Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation

References

• Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15:195–218.
   PubMed Web of Science ®Google Scholar
• Pulido-Moran M, Moreno-Fernandez J, Ramirez-Tortosa C, et al. Curcumin and health. Molecules. 2016;21:264.
   PubMed Web of Science ®Google Scholar
• Akbik D, Ghadiri M, Chrzanowski W, et al. Curcumin as a wound healing agent. Life Sci. 2014;116:1–7.
   PubMed Web of Science ®Google Scholar
• Thangapazham RL, Sharad S, Maheshwari RK. Skin regenerative potentials of curcumin. Biofactors. 2013;39:141–149.
   PubMed Web of Science ®Google Scholar
• Teow SY, Liew K, Ali SA, et al. Antibacterial action of curcumin against Staphylococcus aureus: a brief review. J Trop Med. 2016;2016:2853045.
   PubMed Web of Science ®Google Scholar
• Hegge AB, Andersen T, Melvik JE, et al. Formulation and bacterial phototoxicity of curcumin loaded alginate foams for wound treatment applications: studies on curcumin and curcuminoides XLII. J Pharm Sci. 2011;100:174–185.
   PubMed Web of Science ®Google Scholar
• Sidhu GS, Singh AK, Thaloor D, et al. Enhancement of wound healing by curcumin in animals. Wound Repair Regen. 1998;6:167–177.
   PubMedGoogle Scholar
• Mehrabani D, Farjam M, Geramizadeh B, et al. The healing effect of curcumin on burn wounds in rat. World J Plast Surg. 2015;4:29–35.
   PubMed Web of Science ®Google Scholar
• Kant V, Gopal A, Pathak NN, et al. Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. Int Immunopharmacol. 2014;20:322–330.
   PubMed Web of Science ®Google Scholar
• Sidhu GS, Mani H, Gaddipati JP, et al. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen. 1999;7:362–374.
   PubMed Web of Science ®Google Scholar
• Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. Eur J Cancer. 2005;41:1955–1968.
   PubMed Web of Science ®Google Scholar
• Mehanny M, Hathout RM, Geneidi AS, et al. Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives. J Control Release. 2016;225:1–30.
   PubMed Web of Science ®Google Scholar
• Merrell JG, McLaughlin SW, Tie L, et al. Curcumin -loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp Pharmacol Physiol. 2009;36:1149–1156.
   PubMed Web of Science ®Google Scholar
• Chereddy KK, Coco R, Memvanga PB, et al. Combined effect of PLGA and curcumin on wound healing activity. J Control Release. 2013;171:208–215.
   PubMed Web of Science ®Google Scholar
• Neuman MG, Nanau RM, Oruña-Sanchez L, et al. Hyaluronic acid and wound healing. J Pharm Pharm Sci. 2015;18:53–60.
   PubMed Web of Science ®Google Scholar
• Dicker KT, Gurski LA, Pradhan-Bhatt S, et al. Hyaluronan: a simple polysaccharide with diverse biological functions. Acta Biomater. 2014;10:1558–1570.
   PubMed Web of Science ®Google Scholar
• Karbownik MS, Nowak JZ. Hyaluronan: towards novel anti-cancer therapeutics. Pharmacol Rep. 2013;65:1056–1074.
   PubMed Web of Science ®Google Scholar
• Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: a key molecule in skin aging. Dermatoendocrinol. 2012;4:253–258.
   PubMedGoogle Scholar
• Kavasi RM, Berdiaki A, Spyridaki I, et al. HA metabolism in skin homeostasis and inflammatory disease. Food Chem Toxicol. 2017;101:128–138.
   PubMed Web of Science ®Google Scholar
• Monslow J, Govindaraju P, Puré E. Hyaluronan – a functional and structural sweet spot in the tissue microenvironment. Front Immunol. 2015;6:231.
   PubMed Web of Science ®Google Scholar
• Slevin M, Kumar S, Gaffney J. Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J Biol Chem. 2002;277:41046–41059.
   PubMed Web of Science ®Google Scholar
• McKee CM, Lowenstein CJ, Horton MR, et al. Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism. J Biol Chem. 1997;272:8013–8018.
   PubMed Web of Science ®Google Scholar
• Oertli B, Beck-Schimmer B, Fan X, et al. Mechanisms of hyaluronan induced up-regulation of ICAM-1 and VCAM-1 expression by murine kidney tubular epithelial cells:hyaluronan triggers cell adhesion molecule expression through a mechanism involving activation of nuclear factor-kappa B and activating protein-1. J Immunol. 1998;161:3431–3437.
   PubMed Web of Science ®Google Scholar
• Bourguignon LY, Wong G, Xia W, et al. Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. J Dermatol Sci. 2013;72:32–44.
   PubMed Web of Science ®Google Scholar
• David-Raoudi M, Tranchepain F, Deschrevel B, et al. Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing. Wound Repair Regen. 2008;16:274–287.
