In vitro fibroblast migration by sustained release of PDGF-BB loaded in chitosan nanoparticles incorporated in electrospun nanofibers for wound dressing applications

References

• Seppa H, Grotendorst G, Seppa S, et al. Platelet-derived growth factor in chemotactic for fibroblasts. J Cell Biol. 1982;92:584–588.
   PubMed Web of Science ®Google Scholar
• Li J, Chen J, Kirsner R. Pathophysiology of acute wound healing. Clin Dermatol. 2007;25:9–18.
   PubMed Web of Science ®Google Scholar
• Gurtner GC, Werner S, Barrandon Y, et al. Wound repair and regeneration. Nature. 2008;453:314–321.
   PubMed Web of Science ®Google Scholar
• Yu J, Moon A, Kim H-RC. Both platelet-derived growth factor receptor (PDGFR)-α and PDGFR-β promote murine fibroblast cell migration. Biochem Biophys Res Commun. 2001;282:697–700.
   PubMed Web of Science ®Google Scholar
• Fiedler J, Röderer G, Günther KP, et al. BMP‐2, BMP‐4, and PDGF‐bb stimulate chemotactic migration of primary human mesenchymal progenitor cells. J Cell Biochem. 2002;87:305–312.
   PubMed Web of Science ®Google Scholar
• Jones A, Cross N. Oncogenic derivatives of platelet-derived growth factor receptors. Cell Mol Life Sci. 2004;61:2912–2923.
   PubMed Web of Science ®Google Scholar
• Tokunaga A, Oya T, Ishii Y, et al. PDGF receptor beta is a potent regulator of mesenchymal stromal cell function. J Bone Miner Res. 2008;23:1519–1528.
   PubMed Web of Science ®Google Scholar
• Mustoe TA, Cutler NR, Allman RM, et al. A phase II study to evaluate recombinant platelet-derived growth factor-BB in the treatment of stage 3 and 4 pressure ulcers. Arch Surg. 1994;129:213–219.
   PubMed Web of Science ®Google Scholar
• Pierce GF, Tarpley JE, Allman RM, et al. Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB. Am J Pathol. 1994;145:1399.
   PubMed Web of Science ®Google Scholar
• Pierce GF, Tarpley JE, Tseng J, et al. Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds. J Clin Invest. 1995;96:1336.
   PubMed Web of Science ®Google Scholar
• Robson MC, Mustoe TA, Hunt TK. The future of recombinant growth factors in wound healing. Am J Surg. 1998;176:80S–82S.
   PubMed Web of Science ®Google Scholar
• Margolis DJ, Crombleholme T, Herlyn M. Clinical protocol: hase I trial to evaluate the safety of H5. 020CMV. PDGF‐B for the treatment of a diabetic insensate foot ulcer. Wound Repair Regen. 2000;8:480–493.
   PubMed Web of Science ®Google Scholar
• Greenhalgh DG, Sprugel KH, Murray MJ, et al. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol. 1990;136:1235.
   PubMed Web of Science ®Google Scholar
• Vasquez R, Marien BJ, Gram C, et al. Proliferative capacity of venous ulcer wound fibroblasts in the presence of platelet-derived growth factor. Vasc Endovascular Surg. 2004;38:355–360.
   PubMedGoogle Scholar
• Eatemadi A, Daraee H, Zarghami N, et al. Nanofiber: synthesis and biomedical applications. Artif Cells Nanomed Biotechnol. 2016;44:111–121.
   PubMed Web of Science ®Google Scholar
• Safaeijavan R, Soleimani M, Divsalar A, et al. Biological behavior study of gelatin coated PCL nanofiberous electrospun scaffolds using fibroblasts. J Paramed Sci. 2013;5:67–73.
   Google Scholar
• Ghiaee A, Farahmand M, Ardeshirylajimi A. Incorporated dexamethasone influence in the PEO nanofibers on the proliferation of mesenchymal stem cells. J Paramed Sci. 2016;7:39–44.
   Google Scholar
• Jafari-Aghdam N, Adibkia K, Payab S, et al. Methylprednisolone acetate–Eudragit® RS100 electrospuns: preparation and physicochemical characterization. Artif Cells Nanomed Biotechnol. 2016;44:497–503.
