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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 45, 2017 - Issue 4
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Articles

Zero-link polymerized hemoglobin (OxyVita®Hb) stabilizes the heme environment: potential for lowering vascular oxidative stress

Hanna WollockoOXYVITA Inc., New Windsor, NY, USA; Correspondence[email protected]
,
Sarah AnveryDepartment of Chemistry, State University of New York, New Paltz, NY, USA;
,
Jacek WollockoOXYVITA Inc., New Windsor, NY, USA;
,
John M. HarringtonDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, GA
&
John P. HarringtonOXYVITA Inc., New Windsor, NY, USA; ;Department of Chemistry, State University of New York, New Paltz, NY, USA;
Pages 701-709 | Received 12 Sep 2016, Accepted 18 Nov 2016, Published online: 09 Dec 2016

References

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  • Harrington JP, Wollocko H. 2013. Zero-Link Hemoglobin (OxyVita®): impact of molecular design characteristics on pre-clinical studies, Chapter 15. In Hemoglobin-based oxygen carriers as red cell substitutes and oxygen therapeutics. New York: Springer.
  • Harrington JP, Wollocko J, Kostecki E, Wollocko H. 2011. Physicochemical characteristics of OxyVita hemoglobin, a zero-linked polymer: liquid and powder preparations. Artif Cells Blood Substit Immobil Biotechnol. 39:12–18.
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  • Song BK, Nugent WH, Moon-Massat PF, Auker CR, McCarron R, Pittman RN. 2013. Effects of top-loading a zero-link bovine hemoglobin (ZL-HbBv), OxyVitaTM, on systemic and microcirculatory variables. Military Med. 178:570–577.

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