Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains

References

• Raimondo G, Locarnini S, Pollicino T, et al. Update of the statements on biology and clinical impact of occult hepatitis b virus infection. J Hepatol. 2019;71(2):397–408. doi: 10.1016/j.jhep.2019.03.034
   PubMed Web of Science ®Google Scholar
• Lelie N, Bruhn R. Detection of different categories of hepatitis B virus (HBV) infection in a multi-regional study comparing the clinical sensitivity of hepatitis B surface antigen and HBV-DNA testing. Transfus. 2017;57(1):24–35. doi: 10.1111/trf.13819
   PubMed Web of Science ®Google Scholar
• Squadrito G, Spinella R, Raimondo G. The clinical significance of occult HBV infection. Ann Gastroenterol. 2014;27(1):15–19.
   PubMedGoogle Scholar
• Candotti D, Assennato SM, Laperche S, et al. Multiple HBV transfusion transmissions from undetected occult infections: revising the minimal infectious dose. Gut. 2019;68(2):313–321. doi: 10.1136/gutjnl-2018-316490
   PubMed Web of Science ®Google Scholar
• Candotti D, Grabarczyk P, Ghiazza P, et al. Characterization of occult hepatitis B virus from blood donors carrying genotype A2 or genotype D strains. J Hepatol. 2008;49(4):537–547. doi: 10.1016/j.jhep.2008.04.017
   PubMed Web of Science ®Google Scholar
• Katsoulidou A, Paraskevis D, Magiorkinis E, et al. Molecular characterization of occult hepatitis B cases in Greek blood donors. J Med Virol. 2009;81(5):815–825. doi: 10.1002/jmv.21499
   PubMed Web of Science ®Google Scholar
• Candotti D, Lin CK, Belkhiri D, et al. Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence. Gut. 2012;61(12):1744–1753. doi: 10.1136/gutjnl-2011-301281
   PubMed Web of Science ®Google Scholar
• Yuan Q, Ou SH, Chen CR, et al. Molecular characteristics of occult hepatitis B virus from blood donors in southeast China. J Clin Microbiol. 2010;48(2):357–362. doi: 10.1128/JCM.01781-09
   PubMed Web of Science ®Google Scholar
• Fang Y, Teng X, Xu WZ, et al. Molecular characterization and functional analysis of occult hepatitis B virus infection in Chinese patients infected with genotype C. J Med Virol. 2009;81(5):826–835. doi: 10.1002/jmv.21463
   PubMed Web of Science ®Google Scholar
• Biswas S, Candotti D, Allain JP. Specific amino acid substitutions in the S protein prevent its excretion in vitro and may contribute to occult hepatitis B virus infection. J Virol. 2013;87(14):7882–7892. doi: 10.1128/JVI.00710-13
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zhang L, Dai Y, et al. Occult hepatitis B virus infection: influence of S protein variants. Virol J. 2016;13:1–11. doi: 10.1186/s12985-015-0456-4
   PubMed Web of Science ®Google Scholar
• Bruss V. Hepatitis B virus morphogenesis. World J Gastroenterol. 2007;13(1):65–73. doi: 10.3748/wjg.v13.i1.65
   PubMed Web of Science ®Google Scholar
• Suffner S, Gerstenberg N, Patra M, et al. Domains of the hepatitis B virus small surface protein S mediating oligomerization. J Virol. 2018;92(11):1–15. doi: 10.1128/JVI.02232-17
   Web of Science ®Google Scholar
• Mangold CM, Unckell F, Werr M, et al. Secretion and antigenicity of hepatitis B virus small envelope proteins lacking cysteines in the major antigenic region. Virol. 1995;211(2):535–543. doi: 10.1006/viro.1995.1435
   PubMed Web of Science ®Google Scholar
• El Chaar M, Candotti D, Crowther RA, et al. Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection. Hepatol. 2010;52(5):1600–1610. doi: 10.1002/hep.23886
   PubMed Web of Science ®Google Scholar
