Development and optimization of sulforaphane-loaded nanostructured lipid carriers by the Box-Behnken design for improved oral efficacy against cancer: in vitro, ex vivo and in vivo assessments

References

• Zhang Y, Talalay P, Cho CG, et al. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA. 1992;89:2399–2403.
   PubMed Web of Science ®Google Scholar
• Jackson SJ, Singletary KW. Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. J Nutr. 2004;134:2229–2236.
   PubMed Web of Science ®Google Scholar
• Clarke JD, Dashwood RH, Ho E. Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 2008;269:291–304.
   PubMed Web of Science ®Google Scholar
• Parnaud G, Li P, Cassar G, et al. Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells. Nutr Cancer. 2004;48:198–206.
   PubMed Web of Science ®Google Scholar
• Hahm ER, Singh SV. Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. Cancer Prev Res. 2010;3:484–494.
   PubMed Web of Science ®Google Scholar
• Rausch V, Liu L, Kallifatidis G, et al. Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. Cancer Res. 2010;70:5004–5013.
   PubMed Web of Science ®Google Scholar
• Kallifatidis G, Rausch V, Baumann B, et al. Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. Gut 2009;58:949–963.
   PubMed Web of Science ®Google Scholar
• Lampe JW. Sulforaphane: from chemoprevention to pancreatic cancer treatment? Gut. 2009;58:900–902.
   PubMed Web of Science ®Google Scholar
• Jin Y, Wang M, Rosen RT, et al. Thermal degradation of sulforaphane in aqueous solution. J Agric Food Chem. 1999;47:3121–3123.
   PubMed Web of Science ®Google Scholar
• Qian X, Hao L, Qipeng Y. Effect of temperature, pH and light on the stability of sulforaphane solution. Chinese Pharm J. 2007;142:193–196.
   Google Scholar
• Khurana RK, Mahajan M, Teenu, et al. The sojourn from parenteral to oral taxanes using nanocarrier systems: a patent review. Recent Pat Drug Deliv Formul. 2016;10:44–58.
   PubMedGoogle Scholar
• Ahmad J, Singhal M, Amin S, et al. Bile salt stabilized vesicles (Bilosomes): a novel nano-pharmaceutical design for oral delivery of proteins and peptides. Curr Pharm Des. 2017;23:1575–1588.
   PubMed Web of Science ®Google Scholar
• Rizwanullah M, Ahmad J, Amin S. Nanostructured lipid carriers: a novel platform for chemotherapeutics. Curr Drug Deliv. 2016;13:4–26.
   PubMed Web of Science ®Google Scholar
• Rizwanullah M, Amin S, Ahmad J. Improved pharmacokinetics and antihyperlipidemic efficacy of rosuvastatin-loaded nanostructured lipid carriers. J Drug Target. 2017;25:58–74.
   PubMed Web of Science ®Google Scholar
• Jaiswal P, Gidwani B, Vyas A. Nanostructured lipid carriers and their current application in targeted drug delivery. Artif Cells Nanomed Biotechnol. 2016;44:27–40.
   PubMed Web of Science ®Google Scholar
• Beloqui A, Solinís MÁ, Rodríguez-Gascón A, et al. Nanostructured lipid carriers: promising drug delivery systems for future clinics. Nanomedicine 2016;12:143–161.
   PubMed Web of Science ®Google Scholar
• Khan A, Imam SS, Aqil M, et al. Brain targeting of temozolomide via the intranasal route using lipid-based nanoparticles: brain pharmacokinetic and scintigraphic analyses. Mol Pharm. 2016;13:3773–3782.
   PubMed Web of Science ®Google Scholar
• Akhter MH, Rizwanullah M, Ahmad J, et al. Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics. Artif Cells Nanomed Biotechnol. 2017;1–12. doi: https://doi.org/10.1080/21691401.2017.1366333
   Google Scholar
• Ling G, Zhang T, Zhang P, et al. Nanostructured lipid-carrageenan hybrid carriers (NLCCs) for controlled delivery of mitoxantrone hydrochloride to enhance anticancer activity bypassing the BCRP-mediated efflux. Drug Dev Ind Pharm. 2016;42:1351–1359.
   PubMed Web of Science ®Google Scholar
• Shete HK, Selkar N, Vanage GR, et al. Tamoxifen nanostructured lipid carriers: enhanced in vivo antitumor efficacy with reduced adverse drug effects. Int J Pharm. 2014;468:1–14.
   PubMed Web of Science ®Google Scholar
• Ahmad J, Akhter S, Rizwanullah M, et al. Nanotechnology-based inhalation treatments for lung cancer: state of the art. Nanotechnol Sci Appl. 2015;8:55–66.
   PubMed Web of Science ®Google Scholar
• Conaway CC, Wang CX, Pittman B, et al. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res. 2005;65:8548–8557.
   PubMed Web of Science ®Google Scholar
• Hanlon N, Coldham N, Gielbert A, et al. Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. Br J Nutr. 2008;99:559–564.
   PubMed Web of Science ®Google Scholar
• Qidwai A, Khan S, Md S, et al. Nanostructured lipid carrier in photodynamic therapy for the treatment of basal-cell carcinoma. Drug Deliv. 2016;23:1476–1485.
