References
- Martin JSH, Monaghan TM, Wilcox MH. Clostridium difficile infection: epidemiology, diagnosis and understanding transmission. Nat Rev Gastroenterol Hepatol. 2016;13:206–216. Available from: http://search.proquest.com/docview/1777078996/. doi: 10.1038/nrgastro.2016.25
- Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431–455. Available from: http://www.jstor.org/stable/10.1086/651706.
- Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372:825–834. Available from: https://doi.org/10.1056/NEJMoa1408913.
- Janoir C, Denève C, Bouttier S, et al. Adaptive Strategies and pathogenesis of Clostridium difficile from In vivo transcriptomics. Infect Immun. 2013;81:3757–3769. Available from: https://iai.asm.org/content/81/10/3757. doi: 10.1128/IAI.00515-13
- Rupnik M, Janezic S. An update on Clostridium difficile toxinotyping. J Clin Microbiol. 2016;54:13–18. Available from: https://jcm.asm.org/content/54/1/13. doi: 10.1128/JCM.02083-15
- Carter GP, Rood JI, Lyras D. The role of toxin A and toxin B in the virulence of Clostridium difficile. Trends Microbiol. 2012;20:21–29. Available from: http://www.sciencedirect.com/science/article/pii/S0966842X1100196X. doi: 10.1016/j.tim.2011.11.003
- Luo Y, Cheong E, Bian Q, et al. Different molecular characteristics and antimicrobial resistance profiles of Clostridium difficile in the Asia-Pacific region. Emerg Microbes Infect. 2019;8:1553–1562. Available from: https://doi.org/10.1080/22221751.2019.1682472.
- Gerding DN, Johnson S, Rupnik M, et al. Clostridium difficile binary toxin CDT. Gut Microbes. 2014;5:15–27. Available from: https://doi.org/10.4161/gmic.26854.
- Peng Z, Addisu A, Alrabaa S, et al. Antibiotic resistance and toxin production of Clostridium difficile isolates from the hospitalized patients in a large hospital in Florida. Front Microbiol. 2017;8:2584. Available from: https://www.frontiersin.org/article/10.3389/fmicb.2017.02584.
- Setlow P. Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals. J Appl Microbiol. 2006;101:514–525. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2672.2005.02736.x.
- Rodriguez-Palacios A, LeJeune JT. Moist-heat resistance, spore aging, and superdormancy in Clostridium difficile. Appl Environ Microbiol. 2011;77:3085–3091. Available from: https://aem.asm.org/content/77/9/3085. doi: 10.1128/AEM.01589-10
- Deakin LJ, Clare S, Fagan RP, et al. The Clostridium difficile spo0A gene is a persistence and transmission factor. Infect Immun. 2012;80:2704–2711. Available from: https://iai.asm.org/content/80/8/2704. doi: 10.1128/IAI.00147-12
- Higgins D, Dworkin J. Recent progress in Bacillus subtilis sporulation. FEMS Microbiol Rev. 2012;36:131–148. Available from: https://doi.org/10.1111/j.1574-6976.2011.00310.x.
- Zhu D, Sorg JA, Sun X. Clostridioides difficile biology: sporulation, germination, and corresponding therapies for C. difficile infection. Front Cell Infect Microbiol. 2018;8:29. Available from: https://www.frontiersin.org/article/10.3389/fcimb.2018.00029.
- Leffler DA, Lamont JT. Clostridium difficile infection. N Engl J Med. 2015;372:1539–1548. Available from: https://doi.org/10.1056/NEJMra1403772.
- Britton RA, Young VB. Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. Trends Microbiol. 2012;20:313–319. Available from: http://www.sciencedirect.com/science/article/pii/S0966842X12000649. doi: 10.1016/j.tim.2012.04.001
- Sorg JA, Sonenshein AL. Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol. 2008;190:2505–2512. Available from: https://jb.asm.org/content/190/7/2505. doi: 10.1128/JB.01765-07
- Zidaric V, Rupnik M. Sporulation properties and antimicrobial susceptibility in endemic and rare Clostridium difficile PCR ribotypes. Anaerobe. 2016;39:183–188. Available from: http://www.sciencedirect.com/science/article/pii/S1075996416300373. doi: 10.1016/j.anaerobe.2016.04.010
- Cheng VCC, Yam WC, Lam OTC, et al. Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong. Eur J Clin Microbiol Infect Dis. 2011;30:1371. Available from: https://doi.org/10.1007/s10096-011-1231-0.
