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Articles

Development and characterization of morin hydrate loaded microemulsion for the management of Alzheimer’s disease

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Pages 1620-1630 | Received 27 Jul 2016, Accepted 22 Dec 2016, Published online: 19 Jan 2017

References

  • Agrawal AG, Kumar A, Gide PS. 2015. Self emulsifying drug delivery system for enhanced solubility and dissolution of glipizide. Colloids Surf B Biointerfaces. 126:553–560.
  • Auld DS, Kornecook TJ, Bastianetto S, Quirion R. 2002. Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies. Prog Neurobiol. 68:209–245.
  • Cho H-J, Ku W-S, Termsarasab U, Yoon I, Chung C-W, Moon HT, et al. 2012. Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations. Int J Pharm. 423:153–160.
  • de Bruin N, Pouzet B. 2006. Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: deficits induced by scopolamine and by prolonging the retention interval. Pharmacol Biochem Behav. 85:253–260.
  • Deshmukh R, Sharma V, Mehan S, Sharma N, Bedi K. 2009. Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine—a PDE1 inhibitor. Eur J Pharmacol. 620:49–56.
  • Drewes G. 2004. MARKing tau for tangles and toxicity. Trends Biochem Sci. 29:548–555.
  • Ellman GL, Courtney KD, Andres V, Featherstone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 7:88–95.
  • Ellman GL. 1959. Tissue sulfhydryl groups. Arch Biochem Biophys. 82:70–77.
  • Fortuna A, Alves G, Serralheiro A, Sousa J, Falcão A. 2014. Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules. Eur J Pharm Biopharm. 88:8–27.
  • Gabathuler R. 2010. Approaches to transport therapeutic drugs across the blood–brain barrier to treat brain diseases. Neurobiol Dis. 37:48–57.
  • Ghalamfarsa G, Hojjat-Farsangi M, Mohammadnia-Afrouzi M, Anvari E, Farhadi S, Yousefi M, et al. 2016. Application of nanomedicine for crossing the blood–brain barrier: theranostic opportunities in multiple sclerosis. J Immunotoxicol 13:603–619.
  • Giacobini E. 2004. Cholinesterase inhibitors: new roles and therapeutic alternatives. Pharmacol Res. 50:433–440.
  • Gong EJ, Park HR, Kim ME, Piao S, Lee E, Jo D-G, et al. 2011. Morin attenuates tau hyperphosphorylation by inhibiting GSK3β. Neurobiol Dis. 44:223–230.
  • Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. 1982. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 126:131–138.
  • Kumar MR, Muralidharan S. 2015. Method development and validation of Bio Flavanoid-Morin hydrate by RP-HPLC in human plasma. J Young Pharm. 7:195.
  • Moghimipour E, Salimi A, Eftekhari S. 2013. Design and characterization of microemulsion systems for naproxen. Adv Pharm Bull. 3:63–71.
  • Patel RB, Patel MR, Bhatt KK, Patel BG. 2013. Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of carbamazepine. Bull Faculty Pharm Cairo Univ. 51:243–253.
  • Pathak R, Dash RP, Misra M, Nivsarkar M. 2014. Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route. Acta Pharm Sin B. 4:151–160.
  • Patil SS, Sunyer B, Höger H, Lubec G. 2009. Evaluation of spatial memory of C57BL/6J and CD1 mice in the Barnes maze, the Multiple T-maze and in the Morris water maze. Behav Brain Res. 198:58–68.
  • Shahiwala A, Dash D. 2010. Preparation and evaluation of microemulsion based formulations for rapid-onset intranasal delivery of zonisamide. Adv Sci Lett. 3:442–446.
  • Sharma D, Bansal PK, Mishra N. 2016. Role of lipidic nanoparticles for management of Alzheimer's diseases. Asian J Biomater Res. 2:1–8.
  • Shinde RL, Bharkad GP, Devarajan PV. 2015. Intranasal microemulsion for targeted nose to brain delivery in neurocysticercosis: role of docosahexaenoic acid. Eur J Pharm Biopharm. 96:363–379.
  • Shinde RL, Jindal AB, Devarajan PV. 2011. Microemulsions and nanoemulsions for targeted drug delivery to the brain. Curr Nanosci. 7:119–133.
  • Sintov AC, Levy HV, Botner S. 2010. Systemic delivery of insulin via the nasal route using a new microemulsion system: in vitro and in vivo studies. J Control Release. 148:168–176.
  • Talegaonkar S, Azeem A, Ahmad FJ, Khar RK, Pathan SA, Khan ZI. 2008. Microemulsions: a novel approach to enhanced drug delivery. Recent Pat Drug Deliv Formul. 2:238–257.
  • Vyas TK, Babbar A, Sharma R, Singh S, Misra A. 2006. Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting. J Pharm Sci. 95:570–580.
  • Wills E. 1966. Mechanisms of lipid peroxide formation in animal tissues. Biochem J. 99:667.
  • Zhang J, Peng Q, Shi S, Zhang Q, Sun X, Gong T, et al. 2011. Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex. Int J Nanomedicine. 6:3405–3414.

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