Controlled formation of polylysinized inner pores in injectable microspheres of low molecular weight poly(lactide-co-glycolide) designed for efficient loading of therapeutic cells

References

• Lee YS, Lim KS, Oh JE, et al. Development of porous PLGA/PEI1.8k biodegradable microspheres for the delivery of mesenchymal stem cells (MSCs). J Control Release. 2015;205:128–133.
   PubMed Web of Science ®Google Scholar
• Li YY, Diao HJ, Chik TK, et al. Delivering mesenchymal stem cells in collagen microsphere carriers to rabbit degenerative disc: reduced risk of osteophyte formation. Tissue Eng A. 2014;20:1379–1391.
   PubMed Web of Science ®Google Scholar
• Bidarra SJ, Barrias CC, Granja PL. Injectable alginate hydrogels for cell delivery in tissue engineering. Acta Biomater. 2014;10:1646–1662.
   PubMed Web of Science ®Google Scholar
• Hamajima S, Hayashi T, Sato Y, et al. Osteoanagenesis after transplantation of bone marrow-derived mesenchymal stem cells using polyvinylidene chloride film as a scaffold. Dent Mater J. 2011;30:707–716.
   PubMed Web of Science ®Google Scholar
• Fang J, Zhang Y, Yan S, et al. Poly(l-glutamic acid)/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration. Acta Biomater. 2014;10:276–288.
   PubMed Web of Science ®Google Scholar
• Liao JF, Wang BY, Huang YX, et al. Injectable alginate hydrogel cross-linked by calcium gluconate loaded porous microspheres for cartilage tissue engineering. ACS Omega. 2017;2:443–454.
   PubMed Web of Science ®Google Scholar
• Qutachi O, Vetsch JR, Gill D, et al. Injectable and porous PLGA microspheres that form highly porous scaffolds at body temperature. Acta Biomater. 2014;10:5090–5098.
   PubMed Web of Science ®Google Scholar
• Newsholme EA, Leech AR. Functional biochemistry in health and disease. Chichester, West Sussex: Wiley-Blackwell; 2009.
   Google Scholar
• Yu M, Zhou KC, Zhang FQ, et al. Porous HA microspheres as drug delivery: effects of porosity and pore structure on drug loading and in vitro release. Ceram Int. 2014;40:12617–12621.
   Web of Science ®Google Scholar
• Baeza A, Ruiz-Molina D, Vallet RM. Recent advances in porous nanoparticles for drug delivery in antitumoral applications: inorganic nanoparticles and nanoscale metal-organic frameworks. Expert Opin Drug Deliv. 2017;14:783–796.
   PubMed Web of Science ®Google Scholar
• Mimura T, Yamagami S, Yokoo S, et al. Cultured human corneal endothelial cell transplantation with a collagen sheet in a rabbit model. Invest Ophthalmol Vis Sci. 2004;45:2992–2997.
   PubMed Web of Science ®Google Scholar
• Shimmura S, Miyashita H, Konomi K, et al. Transplantation of corneal endothelium with Descemet's membrane using a hydroxyethyl methacrylate polymer as a carrier. Br J Ophthalmol. 2005;89:134–137.
   PubMed Web of Science ®Google Scholar
• Mimura T, Yokoo S, Araie M, et al. Treatment of rabbit bullous keratopathy with precursors derived from cultured human corneal endothelium. Invest Ophthalmol Vis Sci. 2005;46:3637–3644.
   PubMed Web of Science ®Google Scholar
• Hsu W-M, Chen K-H, Lai J-Y, et al. Transplantation of human corneal endothelial cells using functional biomaterials: poly(N-isopropylacrylamide) and gelatin. J Exp Clin Med. 2013;5:56–64.
   Google Scholar
• Makadia HK, Siegel SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel). 2011;3:1377–1397.
   PubMed Web of Science ®Google Scholar
• Yassin MA, Leknes KN, Pedersen TO, et al. Cell seeding density is a critical determinant for copolymer scaffolds-induced bone regeneration. J Biomed Mater Res. 2015;103:3649–3658.
