Inhibition of Wnt signalling pathway by XAV939 enhances radiosensitivity in human cervical cancer HeLa cells

References

• Saei Ghare Naz M, Kariman N, Ebadi A, et al. Educational interventions for cervical cancer screening behavior of women: a systematic review. Asian Pac J Cancer Prev. 2018;19:875–884.
   PubMedGoogle Scholar
• Manzo-Merino J, Contreras-Paredes A, Vazquez-Ulloa E, et al. The role of signaling pathways in cervical cancer and molecular therapeutic targets. Arch Med Res. 2014;45(7):525–539.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhao Y, Wang Y, et al. The role of galectins in cervical cancer biology and progression. Biomed Res Int. 2018;2018:2175927.
   PubMed Web of Science ®Google Scholar
• Di C, Sun C, Li H, et al. Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/DeltaNp73. Cell Cycle. 2015;14(23):3725–3733.
   PubMed Web of Science ®Google Scholar
• Oike T, Niimi A, Okonogi N, et al. Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy. Sci Rep. 2016;6(1):22275.
   PubMed Web of Science ®Google Scholar
• Kubo N, Noda SE, Takahashi A, et al. Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460. J Radiat Res. 2015;56(2):229–238.
   PubMed Web of Science ®Google Scholar
• Jin X, Li F, Zheng X, et al. Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells. Sci Rep. 2015;5(1):13815.
   PubMed Web of Science ®Google Scholar
• Zhang P, Hu X, Liu B, et al. Effects of 12C6+ heavy ion radiation on dendritic cells function. Med Sci Monit. 2018;24:1457–1463.
   PubMed Web of Science ®Google Scholar
• Kamada T, Tsujii H, Blakely EA, et al. Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience. Lancet Oncol. 2015;16(2):e93–e100.
   PubMed Web of Science ®Google Scholar
• Ando K, Kase Y. Biological characteristics of carbon-ion therapy. Int J Radiat Biol. 2009;85(9):715–728.
   PubMed Web of Science ®Google Scholar
• Steitz J, Naumann P, Ulrich S, et al. Worst case optimization for interfractional motion mitigation in carbon ion therapy of pancreatic cancer. Radiat Oncol. 2016;11(1):134.
   PubMed Web of Science ®Google Scholar
• Keta OD, Todorovic DV, Bulat TM, et al. Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. Exp Biol Med (Maywood). 2017;242(10):1015–1024.
   PubMed Web of Science ®Google Scholar
• Glowa C, Peschke P, Brons S, et al. Carbon ion radiotherapy: impact of tumor differentiation on local control in experimental prostate carcinomas. Radiat Oncol. 2017;12(1):174.
   PubMed Web of Science ®Google Scholar
• Zhou C, Rong Y, Konishi T, et al. Effect of carbon-ion radiation on drug transporters organic anion transporting polypeptides in breast cancer cells. Radiat Res. 2017;187(6):689–700.
   PubMed Web of Science ®Google Scholar
• Shiba S, Wakatsuki M, Kato S, et al. Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion. J Radiat Res. 2016;57(6):684–690.
   PubMed Web of Science ®Google Scholar
• Kim EH, Kim MS, Furusawa Y, et al. Metformin enhances the radiosensitivity of human liver cancer cells to ϒ-rays and carbon ion beams. Oncotarget. 2016;7(49):80568–80578.
   PubMedGoogle Scholar
• Vigano L, Capussotti L, De Rosa G, et al. Liver resection for colorectal metastases after chemotherapy: impact of chemotherapy-related liver injuries, pathological tumor response, and micrometastases on long-term survival. Ann Surg. 2013;258:731–740.
   PubMed Web of Science ®Google Scholar
• Ge YX, Wang CH, Hu FY, et al. New advances of TMEM88 in cancer initiation and progression, with special emphasis on Wnt signaling pathway. J Cell Physiol. 2018;233(1):79–87.
   PubMed Web of Science ®Google Scholar
• Jing Q, Li G, Chen X, et al. Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck. J Cell Mol Med. 2019;23(7):4711–4722.
   PubMed Web of Science ®Google Scholar
• Yang G, Shen T, Yi X, et al. Crosstalk between long non-coding RNAs and Wnt/beta-catenin signalling in cancer. J Cell Mol Med. 2018;22(4):2062–2070.
   PubMed Web of Science ®Google Scholar
• Stakheev D, Taborska P, Strizova Z, et al. The WNT/β-catenin signaling inhibitor XAV939 enhances the elimination of LNCaP and PC-3 prostate cancer cells by prostate cancer patient lymphocytes in vitro. Sci Rep. 2019;9(1):4761.
   PubMed Web of Science ®Google Scholar
• Guo W, Shen F, Xiao W, et al. Wnt inhibitor XAV939 suppresses the viability of small cell lung cancer NCI-H446 cells and induces apoptosis. Oncol Lett. 2017;14:6585–6591.
   PubMed Web of Science ®Google Scholar
• Perez-Plasencia C, Duenas-Gonzalez A, Alatorre-Tavera B. Second hit in cervical carcinogenesis process: involvement of Wnt/beta catenin pathway. Int Arch Med. 2008;1(1):10.
