Cytoplasmic p27 is a novel prognostic biomarker and oncogenic protein for nasopharyngeal carcinoma

References

• Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13(12):1501–1512.
   PubMed Web of Science ®Google Scholar
• Currier AW, Kolb EA, Gorlick RG, et al. p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma. Sci Rep. 2019;9(1):6161.
   PubMedGoogle Scholar
• Fiedler M, Renner P, Schubert J, et al. Predictive value of FHIT, p27, and pERK1/ERK2 in salivary gland carcinomas: a retrospective study. Clin Oral Invest. 2019;23(10):3801.
   PubMed Web of Science ®Google Scholar
• Toyoshima H, Hunter T. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 1994;78(1):67–74.
   PubMed Web of Science ®Google Scholar
• Denicourt C, Saenz CC, Datnow B, et al. Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res. 2007;67(19):9238–9243.
   PubMed Web of Science ®Google Scholar
• Fillies T, Woltering M, Brandt B, et al. Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas. Oncol Rep. 2007; 17:355.
   PubMed Web of Science ®Google Scholar
• Ahn J, Hong SA, Lee SE, et al. Cytoplasmic localization of Jab1 and p27 Kip1 might be associated with invasiveness of papillary thyroid carcinoma. Endocr J. 2009;56(5):707–713.
   PubMed Web of Science ®Google Scholar
• Wander SA, Zhao D, Slingerland JM. p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies. Clin Cancer Res. 2011;17(1):12–18.
   PubMed Web of Science ®Google Scholar
• Vallonthaiel AG, Singh MK, Dinda AK, et al. Prognostic significance of cytoplasmic p27 in oral squamous cell carcinoma. J Oral Pathol Med. 2016;45(7):475–480.
   PubMed Web of Science ®Google Scholar
• Shin I, Yakes FM, Rojo F, et al. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med. 2002;8(10):1145–1152.
   PubMed Web of Science ®Google Scholar
• Besson A, Gurian-West M, Schmidt A, et al. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev. 2004;18(8):862–876.
   PubMed Web of Science ®Google Scholar
• Song LB, Zeng MS, Liao WT, et al. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res. 2006;66(12):6225–6232.
   PubMed Web of Science ®Google Scholar
• Song LB, Liao WT, Mai HQ, et al. The clinical significance of twist expression in nasopharyngeal carcinoma. Cancer Lett. 2006;242(2):258–265.
   PubMed Web of Science ®Google Scholar
• Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–1474.
   PubMed Web of Science ®Google Scholar
• Remmele W, Stegner HE. Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe. 1987;8(3):138–140.
   PubMed Web of Science ®Google Scholar
• Ihnen M, Kress K, Kersten JF, et al. Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients. BMC Cancer. 2012;12(1):140.
   PubMedGoogle Scholar
• Lim S, Kaldis P. Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development. 2013;140(15):3079–3093.
   PubMed Web of Science ®Google Scholar
• Baba Y, Tsukuda M, Mochimatsu I, et al. Reduced expression of p16 and p27 proteins in nasopharyngeal carcinoma. Cancer Detect Prev. 2001;25(5):414–419.
   PubMedGoogle Scholar
• Hwang CF, Su CY, Huang SC, et al. Low expression levels of p27 correlate with loco-regional recurrence in nasopharyngeal carcinoma. Cancer Lett. 2003;189(2):231–236.
   PubMed Web of Science ®Google Scholar
• Salerno G, Di Vizio D, Staibano S, et al. Prognostic value of p27Kip1 expression in basaloid squamous cell carcinoma of the larynx. BMC Cancer. 2006;6(1):146.
   PubMedGoogle Scholar
• Moreno-Galindo C, Hermsen M, García-Pedrero JM, et al. p27 and BCL2 expression predicts response to chemotherapy in head and neck squamous cell carcinomas. Oral Oncology. 2014;50(2):128–134.
   PubMed Web of Science ®Google Scholar
• Gao L, Gu W, Zheng J, et al. Clinicopathological and prognostic significance of p27 expression in oral squamous cell carcinoma: a meta-analysis. Int J Biol Markers. 2013;28(4):329–335.
   Web of Science ®Google Scholar
• Roy A, Lahiry L, Banerjee D, et al. Increased cytoplasmic localization of p27kip1 and its modulation of RhoA activity during progression of chronic myeloid leukemia. PLoS One. 2013;8(10):e76527.
   PubMed Web of Science ®Google Scholar
• Viglietto G, Motti ML, Bruni P, et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med. 2002;8(10):1136–1144.
   PubMed Web of Science ®Google Scholar
• Shimada M, Kitagawa K, Dobashi Y, et al. High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers. Cancer Sci. 2009;100(5):866–872.
   PubMed Web of Science ®Google Scholar
• Chu S, McDonald T, Bhatia R. Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors. Leukemia. 2010;24(4):779–787.
   PubMed Web of Science ®Google Scholar
• Wu FY, Wang SE, Sanders ME, et al. Reduction of cytosolic p27Kip1 inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res. 2006;66(4):2162–2172.
   PubMed Web of Science ®Google Scholar
• Gu TL, Tothova Z, Scheijen B, et al. NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a. Blood. 2004;103(12):4622–4629.
   PubMed Web of Science ®Google Scholar
• Zhao D, Besser AH, Wander SA, et al. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene. 2015;34(43):5447–5459.
   PubMed Web of Science ®Google Scholar