References
- Goldstein T, Anthony SJ, Gbakima A, et al. The discovery of Bombali virus adds further support for bats as hosts of Ebolaviruses. Nat Microbiol. 2018;3(10):1084–1089. doi: 10.1038/s41564-018-0227-2
- Kuhn JH, Adachi T, Adhikari NKJ, et al. New filovirus disease classification and nomenclature. Nat Rev Microbiol. 2019;17(5):261–263. doi: 10.1038/s41579-019-0187-4
- Daniel S, Chertow MB. Clinical manifestations and diagnosis of Ebola virus disease. Uptodate. 2018.
- Kratz T, Roddy P, Tshomba Oloma A, et al. Ebola virus disease outbreak in Isiro, Democratic Republic of the Congo, 2012: signs and symptoms, management and outcomes. PLoS One. 2015;10(6):e0129333. doi: 10.1371/journal.pone.0129333
- Groseth A, Feldmann H, Strong JE. The ecology of Ebola virus. Trends Microbiol. 2007;15(9):408–416. doi: 10.1016/j.tim.2007.08.001
- Geographers AoA. A new map of standardized terrestrial ecosystems of Africa. 2013.
- De Nys HM, Kingebeni PM, Keita AK, et al. Survey of Ebola viruses in Frugivorous and insectivorous bats in Guinea, Cameroon, and the Democratic Republic of the Congo, 2015-2017. Emerg Infect Dis. 2018;24(12):2228–2240. doi: 10.3201/eid2412.180740
- Leroy EM, Rouquet P, Formenty P, et al. Multiple Ebola virus transmission events and rapid decline of Central African wildlife. Science. 2004;303(5656):387–390. doi: 10.1126/science.1092528
- Judson SD, Fischer R, Judson A, et al. Ecological Contexts of index cases and spillover events of different Ebolaviruses. PLoS Pathog. 2016;12(8):e1005780. doi: 10.1371/journal.ppat.1005780
- Plowright RK, Parrish CR, McCallum H, et al. Pathways to zoonotic spillover. Nat Rev Microbiol. 2017;15(8):502–510. doi: 10.1038/nrmicro.2017.45
- Schmidt JP, Park AW, Kramer AM, et al. Spatiotemporal fluctuations and triggers of Ebola virus spillover. Emerg Infect Dis. 2017;23(3):415–422. doi: 10.3201/eid2303.160101
- Breman JG, Heymann DL, Lloyd G, et al. Discovery and description of Ebola Zaire virus in 1976 and relevance to the West African epidemic during 2013-2016. J Infect Dis. 2016;214(Suppl 3):S93–S101. doi: 10.1093/infdis/jiw207
- Georges AJ, Leroy EM, Renaut AA, et al. Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: epidemiologic and health control issues. J Infect Dis. 1999;179(Suppl 1):S65–S75. doi: 10.1086/514290
- Grard G, Biek R, Tamfum JJ, et al. Emergence of divergent Zaire ebola virus strains in Democratic Republic of the Congo in 2007 and 2008. J Infect Dis. 2011;204(Suppl 3):S776–S784. doi: 10.1093/infdis/jir364
- Muyembe-Tamfum JJ, Kipasa M, Kiyungu C, et al. Ebola outbreak in Kikwit, Democratic Republic of the Congo: discovery and control measures. J Infect Dis. 1999;179(Suppl 1):S259–S262. doi: 10.1086/514302
- Feldmann H, Geisbert TW. Ebola haemorrhagic fever. Lancet. 2011;377(9768):849–862. doi: 10.1016/S0140-6736(10)60667-8
- Leroy EM, Gonzalez JP, Baize S. Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa. Clin Microbiol Infect. 2011;17(7):964–976. doi: 10.1111/j.1469-0691.2011.03535.x
- Leroy EM, Labouba I, Maganga GD, et al. Ebola in West Africa: the outbreak able to change many things. Clin Microbiol Infect. 2014;20(10):O597–O599. doi: 10.1111/1469-0691.12781
- Garske T, Cori A, Ariyarajah A, et al. Heterogeneities in the case fatality ratio in the West African Ebola outbreak 2013-2016. Philos Trans R Soc Lond B Biol Sci. 2017;372(1721):20160308. doi: 10.1098/rstb.2016.0308
- Huber C, Finelli L, Stevens W. The economic and social burden of the 2014 Ebola outbreak in West Africa. J Infect Dis. 2018;218(Suppl_5):S698–S704.
- Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Organ. 1978;56(2):271–293.
- Nkoghe D, Nnegue S, Mve MT, et al. [Isolated case of haemorrhagic fever observed in Gabon during the 2002 outbreak of Ebola but distant from epidemic zones]. Med Trop (Mars). 2005;65(4):349–354.
- Fasina FO, Shittu A, Lazarus D, et al. Transmission dynamics and control of Ebola virus disease outbreak in Nigeria, July to September 2014. Euro Surveill. 2014;19(40):20920. doi: 10.2807/1560-7917.ES2014.19.40.20920
- Otu A, Ameh S, Osifo-Dawodu E, et al. An account of the Ebola virus disease outbreak in Nigeria: implications and lessons learnt. BMC Public Health. 2018;18(1):3. doi: 10.1186/s12889-017-4535-x
- CDC. 2014. Available from: https://www.cdc.gov/media/releases/2014/s930-ebola-confirmed-case.html.
- Fernandez M. Dallas closes the door on its Ebola scare. New York Times. 2014. Available from: https://www.nytimes.com/2014/11/08/us/dallas-celebrates-as-ebola-monitoring-nears-an-end.html.
- NBC 2014. Available from: https://abcnews.go.com/Health/ebola-america-timeline/story?id=26159719
- Diarra B, Safronetz D, Sarro YD, et al. Laboratory response to 2014 Ebola virus outbreak in Mali. J Infect Dis. 2016;214(Suppl 3):S164–S168. doi: 10.1093/infdis/jiw200
- WHO. (2014). Available from: https://www.who.int/csr/disease/ebola/ebola-6-months/guinea/en/.
- BBC. (2015). Available from: https://www.bbc.com/news/health-31908301.
- Jose María Marimón RC, Perez-Molina JA, Miro JM. Difficulties faced by the Spanish Health Care Systems in the Ebola epidemic 2014. Available from: https://www.escmid.org/news_media/news/news_on_ebola/ebola_in_spain/.
- Parra JM, Salmeron OJ, Velasco M. The first case of Ebola virus disease acquired outside Africa. N Engl J Med. 2014;371(25):2439–2440. doi: 10.1056/NEJMc1412662
- Salce L, Barbato S, Renna D, et al. First Italian Ebola virus disease case: management of hospital internal and external communication. New Microbiol. 2015;38(4):565–570.
- WHO. (2015). Available from: https://www.who.int/csr/don/13-may-2015-ebola/en/.
- Smale A. Ebola patient dies in German hospital. New York Times. 2014. Available from: https://www.nytimes.com/2014/10/15/world/europe/ebola-patient-dies-in-german-hospital.html.
- Jeremy Ashkenas LB, Burgess J, Fairfield H, et al. How many Ebola patients have been treated outside Africa? New York Times. 2015. Available from: https://www.nytimes.com/interactive/2014/07/31/world/africa/ebola-virus-outbreak-qa.html?mtrref=undefined&gwh=E264B895E9AE989D789DCBE9596FEB36&gwt=pay&assetType=REGIWALL.
- Ka D, Fall G, Diallo VC, et al. Ebola virus imported from Guinea to Senegal, 2014. Emerg Infect Dis. 2017;23(6):1026–1028. doi: 10.3201/eid2306.161092
- Le Guenno B, Formenty P, Wyers M, et al. Isolation and partial characterisation of a new strain of Ebola virus. Lancet. 1995;345(8960):1271–1274. doi: 10.1016/S0140-6736(95)90925-7
- Le Guenno B, Formenty P, Boesch C. Ebola virus outbreaks in the Ivory Coast and Liberia, 1994-1995. Curr Top Microbiol Immunol. 1999;235:77–84.
