6,365
Views
69
CrossRef citations to date
0
Altmetric
Articles

Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

, , ORCID Icon, , ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 155-168 | Received 18 Aug 2019, Accepted 01 Jan 2020, Published online: 21 Jan 2020

References

  • Zaki AM, van Boheemen S, Bestebroer TM, et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012 Nov 8;367(19):1814–1820. doi: 10.1056/NEJMoa1211721
  • WHO. MERS situation update http://www.emro.who.int/health-topics/mers-cov/mers-outbreaks.html2019 [updated 2019–05]. Available from: https://www.who.int/emergencies/mers-cov/en/.
  • Adney DR, van Doremalen N, Brown VR, et al. Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels. Emerg Infect Dis. 2014 Dec;20(12):1999–2005. doi: 10.3201/eid2012.141280
  • Azhar EI, El-Kafrawy SA, Farraj SA, et al. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014 Jun 26;370(26):2499–2505. doi: 10.1056/NEJMoa1401505
  • Haagmans BL, Al Dhahiry SH, Reusken CB, et al. Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation. Lancet Infect Dis. 2014 Feb;14(2):140–145. doi: 10.1016/S1473-3099(13)70690-X
  • Raj VS, Farag EA, Reusken CB, et al. Isolation of MERS coronavirus from a dromedary camel, Qatar, 2014. Emerg Infect Dis. 2014 Aug;20(8):1339–1342. doi: 10.3201/eid2008.140663
  • Al-Abdallat MM, Payne DC, Alqasrawi S, et al. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description. Clin Infect Dis. 2014 Nov 1;59(9):1225–1233. doi: 10.1093/cid/ciu359
  • Assiri A, McGeer A, Perl TM, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med. 2013 Aug 1;369(5):407–416. doi: 10.1056/NEJMoa1306742
  • Fagbo SF, Skakni L, Chu DK, et al. Molecular epidemiology of hospital outbreak of Middle East respiratory syndrome, Riyadh, Saudi Arabia, 2014. Emerg Infect Dis. 2015 Nov;21(11):1981–1988. doi: 10.3201/eid2111.150944
  • Korea Centers for Disease Control Prevention. Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea, 2015. Osong Public Health Res Perspect. 2015 Aug;6(4):269–278. doi: 10.1016/j.phrp.2015.08.006
  • Oboho IK, Tomczyk SM, Al-Asmari AM, et al. 2014 MERS-CoV outbreak in Jeddah–a link to health care facilities. N Engl J Med. 2015 Feb 26;372(9):846–854. doi: 10.1056/NEJMoa1408636
  • Park HY, Lee EJ, Ryu YW, et al. Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, May to June 2015. Euro Surveill. 2015 Jun 25;20(25):1–6. doi: 10.2807/1560-7917.ES2015.20.25.21169
  • Drosten C, Meyer B, Muller MA, et al. Transmission of MERS-coronavirus in household contacts. N Engl J Med. 2014 Aug 28;371(9):828–835. doi: 10.1056/NEJMoa1405858
  • Widagdo W, Raj VS, Schipper D, et al. Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels. J Virol. 2016 May;90(9):4838–4842. doi: 10.1128/JVI.02994-15
  • Raj VS, Mou H, Smits SL, et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature. 2013 Mar 14;495(7440):251–254. doi: 10.1038/nature12005
  • Wang N, Shi X, Jiang L, et al. Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4. Cell Res. 2013 Aug;23(8):986–993. doi: 10.1038/cr.2013.92
  • Gierer S, Bertram S, Kaup F, et al. The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies. J Virol. 2013 May;87(10):5502–5511. doi: 10.1128/JVI.00128-13
  • Qian Z, Dominguez SR, Holmes KV. Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation. PLoS One. 2013;8(10):e76469. doi: 10.1371/journal.pone.0076469