   PubMed Web of Science ®Google Scholar
• Ahmad J, Mir SR, Kohli K, et al. Quality by design approach for self nanoemulsifying system of paclitaxel. Sci Adv Mater. 2014;6:1778–1791.
   Web of Science ®Google Scholar
• Ahmad J, Mir SR, Kohli K, et al. Effect of oil and co-surfactant on the formation of Solutol HS 15 based colloidal drug carrier by Box–Behnken statistical design. Colloids Surf A: Physicochem Eng Asp. 2014;453:68–77.
   Web of Science ®Google Scholar
• Patil GB, Patil ND, Deshmukh PK, et al. Nanostructured lipid carriers as a potential vehicle for Carvedilol delivery: application of factorial design approach. Artif Cells Nanomed Biotechnol. 2016;44:12–19.
   PubMed Web of Science ®Google Scholar
• Zhang T, Chen J, Zhang Y, et al. Characterization and evaluation of nanostructured lipid carrier as a vehicle for oral delivery of etoposide. Eur J Pharm Sci. 2011;43:174–179.
   PubMed Web of Science ®Google Scholar
• Neupane YR, Srivastava M, Ahmad N, et al. Lipid based nanocarrier system for the potential oral delivery of decitabine: formulation design, characterization, ex vivo, and in vivo assessment. Int J Pharm. 2014;477:601–612.
   PubMed Web of Science ®Google Scholar
• Sharma K, Hallan SS, Lal B, et al. Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability. Artif Cells Nanomed Biotechnol. 2016;44:1448–1456.
   PubMed Web of Science ®Google Scholar
• Soni K, Mujtaba A, Kohli K. Lipid drug conjugate nanoparticle as a potential nanocarrier for the oral delivery of pemetrexed diacid: formulation design, characterization, ex vivo, and in vivo assessment. Int J Biol Macromol. 2017;103:139–151.
   PubMed Web of Science ®Google Scholar
• Ahmad J, Mir SR, Kohli K, et al. Solid-nanoemulsion preconcentrate for oral delivery of paclitaxel: formulation design, biodistribution, and γ scintigraphy imaging. Biomed Res Int. 2014;2014:984756.
   PubMed Web of Science ®Google Scholar
• Singh A, Neupane YR, Panda BP, et al. Lipid based nanoformulation of lycopene improves oral delivery: formulation optimization, ex vivo assessment and its efficacy against breast cancer. J Microencapsul. 2017;34:416–429.
   PubMed Web of Science ®Google Scholar
• Tran TH, Nguyen AN, Kim JO, et al. Enhancing activity of artesunate against breast cancer cells via induced-apoptosis pathway by loading into lipid carriers. Artif Cells Nanomed Biotechnol. 2016;44:1979–1987.
   PubMed Web of Science ®Google Scholar
• Sanna V, Pala N, Dessì G, et al. Single-step green synthesis and characterization of gold-conjugated polyphenol nanoparticles with antioxidant and biological activities. Int J Nanomedicine. 2014;9:4935–4951.
   PubMed Web of Science ®Google Scholar
• Kheiri Manjili H, Sharafi A, Attari E, et al. Pharmacokinetics and in vitro and in vivo delivery of sulforaphane by PCL-PEG-PCL copolymeric-based micelles. Artif Cells Nanomed Biotechnol. 2017;45:1728–1739.
   PubMed Web of Science ®Google Scholar
• Tan SW, Billa N, Roberts CR, et al. Surfactant effects on the physical characteristics of Amphotericin-B containing nanostructured lipid carriers. Colloids Surf A: Physicochem Eng Asp. 2010;372:73–79.
   Web of Science ®Google Scholar
• Liu J, Gong T, Wang C, et al. Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization. Int J Pharm. 2007;340:153–162.
   PubMed Web of Science ®Google Scholar
• Rahman Z, Zidan AS, Khan MA. Non-destructive methods of characterization of risperidone solid lipid nanoparticles. Eur J Pharm Biopharm. 2010;76:127–137.
   PubMed Web of Science ®Google Scholar
• Moghddam SM, Ahad A, Aqil M, et al. Optimization of nanostructured lipid carriers for topical delivery of nimesulide using Box-Behnken design approach. Artif Cells Nanomed Biotechnol. 2017;45:617–624.
   PubMed Web of Science ®Google Scholar
• Mishra A, Imam SS, Aqil M, et al. Carvedilol nano lipid carriers: formulation, characterization and in-vivo evaluation. Drug Deliv. 2016;23:1486–1494.
   PubMed Web of Science ®Google Scholar
• Jenning V, Thünemann AF, Gohla SH. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int J Pharm. 2000;199:167–177.
   PubMed Web of Science ®Google Scholar
• Alam S, Aslam M, Khan A, et al. Nanostructured lipid carriers of pioglitazone for transdermal application: from experimental design to bioactivity detail. Drug Deliv. 2016;23:601–609.
   PubMed Web of Science ®Google Scholar
• Aslam M, Aqil M, Ahad A, et al. Application of Box–Behnken design for preparation of glibenclamide loaded lipid based nanoparticles: optimization, in vitro skin permeation, drug release and in vivo pharmacokinetic study. J Mol Liq. 2016;219:897–908.
   Web of Science ®Google Scholar
• Beloqui A, Solinís MÁ, Gascón AR, et al. Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier. J Control Release. 2013;166:115–123.
   PubMed Web of Science ®Google Scholar