tissue Eng Part A. 2015;21(11–12):1785–1794. doi:https://doi.org/10.1089/ten.tea.2014.0691. PubMed-ID: 25693425. PMCID: PMC4449703
- Lin F-X, Zheng G-Z, Chang B, Chen R-C, Zhang Q-H, Xie P, et al. Connexin 43 modulates osteogenic differentiation of bone marrow stromal cells through GSK-3beta/beta-catenin signaling pathways. Cell Physiol Biochem. 2018;47(1):161–175. PubMed-ID: 29763908. doi:https://doi.org/10.1159/000489763.
- Schajnovitz A, Itkin T, D’Uva G, Kalinkovich A, Golan K, Ludin A, et al. CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions. Nat Immunol. 2011;12(5):391–398. PubMed-ID: 21441933. doi:https://doi.org/10.1038/ni.2017.
- Gonzalez-Nieto D, Li L, Kohler A, Ghiaur G, Ishikawa E, Sengupta A, et al. Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood. 2012;119(22):5144–5154. PubMed-ID: 22498741. PMCID: PMC3369607. doi:https://doi.org/10.1182/blood-2011-07-368506.
- Lemcke H, Gaebel R, Skorska A, Voronina N, Lux CA, Petters J, et al. Mechanisms of stem cell based cardiac repair-gap junctional signaling promotes the cardiac lineage specification of mesenchymal stem cells. Sci Rep. 2017;7(1):9755. PubMed-ID: 28852100. PMCID: PMC5574972. doi:https://doi.org/10.1038/s41598-017-10122-6.
- Xu M, Wani M, Dai Y-S, Wang J, Yan M, Ayub A, et al. Differentiation of bone marrow stromal cells into the cardiac phenotype requires intercellular communication with myocytes. Circulation. 2004;110(17):2658–2665. PubMed-ID: 15492307. doi:https://doi.org/10.1161/01.CIR.0000145609.20435.36.
- Singh AK, Cancelas JA. Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance. Int J Mol Sci. 2020;21(3):796. doi:https://doi.org/10.3390/ijms21030796. PubMed-ID: 31991829. PMCID: PMC7038046
- Chosa N, Ishisaki A. Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell-cell adhesion through N-cadherin. Jpn Dent Sci Rev. 2018;54(1):37–44. doi:https://doi.org/10.1016/j.jdsr.2017.10.001. PubMed-ID: 29629000. PMCID: PMC5884250
- Klee P, Lamprianou S, Charollais A, Caille D, Sarro R, Cederroth M, et al. Connexin implication in the control of the murine beta-cell mass. Pediatr Res. 2011;70(2):142–147. PubMed-ID: 21527868. doi:https://doi.org/10.1203/PDR.0b013e318220f106.
- Esseltine JL, Shao Q, Brooks C, Sampson J, Betts DH, Séguin CA, et al. Connexin43 mutant patient-derived induced pluripotent stem cells exhibit altered differentiation potential. J Bone Miner Res. 2017;32(6):1368–1385. PubMed-ID: 28177159. doi:https://doi.org/10.1002/jbmr.3098.
- Wiesner M, Berberich O, Hoefner C, Blunk T, Bauer-Kreisel P. Gap junctional intercellular communication in adipose-derived stromal/stem cells is cell density-dependent and positively impacts adipogenic differentiation. J Cell Physiol. 2018;233(4):3315–3329. doi:https://doi.org/10.1002/jcp.26178. PubMed-ID: 28888046