- Goba A, Khan SH, Fonnie M, et al. An outbreak of Ebola virus disease in the Lassa fever zone. J Infect Dis. 2016;214(Suppl 3):S110–S121. doi: 10.1093/infdis/jiw239
- Munster VJ, Bausch DG, de Wit E, et al. Outbreaks in a rapidly changing Central Africa — lessons from Ebola. N Engl J Med. 2018;379(13):1198–1201. doi: 10.1056/NEJMp1807691
- Dudas G, Carvalho LM, Bedford T, et al. Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature. 2017;544(7650):309–315. doi: 10.1038/nature22040
- Coltart CE, Lindsey B, Ghinai I, et al. The Ebola outbreak, 2013–2016: old lessons for new epidemics. Philos Trans R Soc Lond B Biol Sci. 2017 May 26;372(1721):20160297. doi: 10.1098/rstb.2016.0297
- Forna A, Nouvellet P, Dorigatti I, et al. Case fatality ratio estimates for the 2013 - 2016 West African Ebola epidemic: application of Boosted Regression Trees for imputation. Clin Infect Dis. 2019. doi: 10.1093/cid/ciz678/5536742
- Maganga GD, Kapetshi J, Berthet N, et al. Ebola virus disease in the Democratic Republic of Congo. N Engl J Med. 2014;371(22):2083–2091. doi: 10.1056/NEJMoa1411099
- Nsio J, Kapetshi J, Makiala S, et al. 2017 outbreak of Ebola virus disease in northern Democratic Republic of Congo. J Infect Dis. 2019. doi: 10.1093/infdis/jiz107/5426903
- The Ebola Outbreak Epidemiology Team. Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April–May, 2018: an epidemiological study. Lancet. 2018;392(10143):213–221. doi: 10.1016/S0140-6736(18)31387-4
- Wenham C. What we have learnt about the World Health Organization from the Ebola outbreak. Philos Trans R Soc Lond B Biol Sci. 2017;372(1721):20160307. doi: 10.1098/rstb.2016.0307
- Wells CR, Pandey A, Parpia AS, et al. Ebola vaccination in the Democratic Republic of the Congo. Proc Natl Acad Sci U S A. 2019;116(20):10178–10183. doi: 10.1073/pnas.1817329116
- WHO. Ebola virus disease, Democratic Republic of the Congo – external situation report 3. 2018.
- National Coordination Committee MoH-DRotC. National plan for the response to the Ebola virus disease epidemic in North Kivu Province. 2018.
- Dyer O. Ebola: new outbreak appears in Congo a week after epidemic was declared over. BMJ. 2018;362:k3421. doi: 10.1136/bmj.k3421
- MacNeil A, Farnon EC, Wamala J, et al. Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda. Emerg Infect Dis. 2010;16(12):1969–1972. doi: 10.3201/eid1612.100627
- Vinck P, Pham PN, Bindu KK, et al. Institutional trust and misinformation in the response to the 2018–19 Ebola outbreak in North Kivu, DR Congo: a population-based survey. Lancet Infect Dis. 2019;19(5):529–536. doi: 10.1016/S1473-3099(19)30063-5
- Claude KM, Underschultz J, Hawkes MT. Ebola virus epidemic in war-torn eastern DR Congo. Lancet. 2018;392(10156):1399–1401. doi: 10.1016/S0140-6736(18)32419-X
- WHO. Ebola outbreak in the Democratic Republic of the Congo declared a public health emergency of international concern 2019. Available from: https://www.who.int/news-room/detail/17-07-2019-ebola-outbreak-in-the-democratic-republic-of-the-congo-declared-a-public-health-emergency-of-international-concern.
- WHO. Ebola virus disease – Republic of Uganda 2019. Available from: https://www.who.int/csr/don/13-june-2019-ebola-uganda/en/.
- Van Norman GA. Expanding patient access to investigational new drugs: overview of intermediate and widespread treatment investigational new drugs, and emergency authorization in public health Emergencies. JACC Basic Transl Sci. 2018;3(3):403–414. doi: 10.1016/j.jacbts.2018.02.001
- WHO. Workshop on expanded access to experimental Ebola vaccines during outbreaks. 2017.
- Callaway E. ‘Make Ebola a thing of the past’: first vaccine against deadly virus approved. Nature. 2019;575(7783):425–426. doi: 10.1038/d41586-019-03490-8
- First FDA-approved vaccine for the prevention of Ebola virus disease, marking a critical milestone in public health preparedness and response [Internet]. 2019. Available from: https://www.fda.gov/news-events/press-announcements/first-fda-approved-vaccine-prevention-ebola-virus-disease-marking-critical-milestone-public-health
- Ebola Vaccine Trial (Ad26.ZEBOV/MVA-BN-Filo) [Internet]. 2019. Available from: https://clinicaltrials.gov/ct2/show/NCT04028349.
