Niosomes gel of apigenin to improve the topical delivery: development, optimization, ex vivo permeation, antioxidant study, and in vivo evaluation

References

• Chandrasekara A, Shahidi F. Herbal beverages: bioactive compounds and their role in disease risk reduction - A review. J Tradit Complement Med. 2018;8(4):451–458. doi: 10.1016/j.jtcme.2017.08.006.
   PubMedGoogle Scholar
• Shukla S, Gupta S. Apigenin: a promising molecule for cancer prevention. Pharm Res. 2010;27(6):962–978. doi: 10.1007/s11095-010-0089-7.
   PubMed Web of Science ®Google Scholar
• Imam SS, Alshehri S, Altamimi MA, et al. Formulation of chitosan-coated apigenin bilosomes: in vitro characterization, antimicrobial and cytotoxicity assessment. Polymers (Basel). 2022;14(5):921. doi: 10.3390/polym14050921.
   PubMed Web of Science ®Google Scholar
• Telange DR, Patil AT, Pethe AM, et al. Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential. Eur J Pharm Sci. 2017;108:36–49. doi: 10.1016/j.ejps.2016.12.009.
   PubMed Web of Science ®Google Scholar
• Yan X, Qi M, Li P, et al. Apigenin in cancer therapy: anti-cancer effects and mechanisms of action. Cell Biosci. 2017;7(1):50. doi: 10.1186/s13578-017-0179-x.
   PubMed Web of Science ®Google Scholar
• Hong S, Dia VP, Zhong Q. Synergistic anti-inflammatory activity of apigenin and curcumin co-encapsulated in caseins assessed with lipopolysaccharide-stimulated RAW 264.7 macrophages. Int J Biol Macromol. 2021;193(Pt A):702–712. doi: 10.1016/j.ijbiomac.2021.10.153.
   PubMedGoogle Scholar
• Jiang J, Tang T, Peng Y, et al. Research progress on antidiabetic activity of apigenin derivatives. Med Chem Res. 2022;31(11):1831–1841. doi: 10.1007/s00044-022-02933-8.
   Web of Science ®Google Scholar
• Zhang J, Liu D, Huang Y, et al. Biopharmaceutics classification and intestinal absorption study of apigenin. Int J Pharm. 2012;436(1-2):311–317. 2012doi: 10.1016/j.ijpharm.2012.07.002.
   PubMedGoogle Scholar
• Griffiths LA, Smith GE. Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro. Biochem J. 1972;128(4):901–911. doi: 10.1042/bj1280901.
   PubMed Web of Science ®Google Scholar
• Chen Z, Kong S, Song F, et al. Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of flos chrysanthemi in rats. Fitoterapia. 2012;83(8):1616–1622. doi: 10.1016/j.fitote.2012.09.011.
   PubMed Web of Science ®Google Scholar
• Ranade VV. Drug delivery systems. 6. Transdermal drug delivery. J Clin Pharmacol. 1991;31(5):401–418. doi: 10.1002/j.1552-4604.1991.tb01895.x.
   PubMed Web of Science ®Google Scholar
• El Menshawe SF, Aboud HM, Elkomy MH, et al. A novel nanogel loaded with chitosan decorated bilosomes for transdermal delivery of terbutaline sulfate: artificial neural network optimization, in vitro characterization and in vivo evaluation. Drug Deliv Transl Res. 2020;10(2):471–485. doi: 10.1007/s13346-019-00688-1.
   PubMed Web of Science ®Google Scholar
• Ananth P, Koland M. Topical delivery of fenugreek seed extract loaded solid lipid nanoparticles based hydrogels for alopecia. JPRI. 2021;202133(40A):231–241. doi: 10.9734/jpri/2021/v33i40A32239.
   Google Scholar
• Altamimi MA, Hussain A, Alshehri S, et al. Development and evaluations of transdermally delivered luteolin loaded cationic nanoemulsion: in vitro and ex vivo evaluations. Pharmaceutics. 2021;13(8):1218. doi: 10.3390/pharmaceutics13081218.
   PubMed Web of Science ®Google Scholar
• Okonogi S, Riangjanapatee P. Physicochemical characterization of lycopene-loaded nanostructured lipid carrier formulations for topical administration. Int J Pharm. 2015;478(2):726–735. doi: 10.1016/j.ijpharm.2014.12.002.
   PubMed Web of Science ®Google Scholar
• Mitri K, Shegokar R, Gohla S, et al. Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance. Int J Pharm. 2011;414(1-2):267–275. doi: 10.1016/j.ijpharm.2011.05.008.
