The cytochrome d oxidase complex regulated by fexA is an Achilles' heel in the in vivo survival of Vibrio vulnificus

References

• Strom MS, Paranjpye RN. Epidemiology and pathogenesis of vibrio vulnificus. Microbes and Infection/Institut Pasteur. 2000;2(2):177–188. doi: 10.1016/S1286-4579(00)00270-7
   PubMed Web of Science ®Google Scholar
• Kim YR, Lee SE, Kim CM, et al. Characterization and pathogenic significance of vibrio vulnificus antigens preferentially expressed in septicemic patients. Infect Immun. 2003;71(10):5461–5471. doi: 10.1128/IAI.71.10.5461-5471.2003
   PubMed Web of Science ®Google Scholar
• Taylor CT, Colgan SP. Hypoxia and gastrointestinal disease. J Mol Med. 2007;85(12):1295–1300. doi: 10.1007/s00109-007-0277-z
   PubMed Web of Science ®Google Scholar
• Mekalanos JJ. Environmental signals controlling expression of virulence determinants in bacteria. J Bacteriol. 1992;174(1):1–7. doi: 10.1128/jb.174.1.1-7.1992
   PubMed Web of Science ®Google Scholar
• Salmon K, Hung SP, Mekjian K, et al. Global gene expression profiling in Escherichia coli K12. The effects of oxygen availability and FNR. J Biol Chem. 2003;278(32):29837–29855. doi: 10.1074/jbc.M213060200
   PubMed Web of Science ®Google Scholar
• Sawers G. The aerobic/anaerobic interface. Curr Opin Microbiol. 1999;2(2):181–187. doi: 10.1016/S1369-5274(99)80032-0
   PubMed Web of Science ®Google Scholar
• Lynch AS, Lin EC. Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters. J Bacteriol. 1996;178(21):6238–6249. doi: 10.1128/jb.178.21.6238-6249.1996
   PubMed Web of Science ®Google Scholar
• Gunsalus RP, Park SJ. Aerobic-anaerobic gene regulation in Escherichia coli: control by the ArcAB and Fnr regulons. Res Microbiol. 1994;145(5–6):437–450. doi: 10.1016/0923-2508(94)90092-2
   PubMed Web of Science ®Google Scholar
• Kim YR, Lee SE, Kook H, et al. Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells. Cell Microbiol. 2008;10(4):848–862. doi: 10.1111/j.1462-5822.2007.01088.x
   PubMed Web of Science ®Google Scholar
• Duong-Nu TM, Jeong K, Hong SH, et al. All three TonB systems are required for vibrio vulnificus CMCP6 tissue invasiveness by controlling flagellum expression. Infect Immun. 2016;84(1):254–265. doi: 10.1128/IAI.00821-15
   PubMed Web of Science ®Google Scholar
• Kim HU, Kim SY, Jeong H, et al. Integrative genome-scale metabolic analysis of vibrio vulnificus for drug targeting and discovery. Mol Syst Biol. 2011;7:460. doi: 10.1038/msb.2010.115
   PubMed Web of Science ®Google Scholar
• Ju HM, Hwang IG, Woo GJ, et al. Identification of the vibrio vulnificus fexA gene and evaluation of its influence on virulence. J Microbiol Biotechn. 2005;15(6):1337–1345.
   Web of Science ®Google Scholar
• Miller VL, Mekalanos JJ. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in vibrio cholerae requires toxR. J Bacteriol. 1988;170(6):2575–2583. doi: 10.1128/jb.170.6.2575-2583.1988
   PubMed Web of Science ®Google Scholar
• Kim SY, Thanh XT, Jeong K, et al. Contribution of six flagellin genes to the flagellum biogenesis of vibrio vulnificus and in vivo invasion. Infect Immun. 2014;82(1):29–42. doi: 10.1128/IAI.00654-13
   PubMed Web of Science ®Google Scholar
• Lee SE, Kim SY, Kim CM, et al. The pyrH gene of vibrio vulnificus is an essential in vivo survival factor. Infect Immun. 2007;75(6):2795–2801. doi: 10.1128/IAI.01499-06
   PubMed Web of Science ®Google Scholar
• Kim SY, Lee SE, Kim YR, et al. Regulation of vibrio vulnificus virulence by the LuxS quorum-sensing system. Mol Microbiol. 2003;48(6):1647–1664. doi: 10.1046/j.1365-2958.2003.03536.x
   PubMed Web of Science ®Google Scholar
• Ditta G, Stanfield S, Corbin D, et al. Broad host range DNA cloning system for gram-negative bacteria: construction of a gene bank of Rhizobium meliloti. Proc Natl Acad Sci U S A. 1980;77(12):7347–7351. doi: 10.1073/pnas.77.12.7347
   PubMed Web of Science ®Google Scholar
• Rhee JE, Jeong HG, Lee JH, et al. Aphb influences acid tolerance of vibrio vulnificus by activating expression of the positive regulator CadC. J Bacteriol. 2006;188(18):6490–6497. doi: 10.1128/JB.00533-06
   PubMed Web of Science ®Google Scholar
• Linn T, St Pierre R. Improved vector system for constructing transcriptional fusions that ensures independent translation of lacZ. J Bacteriol. 1990;172(2):1077–1084. doi: 10.1128/jb.172.2.1077-1084.1990
   PubMed Web of Science ®Google Scholar
• Miyoshi S, Shinoda S. Activation mechanism of human Hageman factor-plasma kallikrein-kinin system by vibrio vulnificus metalloprotease. FEBS Lett. 1992;308(3):315–319. doi: 10.1016/0014-5793(92)81301-2
   PubMed Web of Science ®Google Scholar
• Jutras BL, Verma A, Stevenson B. Identification of novel DNA-binding proteins using DNA-affinity chromatography/pull down. Curr Protoc Microbiol. 2012. Chapter 1:Unit1 F 1.
