717
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Effects of resuscitation with polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and oxygen delivery in a rat model of hemorrhagic shock

, , , , , , , & show all
Pages 51-57 | Received 11 Apr 2016, Accepted 28 Apr 2016, Published online: 25 May 2016

References

  • Bian Y, Chang TMS. 2015. A novel nanobiotherapeutic poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] with no cardiac toxicity for the resuscitation of a rat model with 90 minutes of sustained severe hemorrhagic shock with loss of 2/3 blood volume. Artif Cells Blood Substit Biotechnol. 43:1–9.
  • Brugger J, Schick MA, Brock RW, Baumann A, Muellenbach RM, Roewer N, Wunder C. 2010. Carbon monoxide has antioxidative properties in the liver involving P38 map kinase pathway in a murine model of systemic inflammation. Microcirculation. 17:504–513.
  • Cheung AT, To PL, Chan DM, Ramanujam S, Barbosa MA, Chen PC, et al. 2007. Comparison of treatment modalities for hemorrhagic shock. Artif Cells Blood Substit Immobil Biotechnol. 35:173–190.
  • Claire B, Chris T. 2009. Interpretation of arterial blood gases. Surgery. 27:470–474.
  • Elmer J, Alam HB, Wilcox SR. 2012. Hemoglobin-based oxygen carriers for hemorrhagic shock. Resuscitation. 83:285–292.
  • Gould SA, Moore EE, Hoyt DB, Burch JM, Haenel JB, Garcia J, DeWoskin R, Moss GS. 1998. The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. J Am Coll Surg. 187:113–122.
  • Gould SA, Moore EE, Hoyt DB, Ness PM, Norris EJ, Carson JL, et al. 2002. The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. J Am Coll Surg. 195:445–455.
  • Halpem NA, Alicea M, Seabrook B, Isolyte S. 1997. Aphysiologic multielectrolyte solution, is preferable to normal saline to wash cell saver blood: conclusions from a prospective, randomized study in a canine model. Crit Care Med. 25:1–8.
  • Hirano ES, Mantovani M, Morandin RC, Fontelles MJP. 2003. Experimental model of hemorrhagic shock in rat. Acta Cirurgica Bras. 18:465–470.
  • Johnson JL, Moore EE, Gonzalez RJ, Fedel N, Partrick DA, Silliman CC. 2003. Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute. J Trauma. 54:133–140.
  • Jonathan E, Hasan BA, Susan RW. 2012. Hemoglobin-based oxygen carriers for hemorrhagic shock. Resuscitation. 83:285–292.
  • Katz LM, Manning JE, McCurdy S, Pearce LB, Gawryl MS, Wang Y, Brown C; Carolina Resuscitation Research Group. 2002. HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury. Resuscitation. 54:77–87.
  • Leytin V, Mazer D, Mody M, Garvey B, Freedman J. 2003. Hemolink, an o-raffinose cross-linked haemoglobin-based oxygen carrier, does not affect activation and function of human platelets in whole blood in vitro. Br J Haematol. 120:535–541.
  • Moore EE, Moore FA, Fabian TC, Bernard AC. 2009. Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial. J Am Coll Surg. 208:1–13.
  • Rice J, Philbin N, McGwin G, Arnaud F, Johnson T, Flournoy WS, et al. 2006. Bovine polymerized hemoglobin versus Hextend resuscitation in a swine model of severe controlled hemorrhagic shock with delay to definitive care. Shock. 26:302–310.
  • Sampson JB, Davis MR, Mueller DL, Kashyap VS, Jenkins DH, Kerby JD. 2003. A comparison of the hemoglobin-based oxygen carrier HBOC-201 to other low-volume resuscitation fluids in a model of controlled hemorrhagic shock. J Trauma. 55:747–754.
  • Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, O'Hara PJ. 2002. The use of bovinehemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized single-blinded trial. Anesth Analg. 94:799–808.
  • Standl T. 2001. Haemoglobin-based erythrocyte transfusion substitutes. Expert Opin Biol Ther. 1:831–843.
  • Winslow RM. 2000. Blood substitutes. Adv Drug Deliv Rev. 40:131–142.
  • Zhang W, Yan KP, Dai PG, Tian JJ, Zhu HL, Chen C. 2012. A novel hemoglobin-based oxygen carrier, polymerized porcine hemoglobin, inhibits H2O2-induced cytotoxicity of endothelial cells. Artif Organs. 36:151–160.
  • Zhu HL, Dang XD, Yan KP, Dai PG, Ma J, Li Y, Chang TMS, Chen C. 2011a. Pharmacodynamic study of polymerized porcine hemoglobin (pPolyHb) in a rat model of exchange transfusion. Artif Cells, Blood Substit Biotechnol. 39:119–126.
  • Zhu HL, Yan KP, Dang XD, Huang H, Chen EF, Chen B, et al. 2011b. Immune safety evaluation of polymerized porcine hemoglobin (pPolyHb): a potential red blood cell substitute. Artif Cells, Blood Substit Biotechnol. 39:398–405.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.