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Original Articles

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata

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Pages 1619-1625 | Received 26 Aug 2019, Accepted 17 Oct 2019, Published online: 12 Nov 2019

References

  • Pappas PG, Lionakis MS, Arendrup MC, et al. Invasive candidiasis. Nat Rev Dis Primers. 2018;4:18026. doi: 10.1038/nrdp.2018.26
  • Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the infectious diseases society of America. Clin Infect Dis. 2016;62(4):e1–50. doi: 10.1093/cid/civ1194
  • Kullberg BJ, Arendrup MC. Invasive candidiasis. N Engl J Med. 2015;373(15):1445–1456. doi: 10.1056/NEJMra1315399
  • Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20(1):133–163. doi: 10.1128/CMR.00029-06
  • Whaley SG, Rogers PD. Azole resistance in Candida glabrata. Curr Infect Dis Rep. 2016;18(12):41. doi: 10.1007/s11908-016-0554-5
  • Alexander BD, Johnson MD, Pfeiffer CD, et al. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin Infect Dis. 2013;56(12):1724–1732. doi: 10.1093/cid/cit136
  • Pham CD, Iqbal N, Bolden CB, et al. Role of FKS mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance. Antimicrob Agents Chemother. 2014;58(8):4690–4696. doi: 10.1128/AAC.03255-14
  • Hou X, Xiao M, Chen SC, et al. Molecular epidemiology and antifungal susceptibility of Candida glabrata in China (August 2009 to July 2014): a multi-center study. Front Microbiol. 2017;8(880):1–9.
  • Xiao M, Fan X, Hou X, et al. Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant Candida tropicalis and Candida glabrata isolates with delineation of their resistance mechanisms. Infect Drug Resist. 2018;11:155–161. doi: 10.2147/IDR.S152785
  • Perlin DS. Mechanisms of echinocandin antifungal drug resistance. Ann N Y Acad Sci. 2015;1354(1):1–11. doi: 10.1111/nyas.12831
  • Kitada K, Yamaguchi E, Arisawa M. Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of their disruptant strains by sequential integrative transformation. Gene. 1995;165(2):203–206. doi: 10.1016/0378-1119(95)00552-H
  • Katiyar SK, Alastruey-Izquierdo A, Healey KR, et al. Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance. Antimicrob Agents Chemother. 2012;56(12):6304–6309. doi: 10.1128/AAC.00813-12
  • Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts. CLSI, Wayne, PA, USA. 2017.
  • Grahl N, Demers EG, Crocker AW, et al. Use of RNA-protein complexes for genome editing in non-albicans Candida species. mSphere. 2017;2(3):e00218-17. doi: 10.1128/mSphere.00218-17
  • Istel F, Schwarzmuller T, Tscherner M, et al. Genetic transformation of Candida glabrata by electroporation. Bio Protoc. 2015;5(14):1–5.
  • Park S, Kelly R, Kahn JN, et al. Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp isolates. Antimicrob Agents Chemother. 2005;49(8):3264–3273. doi: 10.1128/AAC.49.8.3264-3273.2005
  • Li QQ, Skinner J, Bennett JE. Evaluation of reference genes for real-time quantitative PCR studies in Candida glabrata following azole treatment. BMC Mol Biol. 2012;13(22):1–13.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408. doi: 10.1006/meth.2001.1262
  • Andes D. Use of an animal model of disseminated candidiasis in the evaluation of antifungal therapy. Methods Mol Med. 2005;118:111–128.
  • Charan J, Kantharia ND. How to calculate sample size in animal studies? J Pharmacol Pharmacother. 2013;4(4):303–306. doi: 10.4103/0976-500X.119726
  • Guinea J. Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect. 2014;20(Suppl 6):5–10. doi: 10.1111/1469-0691.12539
  • Perlin DS, Rautemaa-Richardson R, Alastruey-Izquierdo A. The global problem of antifungal resistance: prevalence, mechanisms, and management. Lancet Infect Dis. 2017;17(12):e383–e392. doi: 10.1016/S1473-3099(17)30316-X
  • Niimi K, Woods MA, Maki K, et al. Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression. J Antimicrob Chemother. 2012;67(7):1666–1676. doi: 10.1093/jac/dks112
  • Bizerra FC, Jimenez-Ortigosa C, Souza ACR, et al. Breakthrough candidemia due to multidrug-resistant Candida glabrata during prophylaxis with a low dose of micafungin. Antimicrob Agents Chemother. 2014;58(4):2438–2440. doi: 10.1128/AAC.02189-13
  • Magill SS, Swoboda SM, Shields CE, et al. The epidemiology of Candida colonization and invasive candidiasis in a surgical intensive care unit where fluconazole prophylaxis is utilized: follow-up to a randomized clinical trial. Ann Surg. 2009;249(4):657–665. doi: 10.1097/SLA.0b013e31819ed914
  • Cheng SJ, Clancy CJ, Hartman DJ, et al. Candida glabrata intra-abdominal candidiasis is characterized by persistence within the peritoneal cavity and abscesses. Infect Immun. 2014;82(7):3015–3022. doi: 10.1128/IAI.00062-14
  • Farmakiotis D, Tarrand JJ, Kontoyiannis DP. Drug-resistant Candida glabrata infection in cancer patients. Emerg Infect Dis. 2014;20(11):1833–1840. doi: 10.3201/eid2011.140685