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Drug loading and delivery using nanofibers scaffolds

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Pages 881-888 | Received 24 Dec 2015, Accepted 25 Apr 2016, Published online: 17 May 2016

References

  • Ahire JJ, Dicks LM. 2014. 2, 3-Dihydroxybenzoic acid-containing nanofiber wound dressings inhibit biofilm formation by pseudomonas aeruginosa. Antimicrob Agents Chemotherapy. 58:2098–2104.
  • Blanco E, Shen H, Ferrari M. 2015. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nature Biotechnol. 33:941–951.
  • Cao H, Jiang X, Chai C, Chew SY. 2010. RNA interference by nanofiber-based siRNA delivery system. J Control Release. 144:203–212.
  • Cejkova J, Trosan P, Cejka C, Lencova A, Zajicova A, Javorkova E. 2013. Suppression of alkali-induced oxidative injury in the cornea by mesenchymal stem cells growing on nanofiber scaffolds and transferred onto the damaged corneal surface. Exp Eye Res. 116:312–323.
  • Chen FM, Zhang M, Wu ZF. 2010. Toward delivery of multiple growth factors in tissue engineering. Biomaterials. 31:6279–6308.
  • Chen P, Wu QS, Ding YP, Chu M, Huang ZM, Hu W. 2010. A controlled release system of titanocene dichloride by electrospun fiber and its antitumor activity in vitro. Eur J Pharm Biopharm. 76:413–420.
  • Chen M, Gao S, Dong M, Song J, Yang C, Howard KA, Kjems J, Besenbacher F. 2012. Chitosan/siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano. 6:4835–4844.
  • Chew SY, Wen J, Yim EK, Leong KW. 2005. Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules. 6:2017–2024.
  • Chronakis IS. 2005. Novel nanocomposites and nanoceramics based on polymer nanofibers using electrospinning process—a review. J Material Processing Tech. 167:283–293.
  • Cui W, Qi M, Li X, Huang S, Zhou S, Weng J. 2008. Electrospun fibers of acid-labile biodegradable polymers with acetal groups as potential drug carriers. Int J Pharm. 361:47–55.
  • Dubey P, Bhushan B, Sachdev A, Matai I, Kumar SU, Gopinath P. 2015. Silver‐nanoparticle‐Incorporated composite nanofibers for potential wound‐dressing applications. J ApplPolymer Sci. 132:1–12.
  • Dubois G, Segers VF, Bellamy V, Sabbah L, Peyrard S, Bruneval P. 2008. Self‐assembling peptide nanofibers and skeletal myoblast transplantation in infarcted myocardium. J Biomed Mater Res B: Appl Biomater. 87:222–228.
  • Fujihara K, Kotaki M, Ramakrishna S. 2005. Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers. Biomaterials. 26:4139–4147.
  • Garg T, Goyal AK. 2014. Liposomes: targeted and controlled delivery system. Drug Delivery Lett. 4:62–71.
  • Garg T, Kumar Goyal A. 2012. Iontophoresis: drug delivery system by applying an electrical potential across the skin. Drug Delivery Lett. 2:270–280.
  • Gil ES, Panilaitis B, Bellas E, Kaplan DL. 2013. Functionalized silk biomaterials for wound healing. Adv Healthc Mater. 2:206–217.
  • Guarino V, Cirillo V, Altobelli R, Ambrosio L. 2014. Polymer-based platforms by electric field-assisted techniques for tissue engineering and cancer therapy. Expert Rev Med Devices. 12:113–129.
  • He S, Xia T, Wang H, Wei L, Luo X, Li X. 2012. Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels. Acta Biomater. 8:2659–2669.
  • Im JS, Bai BC, Lee YS. 2010. The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system. Biomaterials. 31:1414–1419.
  • Im JS, Yun J, Lim YM, Kim HI, Lee YS. 2010. Fluorination of electrospun hydrogel fibers for a controlled release drug delivery system. Acta Biomater. 6:102–109.
  • Jannesari M, Varshosaz J, Morshed M, Zamani M. 2011. Composite poly (vinyl alcohol)/poly (vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs. Int J Nanomedicine. 6:993–1003.
  • Jin G, Prabhakaran MP, Kai D, Annamalai SK, Arunachalam KD, Ramakrishna S. 2013. Tissue engineered plant extracts as nanofibrous wound dressing. Biomaterials. 34:724–734.