- Warny M, Pepin J, Fang A, et al. Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe. Lancet. 2005;366:1079–1084. Available from: http://www.sciencedirect.com/science/article/pii/S014067360567420X. doi: 10.1016/S0140-6736(05)67420-X
- Akerlund T, Persson I, Unemo M, et al. Increased sporulation rate of epidemic Clostridium difficile type 027/NAP1. J Clin Microbiol. 2008;46:1530–1533. Available from: https://jcm.asm.org/content/46/4/1530. doi: 10.1128/JCM.01964-07
- He M, Miyajima F, Roberts P, et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet. 2013;45:109–113. doi: 10.1038/ng.2478
- Freeman J, Bauer MP, Baines SD, et al. The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev. 2010;23:529–549. Available from: https://cmr.asm.org/content/23/3/529. doi: 10.1128/CMR.00082-09
- Davies KA, Longshaw CM, Davis GL, et al. Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID). Lancet Infect Dis. 2014;14:1208–1219. Available from: http://www.sciencedirect.com/science/article/pii/S1473309914709910. doi: 10.1016/S1473-3099(14)70991-0
- Tenover FC, Akerlund T, Gerding DN, et al. Comparison of strain typing results for Clostridium difficile isolates from North America. J Clin Microbiol. 2011;49:1831–1837. Available from: https://jcm.asm.org/content/49/5/1831. doi: 10.1128/JCM.02446-10
- Ahmetagic S, Salkic N, Ahmetagic A, et al. Clostridium difficile infection in hospitalized patients at university clinical center Tuzla, Bosnia and Herzegovina: a 4 year experience. Mater Sociomed. 2013;25:153–157. doi: 10.5455/msm.2013.25.153-157
- Rupnik M, Beigot Glaser S, Andlovic A, et al. Diversity of C. difficile PCR ribotypes isolated from hospitalised patients in Slovenia during two-winter-month period. Zdr Vestn. 2013;82:739–745.
- Archives TN. Public Health England. Clostridium difficile Ribotyping Network (CDRN) for England and Northern Ireland 2011–2013 report. 2014.
- Hensgens MPM, Goorhuis A, van Kinschot CMJ, et al. Clostridium difficile infection in an endemic setting in the Netherlands. Eur J Clin Microbiol Infect Dis. 2011;30:587–593. Available from: https://doi.org/10.1007/s10096-010-1127-4.
- Bacci S, Mølbak K, Kjeldsen M, et al. Binary toxin and death after Clostridium difficile infection. Emerg Infect Dis. 2011;17:976–982. doi: 10.3201/eid/1706.101483
- Kuehne SA, Collery MM, Kelly ML, et al. Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain. J Infect Dis. 2014;209:83–86. Available from: https://doi.org/10.1093/infdis/jit426.
- Waslawski S, Lo ES, Ewing S, et al. Clostridium difficile ribotype diversity at six health care institutions in the United States. J Clin Microbiol. 2013;51:1938–1941. doi: 10.1128/JCM.00056-13
- Foster NF, Collins DA, Ditchburn SL, et al. Epidemiology of Clostridium difficile infection in two tertiary-care hospitals in Perth, Western Australia: a cross-sectional study. New Microbes New Infect. 2014;2:64–71. Available from: http://www.sciencedirect.com/science/article/pii/S2052297514500509. doi: 10.1002/nmi2.43
- Herbert R, Hatcher J, Jauneikaite E, et al. Two-year analysis of Clostridium difficile ribotypes associated with increased severity. J Hosp Infect. 2019;103:388–394. Available from: http://www.sciencedirect.com/science/article/pii/S019567011930252X. doi: 10.1016/j.jhin.2019.06.003
- Collins DA, Hawkey PM, Riley T V. Epidemiology of Clostridium difficile infection in Asia. Antimicrob Resist Infect Control. 2013;2:21. Available from: https://doi.org/10.1186/2047-2994-2-21.
- Sawabe E, Kato H, Osawa K, et al. Molecular analysis of Clostridium difficile at a university teaching hospital in Japan: A shift in the predominant type over a five-year period. Eur J Clin Microbiol Infect Dis. 2007;26:695–703. doi: 10.1007/s10096-007-0355-8
- Ryu HS, Kim YS, Seo GS, et al. Risk factors for recurrent Clostridium difficile infection. Intest Res. 2012;10:176–182. Available from: http://www.irjournal.org/journal/view.php?number=594. doi: 10.5217/ir.2012.10.2.176
- Wei HL, Kao CW, Wei SH, et al. Comparison of PCR ribotyping and multilocus variable-number tandem-repeat analysis (MLVA) for improved detection of Clostridium difficile. BMC Microbiol. 2011;11:217. Available from: https://doi.org/10.1186/1471-2180-11-217.
- Cheng VCC, Yam WC, Chan JFW, et al. Clostridium difficile ribotype 027 arrives in Hong Kong. Int J Antimicrob Agents. 2009;34:492–493. Available from: http://www.sciencedirect.com/science/article/pii/S0924857909001939. doi: 10.1016/j.ijantimicag.2009.04.004
- Lim P L, Ling ML, Lee HY, et al. Isolation of the first three cases of Clostridium difficile polymerase chain reaction ribotype 027 in Singapore. Singapore Med J. 2011;52:361–364.
