Lamotrigine loaded PLGA nanoparticles intended for direct nose to brain delivery in epilepsy: pharmacokinetic, pharmacodynamic and scintigraphy study

References

• Gupta S, Kesarla R, Chotai N, et al. Systematic approach for the formulation and optimization of solid lipid nanoparticles of efavirenz by high pressure homogenization using design of experiments for brain targeting and enhanced bioavailability. Biomed Res Int. 2017;2017:1–19.
   Web of Science ®Google Scholar
• Shah P, Sarolia J, Vyas B, et al. PLGA nanoparticles for nose to brain delivery of clonazepam: formulation, optimization by 32 factorial design, in-vitro and in-vivo evaluation. Curr Drug Deliv. 2020;doi: https://doi.org/10.2174/1567201817666200708115627. Epub ahead of print
   Google Scholar
• Singh J, Garg R, Gupta GD. Enhancement of solubility of lamotrigine by solid dispersion and development of orally disintegrating tablets using 32 full factorial design. J Pharm. 2015;2015:828453.
   Google Scholar
• Mishra B, Arya N, Tiwari S. Investigation of formulation variables affecting the properties of lamotrigine nanosuspension using fractional factorial design. DARU. 2010;18(1):1–8.
   PubMed Web of Science ®Google Scholar
• Jafri I, Shoaib MH, Yousuf RI, et al. Effect of permeation enhancers on in vitro release and transdermal delivery of lamotrigine from Eudragit® RS100 polymer matrix-type drug in adhesive patches. Prog Biomater. 2019;8(2):91–100.
   PubMed Web of Science ®Google Scholar
• Ammar HO, Ghorab MM, Mahmoud AA, et al. Lamotrigine loaded poly-ɛ-(d, l-lactide-co-caprolactone) nanoparticles as brain delivery system. Eur J Pharm Sci. 2018;115:77–87.
   PubMed Web of Science ®Google Scholar
• Gulati N, Nagaich U, Saraf S. Intranasal delivery of chitosan nanoparticles for migraine therapy. Sci Pharm. 2013;81(3):843–854.
   PubMedGoogle Scholar
• Al-Ghananeem AM, Saeed H, Florence R, et al. Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses. J Drug Targeting. 2010;18(5):381–388.
   PubMed Web of Science ®Google Scholar
• Joshi A, Patel H, Belgamwar V, et al. Solid lipid nanoparticles of ondansetron HCl for intranasal delivery: development, optimization and evaluation. J Mater Sci Mater Med. 2012;23:2163–2175.
   PubMed Web of Science ®Google Scholar
• Colombo G, Lorenzini L, Zironi E, et al. Brain distribution of ribavirin after intranasal administration. Antiviral Res. 2011;92(3):408–414.
   PubMed Web of Science ®Google Scholar
• Fazil M, Md S, Haque S, et al. Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting. Eur J Pharm Sci. 2012;47(1):6–15.
   PubMed Web of Science ®Google Scholar
• Seju U, Kumar A, Sawant K. Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: in-vitro and in-vivo studies. Acta Biomater. 2011;7(12):4169–4176.
   PubMed Web of Science ®Google Scholar
• Eskandari S, Varshosaz J, Minaiyan M, et al. Brain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: in-vivo pharmacodynamic studies using rat electroshock model. Int J Nanomed. 2011;6:363.
   PubMed Web of Science ®Google Scholar
• Md S, Haque S, Fazil M, et al. Optimized nano-formulation of bromocriptine for direct nose to brain delivery: biodistribution, pharmacokinetic and dopamine estimation by UHPLC/MS method. Expert Opin Drug Deliv. 2014;11(6):827–842.
   PubMed Web of Science ®Google Scholar
• Serralheiro A, Alves G, Fortuna A, et al. Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice. Int J Pharm. 2015;490(1–2):39–46.
   PubMed Web of Science ®Google Scholar
• Shah P, Chavda K, Vyas B, et al. Formulation development of linagliptin solid lipid nanoparticles for oral bioavailability enhancement: role of P-gp inhibition. Drug Deliv Transl Res. 2021;11:1166–1185.