  • Shirato K, Kawase M, Matsuyama S. Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2. J Virol. 2013 Dec;87(23):12552–12561. doi: 10.1128/JVI.01890-13
  • Deacon CF. Physiology and pharmacology of DPP-4 in glucose Homeostasis and the treatment of type 2 diabetes. Front Endocrinol (Lausanne). 2019;10:80. doi: 10.3389/fendo.2019.00080
  • Ohnuma K, Dang NH, Morimoto C. Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function. Trends Immunol. 2008 Jun;29(6):295–301. doi: 10.1016/j.it.2008.02.010
  • Mentlein R. Dipeptidyl-peptidase IV (CD26)–role in the inactivation of regulatory peptides. Regul Pept. 1999 Nov 30;85(1):9–24. doi: 10.1016/S0167-0115(99)00089-0
  • Mortier A, Gouwy M, Van Damme J, et al. CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology. J Leukoc Biol. 2016 Jun;99(6):955–969. doi: 10.1189/jlb.3MR0915-401R
  • Reinhold D, Bank U, Buhling F, et al. Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes. Immunol Lett. 1997 Jun;58(1):29–35. doi: 10.1016/S0165-2478(97)02716-8
  • Barnett A. DPP-4 inhibitors and their potential role in the management of type 2 diabetes. Int J Clin Pract. 2006 Nov;60(11):1454–1470. doi: 10.1111/j.1742-1241.2006.01178.x
  • Klemann C, Wagner L, Stephan M, et al. Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system. Clin Exp Immunol. 2016 Jul;185(1):1–21. doi: 10.1111/cei.12781
  • Ahmed RH, Huri HZ, Al-Hamodi Z, et al. Association of DPP4 gene polymorphisms with type 2 diabetes mellitus in Malaysian Subjects. PLoS One. 2016;11(4):e0154369. doi: 10.1371/journal.pone.0154369
  • Xing X, Han Y, Zhou X, et al. Association between DPP4 gene polymorphism and serum lipid levels in Chinese type 2 diabetes individuals. Neuropeptides. 2016 Dec;60:1–6. doi: 10.1016/j.npep.2016.08.005
  • Aghili N, Devaney JM, Alderman LO, et al. Polymorphisms in dipeptidyl peptidase IV gene are associated with the risk of myocardial infarction in patients with atherosclerosis. Neuropeptides. 2012 Dec;46(6):367–371. doi: 10.1016/j.npep.2012.10.001
  • Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012 Jun 28;9(7):676–682. doi: 10.1038/nmeth.2019
  • Hunt SE, McLaren W, Gil L, et al. Ensembl variation resources. Database (Oxford). 2018 Jan 1;2018:1–13. doi: 10.1093/database/bay119
  • Sherry ST, Ward MH, Kholodov M, et al. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 2001 Jan 1;29(1):308–311. doi: 10.1093/nar/29.1.308
  • Lek M, Karczewski KJ, Minikel EV, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016 Aug 18;536(7616):285–291. doi: 10.1038/nature19057
  • Genomes Project Consortium, Auton A, Brooks LD, et al. A global reference for human genetic variation. Nature. 2015 Oct 1;526(7571):68–74. doi: 10.1038/nature15393
  • Brinkmann C, Hoffmann M, Lubke A, et al. The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells. PLoS One. 2017;12(12):e0189073. doi: 10.1371/journal.pone.0189073
  • Hofmann H, Hattermann K, Marzi A, et al. S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients. J Virol. 2004 Jun;78(12):6134–6142. doi: 10.1128/JVI.78.12.6134-6142.2004
  • Kleine-Weber H, Elzayat MT, Wang L, et al. Mutations in the spike protein of Middle East respiratory syndrome coronavirus transmitted in Korea increase resistance to antibody-mediated Neutralization. J Virol. 2019 Jan 4;93(2):e01381–18. doi:10.1128/JVI.01381-18.