• Julithe R, Abou-Jaoude G, Sureau C. Modification of the hepatitis B virus envelope protein glycosylation pattern interferes with secretion of viral particles, infectivity, and susceptibility to neutralizing antibodies. J Virol. 2014;88(16):9049–9059. doi: 10.1128/JVI.01161-14
   PubMed Web of Science ®Google Scholar
• Yu DM, Li XH, Mom V, et al. N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape. J Hepatol. 2014;60(3):515–522. doi: 10.1016/j.jhep.2013.11.004
   PubMed Web of Science ®Google Scholar
• Bi X, Tong S. Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: role of the small envelope protein. Virol. 2018;518:358–368. doi: 10.1016/j.virol.2018.03.011
   PubMed Web of Science ®Google Scholar
• Kang Y, Li F, Guo H, et al. Amino acid substitutions Q129N and T131N/M133 T in hepatitis B surface antigen (HBsAg) interfere with the immunogenicity of the corresponding HBsAg or viral replication ability. Virus Res. 2018;257:33–39. doi: 10.1016/j.virusres.2018.08.019
   PubMed Web of Science ®Google Scholar
• Jammeh S, Tavner F, Watson R, et al. Effect of basal core promoter and pre-core mutations on hepatitis B virus replication. J Gen Virol. 2008;89(Pt 4):901–909. doi: 10.1099/vir.0.83468-0
   PubMed Web of Science ®Google Scholar
• Liao H, Liu Y, Chen J, et al. Characterization of hepatitis B virus (HBV) preS/S gene mutations in blood donors with occult HBV infection in the Baoji area of North China. Transfus. 2017;57(3pt2):857–866. doi: 10.1111/trf.14046
   PubMed Web of Science ®Google Scholar
• Lin H, Zhao H, Tang X, et al. Serological patterns and molecular characterization of occult hepatitis B virus infection among blood donors. Hepat Mon. 2016;16(10):1–8. doi: 10.5812/hepatmon.40492
   Web of Science ®Google Scholar
• Zheng X, Ye X, Zhang L, et al. Characterization of occult hepatitis B virus infection from blood donors in China. J Clin Microbiol. 2011;49(5):1730–1737. doi: 10.1128/JCM.00145-11
   PubMed Web of Science ®Google Scholar
• Ito K, Qin Y, Guarnieri M, et al. Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site. J Virol. 2010;84(24):12850–12861. doi: 10.1128/JVI.01499-10
   PubMed Web of Science ®Google Scholar
• Tian Y, Xu Y, Zhang Z, et al. The amino acid residues at positions 120 to 123 are crucial for the antigenicity of hepatitis B surface antigen. J Clin Microbiol. 2007;45(9):2971–2978. doi: 10.1128/JCM.00508-07
   PubMed Web of Science ®Google Scholar
• Garcia T, Li J, Sureau C, et al. Drastic reduction in the production of subviral particles does not impair hepatitis B virus virion secretion. J Virol. 2009;83(21):11152–11165. doi: 10.1128/JVI.00905-09
   PubMed Web of Science ®Google Scholar
• Jenna S, Sureau C. Mutations in the carboxyl-terminal domain of the small hepatitis B virus envelope protein impair the assembly of hepatitis delta virus particles. J Virol. 1999;73(4):3351–3358.
   PubMed Web of Science ®Google Scholar
• Siegler VD, Bruss V. Role of transmembrane domains of hepatitis B virus small surface proteins in subviral-particle biogenesis. J Virol. 2013;87(3):1491–1496. doi: 10.1128/JVI.02500-12
   PubMed Web of Science ®Google Scholar
• Bonifacino JS, Cosson P, Shah N, et al. Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum. Embo J. 1991;10(10):2783–2793. doi: 10.1002/j.1460-2075.1991.tb07827.x
   PubMed Web of Science ®Google Scholar
• Berkower I, Spadaccini A, Chen H, et al. Hepatitis B virus surface antigen assembly function persists when entire transmembrane domains 1 and 3 are replaced by a heterologous transmembrane sequence. J Virol. 2011;85(5):2439–2448. doi: 10.1128/JVI.02061-10
   PubMed Web of Science ®Google Scholar