Core/shell multicellular spheroids on chitosan as in vitro 3D coculture tumor models

References

• Hirschhaeuser F, Menne H, Dittfeld C, et al. Multicellular tumor spheroids: an underestimated tool is catching up again. J Biotechnol. 2010;148:3–15.
   PubMed Web of Science ®Google Scholar
• de la Puente P, Muz B, Gilson RC, et al. 3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma. Biomaterials. 2015;73:70–84.
   PubMed Web of Science ®Google Scholar
• Huang YJ, Hsu SH. Acquisition of epithelial-mesenchymal transition and cancer stem-like phenotypes within chitosan-hyaluronan membrane-derived 3D tumor spheroids. Biomaterials. 2014;35:10070–10079.
   PubMed Web of Science ®Google Scholar
• Mehta G, Hsiao AY, Ingram M, et al. Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. J Control Release. 2012;164:192–204.
   PubMed Web of Science ®Google Scholar
• Eetezadi S, De Souza R, Vythilingam M, et al. Effects of doxorubicin delivery systems and mild hyperthermia on tissue penetration in 3d cell culture models of ovarian cancer residual disease. Mol Pharmaceutics. 2015;12:3973–3985.
   PubMed Web of Science ®Google Scholar
• Foty RA, Steinberg MS. The differential adhesion hypothesis: a direct evaluation. Dev Biol. 2005;278:255–263.
   PubMed Web of Science ®Google Scholar
• Wang K, Kievit FM, Florczyk SJ, et al. 3D porous chitosan-alginate scaffolds as an in vitro model for evaluating nanoparticle-mediated tumor targeting and gene delivery to prostate cancer. Biomacromolecules. 2015;16:3362–3372.
   PubMed Web of Science ®Google Scholar
• Xiong G, Flynn TJ, Chen J, et al. Development of an ex vivo breast cancer lung colonization model utilizing a decellularized lung matrix. Integrative Biology: Quantitative Biosciences from Nano to Macro. 2015;7:1518–1525.
   PubMed Web of Science ®Google Scholar
• Kas HS. Chitosan: properties, preparations and application to microparticulate systems. Journal of Microencapsulation. 1997;14:689–711.
   PubMed Web of Science ®Google Scholar
• Kato Y, Onishi H, Machida Y. Application of chitin and chitosan derivatives in the pharmaceutical field. Cpb. 2003;4:303–309.
   Google Scholar
• Shi C, Zhu Y, Ran X, et al. Therapeutic potential of chitosan and its derivatives in regenerative medicine. J Surg Res. 2006;133:185–192.
   PubMed Web of Science ®Google Scholar
• Archana D, Singh BK, Dutta J, et al. In vivo evaluation of chitosan-PVP-titanium dioxide nanocomposite as wound dressing material. Carbohydrate Polymers. 2013;95:530–539.
   PubMed Web of Science ®Google Scholar
• Peng CC, Yang MH, Chiu WT, et al. Composite nano-titanium oxide-chitosan artificial skin exhibits strong wound-healing effect-an approach with anti-inflammatory and bactericidal kinetics. Macromol Biosci. 2008;8:316–327.
   PubMed Web of Science ®Google Scholar
• Kerch G. The potential of chitosan and its derivatives in prevention and treatment of age-related diseases. Marine Drugs. 2015;13:2158–2182.
   PubMed Web of Science ®Google Scholar
• Tsai CW, Kao YT, Chiang IN, et al. Chitosan treatment delays the induction of senescence in human foreskin fibroblast strains. PloS One. 2015;10:e0140747.
   PubMed Web of Science ®Google Scholar
• Tsai CW, Chiang IN, Wang JH, et al. Chitosan delaying human fibroblast senescence through downregulation of TGF-beta signaling pathway. Artificial Cells, Nanomedicine, and Biotechnology. 2017;1–12.
   PubMed Web of Science ®Google Scholar
• Phung YT, Barbone D, Broaddus VC, et al. Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy. J Cancer. 2011;2:507–514.
   PubMed Web of Science ®Google Scholar
• Zhang W, Choi DS, Nguyen YH, et al. Studying cancer stem cell dynamics on PDMS surfaces for microfluidics device design. Sci Rep. 2013;3:2332.