   PubMed Web of Science ®Google Scholar
• Pournaqi F, Ghiaee A, Vakilian S, et al. Improved proliferation and osteogenic differentiation of mesenchymal stem cells on polyaniline composited by polyethersulfone nanofibers. Biologicals. 2017;45:78–84.
   PubMed Web of Science ®Google Scholar
• Jin Q, Wei G, Lin Z, et al. Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo. PLoS One. 2008;3:e1729.
   PubMed Web of Science ®Google Scholar
• Zhao X, Hadjiargyrou M. Induction of cell migration in vitro by an electrospun PDGF-BB/PLGA/PEG-PLA nanofibrous scaffold. J Biomed Nanotechnol. 2011;7:823–829.
   PubMed Web of Science ®Google Scholar
• Karahaliloglu Z, Kilicay E, Denkbas EB. Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material. Artif Cells Nanomed Biotechnol. 2017;45:1172–1185.
   PubMed Web of Science ®Google Scholar
• Wang Y, Qiao W, Yin T. A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles. J Pharmaceut Sci. 2010;99:4805–4811.
   PubMed Web of Science ®Google Scholar
• Vakilian S, Mashayekhan S, Shabani I, et al. Structural stability and sustained release of protein from a multilayer nanofiber/nanoparticle composite. Int J Biol Macromol. 2015;75:248–257.
   PubMed Web of Science ®Google Scholar
• Brenan Mt, Parish C. Intracellular fluorescent labelling of cells for analysis of lymphocyte migration. J Immunol Meth. 1984;74:31–38.
   PubMed Web of Science ®Google Scholar
• Parish CR. Fluorescent dyes for lymphocyte migration and proliferation studies. Immunol Cell Biol. 1999;77:499–508.
   PubMed Web of Science ®Google Scholar
• Ghiaee A, Pournaqi F, Vakilian S, et al. Adapted dexamethasone delivery polyethylene oxide and poly (ɛ-caprolactone) construct promote mesenchymal stem cells chondrogenesis. Artif Cells Nanomed Biotechnol. 2017;45:1640–1648.
   PubMed Web of Science ®Google Scholar
• Nelson RD, Quie PG, Simmons RL. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes. J Immunol. 1975;115:1650–1656.
   PubMed Web of Science ®Google Scholar
• Frazier K, Williams S, Kothapalli D, et al. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol. 1996;107:404–411.
   PubMed Web of Science ®Google Scholar
• Moghadasi Boroujeni S, Mashayekhan S, Vakilian S, et al. The synergistic effect of surface topography and sustained release of TGF-β1 on myogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A. 2016;104:1610–1621.
   PubMed Web of Science ®Google Scholar
• Tanha S, Rafiee‐Tehrani M, Abdollahi M, et al. G‐CSF loaded nanofiber/nanoparticle composite coated with collagen promotes wound healing in vivo. J Biomed Mater Res A. 2017;105:2830–2842.
   PubMed Web of Science ®Google Scholar
• Bashur CA, Dahlgren LA, Goldstein AS. Effect of fiber diameter and orientation on fibroblast morphology and proliferation on electrospun poly (D,L-lactic-co-glycolic acid) meshes. Biomaterials. 2006;27:5681–5688.
   PubMed Web of Science ®Google Scholar
• Liu Y, Franco A, Huang L, et al. Control of cell migration in two and three dimensions using substrate morphology. Experiment Cell Res. 2009;315:2544–2557.
   PubMed Web of Science ®Google Scholar
• Jouybar A, Seyedjafari E, Ardeshirylajimi A, et al. Enhanced skin regeneration by herbal extract‐coated poly‐L‐lactic acid nanofibrous scaffold. Artif Organs. 2017;41:E296–E307.
   PubMed Web of Science ®Google Scholar
• Rauhala HE, Teppo S, Niemelä S, et al. Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration. Anticancer Res. 2013;33:45–52.
   PubMed Web of Science ®Google Scholar
• Heit B, Tavener S, Raharjo E, et al. An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol. 2002;159:91–102.
   PubMed Web of Science ®Google Scholar
• Foxman EF, Kunkel EJ, Butcher EC. Integrating conflicting chemotactic signals. J Cell Biol. 1999;147:577–588.
   PubMed Web of Science ®Google Scholar