   PubMed Web of Science ®Google Scholar
• Bhattamisra SK, Shak AT, Xi LW, et al. Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson’s disease. Int J Pharm. 2020;579:119148.
   PubMed Web of Science ®Google Scholar
• Haque S, Md S, Sahni JK, et al. Development and evaluation of brain targeted intranasal alginate nanoparticles for treatment of depression. J Psychiatr Res. 2014;48:1–12.
   PubMed Web of Science ®Google Scholar
• Alam T, Pandit J, Vohora D, et al. Optimization of nanostructured lipid carriers of lamotrigine for brain delivery: in-vitro characterization and in-vivo efficacy in epilepsy. Expert Op Drug Deliv. 2015;12(2):181–194.
   PubMed Web of Science ®Google Scholar
• Yu A, Lv J, Yuan F, et al. mPeg-Pla/TPgs mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus. Int J Nanomed. 2017;12:8353–8362.
   PubMed Web of Science ®Google Scholar
• Chaturvedi M, Kumar M, Pathak K. A review on mucoadhesive polymer used in nasal drug delivery system. J Adv Pharm Technol Res. 2011;2(4):215.
   PubMedGoogle Scholar
• Gentile P, Chiono V, Carmagnola I, et al. An overview of poly (lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering. Int J Mol Sci. 2014;15(3):3640–3659.
   PubMed Web of Science ®Google Scholar
• Nigam K, Kaur A, Tyagi A, et al. Nose-to-brain delivery of lamotrigine-loaded PLGA nanoparticles. Drug Deliv Transl Res. 2019;9(5):879–890.
   PubMed Web of Science ®Google Scholar
• Lalani J, Patil S, Kolate A, et al. Protein-functionalized PLGA nanoparticles of lamotrigine for neuropathic pain management. AAPS PharmSciTech. 2015;16(2):413–427.
   PubMed Web of Science ®Google Scholar
• González AG. Optimization of pharmaceutical formulations based on response-surface experimental designs. Int J Pharm. 1993;97(1–3):149–159.
   Web of Science ®Google Scholar
• Dudhipala N, Yadav K. Lipid nanoparticles of zaleplon for improved oral delivery by Box–Behnken design: optimization, in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2017;43(7):1205–1214.
   PubMed Web of Science ®Google Scholar
• Laddha U, Kshirsagar S. Formulation of nanoparticles loaded in situ gel for treatment of dry eye disease: in vitro, ex vivo and in vivo evidences. J Drug Deliv Sci Technol. 2021;61:102112.
   Web of Science ®Google Scholar
• Shirsat M. Development & validation of a stability-indicating HPLC method for analysis of lamotrigine in bulk drug & formulations. Int J Univ Pharm Bio-Sci. 2013;2:334–353.
   Google Scholar
• Ranjan AP, Mukerjee A, Helson L, et al. Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy. J Nanobiotechnol. 2012;10(1):38.
   PubMed Web of Science ®Google Scholar
• Md S, Khan RA, Mustafa G, et al. Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: pharmacodynamic, pharmacokinetic and scintigraphy study in mice model. Eur J Pharm Sci. 2013;48(3):393–405.
   PubMed Web of Science ®Google Scholar
• Keshari P, Sonar Y, Mahajan H. Curcumin loaded TPGS micelles for nose to brain drug delivery: in vitro and in vivo studies. Mater Technol Adv Performance Mater. 2019;34(7):423–432.
   Google Scholar
• Chalikwar S, Belgamwar V, Talele V, et al. Formulation and evaluation of nimodipine-loaded solid lipid nanoparticles delivered via lymphatic transport system. Colloids Surf, B. 2012;97:109–116.
   PubMed Web of Science ®Google Scholar
• Lalani J, Raichandani Y, Mathur R, et al. Comparative receptor based brain delivery of tramadol-loaded poly (lactic-co-glycolic acid) nanoparticles. J Biomed Nanotechnol. 2012;8(6):918–927.
   PubMed Web of Science ®Google Scholar
• Parhizkar M, Reardon PJ, Knowles JC, et al. Electrohydrodynamic encapsulation of cisplatin in poly (lactic-co-glycolic acid) nanoparticles for controlled drug delivery. Nanomed Nanotechnol Biol Med. 2016;12(7):1919–1929.
