Advanced search
Publication Cover
Tissue Barriers Volume 12, 2024 - Issue 3
Submit an article Journal homepage
35
Views
0
CrossRef citations to date
0
Altmetric
Article Commentary

Ubiquitylated histone H2A: a molecular Jekyll and Hyde in the epidermis

Lina DagninoDepartment of Physiology and Pharmacology, Department of Oncology, London Health Research Institute, Children’s Health Research Institute, The University of Western Ontario, London, Ontario, CanadaCorrespondence[email protected]
View further author information
Article: 2236007 | Received 03 Jul 2023, Accepted 08 Jul 2023, Published online: 17 Jul 2023

References

  • Zijl S, Salameti V, Louis B, Negri VA, Watt FM. Dynamic regulation of human epidermal differentiation by adhesive and mechanical forces. Curr Top Dev Biol. 2022;150:1–4.
  • Martin P. Wound healing–aiming for perfect skin regeneration. Science. 1997;276(5309):75–81. doi:10.1126/science.276.5309.75.
  • Turksen K, Troy TC. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development. 2002;129(7):1775–1784. doi:10.1242/dev.129.7.1775.
  • Urban K, Mehrmal S, Uppal P, Giesey RL, Delost GR. The global burden of skin cancer: A longitudinal analysis from the global burden of disease study, 1990-2017. JAAD Int. 2021;2:98–108. doi:10.1016/j.jdin.2020.10.013.
  • Tsang DA, Tam SYC, Oh CC. Molecular alterations in cutaneous squamous cell carcinoma in immunocompetent and immunosuppressed hosts—A systematic review. Cancers Basel. 2023;15(6):1832. doi:10.3390/cancers15061832.
  • Droll S, Bao X. Oh, the mutations you’ll acquire! A systematic overview of cutaneous squamous cell carcinoma. Cell Physiol Biochem. 2021;55:89–119.
  • Yao Q, Epstein CB, Banskota S, Issner R, Kim Y, Bernstein BE, Pinello L, Asgari MM. Epigenetic alterations in keratinocyte carcinoma. J Invest Dermatol. 2021;141(5):1207–1218. doi:10.1016/j.jid.2020.10.018.
  • Curtius K, Wright NA, Graham TA. An evolutionary perspective on field cancerization. Nat Rev Cancer. 2018;18(1):19–32. doi:10.1038/nrc.2017.102.
  • Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A. Field cancerization: Definition, epidemiology, risk factors, and outcomes. J Am Acad Dermatol. 2020;83(3):709–717. doi:10.1016/j.jaad.2020.03.126.
  • Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GL, Dotto G, et al. Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012;149(6):1207–1220. doi:10.1016/j.cell.2012.03.048.
  • MacCarthy-Morrogh L, Martin P. The hallmarks of cancer are also the hallmarks of wound healing. Sci Signal. 2020;13. doi:10.1126/scisignal.aay8690.
  • Antonio N, Bønnelykke-Behrndtz ML, Ward LC, Collin J, Christensen IJ, Steiniche T, Schmidt H, Feng Y, Martin P. The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer. The EMBO Journal. 2015;34(17):2219–2236. doi:10.15252/embj.201490147.
  • Levra Levron C, Watanabe M, Proserpio V, Piacenti G, Lauria A, Kaltenbach S, Tamburrini A, Nohara T, Anselmi F, Duval C, et al. Tissue memory relies on stem cell priming in distal undamaged areas. Nat Cell Biol. 2023;25(5):740–753. doi:10.1038/s41556-023-01120-0.
  • Tamburri S, Conway E, Pasini D. Polycomb-dependent histone H2A ubiquitination links developmental disorders with cancer. Trends Genet. 2022;38(4):333–352. doi:10.1016/j.tig.2021.07.011.
  • Tamburri S, Lavarone E, Fernández-Pérez D, Conway E, Zanotti M, Manganaro D, Pasini D. Histone H2AK119 mono-ubiquitination is essential for polycomb-mediated transcriptional repression. Molecular Cell. 2020;77(4):840–56.e5. doi:10.1016/j.molcel.2019.11.021.
  • Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, et al. PRC1 fine-tunes gene repression and activation to safeguard skin development and stem cell specification. Cell Stem Cell. 2018;22(5):726–39.e7. doi:10.1016/j.stem.2018.04.005.
  • Harrs C, van den Akker PC, Baardman R, Duipmans JC, Horváth B, van Kester MS, Lemmink HH, Rácz E, Bolling MC, Diercks GFH, et al. The aggressive behaviour of squamous cell carcinoma in epidermolysis bullosa: analysis of clinical outcomes and tumour characteristics in the Dutch EB Registry. Br J Dermatol. 2022;187(5):824–826. doi:10.1111/bjd.21769.
  • Bonamonte D, Filoni A, De Marco A, Lospalluti L, Nacchiero E, Ronghi V, Colagrande A, Giudice G, Cazzato G. Squamous cell carcinoma in patients with inherited epidermolysis bullosa: Review of current literature. Cells. 2022;11(8):1365. doi:10.3390/cells11081365.
  • Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, et al. Naked mole rat cells have a stable epigenome that resists iPSC reprogramming. Stem Cell Rep. 2017;9(5):1721–1734. doi:10.1016/j.stemcr.2017.10.001.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.