   Web of Science ®Google Scholar
• Miura S, Teramura Y, Iwata H. Encapsulation of islets with ultra-thin polyion complex membrane through poly(ethylene glycol)-phospholipids anchored to cell membrane. Biomaterials. 2006;27:5828–5835.
   PubMed Web of Science ®Google Scholar
• Yu WY, Sheridan C, Grierson I, et al. Progenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma. J Biomed Biotechnol. 2011; Article ID 412743.
   Google Scholar
• Kim TK, Yoon JJ, Lee DS, et al. Gas foamed open porous biodegradable polymeric microspheres. Biomaterials. 2006;27:152–159.
   PubMed Web of Science ®Google Scholar
• Bible E, Chau DY, Alexander MR, et al. Attachment of stem cells to scaffold particles for intra-cerebral transplantation. Nat Protoc. 2009;4:1440–1453.
   PubMed Web of Science ®Google Scholar
• Cilurzo F, Selmin F, Minghetti P, et al. Injectability evaluation: an open issue. AAPS PharmSciTech. 2011;12:604–609.
   PubMed Web of Science ®Google Scholar
• Giannola LI, De Caro V, Giandalia G, et al. Ocular gelling microspheres: in vitro precorneal retention time and drug permeation through reconstituted corneal epithelium. J Ocul Pharmacol Ther. 2008;24:186–196.
   PubMed Web of Science ®Google Scholar
• Grotzky A, Manaka Y, Fornera S, et al. Quantification of α-polylysine: a comparison of four UV/vis spectrophotometric methods. Anal Methods. 2010;2:1448–1455.
   Web of Science ®Google Scholar
• Bertram JP, Jay SM, Hynes SR, et al. Functionalized poly(lactic-co-glycolic acid) enhances drug delivery and provides chemical moieties for surface engineering while preserving biocompatibility. Acta Biomater. 2009;5:2860–2871.
   PubMed Web of Science ®Google Scholar
• Yeo Y, Park KN. Control of encapsulation efficiency and initial burst in polymeric microparticle systems. Arch Pharm Res. 2004;27:1–12.
   PubMed Web of Science ®Google Scholar
• Hong Y, Gao C, Shi Y, et al. Preparation of porous polylactide microspheres by emulsion-solvent evaporation based on solution induced phase separation. Polym Adv Technol. 2005;16:622–627.
   Web of Science ®Google Scholar
• Ikem VO, Menner A, Bismarck A. High-porosity macroporous polymers synthesized from titania-particle-stabilized medium and high internal phase emulsions. Langmuir. 2010;26:8836–8841.
   PubMed Web of Science ®Google Scholar
• Seekell RP, Lock AT, Peng YF, et al. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci USA. 2016;113:12380–12385.
   PubMed Web of Science ®Google Scholar
• Sterile hypodermic syringes for single use — Part 1: syringes for manual use. The International Organization for Standardization, ISO 7886-1. Geneva, Switzerland; 2017.
   Google Scholar
• Volodkin D, Ball V, Schaaf P, et al. Complexation of phosphocholine liposomes with polylysine. Stabilization by surface coverage versus aggregation. Biochim Biophys Acta. 2007;1768:280–290.
   PubMed Web of Science ®Google Scholar
• Holmes B, Fang X, Zarate A, et al. Enhanced human bone marrow mesenchymal stem cell chondrogenic differentiation in electrospun constructs with carbon nanomaterials. Carbon. 2016;97:1–13.
   Web of Science ®Google Scholar
• Nilsen-Nygaard J, Strand SP, Varum KM, et al. Chitosan: gels and interfacial properties. Polymers. 2015;7:552–579.
   Web of Science ®Google Scholar
• Doagă IO, Savopol T, Neagu M, et al. The kinetics of cell adhesion to solid scaffolds: an experimental and theoretical approach. J Biol Phys. 2008;34:495–509.
   PubMed Web of Science ®Google Scholar
• Leferink AM, Hendrikson WJ, Rouwkema J, et al. Increased cell seeding efficiency in bioplotted three-dimensional PEOT/PBT scaffolds. J Tissue Eng Regen Med. 2016;10:679–689.
   PubMed Web of Science ®Google Scholar