  • Jung SM, Yoon GH, Lee HC, Shin HS. 2015. Chitosan nanoparticle/PCL nanofiber composite for wound dressing and drug delivery. J Biomater Sci Polym Ed. 26:252–263.
  • Khan SP, Bhasin K, Newaz GM. 2001. Optimizing process variables to control fiber diameter of electrospun polycaprolactone nanofiber using factorial design. In MRS Proceedings. Cambridge, United Kingdom: Cambridge Univ Press.
  • Khil MS, Cha DI, Kim HY, Kim IS, Bhattarai N. 2003. Electrospun nanofibrous polyurethane membrane as wound dressing. J Biomed Mater Res Part B Appl Biomater. 67:675–679.
  • Kim HS, Yoo HS. 2010. MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: in vitro and in vivo evaluation. J Control Release. 145:264–271.
  • Kim H, Yoo H. 2013. Matrix metalloproteinase-inspired suicidal treatments of diabetic ulcers with siRNA-decorated nanofibrous meshes. Gene Ther. 20:378–385.
  • Kim K, Luu YK, Chang C, Fang D, Hsiao BS, Chu B, Hadjiargyrou M. 2004. Incorporation and controlled release of a hydrophilic antibiotic using poly (lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release. 98:47–56.
  • Kim TH, Kim JJ, Kim HW. 2014. Basic fibroblast growth factor-loaded, mineralized biopolymer-nanofiber scaffold improves adhesion and proliferation of rat mesenchymal stem cells. Biotechnology Lett. 36:383–390.
  • Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. 2002. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res. 60:613–621.
  • Li WJ, Danielson KG, Alexander PG, Tuan RS. 2003. Biological response of chondrocytes cultured in three‐dimensional nanofibrous poly (ε‐caprolactone) scaffolds. J Biomed Mater Res A. 67:1105–1114.
  • Li C, Vepari C, Jin HJ, Kim HJ, Kaplan DL. 2006. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials. 27:3115–3124.
  • Liao IC, Leong KW. 2011. Efficacy of engineered FVIII-producing skeletal muscle enhanced by growth factor-releasing co-axial electrospun fibers. Biomaterials. 32:1669–1677.
  • Liao IC, Chen S, Liu JB, Leong KW. 2009. Sustained viral gene delivery through core-shell fibers. J Control Release. 139:48–55.
  • Liu D, Liu S, Jing X, Li X, Li W, Huang Y. 2012a. Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats. Biomaterials. 33:4362–4369.
  • Liu X, Lin T, Gao Y, Xu Z, Huang C, Yao G. 2012b. Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing. J Biomed Mater Res B Appl Biomater. 100:1556–1565.
  • Liu S, Wang X, Zhang Z, Zhang Y, Zhou G, Huang Y, Xie Z, Jing X. 2015. Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice. Nanomedicine. 11:1047–1056.
  • Loo TL, Dion RL, Dixon RL, Rall DP. 1966. The antitumor agent, 1, 3‐bis (2‐chloroethyl)‐1‐nitrosourea. J Pharm Sci. 55:492–497.
  • Luu Y, Kim K, Hsiao BS, Chu B, Hadjiargyrou M. 2003. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA-PEG block copolymers. J Control Release. 89:341–353.
  • Ma Z, He W, Yong T, Ramakrishna S. 2005. Grafting of gelatin on electrospun poly(caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell orientation. Tissue Eng. 11:1149–1158.
  • Ma G, Fang D, Liu Y, Zhu X, Nie J. 2011. Paclitaxel loaded electrospun porous nanofibers as mat potential application for chemotherapy against prostate cancer. Carbohydr Polym. 86:505–512.
  • Meng Z, Xu XX, Zheng W, Zhou HM, Li L, Zheng YF, Lou X. 2011. Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system. Colloids Surf B Biointerfaces. 84:97–102.
  • Merrell JG, McLaughlin SW, Tie L, Laurencin CT, Chen AF, Nair LS. 2009. Curcumin‐loaded poly (ɛ‐caprolactone) nanofibres: Diabetic wound dressing with anti‐oxidant and anti‐inflammatory properties. Clin Exp Pharmacol Physiol. 36:1149–1156.
  • Mi K, Xing Z. 2015. CD44+/CD24− breast cancer cells exhibit phenotypic reversion in three-dimensional self-assembling peptide RADA16 nanofiber scaffold. Int J Nanomed. 10:3043.