   PubMedGoogle Scholar
• He G, Shankar RA, Chzhan M, et al. Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging. Proc Natl Acad Sci U S A. 1999;96(8):4586–4591. doi: 10.1073/pnas.96.8.4586
   PubMed Web of Science ®Google Scholar
• Salmon KA, Hung SP, Steffen NR, et al. Global gene expression profiling in Escherichia coli K12: effects of oxygen availability and ArcA. J Biol Chem. 2005;280(15):15084–15096. doi: 10.1074/jbc.M414030200
   PubMed Web of Science ®Google Scholar
• Chao G, Shen J, Tseng CP, et al. Aerobic regulation of isocitrate dehydrogenase gene (icd) expression in Escherichia coli by the arcA and fnr gene products. J Bacteriol. 1997;179(13):4299–4304. doi: 10.1128/jb.179.13.4299-4304.1997
   PubMed Web of Science ®Google Scholar
• Park SJ, Chao G, Gunsalus RP. Aerobic regulation of the sucABCD genes of Escherichia coli, which encode alpha-ketoglutarate dehydrogenase and succinyl coenzyme A synthetase: roles of ArcA, Fnr, and the upstream sdhCDAB promoter. J Bacteriol. 1997;179(13):4138–4142. doi: 10.1128/jb.179.13.4138-4142.1997
   PubMed Web of Science ®Google Scholar
• Nystrom T, Larsson C, Gustafsson L. Bacterial defense against aging: role of the Escherichia coli ArcA regulator in gene expression, readjusted energy flux and survival during stasis. EMBO J. 1996;15(13):3219–3228. doi: 10.1002/j.1460-2075.1996.tb00686.x
   PubMed Web of Science ®Google Scholar
• Nunn WD. A molecular view of fatty acid catabolism in Escherichia coli. Microbiol Rev. 1986;50(2):179–192.
   PubMedGoogle Scholar
• Lin EC, Iuchi S. Regulation of gene expression in fermentative and respiratory systems in Escherichia coli and related bacteria. Annu Rev Genet. 1991;25:361–387. doi: 10.1146/annurev.ge.25.120191.002045
   PubMed Web of Science ®Google Scholar
• Liu X, De Wulf P. Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling. J Biol Chem. 2004;279(13):12588–12597. doi: 10.1074/jbc.M313454200
   PubMed Web of Science ®Google Scholar
• Shalel-Levanon S, San KY, Bennett GN. Effect of ArcA and FNR on the expression of genes related to the oxygen regulation and the glycolysis pathway in Escherichia coli under microaerobic growth conditions. Biotechnol Bioeng. 2005;92(2):147–159. doi: 10.1002/bit.20583
   PubMed Web of Science ®Google Scholar
• Endley S, McMurray D, Ficht TA. Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infection. J Bacteriol. 2001;183(8):2454–2462. doi: 10.1128/JB.183.8.2454-2462.2001
   PubMed Web of Science ®Google Scholar
• Henard CA, Bourret TJ, Song M, et al. Control of redox balance by the stringent response regulatory protein promotes antioxidant defenses of Salmonella. J Biol Chem. 2010;285(47):36785–36793. doi: 10.1074/jbc.M110.160960
   PubMed Web of Science ®Google Scholar
• Alexeeva S, Hellingwerf KJ, de Mattos MJT. Requirement of ArcA for redox regulation in Escherichia coli under microaerobic but not anaerobic or aerobic conditions. J Bacteriol. 2003;185(1):204–209. doi: 10.1128/JB.185.1.204-209.2003
   PubMed Web of Science ®Google Scholar
• Tribelli PM, Nikel PI, Oppezzo OJ, et al. Anr, the anaerobic global regulator, modulates the redox state and oxidative stress resistance in Pseudomonas extremaustralis. Microbiology. 2013;159(Pt 2):259–268. doi: 10.1099/mic.0.061085-0
   PubMed Web of Science ®Google Scholar
• Atsumi T, McCarter L, Imae Y. Polar and lateral flagellar motors of marine vibrio are driven by different ion-motive forces. Nature. 1992;355(6356):182–184. doi: 10.1038/355182a0
   PubMed Web of Science ®Google Scholar
• Lee JH, Rho JB, Park KJ, et al. Role of flagellum and motility in pathogenesis of vibrio vulnificus. Infect Immun. 2004;72(8):4905–4910. doi: 10.1128/IAI.72.8.4905-4910.2004
   PubMed Web of Science ®Google Scholar