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Research Article

Anticancer potentials of metformin loaded coconut oil nanoemulsion on MCF-7, HepG2 and HCT-116 cell lines

, , , , , , , , & ORCID Icon show all
Pages 419-427 | Received 21 Feb 2023, Accepted 02 Aug 2023, Published online: 17 Aug 2023

References

  • Siegel RL, Miller KD, Wagle NS, et al. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48. doi: 10.3322/caac.21763.
  • Emam SE, Ando H, Lila ASA, et al. Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways. Sci Rep. 2018;8(1):14493. doi: 10.1038/s41598-018-32861-w.
  • Chaitanya TS, Patil SN, Ghosh S, et al. Chapter 18 - Cross-presentation-based nanovaccine for cancer immunotherapy. In: rahman M, Beg S, Almalki WH, Alhakamy NA, Choudhry H, editors. Nanotherapeutics in cancer vaccination and challenges. Academic Press, Amsterdam; 2022. p. 349–396.
  • Schiliro C, Firestein BL. Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation. Cells. 2021;10(5), 1056) doi: 10.3390/cells10051056.
  • Lila AS, Kiwada H, Ishida T. Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances overall therapeutic efficacy of the encapsulated oxaliplatin. Biol Pharm Bull. 2014;37(2):206–211. doi: 10.1248/bpb.b13-00540.
  • Bailey CJ. Metformin: historical overview. Diabetologia. 2017;60(9):1566–1576. doi: 10.1007/s00125-017-4318-z.
  • Mathur R, Alexander CJ, Yano J, et al. Use of metformin in polycystic ovary syndrome. Am J Obstet Gynecol. 2008;199(6):596–609. doi: 10.1016/j.ajog.2008.09.010.
  • Mokhtar FA, Selim NM, Elhawary SS, et al. Green biosynthesis of silver nanoparticles using annona glabra and annona squamosa extracts with antimicrobial, anticancer, apoptosis potentials, assisted by in silico modeling, and metabolic profiling. Pharmaceuticals. 2022;15(11), 1354. doi: 10.3390/ph15111354.
  • Liu J, Aylor KW, Chai W, et al. Metformin prevents endothelial oxidative stress and microvascular insulin resistance during obesity development in male rats. Am J Physiol Endocrinol Metab. 2022;322(3):E293–E306. doi: 10.1152/ajpendo.00240.2021.
  • Abd-Rabou AA, Abdelaziz AM, Shaker OG, et al. Metformin-loaded lecithin nanoparticles induce colorectal cancer cytotoxicity via epigenetic modulation of noncoding RNAs. Mol Biol Rep. 2021;48(10):6805–6820. doi: 10.1007/s11033-021-06680-8.
  • Morales DR, Morris AD. Metformin in cancer treatment and prevention. Annu Rev Med. 2015;66:17–29. doi: 10.1146/annurev-med-062613-093128.
  • Cheung YM, Hughes M, Harrod J, et al. The effects of diabetes and glycemic control on cancer outcomes in individuals with metastatic breast cancer. J Clin Endocrinol Metab. 2022;107(9):2511–2521. doi: 10.1210/clinem/dgac375.
  • Scully T, Ettela A, LeRoith D, et al. Obesity, type 2 diabetes, and cancer risk. Front Oncol. 2020;10:615375. doi: 10.3389/fonc.2020.615375.
  • Gandini S, Puntoni M, Heckman-Stoddard BM, et al. Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders. Cancer Prev Res. 2014;7(9):867–885. doi: 10.1158/1940-6207.CAPR-13-0424.
  • Chae YK, Arya A, Malecek MK, et al. Repurposing metformin for cancer treatment: current clinical studies. Oncotarget. 2016;7(26):40767–40780. doi: 10.18632/oncotarget.8194.
  • Rao M, Gao C, Guo M, et al. Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis. Cancer Manag Res. 2018;10:4881–4890. doi: 10.2147/CMAR.S174535.
  • Marina AM, Che Man YB, Amin I. Virgin coconut oil: emerging functional food oil. Trends Food Sci Technol. 2009;20(10):481–487. doi: 10.1016/j.tifs.2009.06.003.
  • Verma P, Naik S, Nanda P, et al. In vitro anticancer activity of virgin coconut oil and its fractions in liver and oral cancer cells. Anticancer Agents Med Chem. 2019;19(18):2223–2230. doi: 10.2174/1871520619666191021160752.
  • Sonneville-Aubrun O, Simonnet JT, L'Alloret F. Nanoemulsions: a new vehicle for skincare products. Adv Colloid Interface Sci. 2004;108-109:145–149. doi: 10.1016/j.cis.2003.10.026.
  • Rai VK, Mishra N, Yadav KS, et al. Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: formulation development, stability issues, basic considerations and applications. J Control Release. 2018;270:203–225. doi: 10.1016/j.jconrel.2017.11.049.
  • Sánchez-López E, Guerra M, Dias-Ferreira J, et al. Current applications of nanoemulsions in cancer therapeutics. Nanomaterials. 2019;9(6):821. doi: 10.3390/nano9060821.
  • Abdallah MH, Abu Lila AS, Unissa R, et al. Preparation, characterization and evaluation of anti-inflammatory and anti-nociceptive effects of brucine-loaded nanoemulgel. Colloids Surf B Biointerfaces. 2021;205:111868. doi: 10.1016/j.colsurfb.2021.111868.
  • Vichai V, Kirtikara K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc. 2006;1(3):1112–1116. doi: 10.1038/nprot.2006.179.
  • Houghton P, Fang R, Techatanawat I, et al. The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity. Methods. 2007;42(4):377–387. doi: 10.1016/j.ymeth.2007.01.003.
  • Nunez R. DNA measurement and cell cycle analysis by flow cytometry. Curr Issues Mol Biol. 2001;3:67–70.
  • Moin A, Wani SUD, Osmani RA, et al. Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer. Drug Deliv. 2021;28(1):1626–1636. doi: 10.1080/10717544.2021.1958106.
  • Alkhatib MH, Alyamani SA, Abdu F. Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress. Drug Deliv. 2020;27(1):422–430. doi: 10.1080/10717544.2020.1736209.
  • Choudhury H, Pandey M, Gorain B, et al. Chapter 9 - Nanoemulsions as effective carriers for the treatment of lung cancer. In: Kesharwani P, editor. Nanotechnology-based targeted drug delivery systems for lung. Cancer: Academic Press; 2019. p. 217–247.
  • Cheng Z, Li M, Dey R, et al. Nanomaterials for cancer therapy: current progress and perspectives. J Hematol Oncol. 2021;14(1):85. doi: 10.1186/s13045-021-01096-0.
  • Al Saqr A, Khafagy ES, Aldawsari MF, et al. Screening of apoptosis pathway-mediated anti-proliferative activity of the phytochemical compound furanodienone against human non-small lung cancer A-549 cells. Life. 2022;12(1), 114. doi: 10.3390/life12010114.
  • Li B, Zhou P, Xu K, et al. Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma. Int J Biol Sci. 2020;16(1):74–84. doi: 10.7150/ijbs.33787.