Advanced search
Publication Cover
Emerging Microbes & Infections Volume 8, 2019 - Issue 1
Submit an article Journal homepage
1,996
Views
6
CrossRef citations to date
0
Altmetric
Letters

Housecleaning of pyrimidine nucleotide pool coordinates metabolic adaptation of nongrowing Mycobacterium tuberculosis

Kun-Xiong Shia Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Yong-Kai Wua Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China;b Department of Microbiology, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaView further author information
,
Bi-Kui Tangc Department of Life Science, Bengbu Medical College, Bengbu, People’s Republic of ChinaView further author information
,
Guo-Ping Zhaob Department of Microbiology, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China;d Department of Microbiology and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong, People’s Republic of China;e CAS-Key Laboratory of Synthetic Biology, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4691-3257View further author information
ORCID Icon &
Liang-Dong Lyua Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6391-6030View further author information
ORCID Icon
Pages 40-44 | Received 21 Oct 2018, Accepted 03 Dec 2018, Published online: 16 Jan 2019

References

  • Ehrt S, Schnappinger D, Rhee KY. Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis. Nat Rev Microbiol. 2018;16:496–507. doi: 10.1038/s41579-018-0013-4
  • Boshoff HI, Barry CE. 3rd Tuberculosis - metabolism and respiration in the absence of growth. Nat Rev Microbiol. 2005;3:70–80. doi: 10.1038/nrmicro1065
  • Fan XY, Tang BK, Xu YY, et al. Oxidation of dCTP contributes to antibiotic lethality in stationary-phase mycobacteria. Proc Natl Acad Sci U S A. 2018;115:2210–2215. doi: 10.1073/pnas.1719627115
  • Lyu LD, Tang BK, Fan XY, et al. Mycobacterial MazG safeguards genetic stability via housecleaning of 5-OH-dCTP. PLoS Pathog. 2013;9:e1003814. doi: 10.1371/journal.ppat.1003814
  • Baek SH, Li AH, Sassetti CM. Metabolic regulation of mycobacterial growth and antibiotic sensitivity. PLoS Biol. 2011;9:e1001065. doi: 10.1371/journal.pbio.1001065
  • Manina G, Dhar N, McKinney JD. Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms. Cell Host Microbe. 2015;17:32–46. doi: 10.1016/j.chom.2014.11.016
  • Boshoff HI, Reed MB, Barry CE, et al. Dnae2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis. Cell. 2003;113:183–193. doi: 10.1016/S0092-8674(03)00270-8
  • Peters JE, Craig NL. Tn7 transposes proximal to DNA double-strand breaks and into regions where chromosomal DNA replication terminates. Mol Cell. 2000;6:573–582. doi: 10.1016/S1097-2765(00)00056-3
  • Griffin JE, Gawronski JD, Dejesus MA, et al. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog. 2011;7:e1002251. doi: 10.1371/journal.ppat.1002251
  • Fields CJ, Switzer RL. Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression. J Bacteriol. 2007;189:6236–6245. doi: 10.1128/JB.00803-07
  • Lee W, VanderVen BC, Fahey RJ, et al. Intracellular Mycobacterium tuberculosis exploits host-derived fatty acids to limit metabolic stress. J Biol Chem. 2013;288:6788–6800. doi: 10.1074/jbc.M112.445056
  • Kana BD, Gordhan BG, Downing KJ, et al. The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro. Mol Microbiol. 2008;67:672–684. doi: 10.1111/j.1365-2958.2007.06078.x
  • Eoh H, Wang Z, Layre E, et al. Metabolic anticipation in Mycobacterium tuberculosis. Nat Microbiol. 2017;2:Article no. 17084. doi: 10.1038/nmicrobiol.2017.84
  • Casonato S, Cervantes Sánchez A, Haruki H, et al. Whib5, a transcriptional regulator that contributes to Mycobacterium tuberculosis virulence and reactivation. Infect Immun. 2012;80:3132–3144. doi: 10.1128/IAI.06328-11
  • Watanabe S, Zimmermann M, Goodwin MB, et al. Fumarate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis. PLoS Pathog. 2011;7:e1002287. doi: 10.1371/journal.ppat.1002287

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.