   PubMedGoogle Scholar
• Afifi MM, Austin LA, Mackey MA, et al. XAV939: from a small inhibitor to a potent drug bioconjugate when delivered by gold nanoparticles. Bioconjug Chem. 2014;25(2):207–215.
   PubMed Web of Science ®Google Scholar
• Pan F, Shen F, Yang L, et al. Inhibitory effects of XAV939 on the proliferation of small-cell lung cancer H446 cells and Wnt/β-catenin signaling pathway in vitro. Oncol Lett. 2018;16:1953–1958.
   PubMed Web of Science ®Google Scholar
• Mao A, Zhao Q, Zhou X, et al. MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells. Sci Rep. 2016;6(1):27346.
   PubMed Web of Science ®Google Scholar
• Durante M. New challenges in high-energy particle radiobiology. Br J Radiol. 2014;87(1035):20130626.
   PubMed Web of Science ®Google Scholar
• Uren A, Fallen S, Yuan H, et al. Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression. Cancer Res. 2005;65:6199–6206.
   PubMed Web of Science ®Google Scholar
• Bocchicchio S, Tesone M, Irusta G. Convergence of Wnt and Notch signaling controls ovarian cancer cell survival. J Cell Physiol. 2019;234(12):22130–22143.
   PubMed Web of Science ®Google Scholar
• Suebsoonthron J, Jaroonwitchawan T, Yamabhai M, et al. Inhibition of WNT signaling reduces differentiation and induces sensitivity to doxorubicin in human malignant neuroblastoma SH-SY5Y cells. Anticancer Drugs. 2017;28(5):469–479.
   PubMed Web of Science ®Google Scholar
• Ono M, Yin P, Navarro A, et al. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril. 2014;101(5):1441–1449.
   PubMed Web of Science ®Google Scholar
• Ma L, Wang X, Jia T, et al. Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells. Oncotarget. 2015;6(28):25390–25401.
   PubMedGoogle Scholar
• Renna C, Salaroli R, Cocchi C, et al. XAV939-mediated ARTD activity inhibition in human MB cell lines. PLoS One. 2015;10(4):e0124149.
   PubMed Web of Science ®Google Scholar
• Tai D, Wells K, Arcaroli J, et al. Targeting the WNT signaling pathway in cancer therapeutics. Oncologist. 2015;20(10):1189–1198.
   PubMed Web of Science ®Google Scholar
• Krishnamurthy N, Kurzrock R. Targeting the Wnt/β-catenin pathway in cancer: update on effectors and inhibitors. Cancer Treat Rev. 2018;62:50–60.
   PubMed Web of Science ®Google Scholar
• Tortelote GG, Reis RR, de Almeida Mendes F, et al. Complexity of the Wnt/betacatenin pathway: searching for an activation model. Cell Signal. 2017;40:30–43.
   PubMed Web of Science ®Google Scholar
• Tian XH, Hou WJ, Fang Y, et al. XAV939, a tankyrase 1 inhibitor, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway. J Exp Clin Cancer Res. 2013;32(1):100.
   PubMed Web of Science ®Google Scholar
• Hu XY, Hou PF, Li TT, et al. The roles of Wnt/β-catenin signaling pathway related lncRNAs in cancer. Int J Biol Sci. 2018;14(14):2003–2011.
   PubMed Web of Science ®Google Scholar
• Taciak B, Pruszynska I, Kiraga L, et al. Wnt signaling pathway in development and cancer. J Physiol Pharmacol. 2018;69(2):185–196.
   Web of Science ®Google Scholar
• Emons G, Spitzner M, Reineke S, et al. Chemoradiotherapy resistance in colorectal cancer cells is mediated by Wnt/β-catenin signaling. Mol Cancer Res. 2017;15(11):1481–1490.
   PubMed Web of Science ®Google Scholar
• Yamada N, Noguchi S, Mori T, et al. Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells. Cancer Lett. 2013;335(2):332–342.
   PubMed Web of Science ®Google Scholar
• Che Y, Li J, Li Z, et al. Osthole enhances antitumor activity and irradiation sensitivity of cervical cancer cells by suppressing ATM/NF-κB signaling. Oncol Rep. 2018;40:737–747.
   PubMed Web of Science ®Google Scholar
• Ma H, Takahashi A, Yoshida Y, et al. Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells. Radiat Oncol. 2015;10(1):225.
   PubMed Web of Science ®Google Scholar
• Fu HC, Yang YC, Chen YJ, et al. Increased expression of SKP2 is an independent predictor of locoregional recurrence in cervical cancer via promoting DNA-damage response after irradiation. Oncotarget. 2016;7(28):44047–44061.
   PubMedGoogle Scholar
• Wu X, Luo F, Li J, et al. Tankyrase 1 inhibitor XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. Int J Oncol. 2016;48(4):1333–1340.
   PubMed Web of Science ®Google Scholar
• Nie X, Guo E, Wu C, et al. SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway. Cancer Med. 2019;8(4):1779–1792.
   PubMed Web of Science ®Google Scholar