1,694
Views
28
CrossRef citations to date
0
Altmetric
Research Article

Design of mannosylated oral amphotericin B nanoformulation: efficacy and safety in visceral leishmaniasis

, , , , , , , , & show all
Pages 521-531 | Received 23 Oct 2017, Accepted 17 Jan 2018, Published online: 31 Jan 2018

References

  • Wasan KM, Wasan EK, Gershkovich P, et al. Highly effective oral amphotericin B formulation against murine visceral leishmaniasis. J Infect Dis. 2009;200:357–360.
  • Croft SL, Sundar S, Fairlamb AH. Drug resistance in leishmaniasis. Clin Microbiol Rev. 2006;19:111–126.
  • Tonomura Y, Yamamoto E, Kondo C, et al. Amphotericin B-induced nephrotoxicity: characterization of blood and urinary biochemistry and renal morphology in mice. Hum Exp Toxicol. 2009;28:293–300.
  • Daraee H, Etemadi A, Kouhi M, et al. Application of liposomes in medicine and drug delivery. Artif Cells Nanomed Biotechnol. 2016;44:381–391.
  • Amidon GL, Lennernäs H, Shah VP, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceut Res. 1995;12:413–420.
  • Engwerda CR, Ato M, Kaye PM. Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis. Trends Parasitol. 2004;20:524–530.
  • Chaubey P, Mishra B. Mannose-conjugated chitosan nanoparticles loaded with rifampicin for the treatment of visceral leishmaniasis. Carbohydr Polym. 2014;101:1101–1108.
  • Bernkop-Schnürch A, Schwarz V, Steininger S. Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm Res. 1999;16:876–881.
  • Bonengel S, Bernkop-Schnürch A. Thiomers-from bench to market. J Control Release. 2014;195:120–129.
  • Leitner VM, Walker GF, Bernkop-Schnürch A. Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins. Eur J Pharm Biopharm. 2003;56:207–214.
  • Shahnaz G, Edagwa BJ, McMillan J, et al. Development of mannose-anchored thiolated amphotericin B nanocarriers for treatment of visceral leishmaniasis. Nanomedicine. 2017;12:99–115.
  • Sohail MF, Javed I, Hussain SZ, et al. Folate grafted thiolated chitosan enveloped nanoliposomes with enhanced oral bioavailability and anticancer activity of docetaxel. J Mater Chem B. 2016;4:6240–6248.
  • Ng LG, Hsu A, Mandell MA, et al. Migratory dermal dendritic cells act as rapid sensors of protozoan parasites. PLoS Pathog. 2008;4:e1000222.
  • Weischenfeldt J, Porse B. Bone marrow-derived macrophages (BMM): isolation and applications. Cold Spring Harb Protoc. 2008 [cited 2008 Dec 1]. DOI:https://doi.org/10.1101/pdb.prot5080.
  • Terrazas C, Oghumu S, Varikuti S, et al. Uncovering Leishmania-macrophage interplay using imaging flow cytometry. J Immunol Methods. 2015;423:93–98.
  • de Costa-Silva TA, Grecco SS, de Sousa FS, et al. Immunomodulatory and antileishmanial activity of phenylpropanoid dimers isolated from Nectandra leucantha. J Nat Prod. 2015;78:653–657.
  • Iqbal J, Shahnaz G, Dünnhaupt S, et al. Preactivated thiomers as mucoadhesive polymers for drug delivery. Biomaterials. 2012;33:1528–1535.
  • Rahmat D, Müller C, Barthelmes J, et al. Thiolated hydroxyethyl cellulose: design and in vitro evaluation of mucoadhesive and permeation enhancing nanoparticles. Eur J Pharm Biopharm. 2013;83:149–155.
  • Rahmat D, Sakloetsakun D, Shahnaz G, et al. HEC-cysteamine conjugates: influence of degree of thiolation on efflux pump inhibitory and permeation enhancing properties. Int J Pharm. 2012;422:40–46.
  • Radwan MA, AlQuadeib BT, Šiller L, et al. Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats. Drug Deliv. 2017;24:40–50.
  • Wang H, Yu X, Su C, et al. Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells. Artif Cells Nanomed Biotechnol. 2018;9:1–9.
  • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8:958–969.
  • Mukbel RM, Patten C Jr, Gibson K, et al. Macrophage killing of Leishmania amazonensis amastigotes requires both nitric oxide and superoxide. Am J Trop Med Hyg. 2007;76:669–675.
  • Kane MM, Mosser DM. The role of IL-10 in promoting disease progression in leishmaniasis. J Immunol. 2001;166:1141–1147.
  • Forget G, Gregory DJ, Whitcombe LA, et al. Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production. Infect Immun. 2006;74:6272–6279.
  • Fang G, Tang B, Chao Y, et al. Cysteine-functionalized nanostructured lipid carriers for oral delivery of docetaxel: a permeability and pharmacokinetic study. Mol Pharm. 2015;12:2384–2395.
  • Ahmad N, Alam MA, Ahmad R, et al. Preparation and characterization of surface-modified PLGA-polymeric nanoparticles used to target treatment of intestinal cancer. Artif Cells Nanomed Biotechnol. 2017 [cited 2017 May 14]: [15 p.]. DOI:https://doi.org/10.1080/21691401.2017.1324466.
  • Iqbal J, Shahnaz G, Perera G, et al. Thiolated chitosan: development and in vivo evaluation of an oral delivery system for leuprolide. Eur J Pharm Biopharm. 2012;80:95–102.
  • Javed I, Hussain SZ, Ullah I, et al. Synthesis, characterization and evaluation of lecithin-based nanocarriers for the enhanced pharmacological and oral pharmacokinetic profile of amphotericin B. J Mater Chem B. 2015;3:8359–8365.
  • Sarwar HS, Akhtar S, Sohail MF, et al. Redox biology of Leishmania and macrophage targeted nanoparticles for therapy. Nanomedicine. 2017;12:1713–1725.
  • Agbaje E, Adeneye A, Daramola A. Biochemical and toxicological studies of aqueous extract of Syzigium aromaticum (L.) Merr. & Perry (Myrtaceae) in rodents. Afric J Tradit Complement Altern Med. 2009;6:241–254.
  • Ozer J, Ratner M, Shaw M, et al. The current state of serum biomarkers of hepatotoxicity. Toxicology. 2008;245:194–205.
  • Thapa B, Walia A. Liver function tests and their interpretation. Indian J Pediatr. 2007;74:663–671.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.