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Original Articles

Subinhibitory concentrations of Honokiol reduce α-Hemolysin (Hla) secretion by Staphylococcus aureus and the Hla-induced inflammatory response by inactivating the NLRP3 inflammasome

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Pages 707-716 | Received 24 Jan 2019, Accepted 08 May 2019, Published online: 23 May 2019

References

  • Xiao M, Zhao R, Zhang Q, et al. Genotypic diversity of staphylococcus aureus α-hemolysin gene (hla) and its association with clonal background: implications for vaccine development. PLoS ONE. 2016;11:e0149112. doi: 10.1371/journal.pone.0149112
  • Rodvold KA, McConeghy KW. Methicillin-resistant staphylococcus aureus therapy: past, present, and future. Clin Infect Dis. 2014;58:S20–S27. doi: 10.1093/cid/cit614
  • Kong C, Neoh H, Nathan S. Targeting staphylococcus aureus toxins: a potential form of anti-virulence therapy. Toxins. 2016;8:72. doi: 10.3390/toxins8030072
  • Schlievert PM, Dinges MM, Orwin PM. Exotoxins of Staphylococcus aureus. Clin Microbiol Rev. 2000;13:16–34. doi: 10.1128/CMR.13.1.16
  • Dinges MM, Orwin PM, Schlievert PM. Exotoxins of staphylococcus aureus. Clin Microbiol Rev. 2000;13:16–34. doi: 10.1128/CMR.13.1.16
  • Bubeck Wardenburg J, Patel RJ, Schneewind O. Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun. 2007;75:1040–1044. doi: 10.1128/IAI.01313-06
  • McGilligan VE, Gregory-Ksander MS, Li D, et al. Staphylococcus aureus activates the NLRP3 inflammasome in human and rat conjunctival goblet cells. PLoS ONE. 2013;8:e74010. doi: 10.1371/journal.pone.0074010
  • Tattoli I, Travassos LH, Carneiro LA, et al. The nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol. 2007;29:289–301. doi: 10.1007/s00281-007-0083-2
  • Low FD. Staphylococcus aureus infections. N Engl J Med. 1998;339:520–532. doi: 10.1056/NEJM199808203390806
  • McElroy MC, Harty HR, Hosford GE, et al. Alpha-toxin damages the air-blood barrier of the lung in a rat model of staphylococcus aureus-induced pneumonia. Infect Immun. 1999;67:5541–5544.
  • Seeger W, Birkemeyer RG, Ermert L, et al. Staphylococcal alpha-toxin-induced vascular leakage in isolated perfused rabbit lungs. Lab Invest. 1990;63:341–349.
  • Kebaier C, Chamberland RR, Allen IC, et al. Staphylococcus aureus-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome. J Infect Dis. 2012;205:807–817. doi: 10.1093/infdis/jir846
  • Xu HL, Tang W, Du GH, et al. Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of magnolia officinalis. Drug Discov Ther. 2011;5:202–210. doi: 10.5582/ddt.2011.v5.5.202
  • Guo LY, Yan Z, Zheng X, et al. A comparison of various optimization algorithms of protein- ligand docking programs by fitness accuracy. J Mol Model. 2014;20:2251. doi: 10.1007/s00894-014-2251-3
  • Shah S, Stapleton PD, Taylor PW. The polyphenol (-)-epicatechin gallate disrupts the secretion of virulence-related proteins by Staphylococcus aureus. Lett Appl Microbiol. 2008;46:181–185. doi: 10.1111/j.1472-765X.2007.02296.x
  • Chen PJ, Wang Y-L, Kuo L-M, et al. Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα. Sci Rep. 2016;6:26554. doi: 10.1038/srep26554
  • Bubeck Wardenburg J, Schneewind O. Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med. 2008;205:287–294. doi: 10.1084/jem.20072208
  • Zhang XP, Hu XM, Rao XC. Apoptosis induced by Staphylococcus aureus toxins. Microbiol Res. 2017;205:19–24. doi: 10.1016/j.micres.2017.08.006
  • Hopkins AL, Groom CR. The druggable genome. Nat Rev Drug Discov. 2002;1:727–730. doi: 10.1038/nrd892
  • Bhakdi S, Tranum-Jensen J. Alpha-toxin of Staphylococcus aureus. Microbiol Rev. 1991;55:733–751.
  • Sinha P, Srivastava S, Mishra N, Yadav NP. New perspectives on anticancer plant drugs: contribution to modern therapeutics. Biomed Res Int. 2014;2014:1–19. doi: 10.1155/2014/301304
  • He XW, Ping O, Zhongwei Y, et al. Eriodictyol protects against Staphylococcus aureus-induced lung cell injury by inhibiting alpha-hemolysin expression. World J Microb Biot. 2018;34:64. doi: 10.1007/s11274-018-2419-6
  • Ouyang P, Sun M, He X, et al. Sclareol protects Staphylococcus aureus-induced lung cell injury via inhibiting alpha-hemolysin expression. J Microbiol Biotechnol. 2017;27:19–25. doi: 10.4014/jmb.1606.06039
  • Accarias S, Lugo-Villarino G, Foucras G, et al. Pyroptosis of resident macrophages differentially orchestrates inflammatory responses to staphylococcus aureus in resistant and susceptible mice. Eur J Immuno. 2015;45:794–806. doi: 10.1002/eji.201445098
  • Pishchany G, McCoy AL, Torres VJ, et al. Specificity for human hemoglobin enhances staphylococcus aureus infection. Cell Host Microbe. 2010;8:544–550. doi: 10.1016/j.chom.2010.11.002
  • Munoz-Planillo R, Franchi L, Miller LS, et al. A critical role for hemolysins and bacterial lipoproteins in staphylococcus aureus-induced activation of the NLRP3 inflammasome. J Immunol. 2009;183:3942–3948. doi: 10.4049/jimmunol.0900729
  • Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes. Cell. 2014;157:1013–1022. doi: 10.1016/j.cell.2014.04.007
  • Wang YJ, Gong GQ, Chen S, et al. NLRP3 inflammasome sequential changes in staphylococcus aureus-induced mouse model of acute rhinosinusitis. Int J Mol Sci. 2014;15:5806–5820.
  • O’Reilly M, de Azavedo JC, Kennedy S, et al. Inactivation of the alpha-haemolysin gene of Staphylococcus aureus 8325-4 by site-directed mutagenesis and studies on the expression of its haemolysins. Microb Pathog. 1986;1:125–138. doi: 10.1016/0882-4010(86)90015-X
  • Larzábal M, Mercado EC, Vilte DA, et al. Designed coiled-coil peptides inhibit the type three secretion system of enteropathogenic escherichia coli. PLoS ONE. 2010;5:e9046. doi: 10.1371/journal.pone.0009046
  • Bhakdi S, Fussle R, Tranum-Jensen J. Staphylococcal alpha-toxin: oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles. Proc Natl Acad Sci USA. 1981;78:5475–5479. doi: 10.1073/pnas.78.9.5475