A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium

References

• Malhi GS, Mann JJ. Depression. Lancet. 2018;392(10161):2299–2312.
   PubMed Web of Science ®Google Scholar
• Jakobsen JC, Katakam KK, Schou A, et al. Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and trial sequential analysis. BMC Psychiatry. 2017;17(1):58.
   PubMed Web of Science ®Google Scholar
• Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet. 2018;391(10128):1357–1366.
   PubMed Web of Science ®Google Scholar
• Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John’s wort) in depression: a meta-analysis. J Affect Disord. 2017;210:211–221.
   PubMed Web of Science ®Google Scholar
• Ng QX, Peters C, Ho CYX, et al. A meta-analysis of the use of probiotics to alleviate depressive symptoms. J Affect Disord. 2018;228:13–19.
   PubMed Web of Science ®Google Scholar
• Ukiya M, Akihisa T, Yasukawa K, et al. Constituents of compositae plants. 2. Triterpene diols, triols, and their 3-o-fatty acid esters from edible chrysanthemum flower extract and their anti-inflammatory effects. J Agric Food Chem. 2001;49(7):3187–3197.
   PubMed Web of Science ®Google Scholar
• Yoo KY, Kim IH, Cho JH, et al. Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils. Neural Regen Res. 2016;11(2):270–277.
   PubMed Web of Science ®Google Scholar
• Ng QX, Ramamoorthy K, Loke W, et al. Clinical role of aspirin in mood disorders: a systematic review. Brain Sci. 2019;9(11):296.
   PubMed Web of Science ®Google Scholar
• Achtyes E, Keaton SA, Smart L, et al. Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression. Brain Behav Immun. 2020;83:239–247.
   PubMed Web of Science ®Google Scholar
• Han NR, Moon PD, Ryu KJ, et al. Inhibitory effect of naringenin via IL-13 level regulation on thymic stromal lymphopoietin-induced inflammatory reactions. Clin Exp Pharmacol Physiol. 2018;45(4):362–369.
   PubMed Web of Science ®Google Scholar
• Wojnar W, Zych M, Kaczmarczyk-Sedlak I. Antioxidative effect of flavonoid naringenin in the lenses of type 1 diabetic rats. Biomed Pharmacother. 2014;307:1024–1031.
   Google Scholar
• Cavia-Saiz M, Busto MD, Pilar-Izquierdo MC, et al. Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study. J Sci Food Agric. 2010;90(7):1238–1244.
   PubMed Web of Science ®Google Scholar
• Chandrika BB, Steephan M, Kumar TRS, et al. Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors. Life Sci. 2016;160:47–56.
   PubMed Web of Science ®Google Scholar
• Jia B, Yu D, Yu G, et al. Naringenin improve hepatitis C virus infection induced insulin resistance by increase PTEN expression via p53-dependent manner. Biomed Pharmacother. 2018;103:746–754.
   PubMed Web of Science ®Google Scholar
• Bansal Y, Singh R, Saroj P, et al. Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression. Toxicol Appl Pharmacol. 2018;355:257–268.
   PubMed Web of Science ®Google Scholar
• Kwatra M, Jangra A, Mishra M, et al. Naringin and sertraline ameliorate doxorubicin-induced behavioral deficits through modulation of serotonin level and mitochondrial complexes protection pathway in rat hippocampus. Neurochem Res. 2016;41(9):2352–2366.
   PubMed Web of Science ®Google Scholar
• Li R, Wang X, Qin T, et al. Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain. Behav Brain Res. 2016;296:318–325.
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature. 2008;455(7216):1054–1056.
   PubMed Web of Science ®Google Scholar
• Nicholson JK, Connelly J, Lindon JC, et al. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov. 2002;1(2):153–161.
   PubMed Web of Science ®Google Scholar
• Ong ES, Chor CF, Zou L, et al. A multi-analytical approach for metabolomic profiling of zebrafish (Danio rerio) livers. Mol Biosyst. 2009;5(3):288–298.
   PubMedGoogle Scholar
• Wang P, Ng QX, Zhang H, et al. Metabolite changes behind faster growth and less reproduction of Daphnia similis exposed to low-dose silver nanoparticles. Ecotoxicol Environ Saf. 2018;163:266–273.
   PubMed Web of Science ®Google Scholar
• Sánchez MG, Morissette M, Di Paolo T. Oestradiol modulation of serotonin reuptake transporter and serotonin metabolism in the brain of monkeys. J Neuroendocrinol. 2013;25(6):560–569.
   PubMed Web of Science ®Google Scholar
• Albert PR, Lemonde S. 5-HT1A receptors, gene repression, and depression: guilt by association. Neuroscientist. 2004;10(6):575–593.
   PubMed Web of Science ®Google Scholar
• Myint AM. Kynurenines: from the perspective of major psychiatric disorders. Febs J. 2012;279(8):1375–1385.
   PubMed Web of Science ®Google Scholar
• Ozden A, Angelos H, Feyza A, et al. Altered plasma levels of arginine metabolites in depression. J Psychiatr Res. 2020;120:21–28.
