Phytol-loaded PLGA nanoparticle as a modulator of Alzheimer’s toxic Aβ peptide aggregation and fibrillation associated with impaired neuronal cell function

References

• Shanmuganathan B, Malar DS, Sathya S, et al. Antiaggregation potential of Padina gymnospora against the toxic Alzheimer’s beta-amyloid peptide 25–35 and cholinesterase inhibitory property of its bioactive compounds. PLoS One. 2015;10:e0141708.
   PubMed Web of Science ®Google Scholar
• Pryor NE, Moss MA, Hestekin CN. Unraveling the early events of amyloid-β protein (Aβ) aggregation: techniques for the determination of Aβ aggregate size. IJMS. 2012;13:3038–3072.
   Web of Science ®Google Scholar
• Shanmuganathan B, Pandima Devi K. Evaluation of the nutritional profile and antioxidant and anti-cholinesterase activities of Padina gymnospora (Phaeophyceae). Eur J Phycol. 2016;51:482–490.
   Web of Science ®Google Scholar
• Chen Y, Liu L. Modern methods for delivery of drugs across the blood–brain barrier. Adv Drug Deliv Rev. 2012;64:640–665.
   PubMed Web of Science ®Google Scholar
• Choi EY, Hwang HJ, Kim IH, et al. Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats. Food Chem Toxicol. 2009;47:134–139.
   PubMed Web of Science ®Google Scholar
• Silva RO, Sousa FB, Damasceno SR, et al. Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cytokine production and oxidative stress. Fundam Clin Pharmacol. 2014;28:455–464.
   PubMed Web of Science ®Google Scholar
• Yoo KY, Park SY. Terpenoids as potential anti-Alzheimer’s disease therapeutics. Molecules. 2012;17:3524–3538.
   PubMed Web of Science ®Google Scholar
• Costa JP, Ferreira PB, De Sousa DP, et al. Anticonvulsant effect of phytol in a pilocarpine model in mice. Neurosci Lett. 2012;523:115–118.
   PubMed Web of Science ®Google Scholar
• Chang HJ, Kim HJ, Chun HS. Quantitative structure − activity relationship (QSAR) for neuroprotective activity of terpenoids. Life Sci. 2007;80:835–841.
   PubMed Web of Science ®Google Scholar
• Anand P, Kunnumakkara AB, Newman RA, et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–818.
   PubMed Web of Science ®Google Scholar
• Fonseca-Santos B, Gremião MP, Chorilli M. Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease. Int J Nanomedicine. 2015;10:4981.
   PubMed Web of Science ®Google Scholar
• Soppimath KS, Aminabhavi TM, Kulkarni AR, et al. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release. 2001;70:1–20.
   PubMed Web of Science ®Google Scholar
• Nicolas J, Mura S, Brambilla D, et al. Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery. Chem Soc Rev. 2013;42:1147–1235.
   PubMed Web of Science ®Google Scholar
• Sahni JK, Doggui S, Ali J, et al. Neurotherapeutic applications of nanoparticles in Alzheimer’s disease. J Control Release. 2011; 152:208–231.
   PubMed Web of Science ®Google Scholar
• Stevanovic M, Uskokovic D. Poly (lactide-co-glycolide)-based micro and nanoparticles for the controlled drug delivery of vitamins. Curr Nanosci. 2009;5:1–4.
   Web of Science ®Google Scholar
• Mathew A, Fukuda T, Nagaoka Y, et al. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer’s disease. PLoS One. 2012;7:e32616.
   PubMed Web of Science ®Google Scholar
• Ray S, Ghosh S, Mandal S. Development of bicalutamide-loaded PLGA nanoparticles: preparation, characterization and in-vitro evaluation for the treatment of prostate cancer. Artif Cells Nanomed Biotechnol. 2017;45:944–954.
   PubMed Web of Science ®Google Scholar
• Blois MS. Antioxidant determinations by the use of a stable free radical. Nature. 1958;181:1199–1200.
   Web of Science ®Google Scholar
• Hafezi Ghahestani Z, Alebooye Langroodi F, Mokhtarzadeh A, et al. Evaluation of anti-cancer activity of PLGA nanoparticles containing crocetin. Artif Cells Nanomed Biotechnol. 2017;45:955–960.
   PubMed Web of Science ®Google Scholar
• Sah AK, Suresh PK, Verma VK. PLGA nanoparticles for ocular delivery of loteprednol etabonate: a corneal penetration study. Artif Cells Nanomed Biotechnol. 2017;45:1156–1164.
   PubMed Web of Science ®Google Scholar
• Fornaguera C, Feiner-Gracia N, Calderó G, et al. Galantamine-loaded PLGA nanoparticles, from nano-emulsion templating, as novel advanced drug delivery systems to treat neurodegenerative diseases. Nanoscale. 2015;7:12076–12084.
   PubMed Web of Science ®Google Scholar
• Lamprecht A, Schäfer U, Lehr CM. Size-dependent bioadhesion of micro-and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res. 2001;18:788–793.
   PubMed Web of Science ®Google Scholar
• Wisse E, De Leeuw AM. Structural elements determining transport and exchange processes in the liver. In: Daviss SS, Illum L, McVie JG, Tomlinson E, editors. Microspheres and drug therapy, pharmaceutical, immunological and medical aspects. Amsterdam (The Netherlands): Elsevier; 1984 . p. 1–23.
   Google Scholar
• Allemann E, Gurny R, Doelker E. Drug-loaded nanoparticles: preparation methods and drug targeting issues. Eur J Pharm Biopharm. 1993;39:173–191.
   Web of Science ®Google Scholar
• He C, Hu Y, Yin L, et al. Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials. 2010;31:3657–3666.
   PubMed Web of Science ®Google Scholar
• Yue PF, Yuan HL, Yang M, et al. Preparation, characterization, and pharmacokinetic evaluation of puerarin submicron emulsion. PDA J Pharm Sci Technol. 2008;62:32–45.
   PubMedGoogle Scholar
• Yang H, Hao Y, Liu Q, et al. Preparation and in vitro study of hydrochloric norvancomycin encapsulated poly (d,l-lactide-co-glycolide, PLGA) microspheres for potential use in osteomyelitis. Artif Cells Nanomed Biotechnol. 2017;45:1326–1330.
   PubMed Web of Science ®Google Scholar
• Pool H, Quintanar D, d Dios Figueroa J, et al. Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles. J Nanomater. 2012;2012:86.
   Web of Science ®Google Scholar
• Lee JH, Yeo Y. Controlled drug release from pharmaceutical nanocarriers. Chem Eng Sci. 2015;125:75–84.
   PubMed Web of Science ®Google Scholar
• Fornaguera C, Llinàs M, Solans C, et al. Design and in vitro evaluation of biocompatible dexamethasone-loaded nanoparticle dispersions, obtained from nano-emulsions, for inhalatory therapy. Colloid Surface B. 2015;125:58–64.
   PubMed Web of Science ®Google Scholar
• Hodges JR. Alzheimer’s centennial legacy: origins, landmarks and the current status of knowledge concerning cognitive aspects. Brain. 2006;129:2811–2822.
   PubMed Web of Science ®Google Scholar
• Jiang T, Sun Q, Chen S. Oxidative stress: a major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease. Prog Neurobiol. 2016;147:1–19.
   PubMed Web of Science ®Google Scholar
• Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev. 2012;2012:914273.
   PubMed Web of Science ®Google Scholar
• Adochitei A, Drochioiu G. Rapid characterization of peptide secondary structure by FT-IR spectroscopy. Rev Roum Chim. 2011;56:783–791.
   Web of Science ®Google Scholar