- Kato H, Ito Y, van den Berg R, et al. First isolation of Clostridium difficile 027 in Japan. Wkly Releases. 2007;12. Available from: https://www.eurosurveillance.org/content/10.2807/esw.12.02.03110-en.
- Wong SH, Ip M, Hawkey PM, et al. High morbidity and mortality of Clostridium difficile infection and its associations with ribotype 002 in Hong Kong. J Infect. 2016;73:115–122. Available from: http://www.sciencedirect.com/science/article/pii/S0163445316300950. doi: 10.1016/j.jinf.2016.05.010
- Furuya-Kanamori L, Riley TV, Paterson DL, et al. Comparison of Clostridium difficile ribotypes circulating in Australian hospitals and communities. J Clin Microbiol. 2017;55:216–225. Available from: https://jcm.asm.org/content/55/1/216. doi: 10.1128/JCM.01779-16
- Chow V, Kwong T, So E, et al. Surveillance of antibiotic resistance among common Clostridium difficile ribotypes in Hong Kong. Sci Rep. 2017;7:17218. doi: 10.1038/s41598-017-17523-7
- Edwards AN, Suárez JM, Mcbride SM. Culturing and maintaining Clostridium difficile in an anaerobic environment. J Vis Exp. 2013. Available from: http://dx.doi.org/10.3791/50787.
- Sorg JA, Dineen SS. Laboratory maintenance of Clostridium difficile. Curr Protoc Microbiol. 2009. Available from: https://doi.org/10.1002/9780471729259.mc09a01s12.
- Burns DA, Minton NP. Sporulation studies in Clostridium difficile. J Microbiol Methods. 2011;87:133–138. Available from: http://www.sciencedirect.com/science/article/pii/S016770121100282X. doi: 10.1016/j.mimet.2011.07.017
- Heeg D, Burns DA, Cartman ST, et al. Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts. PLoS One. 2012;7:1–9. Available from: https://doi.org/10.1371/journal.pone.0032381.
- Burns DA, Heap JT, Minton NP. Slec is essential for germination of Clostridium difficile spores in nutrient-rich medium supplemented with the bile salt taurocholate. J Bacteriol. 2010;192:657–664. Available from: https://jb.asm.org/content/192/3/657. doi: 10.1128/JB.01209-09
- Collery MM, Kuehne SA, Mcbride SM, et al. What’s a SNP between friends: the influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives. Virulence. 2017;8:767–781. doi: 10.1080/21505594.2016.1237333
- Reeves AE, Theriot CM, Bergin IL, et al. The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile infection. Gut Microbes. 2011;2:145–158. doi: 10.4161/gmic.2.3.16333
- Theriot CM, Koumpouras CC, Carlson PE, et al. Cefoperazone-treated mice as an experimental platform to assess differential virulence of Clostridium difficile strains. Gut Microbes. 2011;2:326–334. doi: 10.4161/gmic.19142
- Ghose C. Clostridium difficile infection in the twenty-first century. Emerg Microbes Infect. 2013;2:1–8. Available from: https://doi.org/10.1038/emi.2013.62.
- Fawley WN, Underwood S, Freeman J, et al. Efficacy of hospital cleaning agents and germicides against epidemic Clostridium difficile strains. Infect Control Hosp Epidemiol. 2007;28:920–925. doi: 10.1086/519201
- Wilcox MH, Fawley WN. Hospital disinfectants and spore formation by Clostridium difficile. Lancet. 2000;356:1324. Available from: http://www.sciencedirect.com/science/article/pii/S0140673600028191. doi: 10.1016/S0140-6736(00)02819-1
- Merrigan M, Venugopal A, Mallozzi M, et al. Human hypervirulent Clostridium difficile strains exhibit increased sporulation as well as robust toxin production. J Bacteriol. 2010;192:4904–4911. Available from: https://jb.asm.org/content/192/19/4904. doi: 10.1128/JB.00445-10
- Ramirez N, Liggins M, Abel-Santos E. Kinetic evidence for the presence of putative germination receptors in Clostridium difficile spores. J Bacteriol. 2010;192:4215–4222. Available from: https://jb.asm.org/content/192/16/4215. doi: 10.1128/JB.00488-10
- Oka K, Osaki T, Hanawa T, et al. Molecular and microbiological characterization of Clostridium difficile isolates from single, relapse, and reinfection cases. J Clin Microbiol. 2012;50:915–921. Available from: https://jcm.asm.org/content/50/3/915. doi: 10.1128/JCM.05588-11