   PubMed Web of Science ®Google Scholar
• Kristiansen RG, Rose CF, Fuskevåg OM, et al. GHS-R1a deficiency alleviates depression-related behaviors after chronic social defeat stress. Front Neurosci. 2019;13:364.
   PubMed Web of Science ®Google Scholar
• Fei L, Xiao-Chun Z, Qing-Mo L. 1-methylhydantoin inhibits secretion of growth hormone in rabbits. Chin Pharmacol Bull. 2017;33:401–406.
   Google Scholar
• Cao X, Li LP, Wang Q, et al. Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med. 2013;19(6):773–777.
   PubMed Web of Science ®Google Scholar
• Whittington HJ, Ostrowski PJ, McAndrew DJ, et al. Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion. Cardiovasc Res. 2018;114(6):858–869.
   PubMed Web of Science ®Google Scholar
• Rosa JM, Pazini FL, Cunha MP, et al. Antidepressant effects of creatine on amyloid β1-40-treated mice: the role of GSK-3β/Nrf2 pathway. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:270–278.
   PubMed Web of Science ®Google Scholar
• Serretti A, Mandelli L, Lattuada E, et al. Depressive syndrome in major psychoses: a study on 1351 subjects. Psychiatry Res. 2004;127(1–2):85–99.
   PubMed Web of Science ®Google Scholar
• Bowtell JL, Marwood S, Bruce M, et al. Tricarboxylic acid cycle intermediate pool size: functional importance for oxidative metabolism in exercising human skeletal muscle. Sports Med. 2007;37(12):1071–1088.
   PubMed Web of Science ®Google Scholar
• Sahlin K, Tonkonogi M, Söderlund K. Energy supply and muscle fatigue in humans. Acta Physiol Scand. 1998;162(3):261–266.
   PubMedGoogle Scholar
• Iqbal M, Ullah S, Zafar S, et al. Effect of exercise interventions on kainate induced status epilepticus and associated co-morbidities; a systematic review and meta-analysis. Neurochem Res. 2019;44(5):1005–1019.
   PubMed Web of Science ®Google Scholar
• Jiménez-Fernández S, Gurpegui M, Díaz-Atienza F, et al. Oxidative stress and antioxidant parameters in patients with major depressive disorder compared to healthy controls before and after antidepressant treatment: results from a meta-analysis. J Clin Psychiatry. 2015;76(12):1658–1667.
   PubMed Web of Science ®Google Scholar
• Quirós PM. Determination of aconitase activity: a substrate of the mitochondrial lon protease. Methods Mol Biol. 2018;1731:49–56.
   PubMedGoogle Scholar
• Vasquez-Vivar J, Kalyanaraman B, Kennedy MC. Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation. J Biol Chem. 2000;275(19):14064–14069.
   PubMed Web of Science ®Google Scholar
• Fricker RA, Green EL, Jenkins SI, et al. The influence of nicotinamide on health and disease in the central nervous system. Int J Tryptophan Res. 2018;11:32–24.
   Web of Science ®Google Scholar
• Gasperi V, Sibilano M, Savini I, et al. Niacin in the central nervous system: an update of biological aspects and clinical applications. IJMS. 2019;20(4):974.
   Web of Science ®Google Scholar
• Weiss N, Mochel F, Rudler M, et al. Peak hyperammonemia and atypical acute liver failure: the eruption of an urea cycle disorder during hyperemesis gravidarum. J Hepatol. 2017; 68: 185–192.
   Web of Science ®Google Scholar
• Kristiansen RG, Rose CF, Fuskevåg OM, et al. L-Ornithine phenylacetate reduces ammonia in pigs with acute liver failure through phenylacetylglycine formation: a novel ammonia-lowering pathway. Am J Physiol Gastrointest Liver Physiol. 2014;307:1024–1031.
   Web of Science ®Google Scholar
• Kasumov T, Brunengraber LL, Comte B, et al. New secondary metabolites of phenylbutyrate in humans and rats. Drug Metab Dispos. 2004;32(1):10–19.
   PubMed Web of Science ®Google Scholar
• Zheng P, Gao HC, Li Q, et al. Plasma metabonomics as a novel diagnostic approach for major depressive disorder. J Proteome Res. 2012;11(3):1741–1748.
   PubMed Web of Science ®Google Scholar
• Machado-Vieira R, Henter ID, Zarate CA. Jr. New targets for rapid antidepressantaction. Prog Neurobiol. 2017;152:21–37.
   PubMed Web of Science ®Google Scholar
• Duman RS, Sanacora G, Krystal JH. Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments. Neuron. 2019;102(1):75–90.
   PubMed Web of Science ®Google Scholar
• Workman JL, Gobinath AR, Kitay NF, et al. Parity modifies the effects of fluoxetine and corticosterone on behavior, stress reactivity, and hippocampal neurogenesis. Neuropharmacology. 2016;105:443–453.
   PubMed Web of Science ®Google Scholar