   PubMed Web of Science ®Google Scholar
• Tsai CW, Young TH. CD44 expression trends of mesenchymal stem-derived cell, cancer cell and fibroblast spheroids on chitosan-coated surfaces. Pure Appl Chem. 2016;88:843–852.
   Web of Science ®Google Scholar
• May JE, Morse HR, Xu J, et al. Development of a novel, physiologically relevant cytotoxicity model: application to the study of chemotherapeutic damage to mesenchymal stromal cells. Toxicology and Applied Pharmacology. 2012;263:374–389.
   PubMed Web of Science ®Google Scholar
• Cheng NC, Wang S, Young TH. The influence of spheroid formation of human adipose-derived stem cells on chitosan films on stemness and differentiation capabilities. Biomaterials. 2012;33:1748–1758.
   PubMed Web of Science ®Google Scholar
• Chen YH, Wang IJ, Young TH. Formation of keratocyte spheroids on chitosan-coated surface can maintain keratocyte phenotypes. Tissue Engineering Part A. 2009;15:2001–2013.
   PubMed Web of Science ®Google Scholar
• Salvatore V, Focaroli S, Teti G, et al. Changes in the gene expression of co-cultured human fibroblast cells and osteosarcoma cells: the role of microenvironment. Oncotarget. 2015;6:28988–28998.
   PubMedGoogle Scholar
• Ji X, Ji J, Shan F, et al. Cancer-associated fibroblasts from NSCLC promote the radioresistance in lung cancer cell lines. International Journal of Clinical and Experimental Medicine. 2015;8:7002–7008.
   PubMed Web of Science ®Google Scholar
• Zhang T, Lee YW, Rui YF, et al. Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. Stem Cell Res Ther. 2013;4:70.
   PubMed Web of Science ®Google Scholar
• Harati K, Daigeler A, Hirsch T, et al. Tumor-associated fibroblasts promote the proliferation and decrease the doxorubicin sensitivity of liposarcoma cells. Int J Mol Med. 2016;37:1535–1541.
   PubMed Web of Science ®Google Scholar
• Shiga K, Hara M, Nagasaki T, et al. Cancer-associated fibroblasts: their characteristics and their roles in tumor growth. Cancers (Basel). 2015;7:2443–2458.
   PubMed Web of Science ®Google Scholar
• Li XY, Hu SQ, Xiao L. The cancer-associated fibroblasts and drug resistance. Eur Rev Med Pharmacol Sci. 2015;19:2112–2119.
   PubMed Web of Science ®Google Scholar
• Lan SF, Starly B. Alginate based 3D hydrogels as an in vitro co-culture model platform for the toxicity screening of new chemical entities. Toxicology and Applied Pharmacology. 2011;256:62–72.
   PubMed Web of Science ®Google Scholar
• Chandrasekaran S, Geng Y, DeLouise LA, et al. Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines. Biomaterials. 2012;33:9037–9048.
   PubMed Web of Science ®Google Scholar
• Phan-Lai V, Florczyk SJ, Kievit FM, et al. Three-dimensional scaffolds to evaluate tumor associated fibroblast-mediated suppression of breast tumor specific T cells. Biomacromolecules. 2013;14:1330.
   PubMed Web of Science ®Google Scholar
• Shang Y, Tamai M, Ishii R, et al. Hybrid sponge comprised of galactosylated chitosan and hyaluronic acid mediates the co-culture of hepatocytes and endothelial cells. J Biosci Bioeng. 2014;117:99–106.
   PubMed Web of Science ®Google Scholar
• Celli JP. Stromal interactions as regulators of tumor growth and therapeutic response: a potential target for photodynamic therapy? Isr J Chem. 2012;52:757–766.
   PubMed Web of Science ®Google Scholar
• Goers L, Freemont P, Polizzi KM. Co-culture systems and technologies: taking synthetic biology to the next level. Journal of the Royal Society, Interface/the Royal Society. 2014;11:20140065.