- Lamontagne F, Fowler RA, Adhikari NK, et al. Evidence-based guidelines for supportive care of patients with Ebola virus disease. Lancet. 2018;391(10121):700–708. doi: 10.1016/S0140-6736(17)31795-6
- Uyeki TM, Mehta AK, Davey RT, Jr, et al. Clinical management of Ebola virus disease in the United States and Europe. N Engl J Med. 2016;374(7):636–646.
- Fischer WA, 2nd, Crozier I, Bausch DG, et al. Shifting the paradigm — applying universal standards of care to Ebola virus disease. N Engl J Med. 2019;380(15):1389–1391. doi: 10.1056/NEJMp1817070
- Richardson ET, Fallah MP. The genesis of the Ebola virus outbreak in West Africa. Lancet Infect Dis. 2019;19(4):348–349. doi: 10.1016/S1473-3099(19)30055-6
- Rojek A, Horby P, Dunning J. Insights from clinical research completed during the West Africa Ebola virus disease epidemic. Lancet Infect Dis. 2017;17(9):e280–e292. doi: 10.1016/S1473-3099(17)30234-7
- Center NIoHC. Investigational therapeutics for the treatment of people with Ebola virus disease. 2018.
- Friedrich MJ. Multidrug Ebola trial underway in Democratic Republic of Congo. JAMA. 2019;321(7):637.
- Mulangu S, Dodd LE, Davey RT, Jr, et al. A randomized, controlled trial of Ebola virus disease therapeutics. N Engl J Med. 2019;381(24):2293–2303.
- Orphan drug designations and approvals [Internet]. 2019. Available from: https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=714619
- Pigott DM, Millear AI, Earl L, et al. Updates to the zoonotic niche map of Ebola virus disease in Africa. Elife. 2016;5:e16412. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945152/pdf/elife-16412.pdf doi: 10.7554/eLife.16412
- WHO. World Health Organization model list of essential in vitro diagnostics. 2018.
- Broadhurst MJ, Kelly JD, Miller A, et al. ReEBOV Antigen Rapid Test Kit for point-of-care and laboratory-based testing for Ebola virus disease: a field validation study. Lancet. 2015;386(9996):867–874. doi: 10.1016/S0140-6736(15)61042-X
- Jean Louis F, Huang JY, Nebie YK, et al. Implementation of broad screening with Ebola rapid diagnostic tests in Forecariah, Guinea. Afr J Lab Med. 2017;6(1):484. doi: 10.4102/ajlm.v6i1.484
- FDA allows marketing of first rapid diagnostic test for detecting Ebola virus antigens [Internet]. 2019. Available from: https://www.fda.gov/news-events/press-announcements/fda-allows-marketing-first-rapid-diagnostic-test-detecting-ebola-virus-antigens
- Albert H, Nathavitharana RR, Isaacs C, et al. Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better? Eur Respir J. 2016;48(2):516–525. doi: 10.1183/13993003.00543-2016
- Bulabula ANH, Nelson JA, Musafiri EM, et al. Prevalence, predictors, and successful treatment outcomes of Xpert MTB/RIF-identified Rifampicin-resistant tuberculosis in post-conflict Eastern Democratic Republic of the Congo, 2012-2017: a retrospective province-wide cohort study. Clin Infect Dis. 2019;69(8):1278–1287. doi: 10.1093/cid/ciy1105
- Kayomo MK, Hasker E, Aloni M, et al. Outbreak of tuberculosis and multidrug-resistant tuberculosis, Mbuji-Mayi Central Prison, Democratic Republic of the Congo. Emerg Infect Dis. 2018;24(11):2029–2035. doi: 10.3201/eid2411.180769
- Cazabon D, Pande T, Kik S, et al. Market penetration of Xpert MTB/RIF in high tuberculosis burden countries: a trend analysis from 2014 – 2016. Gates Open Res. 2018;2:35. doi: 10.12688/gatesopenres.12842.1
- Ebola virus disease – Democratic Republic of the Congo [Internet]. 2018. Available from: https://www.who.int/csr/don/4-august-2018-ebola-drc/en/
- Spengler JR, Ervin ED, Towner JS, et al. Perspectives on West Africa Ebola virus disease outbreak, 2013-2016. Emerg Infect Dis. 2016;22(6):956–963. doi: 10.3201/eid2206.160021