   PubMed Web of Science ®Google Scholar
• El-Ridy MS, Yehia SA, Mohsen AM, et al. Formulation of niosomal gel for enhanced transdermal lornoxicam delivery: in-Vitro and in-Vivo evaluation. Curr Drug Deliv. 2018;15(1):122–133.
   PubMed Web of Science ®Google Scholar
• He W, Guo X, Xiao L, et al. Study on the mechanisms of chitosan and its derivatives used as transdermal penetration enhancers. Int J Pharm. 2009;382(1-2):234–243. doi: 10.1016/j.ijpharm.2009.07.038.
   PubMed Web of Science ®Google Scholar
• Thanou M, Verhoef JC, Junginger HE. Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Deliv Rev. 2001;50(Suppl 1)(1):S91–S101. doi: 10.1016/s0169-409x(01)00180-6.
   PubMed Web of Science ®Google Scholar
• Nagarwal RC, Singh PN, Kant S, et al. Chitosan coated PLA nanoparticles for ophthalmic delivery: characterization, in-vitro and in-vivo study in rabbit eye. J Biomed Nanotechnol. 2010;6(6):648–657. doi: 10.1166/jbn.2010.1168.
   PubMed Web of Science ®Google Scholar
• Beg S, Hasnain MS, Rahman M, et al. Introduction to quality by design (QbD): fundamentals, principles, and applications. Elsevier: Amsterdam, the Netherlands, 2019; ISBN 9780128157992.
   Google Scholar
• Zafar A, Awad Alsaidan O, Alruwaili NK, et al. Formulation of intranasal surface engineered nanostructured lipid carriers of rotigotine: full factorial design optimization, in vitro characterization, and pharmacokinetic evaluation. Int J Pharm. 2022;627:122232. doi: 10.1016/j.ijpharm.2022.122232.
   PubMedGoogle Scholar
• Yadav P, Rastogi V, Verma A. Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe. Futur J Pharm Sci. 2020;6(1):7. doi: 10.1186/s43094-020-00023-3.
   Web of Science ®Google Scholar
• Manca ML, Manconi M, Nacher A, et al. Development of novel diolein-niosomes for cutaneous delivery of tretinoin: influence of formulation and in vitro assessment. Int J Pharm. 2014;477(1-2):176–186. doi: 10.1016/j.ijpharm.2014.10.031.
   PubMedGoogle Scholar
• Bhalekar MR, Padher S, Ladkat S. Paranjape evaluation of carboxymethyl xyloglucan as SPF booster in oxybenzone cream. International Journal of Applied Research. 2017;3(5):813–816.
   Google Scholar
• Shen PT, Chiu SW, Chang JY, et al. Formation and characterization of hydrogenated soybean lecithin/TPGS nano-dispersions as a potential carrier for active herbal agents. Colloids Surf. A Physicochem. Eng. Aspects. 2021;611:125796. doi: 10.1016/j.colsurfa.2020.125796.
   Web of Science ®Google Scholar
• Sadraei H, Asghari G, Khanabadi M, et al. Anti-inflammatory effect of apigenin and hydroalcoholic extract of dracocephalum kotschyi on acetic acid-induced colitis in rats. Res Pharm Sci. 2017;12(4):322–329. doi: 10.4103/1735-5362.212050.
   PubMedGoogle Scholar
• Sarigullu Ozguney I, Yeşim Karasulu H, Kantarci G, et al. Transdermal delivery of diclofenac sodium through rat skin from various formulations. AAPS PharmSciTech. 2006;7(4):88. 20doi: 10.1208/pt070488.
   PubMed Web of Science ®Google Scholar
• Lee SC, Lee KE, Kim JJ, et al. The effect of cholesterol in the liposome bilayer on the stabilization of incorporated retinol. J Liposome Res. 2005;15(3-4):157–166. doi: 10.1080/08982100500364131.
   PubMed Web of Science ®Google Scholar
• Moghddam SR, Ahad A, Aqil M, et al. Formulation and optimization of niosomes for topical diacerein delivery using 3-factor, 3-level Box-Behnken design for the management of psoriasis. Mater Sci Eng C Mater Biol Appl. 2016;69:789–797. doi: 10.1016/j.msec.2016.07.043.
   PubMed Web of Science ®Google Scholar
• Akbari V, Abedi D, Pardakhty A, et al. Release studies on ciprofloxacin loaded non-ionic surfactant vesicles. Avicenna J Med Biotechnol. 2015; Apr-Jun7(2):69–75.