   PubMed Web of Science ®Google Scholar
• El-Refaie WM, Elnaggar YS, El-Massik MA, et al. Novel curcumin-loaded gel-core hyaluosomes with promising burn-wound healing potential: development, in-vitro appraisal and in-vivo studies. Int J Pharm. 2015;486:88–98.
   PubMed Web of Science ®Google Scholar
• Manca ML, Castangia I, Zaru M, et al. Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring. Biomaterials 2015;71:100–109.
   PubMed Web of Science ®Google Scholar
• Manju S, Sreenivasan K. Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability. J Colloid Interface Sci. 2011;359:318–325.
   PubMed Web of Science ®Google Scholar
• Li J, Shin GH, Chen X, et al. Modified curcumin with hyaluronic acid: combination of pro-drug and nano-micelle strategy to address the curcumin challenge. Food Res Int. 2015;69:202–208.
   Web of Science ®Google Scholar
• Damodarasamy M, Johnson RS, Bentov I, et al. Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds. Wound Repair Regen. 2014;22:521–526.
   PubMed Web of Science ®Google Scholar
• Prieto P, Pineda M, Aguilar M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Biochem. 1999;269:337–341.
   PubMed Web of Science ®Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63.
   PubMed Web of Science ®Google Scholar
• Sahu K, Sharma M, Dube A, et al. Topical antimicrobial photodynamic therapy improves angiogenesis in wounds of diabetic mice. Lasers Med Sci. 2015;30:1923–1929.
   PubMed Web of Science ®Google Scholar
• Zhao R, Yang B, Wang L, et al. Curcumin protects human keratinocytes against inorganic arsenite-induced acute. Oxid Med Cell Longev. 2013;2013:412576.
   PubMedGoogle Scholar
• Balasubramanian S, Eckert RL. Keratinocyte proliferation, differentiation, and apoptosis – differential mechanisms of regulation by curcumin, EGCG and apigenin. Toxicol Appl Pharmacol. 2007;224:214–219.
   PubMed Web of Science ®Google Scholar
• Föger N, Marhaba R, Zöller M. Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells. J Cell Sci. 2001;114:1169–1178.
   PubMed Web of Science ®Google Scholar
• Ghatak S, Misra S, Toole BP. Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells. J Biol Chem. 2005;280:8875–8883.
   PubMed Web of Science ®Google Scholar
• Ghazi K, Deng-Pichon U, Warnet JM, et al. Hyaluronan fragments improve wound healing on in vitro cutaneous model through P2X7 purinoreceptor basal activation: role of molecular weight. PLoS One. 2012;7:e48351.
   PubMed Web of Science ®Google Scholar
• Adinolfi E, Callegari MG, Ferrari D, et al. Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol Biol Cell. 2005;16:3260–3272.
   PubMed Web of Science ®Google Scholar
• Ke C, Sun L, Qiao D, et al. Antioxidant acitivity of low molecular weight hyaluronic acid. Food Chem Toxicol. 2011;49:2670–2675.
   PubMed Web of Science ®Google Scholar
• Campo GM, Avenoso A, Campo S, et al. The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis. Chem Biol Interact. 2004;148:125–138.
   PubMed Web of Science ®Google Scholar
• Chen X, Zhong Z, Xu Z, et al. No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells. Pharmacol Rep. 2011;63:724–732.
   PubMed Web of Science ®Google Scholar
• Rinaudo M, Lardy B, Grange L, et al. Effect of mannitol on hyaluronic acid stability in two in vitro models of oxidative stress. Polymers. 2014;6:1948–1957.
   Web of Science ®Google Scholar
• Reveles KR, Duhon BM, Moore RJ, et al. Epidemiology of methicillin-resistant Staphylococcus aureus diabetic foot infections in a large academic hospital: implications for antimicrobial stewardship. PLoS One. 2016;11:e0161658.
   PubMed Web of Science ®Google Scholar
• Rai D, Singh JK, Roy N, et al. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem J. 2008;410:147–155.
   PubMed Web of Science ®Google Scholar
• Park BS, Kim JG, Kim MR, et al. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric Food Chem. 2005;53:9005–9009.
   PubMed Web of Science ®Google Scholar
• Araújo NC, de Menezes RF, Carneiro VS, et al. Photodynamic inactivation of cariogenic pathogens using curcumin as photosensitizer. Photomed Laser Surg. 2017;35:259–263.
   PubMed Web of Science ®Google Scholar
• Krausz AE, Adler BL, Cabral V, et al. Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine. 2015;11:195–206.
   PubMed Web of Science ®Google Scholar
• Mani H, Sidhu GS, Kumari R, et al. Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing. Biofactors. 2002;16:29–43.
   PubMed Web of Science ®Google Scholar