  • Mottaghitalab F, Farokhi M, Mottaghitalab V, Ziabari M, Divsalar A. 2011. Enhancement of neural cell lines proliferation using nano-structured chitosan/poly (vinyl alcohol) scaffolds conjugated with nerve growth factor. Carbohydr Polym. 86:526–535.
  • Naik S, Chiang AST, Thompson RW, Huang FC. 2003. Formation of silicalite-1 hollow spheres by the self-assembly of nanocrystals. Chem Mater. 15:787–792.
  • Nguyen TT, Ghosh C, Hwang SG, Chanunpanich N, Park JS. 2012. Porous core/sheath composite nanofibers fabricated by coaxial electrospinning as a potential mat for drug release system. Int J Pharm. 439:296–306.
  • Nie H, Wang CH. 2007. Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA. J Control Release. 120:111–121.
  • Patel S, Kurpinski K, Quigley R, Gao H, Hsiao BS, Poo MM, Li S. 2007. Bioactive nanofibers: synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Lett. 7:2122–2128.
  • Rama P, Bonini S, Lambiase A, Golisano O, Paterna P, De Luca M, Pellegrini G. 2001. Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency1. Transplantation. 72:1478–1485.
  • Riboldi SA, Sampaolesi M, Neuenschwander P, Cossu G, Mantero S. 2005. Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering. Biomaterials. 26:4606–4615.
  • Rujitanaroj PO, Wang YC, Wang J, Chew SY. 2011. Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications. Biomaterials. 32:5915–5923.
  • Sadri M, Arab-Sorkhi S, Vatani H, Bagheri-Pebdeni A. 2015. New wound dressing polymeric nanofiber containing green tea extract prepared by electrospinning method. Fibers Polym. 16:1742–1750.
  • Sahoo S, Ang LT, Goh JC, Toh SL. 2010. Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications. J Biomed Mater Res A. 93:1539–1550.
  • Said SS, Aloufy AK, El-Halfawy OM, Boraei NA, El-Khordagui LK. 2011. Antimicrobial PLGA ultrafine fibers: Interaction with wound bacteria. Eur J Pharm Biopharm. 79:108–118.
  • Said SS, El-Halfawy OM, El-Gowelli HM, Aloufy AK, Boraei NA, El-Khordagui LK. 2012. Bioburden-responsive antimicrobial PLGA ultrafine fibers for wound healing. Eur J Pharm Biopharm. 80:85–94.
  • Saraf A, Baggett LS, Raphael RM, Kasper FK, Mikos AG. 2010. Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds. J Control Release. 143:95–103.
  • Schneider A, Wang XY, Kaplan DL, Garlick JA, Egles C. 2009. Biofunctionalized electrospun silk mats as a topical bioactive dressing for accelerated wound healing. Acta Biomater. 5:2570–2578.
  • Schwab IR, Johnson NT, Harkin DG. 2006. Inherent risks associated with manufacture of bioengineered ocular surface tissue. Arch Ophthalmol. 124:1734–1740.
  • Shao S, Li L, Yang G, Li J, Luo C, Gong T, Zhou S. 2011. Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers. Int J Pharm. 421:310–320.
  • Shen X, Xu Q, Xu S, Li J, Zhang N, Zhang L. 2014. Preparation and transdermal diffusion evaluation of the prazosin hydrochloride-loaded electrospun poly (vinyl alcohol) fiber mats. J Nanosci Nanotechnol. 14:5258–5265.
  • Syková E, Jendelová P, Urdzíková L, Lesný P, Hejcl A. 2006. Bone marrow stem cells and polymer hydrogels—two strategies for spinal cord injury repair. Cell Mol Neurobiol. 26:1111–1127.
  • Unnithan AR, Sasikala AR, Murugesan P, Gurusamy M, Wu D, Park CH, Kim CS. 2015. Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing. Int J Biol Macromol. 77:1–8.
  • Varkey M, Gittens SA, Uludag H. 2004. Growth factor delivery for bone tissue repair: an update. Expert Opin Drug Deliv. 1:19–36.
  • Volpato FZ, Almodóvar J, Erickson K, Popat KC, Migliaresi C, Kipper MJ. 2012. Preservation of FGF-2 bioactivity using heparin-based nanoparticles, and their delivery from electrospun chitosan fibers. Acta Biomater. 8:1551–1559.