   PubMed Web of Science ®Google Scholar
• Ethirajan A, Ziener U, Landfester K. Surface-functionalized polymeric nanoparticles as templates for biomimetic mineralization of hydroxyapatite. Chem Mater. 2009;21(11):2218–2225.
   Web of Science ®Google Scholar
• Zhao W, Huang J, Fang B, et al. Modification of polyethersulfone membrane by blending semi-interpenetrating network polymeric nanoparticles. J Membr Sci. 2011;369(1–2):258–266.
   Web of Science ®Google Scholar
• Sallam MA, Helal HM, Mortada SM. Rationally designed nanocarriers for intranasaltherapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition. Int J Nanomed. 2016;25(11):2345–2357.
   Web of Science ®Google Scholar
• Saha GB, Go RT, MacIntyre WJ. Radiopharmaceucticals for cardiovascular imaging. Int J Radiat Appl Instrum Part B. 1992;19(1):1–20.
   PubMedGoogle Scholar
• Sharma D, Sharma RK, Sharma N, et al. Nose-to-brain delivery of PLGA-diazepam nanoparticles. AAPS PharmSciTech. 2015;16(5):1108–1121.
   PubMed Web of Science ®Google Scholar
• Patel S, Chavhan S, Soni H, et al. Brain targeting of risperidone-loaded solid lipid nanoparticles by intranasal route. J Drug Target. 2011;19(6):468–474.
   PubMed Web of Science ®Google Scholar
• Singh A, Saraf SK, Saraf SA. SLN approach for nose-to-brain delivery of alprazolam. Drug Deliv Transl Res. 2012;2(6):498–507.
   PubMed Web of Science ®Google Scholar
• Swarnakar N, Jain A, Singh R, et al. Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. Biomaterials. 2011;32(28):6860–6874.
   PubMed Web of Science ®Google Scholar
• Pathak R, Dash RP, Misra M, et al. Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route. Acta Pharmaceutica Sinica B. 2014;4(2):151–160.
   PubMed Web of Science ®Google Scholar
• Jia L-J, Zhang D-R, Li Z-Y, et al. Preparation and characterization of silybin-loaded nanostructured lipid carriers. Drug Deliv. 2010;17(1):11–18.
   PubMed Web of Science ®Google Scholar
• Jia L, Shen J, Li Z, et al. In-vitro and in-vivo evaluation of paclitaxel-loaded mesoporous silica nanoparticles with three pore sizes. Int J Pharm. 2013;445(1–2):12–19.
   PubMed Web of Science ®Google Scholar
• Singhvi G, Singh M. In-vitro drug release characterization models. Int J Pharm Stud Res. 2011;2(1):77–84.
   Google Scholar
• Kim D-H, Martin DC. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials. 2006;27(15):3031–3037.
   PubMed Web of Science ®Google Scholar
• Pangeni R, Sharma S, Mustafa G, et al. Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson’s disease by reducing oxidative stress. Nanotechnology. 2014;25(48):485102.
   PubMed Web of Science ®Google Scholar
• Lakshmi PK, Sridhar M, Shruthi B. Comparative evaluation of single and bilayered lamotrigine floating tablets. Int J Pharma Investig. 2013;3(3):157.
   PubMedGoogle Scholar
• Saxena V, Hussain MD. Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer. Int J Nanomed. 2012;7:713.
   PubMed Web of Science ®Google Scholar
• Pollard J, Rajabi‐Siahboomi A, Badhan RK, et al. High‐throughput screening of excipients with a biological effect: a kinetic study on the effects of surfactants on efflux‐mediated transport. J Pharm Pharmacol. 2019;71(6):889–897.
   PubMed Web of Science ®Google Scholar
• Kiruba F, Lalan M, Babbar A, et al. Intranasal clobazam delivery in the treatment of status epilepticus. J Pharm Sci. 2011;100(2):692–703.
   PubMed Web of Science ®Google Scholar
• Kumar M, Misra A, Babbar AK, et al. Intranasal nanoemulsion based brain targeting drug delivery system of risperidone. Int J Pharm. 2008;358(1–2):285–291.
   PubMed Web of Science ®Google Scholar