   PubMed Web of Science ®Google Scholar
• Majety M, Pradel LP, Gies M, et al. Fibroblasts influence survival and therapeutic response in a 3d co-culture model. PloS One. 2015;10:e0127948 Jundoi: ARTN e0127948
   PubMed Web of Science ®Google Scholar
• Knight E, Przyborski S. Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro. J Anat. 2015;227:746–756.
   PubMed Web of Science ®Google Scholar
• Jaganathan H, Gage J, Leonard F, et al. Three-dimensional in vitro co-culture model of breast tumor using magnetic levitation. Sci Rep. 2015;4:000342723900001.6468
   Web of Science ®Google Scholar
• Hsiao AY, Torisawa YS, Tung YC, et al. Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials. 2009;30:3020–3027.
   PubMed Web of Science ®Google Scholar
• Hsiao AY, Tung YC, Qu X, et al. 384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids. Biotechnol Bioeng. 2012;109:1293–1304.
   PubMed Web of Science ®Google Scholar
• Ivanov DP, Parker TL, Walker DA, et al. In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment. Journal of Biotechnology. 2015;205:3–13.
   PubMed Web of Science ®Google Scholar
• Akasov R, Gileva A, Zaytseva-Zotova D, et al. 3D in vitro co-culture models based on normal cells and tumor spheroids formed by cyclic RGD-peptide induced cell self-assembly. Biotechnol Lett. 2017;39:45–53.
   PubMed Web of Science ®Google Scholar
• Tsai CC, Chen CL, Liu HC, et al. Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines. J Biomed Sci. 2010;17:64.
   PubMed Web of Science ®Google Scholar
• Takeichi M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development. 1988;102:639–655.
   PubMed Web of Science ®Google Scholar
• Niessen CM, Leckband D, Yap AS. Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation. Physiol Rev. 2011;91:691–731.
   PubMed Web of Science ®Google Scholar
• Ruoslahti E, Reed JC. Anchorage dependence, integrins, and apoptosis. Cell. 1994;77:477–478.
   PubMed Web of Science ®Google Scholar
• Huang ZJ, Wu TT, Liu AY, et al. Differentiation and transdifferentiation potentials of cancer stem cells. Oncotarget. 2015; Nov 246:39550–39563.
   PubMedGoogle Scholar
• Krishnamurthy S, Nor JE. Head and Neck Cancer Stem Cells. J Dent Res. 2012;91:334–340.
   PubMed Web of Science ®Google Scholar
• Foty RA, Steinberg MS. Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy. Int J Dev Biol. 2004;48:397–409.
   PubMed Web of Science ®Google Scholar
• Duguay D, Foty RA, Steinberg MS. Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants. Dev Biol. 2003;253:309–323.
   PubMed Web of Science ®Google Scholar
• Beysens DA, Forgacs G, Glazier JA. Cell sorting is analogous to phase ordering in fluids. Proceedings of the national academy of sciences of the United States of America; 2000 Aug 15; 9467–71.
   Google Scholar
• Tseng H, Balaoing LR, Grigoryan B, et al. A three-dimensional co-culture model of the aortic valve using magnetic levitation. Acta Biomaterialia. 2014;10:173–182.
   PubMed Web of Science ®Google Scholar
• Derycke LD, Bracke ME. N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. Int J Dev Biol. 2004;48:463–476.
   PubMed Web of Science ®Google Scholar
• Stepniak E, Radice GL, Vasioukhin V. Adhesive and signaling functions of cadherins and catenins in vertebrate development. Cold Spring Harb Perspect Biol. 2009;1:a002949.
   PubMed Web of Science ®Google Scholar
• Halbleib JM, Nelson WJ. Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev. 2006;20:3199–3214.
   PubMed Web of Science ®Google Scholar
• Katsamba P, Carroll K, Ahlsena G, et al. Linking molecular affinity and cellular specificity in cadherin-mediated adhesion. Proceedings of the National Academy of Sciences of the United States of America; 2009 Jul 11594–11599.
   Google Scholar
• Iiizumi M, Liu W, Pai SK, et al. Drug development against metastasis-related genes and their pathways: a rationale for cancer therapy. Biochim Biophys Acta. 2008;1786:87–104.
   PubMed Web of Science ®Google Scholar