  • Wang J, An Q, Li D, Wu T, Chen W, Sun B, El-Hamshary H. 2015. Heparin and vascular endothelial growth factor loaded poly (L-lactide-co-caprolactone) nanofiber covered stent-graft for aneurysm treatment. J Biomed Nanotechnol. 11:1947–1960.
  • Widmer MS, Gupta PK, Lu L, Meszlenyi RK, Evans GR, Brandt K, et al. 1998. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials. 19:1945–1955.
  • Williamson MR, Coombes AG. 2004. Gravity spinning of polycaprolactone fibres for applications in tissue engineering. Biomaterials. 25:459–465.
  • Xie C, Li X, Luo X, Yang Y, Cui W, Zou J, Zhou S. 2010. Release modulation and cytotoxicity of hydroxycamptothecin-loaded electrospun fibers with 2-hydroxypropyl-β-cyclodextrin inoculations. Int J Pharm. 391:55–64.
  • Xu X, Yang L, Xu X, Wang X, Chen X, Liang Q, Zeng J, Jing X. 2005. Ultrafine medicated fibers electrospun from W/O emulsions. J Control Release. 108:33–42.
  • Xu X, Chen X, Xu X, Lu T, Wang X, Yang L, Jing X. 2006. BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against glioma C6 cells. J Control Release. 114:307–316.
  • Xu F, Weng B, Gilkerson R, Materon LA, Lozano K. 2015. Development of tannic acid/chitosan/pullulan composite nanofibers from aqueous solution for potential applications as wound dressing. Carbohydr Polym. 115:16–24.
  • Yang Y, Li X, Qi M, Zhou S, Weng J. 2008. Release pattern and structural integrity of lysozyme encapsulated in core–sheath structured poly (DL-lactide) ultrafine fibers prepared by emulsion electrospinning. Eur J Pharm Biopharm. 69:106–116.
  • Yang Y, Li X, Cheng L, He S, Zou J, Chen F, Zhang Z. 2011. Core–sheath structured fibers with pDNA polyplex loadings for the optimal release profile and transfection efficiency as potential tissue engineering scaffolds. Acta Biomater. 7:2533–2543.
  • Yang G, Wang J, Wang Y, Li L, Guo X, Zhou S. 2015. An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy. ACS Nano. 9:1161–1174.
  • Yang Y, Nikkola L, Ylikauppila H, Ashammakhi N. 2006. Investigation of cell attachment on the scaffolds manufactured by electrospun PCL-hyaluronan blend. Paper presented at: TNT2006 “Trends in Nanotechnology” Conference (pp. 4–8).
  • Yoshimoto H, Shin YM, Terai H, Vacanti JP. 2003. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials. 24:2077–2082.
  • Yu YQ, Jiang XS, Gao S, Ma R, Jin Y, Jin X. 2014. Local delivery of vascular endothelial growth factor via nanofiber matrix improves liver regeneration sfter extensive hepatectomy in rats. J Biomed Nanotechnol. 10:3407–3415.
  • Yun J, Im JS, Lee YS, Kim HI. 2011. Electro-responsive transdermal drug delivery behavior of PVA/PAA/MWCNT nanofibers. Eur Polymer J. 47:1893–1902.
  • Zamani M, Morshed M, Varshosaz J, Jannesari M. 2010. Controlled release of metronidazole benzoate from poly ɛ-caprolactone electrospun nanofibers for periodontal diseases. Eur J Pharm Biopharm. 75:179–185.
  • Zamani M, Prabhakaran MP, Ramakrishna S. 2013. Advances in drug delivery via electrospun and electrosprayed nanomaterials. Int J Nanomedicine. 8:2997.
  • Zeng J, Yang L, Liang Q, Zhang X, Guan H, Xu X, Chen X, Jing X. 2005. Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. J Control Release. 105:43–51.
  • Zeng J, Xu X, Chen X, Liang Q, Bian X, Yang L, Jing X. 2003. Biodegradable electrospun fibers for drug delivery. J Control Release. 92:227–231.
  • Zhang Y, Lim CT, Ramakrishna S, Huang ZM. 2005. Recent development of polymer nanofibers for biomedical and biotechnological applications. J Mater Sci Mater Med. 16:933–946.
  • Zhong S, Zhang Y, Lim CT. 2011. Fabrication of large pores in electrospun nanofibrous scaffolds for cellular infiltration: a review. Tissue Eng Part B Rev. 18:77–87.

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