   PubMedGoogle Scholar
• Wagh VD, Deshmukh OJ. Itraconazole niosomes drug delivery system and its antimycotic activity against Candida albicans. ISRN Pharm. 2012;2012:653465. doi: 10.5402/2012/653465.
   PubMedGoogle Scholar
• Alhalmi A, Amin S, Khan Z, et al. Nanostructured lipid Carrier-Based codelivery of raloxifene and naringin: formulation, optimization, in vitro, ex vivo, in vivo assessment, and acute toxicity studies. Pharmaceutics. 2022;14(9):1771. doi: 10.3390/pharmaceutics14091771.
   PubMed Web of Science ®Google Scholar
• Huang Y, Zu Y, Zhao X, et al. Preparation of inclusion complex of apigenin-hydroxypropyl-β-cyclodextrin by using supercritical antisolvent process for dissolution and bioavailability enhancement. Int J Pharm. 2016;511(2):921–930. doi: 10.1016/j.ijpharm.2016.08.007.
   PubMed Web of Science ®Google Scholar
• Khan MI, Madni A, Hirvonen J, et al. Ultrasonic processing technique as a green preparation approach for Diacerein-Loaded niosomes. AAPS PharmSciTech. 2017;18(5):1554–1563. doi: 10.1208/s12249-016-0622-z.
   PubMed Web of Science ®Google Scholar
• Khan DH, Bashir S, Khan MI, et al. Formulation optimization and in vitro characterization of rifampicin and ceftriaxone dual drug-loaded niosomes with high energy probe sonication technique. J Drug Delivery Sci Technol. 2020;58:101763. doi: 10.1016/j.jddst.2020.101763.
   Web of Science ®Google Scholar
• Shilakari Asthana G, Asthana A, Singh D, et al. Etodolac containing topical niosomal gel: formulation development and evaluation. J Drug Deliv. 2016;2016:9324567–9324568. doi: 10.1155/2016/9324567.
   PubMed Web of Science ®Google Scholar
• Negi P, Aggarwal M, Sharma G, et al. Niosome-based hydrogel of resveratrol for topical applications: an effective therapy for pain related disorder(s). Biomed Pharmacother. 2017;88:480–487. doi: 10.1016/j.biopha.2017.01.083.
   PubMed Web of Science ®Google Scholar
• Fetih G. Fluconazole-loaded niosomal gels as a topical ocular drug delivery system for corneal fungal infections. J Drug Delivery Sci Technol. 2016;35:8–15. doi: 10.1016/j.jddst.2016.06.002.
   Web of Science ®Google Scholar
• Qumbar M, Ameeduzzafar , Imam SS, Ali J, Ahmad J, Ali A. Formulation and optimization of lacidipine loaded niosomal gel for transdermal delivery: in-vitro characterization and in-vivo activity.Biomed Pharmacother. 2017; 93:255–266. doi: 10.1016/j.biopha.2017.06.043.
   PubMed Web of Science ®Google Scholar
• ZaidAlkilani A, Hamed R, Abdo H, et al. Formulation and evaluation of Azithromycin-Loaded niosomal gel: optimization, in vitro studies, rheological characterization, and cytotoxicity study. ACS Omega. 2022;7(44):39782–39793. doi: 10.1021/acsomega.2c03762.
   PubMedGoogle Scholar
• Qushawy M, Nasr A, Abd-Alhaseeb M, et al. Design. Optimization and characterization of a transfersomal gel using miconazole nitrate for the treatment of candida skin infections. Pharmaceutics. 2018;10(1):26. doi: 10.3390/pharmaceutics10010026.
   PubMed Web of Science ®Google Scholar
• Shah HS, Gotecha A, Jetha D, et al. Gamma oryzanol niosomal gel for skin cancer: formulation and optimization using quality by design (QbD) approach. AAPS Open. 2021;7(1):9. 2021). doi: 10.1186/s41120-021-00041-2.
   Google Scholar
• Imam SS, Alshehri S, Altamimi MA, et al. Formulation and evaluation of Luteolin-Loaded nanovesicles: in vitro physicochemical characterization and viability assessment. ACS Omega. 2022;7(1):1048–1056. doi: 10.1021/acsomega.1c05628.
   PubMed Web of Science ®Google Scholar
• Elsewedy HS, Younis NS, Shehata TM, et al. Enhancement of anti-Inflammatory activity of optimized niosomal colchicine loaded into jojoba Oil-Based emulgel using response surface methodology. Gels. 2021;202; 8(1):16. doi: 10.3390/gels8010016.
   PubMed Web of Science ®Google Scholar