  • Hoffmann M, Muller MA, Drexler JF, et al. Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses. PLoS One. 2013;8(8):e72942. doi: 10.1371/journal.pone.0072942
  • Shahwan K, Hesse M, Mork AK, et al. Sialic acid binding properties of soluble coronavirus spike (S1) proteins: differences between infectious bronchitis virus and transmissible gastroenteritis virus. Viruses. 2013 Jul 26;5(8):1924–1933. doi: 10.3390/v5081924
  • Rentsch MB, Zimmer G. A vesicular stomatitis virus replicon-based bioassay for the rapid and sensitive determination of multi-species type I interferon. PLoS One. 2011;6(10):e25858. doi: 10.1371/journal.pone.0025858
  • Hoffmann M, Kruger N, Zmora P, et al. The Hemagglutinin of bat-associated Influenza Viruses is activated by TMPRSS2 for pH-dependent entry into bat but not human cells. PLoS One. 2016;11(3):e0152134. doi: 10.1371/journal.pone.0152134
  • Corman VM, Eckerle I, Bleicker T, et al. Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction. Euro Surveill. 2012 Sep 27;17(39):3–8. doi: 10.2807/ese.17.39.20285-en
  • Xiao P, Guo R, Huang S, et al. Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold. Chin Chem Lett. 2014 May;25(5):673–676. doi: 10.1016/j.cclet.2014.03.047
  • Land H, Humble MS. YASARA: a tool to obtain structural guidance in Biocatalytic investigations. Methods Mol Biol. 2018;1685:43–67. doi: 10.1007/978-1-4939-7366-8_4
  • Pettersen EF, Goddard TD, Huang CC, et al. UCSF Chimera–a visualization system for exploratory research and analysis. J Comput Chem. 2004 Oct;25(13):1605–1612. doi: 10.1002/jcc.20084
  • Finkelshtein D, Werman A, Novick D, et al. LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7306–7311. doi: 10.1073/pnas.1214441110
  • van Doremalen N, Miazgowicz KL, Milne-Price S, et al. Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4. J Virol. 2014 Aug;88(16):9220–9232. doi: 10.1128/JVI.00676-14
  • Anoop S, Misra A, Bhatt SP, et al. High circulating plasma dipeptidyl peptidase- 4 levels in non-obese Asian Indians with type 2 diabetes correlate with fasting insulin and LDL-C levels, triceps skinfolds, total intra-abdominal adipose tissue volume and presence of diabetes: a case-control study. BMJ Open Diabetes Res Care. 2017;5(1):e000393. doi: 10.1136/bmjdrc-2017-000393
  • Assiri A, Al-Tawfiq JA, Al-Rabeeah AA, et al. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013 Sep;13(9):752–761. doi: 10.1016/S1473-3099(13)70204-4
  • Song W, Wang Y, Wang N, et al. Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry. Virology. 2014 Dec;471-473:49–53. doi: 10.1016/j.virol.2014.10.006
  • Valerio CM, de Almeida JS, Moreira RO, et al. Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2. Diabetol Metab Syndr. 2017;9(26):1–5.
  • Chu DK, Oladipo JO, Perera RA, et al. Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015. Euro Surveill. 2015;20(49):11–17. doi: 10.2807/1560-7917.ES.2015.20.49.30086
  • Chu DKW, Hui KPY, Perera R, et al. MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3144–3149. doi: 10.1073/pnas.1718769115
  • Corman VM, Jores J, Meyer B, et al. Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerg Infect Dis. 2014 Aug;20(8):1319–1322. doi: 10.3201/eid2008.140596
  • Muller MA, Corman VM, Jores J, et al. MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997. Emerg Infect Dis. 2014 Dec;20(12):2093–2095. doi: 10.3201/eid2012.141026
  • Perera RA, Wang P, Gomaa MR, et al. Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013. Euro Surveill. 2013 Sep 5;18(36):20574. doi: 10.2807/1560-7917.ES2013.18.36.20574
  • Shirato K, Melaku SK, Kawachi K, et al. Middle East respiratory syndrome coronavirus in Dromedaries in Ethiopia Is Antigenically different from the Middle East Isolate EMC. Front Microbiol. 2019;10:1326. doi: 10.3389/fmicb.2019.01326